High-performance modified cellulose paper-based biosensors for medical diagnostics and early cancer screening: A concise review

[Display omitted] •Progress in the development of cellulose paper-based biosensors (PBB) is reviewed.•Nanomaterial-enhanced performance of paper-based devices is analysed.•Advances in microfluidic paper-based devices (μPADs) are evaluated.•Utilization of PBBs and μPADs for cancer biomarkers detectio...

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Bibliographic Details
Published in:Carbohydrate polymers Vol. 229; p. 115463
Main Authors: Ratajczak, Katarzyna, Stobiecka, Magdalena
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.02.2020
Subjects:
antibodies
Antibodies, Immobilized - immunology
Biomarkers, Tumor - blood
Biomarkers, Tumor - immunology
biopolymers
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
biosensors
Cancer biomarkers
Cancer screening
Cellulose
Cellulose - chemistry
Diagnostic applications
diagnostic techniques
Early Detection of Cancer - instrumentation
Early Detection of Cancer - methods
Humans
Immunoassay - instrumentation
Immunoassay - methods
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Microfluidic paper-based analytical devices (μPAD)
micropores
nanomaterials
Nanostructures - chemistry
neoplasms
Neoplasms - diagnosis
nucleic acids
Paper-based biosensors (PBBs)
screening
Cancer biomarkers
Paper-based biosensors (PBBs)
Diagnostic applications
Microfluidic paper-based analytical devices (μPAD)
Cellulose
Cancer screening
ISSN:0144-8617, 1879-1344, 1879-1344
Online Access:Get full text
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Summary:[Display omitted] •Progress in the development of cellulose paper-based biosensors (PBB) is reviewed.•Nanomaterial-enhanced performance of paper-based devices is analysed.•Advances in microfluidic paper-based devices (μPADs) are evaluated.•Utilization of PBBs and μPADs for cancer biomarkers detection is assessed. A remarkable progress in the development of portable paper-based biosensors (PBBs) and microfluidic paper-based analytical devices (μPADs) has recently been achieved. In these devices, a paper formed of microfibers of cellulose, a carbohydrate biopolymer, offers both an ample space in its micropores for analytical reagents storage and a capillary force to drive liquid samples to a dedicated reaction zone for instantaneous detection of the desired analytes. Owing to the low cost and ultra-high sensitivity, these novel devices have become a promising alternative to traditional advanced analytical instruments and offer great potential for applications in medical emergencies, health diagnostics at points-of-care, and broad early-cancer screening. In this review, we focus particularly on recent important achievements in utilization of cellulose and its modifications in portable sensing devices for biomedical applications. The progress in functionalization of cellulose papers with antibodies, nucleic acids and nanomaterials in PBBs and μPADs, is discussed and critically evaluated.
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ISSN:0144-8617
1879-1344
1879-1344
DOI:10.1016/j.carbpol.2019.115463