Platelets induce epithelial to mesenchymal transition in renal proximal tubular epithelial cells through TGF-β signaling pathway

Background Management of chronic kidney disease (CKD) remains a major challenge due limited therapeutic options to reverse fibrosis, which is a critical feature in CKD. Partial epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells (TECs) is a key driver of fibrosis, and has become a...

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Bibliographic Details

Published in:	Molecular medicine (Cambridge, Mass.) Vol. 31; no. 1; pp. 318 - 17
Main Authors:	Rustiasari, Ukhti Jamil, Uil, Melissa, Zhang, Xiaomeng, Claessen, Nike, Butter, Loes, Florquin, Sandrine, Tammaro, Alessandra, Roelofs, Joris J.T.H.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 29.10.2025 BMC
Subjects:	Biomedical and Life Sciences Biomedicine Chronic kidney disease Epithelial-mesenchymal transition Fibrosis Molecular Medicine Platelets TGF-β1 Epithelial-mesenchymal transition TGF-β1 Chronic kidney disease Platelets Fibrosis
ISSN:	1528-3658, 1528-3658
Online Access:	Get full text
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