Obesity and the risk of primary liver cancer: A systematic review and meta-analysis

Background/Aims: In this systematic review and meta-analysis, we aimed to clarify the effect of obesity on the occurrence of and mortality from primary liver cancer.Methods: This study was conducted using a systematic literature search of MEDLINE, EMBASE, and the Cochrane Library until November 2018...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical and molecular hepatology Jg. 27; H. 1; S. 157 - 174
Hauptverfasser: Sohn, Won, Lee, Hyun Woong, Lee, Sangheun, Lim, Jin Hong, Lee, Min Woo, Park, Chan Hyuk, Yoon, Seung Kew
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Korea (South) Korean Association for the Study of the Liver 01.01.2021
The Korean Association for the Study of the Liver
대한간학회
Schlagworte:
Body mass index
carcinoma, hepatocellular
Liver cancer
Mortality
Obesity
Original
risk
내과학
United States > US
Liver cancer
Obesity
Risk
Carcinoma, Hepatocellular
Mortality
ISSN:2287-2728, 2287-285X, 2287-285X
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background/Aims: In this systematic review and meta-analysis, we aimed to clarify the effect of obesity on the occurrence of and mortality from primary liver cancer.Methods: This study was conducted using a systematic literature search of MEDLINE, EMBASE, and the Cochrane Library until November 2018 using the primary keywords “obesity,” “overweight,” “body mass index (BMI),” “body weight,” “liver,” “cancer,” “hepatocellular carcinoma,” “liver cancer,” “risk,” and “mortality.” Studies assessing the relationship between BMI and occurrence of or mortality from primary liver cancer in prospective cohorts and those reporting hazard ratios (HRs) or data that allow HR estimation were included.Results: A total of 28 prospective cohort studies with 8,135,906 subjects were included in the final analysis. These included 22 studies with 6,059,561 subjects for cancer occurrence and seven studies with 2,077,425 subjects for cancerrelated mortality. In the meta-analysis, an increase in BMI was associated with the occurrence of primary liver cancer (HR, 1.69; 95% confidence interval, 1.50–1.90, I2=56%). A BMI-dependent increase in the risk of occurrence of primary liver cancer was reported. HRs were 1.36 (95% CI, 1.02–1.81), 1.77 (95% CI, 1.56–2.01), and 3.08 (95% CI, 1.21–7.86) for BMI >25 kg/m2, >30 kg/m2, and >35 kg/m2, respectively. Furthermore, increased BMI resulted in enhanced liver cancer-related mortality (HR, 1.61; 95% CI, 1.14–2.27, I2=80%).Conclusions: High BMI increases liver cancer mortality and occurrence of primary liver cancer. Obesity is an independent risk factor for the occurrence of and mortality from primary liver cancer.
Bibliographie:SourceType-Scholarly Journals-1
content type line 14
ObjectType-Evidence Based Healthcare-1
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
These authors contributed equally to this work.
Editor: Naoshi Nishida, Kindai University, Japan
ISSN:2287-2728
2287-285X
2287-285X
DOI:10.3350/cmh.2020.0176