Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non-small cell lung cancer

Innate and acquired resistance is the principle factor limiting the efficacy of tyrosine kinase inhibitors in lung cancer. We have observed a dramatic upregulation of the cell surface co-receptor neuropilin-2b in lung cancers clinically treated with tyrosine kinase inhibitors correlating with acquir...

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Bibliographic Details
Published in:	The Journal of thoracic and cardiovascular surgery Vol. 162; no. 2; p. 463
Main Authors:	Dimou, Anastasios, Nasarre, Cecile, Peterson, Yuri K, Pagano, Rose, Gooz, Monika, Nasarre, Patrick, Drabkin, Harry A, Armeson, Kent E, Gibney, Barry C, Gemmill, Robert M, Denlinger, Chadrick E
Format:	Journal Article
Language:	English
Published:	United States 01.08.2021
Subjects:	A549 Cells Acrylamides - pharmacology Aniline Compounds - pharmacology Antineoplastic Agents - pharmacology Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Movement - drug effects Cell Proliferation - drug effects Drug Resistance, Neoplasm Enzyme Activation Gefitinib - pharmacology Glycogen Synthase Kinase 3 beta - metabolism Humans Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - pathology Neoplasm Invasiveness Neuropilin-2 - genetics Neuropilin-2 - metabolism Phosphorylation Protein Kinase Inhibitors - pharmacology Proteolysis Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism lung cancer migration tyrosine kinase inhibitor resistance survival
ISSN:	1097-685X, 1097-685X
Online Access:	Get more information
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