Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis

Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neu...

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Veröffentlicht in:	Journal of neuroimmunology Jg. 300; S. 11 - 14
Hauptverfasser:	Kalinowska-Łyszczarz, Alicja, Michalak, Sławomir, Pawlak, Mikołaj A., Losy, Jacek, Kozubski, Wojciech
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 15.11.2016
Schlagworte:	Adult Allergy and Immunology Biomarkers Biomarkers - blood Cohort Studies Disease Progression Female Follow-Up Studies Human Vascular Cell Adhesion Molecule-1 (VCAM-1) Humans Male Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - diagnosis Neurology Neuromyelitis optica Optic neuritis Optic Neuritis - blood Optic Neuritis - diagnosis Pilot Projects Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Platelet Endothelial Cell Adhesion Molecule-1 - blood Retrospective Studies Vascular Cell Adhesion Molecule-1 - blood Young Adult Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Biomarkers Multiple sclerosis Neuromyelitis optica Human Vascular Cell Adhesion Molecule-1 (VCAM-1) Optic neuritis
ISSN:	0165-5728, 1872-8421, 1872-8421
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Abstract	Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (−) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident. •Serum levels of PECAM-1 and VCAM-1 could correlate with the risk of progression to MS after first optic neuritis incident.•sPECAM-1 and sVCAM-1 levels during first optic neuritis are lower in subjects progressing to MS in a 7-year follow-up.•In our cohort only 2 out of 5 AQP4-IgG (+) optic neuritis patients developed clinically definite NMO in a 7-year follow-up.•Although AQP4-IgGs are considered highly NMO-specific, it remains uncertain if they may appear in other autoimmune diseases.
AbstractList	Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (-) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident. Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (−) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident. •Serum levels of PECAM-1 and VCAM-1 could correlate with the risk of progression to MS after first optic neuritis incident.•sPECAM-1 and sVCAM-1 levels during first optic neuritis are lower in subjects progressing to MS in a 7-year follow-up.•In our cohort only 2 out of 5 AQP4-IgG (+) optic neuritis patients developed clinically definite NMO in a 7-year follow-up.•Although AQP4-IgGs are considered highly NMO-specific, it remains uncertain if they may appear in other autoimmune diseases. Abstract Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (−) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident. Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (-) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident.Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (-) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident.
Author	Kozubski, Wojciech Michalak, Sławomir Losy, Jacek Pawlak, Mikołaj A. Kalinowska-Łyszczarz, Alicja
Author_xml	– sequence: 1 givenname: Alicja surname: Kalinowska-Łyszczarz fullname: Kalinowska-Łyszczarz, Alicja email: akalinowskalyszczarz@ump.edu.pl organization: Division of Neurochemistry and Neuropathology, Department of Neurology, Poznan University of Medical Sciences, 49, Przybyszewskiego st., 60-355 Poznan, Poland – sequence: 2 givenname: Sławomir surname: Michalak fullname: Michalak, Sławomir organization: Division of Neurochemistry and Neuropathology, Department of Neurology, Poznan University of Medical Sciences, 49, Przybyszewskiego st., 60-355 Poznan, Poland – sequence: 3 givenname: Mikołaj A. surname: Pawlak fullname: Pawlak, Mikołaj A. organization: Department of Neurology and Cerebrovascular Disorders, Poznan University of Medical Sciences, 34, Dojazd st., 60-631 Poznan, Poland – sequence: 4 givenname: Jacek surname: Losy fullname: Losy, Jacek email: jlosy@ump.edu.pl organization: Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland – sequence: 5 givenname: Wojciech surname: Kozubski fullname: Kozubski, Wojciech email: wkozubski@ump.edu.pl organization: Department of Neurology, Poznan University of Medical Sciences, 49, Przybyszewskiego st., 60-355 Poznan, Poland
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27806869$$D View this record in MEDLINE/PubMed
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CitedBy_id	crossref_primary_10_1007_s11011_018_0224_4 crossref_primary_10_1186_s12974_019_1482_8 crossref_primary_10_1515_revneuro_2019_0084 crossref_primary_10_3390_jcm11051215 crossref_primary_10_1007_s11910_022_01227_1 crossref_primary_10_1002_acn3_51167
Cites_doi	10.1016/j.jocn.2013.06.013 10.1146/annurev-pathol-011110-130224 10.1001/archneur.57.4.546 10.1001/archneurol.2011.148 10.1007/s00401-015-1417-0 10.1016/j.tracli.2008.04.002 10.1007/s11910-007-0036-0 10.1016/S1474-4422(07)70216-8 10.1007/s10384-005-0281-1 10.1212/WNL.56.10.1319 10.1212/WNL.0000000000001729 10.4049/jimmunol.170.11.5704 10.1002/ana.22366 10.1136/jnnp-2013-305907 10.1016/j.jneuroim.2005.06.019 10.1016/S0165-5728(99)00092-2
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Keywords	Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Biomarkers Multiple sclerosis Neuromyelitis optica Human Vascular Cell Adhesion Molecule-1 (VCAM-1) Optic neuritis
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Snippet	Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction.... Abstract Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial...
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SubjectTerms	Adult Allergy and Immunology Biomarkers Biomarkers - blood Cohort Studies Disease Progression Female Follow-Up Studies Human Vascular Cell Adhesion Molecule-1 (VCAM-1) Humans Male Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - diagnosis Neurology Neuromyelitis optica Optic neuritis Optic Neuritis - blood Optic Neuritis - diagnosis Pilot Projects Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Platelet Endothelial Cell Adhesion Molecule-1 - blood Retrospective Studies Vascular Cell Adhesion Molecule-1 - blood Young Adult
Title	Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis
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