IGFBPL1 Regulates Axon Growth through IGF-1-mediated Signaling Cascades

Activation of axonal growth program is a critical step in successful optic nerve regeneration following injury. Yet the molecular mechanisms that orchestrate this developmental transition are not fully understood. Here we identified a novel regulator, insulin-like growth factor binding protein-like...

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Veröffentlicht in:	Scientific reports Jg. 8; H. 1; S. 2054 - 13
Hauptverfasser:	Guo, Chenying, Cho, Kin-Sang, Li, Yingqian, Tchedre, Kissauo, Antolik, Christian, Ma, Jie, Chew, Justin, Utheim, Tor Paaske, Huang, Xizhong A., Yu, Honghua, Malik, Muhammad Taimur A., Anzak, Nada, Chen, Dong Feng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.02.2018 Nature Publishing Group
Schlagworte:	13/106 13/109 14/19 14/28 38/89 631/378/1687 631/378/2571 82/1 96/95 Animals Axonogenesis Calcium Signaling Calcium signalling Cells, Cultured Central nervous system Humanities and Social Sciences Insulin Insulin-Like Growth Factor Binding Proteins - genetics Insulin-Like Growth Factor Binding Proteins - metabolism Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Mice Mice, Inbred C57BL Molecular modelling multidisciplinary Neuronal Outgrowth Optic nerve PC12 Cells Phosphorylation Protein Binding Rapamycin Rats Regeneration Retina Retinal ganglion cells Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Science Science (multidisciplinary) TOR protein TOR Serine-Threonine Kinases - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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