Risk of Long COVID in People Infected With Severe Acute Respiratory Syndrome Coronavirus 2 After 2 Doses of a Coronavirus Disease 2019 Vaccine: Community-Based, Matched Cohort Study

Abstract We investigated long COVID incidence by vaccination status in a random sample of UK adults from April 2020 to November 2021. Persistent symptoms were reported by 9.5% of 3090 breakthrough severe acute respiratory syndrome coronavirus 2 infections and 14.6% of unvaccinated controls (adjusted...

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Bibliographic Details
Published in:Open forum infectious diseases Vol. 9; no. 9; p. ofac464
Main Authors: Ayoubkhani, Daniel, Bosworth, Matthew L, King, Sasha, Pouwels, Koen B, Glickman, Myer, Nafilyan, Vahé, Zaccardi, Francesco, Khunti, Kamlesh, Alwan, Nisreen A, Walker, A Sarah
Format: Journal Article
Language:English
Published: US Oxford University Press 01.09.2022
Subjects:
Brief Report
COVID-19
coronavirus
long COVID
post-COVID condition
vaccination
ISSN:2328-8957, 2328-8957
Online Access:Get full text
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Summary:Abstract We investigated long COVID incidence by vaccination status in a random sample of UK adults from April 2020 to November 2021. Persistent symptoms were reported by 9.5% of 3090 breakthrough severe acute respiratory syndrome coronavirus 2 infections and 14.6% of unvaccinated controls (adjusted odds ratio, 0.59 [95% confidence interval, .50–.69]), emphasizing the need for public health initiatives to increase population-level vaccine uptake.
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Potential conflicts of interest. K. K. chairs the long COVID research-funded group reporting to the Chief Medical Officer, chairs the Ethnicity Subgroup of the UK Scientific Advisory Group for Emergencies (SAGE), and is a member of SAGE. All other authors report no potential conflicts.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofac464