Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis

Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neu...

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Vydáno v:Journal of neuroimmunology Ročník 300; s. 11 - 14
Hlavní autoři: Kalinowska-Łyszczarz, Alicja, Michalak, Sławomir, Pawlak, Mikołaj A., Losy, Jacek, Kozubski, Wojciech
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 15.11.2016
Témata:
Adult
Allergy and Immunology
Biomarkers
Biomarkers - blood
Cohort Studies
Disease Progression
Female
Follow-Up Studies
Human Vascular Cell Adhesion Molecule-1 (VCAM-1)
Humans
Male
Multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - diagnosis
Neurology
Neuromyelitis optica
Optic neuritis
Optic Neuritis - blood
Optic Neuritis - diagnosis
Pilot Projects
Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)
Platelet Endothelial Cell Adhesion Molecule-1 - blood
Retrospective Studies
Vascular Cell Adhesion Molecule-1 - blood
Young Adult
Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)
Biomarkers
Multiple sclerosis
Neuromyelitis optica
Human Vascular Cell Adhesion Molecule-1 (VCAM-1)
Optic neuritis
ISSN:0165-5728, 1872-8421, 1872-8421
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Shrnutí:Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (−) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident. •Serum levels of PECAM-1 and VCAM-1 could correlate with the risk of progression to MS after first optic neuritis incident.•sPECAM-1 and sVCAM-1 levels during first optic neuritis are lower in subjects progressing to MS in a 7-year follow-up.•In our cohort only 2 out of 5 AQP4-IgG (+) optic neuritis patients developed clinically definite NMO in a 7-year follow-up.•Although AQP4-IgGs are considered highly NMO-specific, it remains uncertain if they may appear in other autoimmune diseases.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0165-5728
1872-8421
1872-8421
DOI:10.1016/j.jneuroim.2016.10.003