Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 29; no. 8; p. 1824
Main Authors: Ferreira-Filho, Vital Cruvinel, Morais, Beatriz, Vieira, Bruno J. C., Waerenborgh, João Carlos, Carmezim, Maria João, Tóth, Csilla Noémi, Même, Sandra, Lacerda, Sara, Jaque, Daniel, Sousa, Célia T., Campello, Maria Paula Cabral, Pereira, Laura C. J.
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 17.04.2024
MDPI
Subjects:
Biocompatibility
Cancer therapies
Chemical Sciences
Coatings
Contrast agents
Contrast Media - chemistry
Dextrans - chemistry
Fever
gadolinium
Gadolinium - chemistry
Gold
Gold - chemistry
gold nanoparticles
Humans
Hyperthermia
Hyperthermia, Induced - methods
iron oxides nanoparticles
Magnetic Iron Oxide Nanoparticles - chemistry
Magnetic properties
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - therapeutic use
Nanomaterials
Nanoparticles
Particle Size
Peptides
Polyethylene glycol
Polymers
Spectrum analysis
superparamagnetism
Surface Properties
Theranostic Nanomedicine
Toxicity
France
iron oxides nanoparticles
hyperthermia
magnetic resonance imaging
gold nanoparticles
superparamagnetism
gadolinium
ISSN:1420-3049, 1420-3049
Online Access:Get full text
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Summary:This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.
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PMCID: PMC11052394
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29081824