Vision Loss after Intravitreal Injection of Autologous “Stem Cells” for AMD

In three women with age-related macular degeneration and with visual acuity ranging from 20/30 to 20/200 before they received bilateral intravitreal injection of autologous “stem cells,” blinding complications developed in each of their eyes. Age-related macular degeneration (AMD) is the leading cau...

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Vydáno v:	The New England journal of medicine Ročník 376; číslo 11; s. 1047 - 1053
Hlavní autoři:	Kuriyan, Ajay E, Albini, Thomas A, Townsend, Justin H, Rodriguez, Marianeli, Pandya, Hemang K, Leonard, Robert E, Parrott, M. Brandon, Rosenfeld, Philip J, Flynn, Harry W, Goldberg, Jeffrey L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Massachusetts Medical Society 16.03.2017
Edice:	Brief Report
Témata:	Acuity Adipose tissue Adipose Tissue - cytology Adipose Tissue - transplantation Aged Aged, 80 and over Autografts Blindness - etiology Bone marrow Clinical trials Clinics Dislocation Edema Enzymes FDA approval Female Hemorrhage Humans Injection Injections Macular degeneration Macular Degeneration - therapy Patients Retina Retinal Detachment - etiology Retinopathy Stem Cell Transplantation - adverse effects Stem cells Transplantation, Autologous - adverse effects Ultrasonic imaging Vision Disorders - etiology Visual Acuity United States > US
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line přístup:	Získat plný text
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Abstract	In three women with age-related macular degeneration and with visual acuity ranging from 20/30 to 20/200 before they received bilateral intravitreal injection of autologous “stem cells,” blinding complications developed in each of their eyes. Age-related macular degeneration (AMD) is the leading cause of vision loss in persons older than 75 years of age in the United States. 1 Progressive dysfunction and loss of retinal pigment epithelium cells and photoreceptors lead to poor visual acuity in patients with non-neovascular AMD. 2 The potential role of delivering subretinal human retinal pigment epithelium, photoreceptor cells, or both, differentiated from pluripotent stem cells, to replace the damaged cells in patients with non-neovascular AMD is being investigated in several clinical trials registered by the Food and Drug Administration (FDA) and approved by institutional review boards. 3 As of November 2, 2016, at . . .
AbstractList	Adipose tissue-derived "stem cells" have been increasingly used by "stem-cell clinics" in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells" at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. The patients' severe visual loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens dislocation. After 1 year, the patients' visual acuity ranged from 20/200 to no light perception. Adipose tissue-derived "stem cells" have been increasingly used by "stem-cell clinics" in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells" at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. The patients' severe visual loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens dislocation. After 1 year, the patients' visual acuity ranged from 20/200 to no light perception.Adipose tissue-derived "stem cells" have been increasingly used by "stem-cell clinics" in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells" at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. The patients' severe visual loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens dislocation. After 1 year, the patients' visual acuity ranged from 20/200 to no light perception. In three women with age-related macular degeneration and with visual acuity ranging from 20/30 to 20/200 before they received bilateral intravitreal injection of autologous “stem cells,” blinding complications developed in each of their eyes. Age-related macular degeneration (AMD) is the leading cause of vision loss in persons older than 75 years of age in the United States. 1 Progressive dysfunction and loss of retinal pigment epithelium cells and photoreceptors lead to poor visual acuity in patients with non-neovascular AMD. 2 The potential role of delivering subretinal human retinal pigment epithelium, photoreceptor cells, or both, differentiated from pluripotent stem cells, to replace the damaged cells in patients with non-neovascular AMD is being investigated in several clinical trials registered by the Food and Drug Administration (FDA) and approved by institutional review boards. 3 As of November 2, 2016, at . . .
Author	Townsend, Justin H Flynn, Harry W Leonard, Robert E Rosenfeld, Philip J Kuriyan, Ajay E Albini, Thomas A Rodriguez, Marianeli Goldberg, Jeffrey L Pandya, Hemang K Parrott, M. Brandon
Author_xml	– sequence: 1 givenname: Ajay E surname: Kuriyan fullname: Kuriyan, Ajay E organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 2 givenname: Thomas A surname: Albini fullname: Albini, Thomas A organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 3 givenname: Justin H surname: Townsend fullname: Townsend, Justin H organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 4 givenname: Marianeli surname: Rodriguez fullname: Rodriguez, Marianeli organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 5 givenname: Hemang K surname: Pandya fullname: Pandya, Hemang K organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 6 givenname: Robert E surname: Leonard fullname: Leonard, Robert E organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 7 givenname: M. Brandon surname: Parrott fullname: Parrott, M. Brandon organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 8 givenname: Philip J surname: Rosenfeld fullname: Rosenfeld, Philip J organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 9 givenname: Harry W surname: Flynn fullname: Flynn, Harry W organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.) – sequence: 10 givenname: Jeffrey L surname: Goldberg fullname: Goldberg, Jeffrey L organization: From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) — both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.)
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28296617$$D View this record in MEDLINE/PubMed
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Snippet	In three women with age-related macular degeneration and with visual acuity ranging from 20/30 to 20/200 before they received bilateral intravitreal injection... Adipose tissue-derived "stem cells" have been increasingly used by "stem-cell clinics" in the United States and elsewhere to treat a variety of disorders. We... Adipose tissue–derived “stem cells” have been increasingly used by “stem-cell clinics” in the United States and elsewhere to treat a variety of disorders. We...
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SubjectTerms	Acuity Adipose tissue Adipose Tissue - cytology Adipose Tissue - transplantation Aged Aged, 80 and over Autografts Blindness - etiology Bone marrow Clinical trials Clinics Dislocation Edema Enzymes FDA approval Female Hemorrhage Humans Injection Injections Macular degeneration Macular Degeneration - therapy Patients Retina Retinal Detachment - etiology Retinopathy Stem Cell Transplantation - adverse effects Stem cells Transplantation, Autologous - adverse effects Ultrasonic imaging Vision Disorders - etiology Visual Acuity
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Title	Vision Loss after Intravitreal Injection of Autologous “Stem Cells” for AMD
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