Nasal high flow clears anatomical dead space in upper airway models

Recent studies showed that nasal high flow (NHF) with or without supplemental oxygen can assist ventilation of patients with chronic respiratory and sleep disorders. The hypothesis of this study was to test whether NHF can clear dead space in two different models of the upper nasal airways. The firs...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Journal of applied physiology (1985) Ročník 118; číslo 12; s. 1525 - 1532
Hlavní autoři:	Möller, Winfried, Celik, Gülnaz, Feng, Sheng, Bartenstein, Peter, Meyer, Gabriele, Oliver, Eickelberg, Schmid, Otmar, Tatkov, Stanislav
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.06.2015
Témata:	Carbon Dioxide - metabolism Continuous Positive Airway Pressure Half-Life Humans Insufflation Krypton Radioisotopes Models, Anatomic Nasal Cavity - anatomy & histology Nasal Cavity - diagnostic imaging Nasal Cavity - physiology Radionuclide Imaging Respiratory Dead Space - physiology Respiratory Physiological Phenomena Tomography, X-Ray Computed
ISSN:	1522-1601
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Recent studies showed that nasal high flow (NHF) with or without supplemental oxygen can assist ventilation of patients with chronic respiratory and sleep disorders. The hypothesis of this study was to test whether NHF can clear dead space in two different models of the upper nasal airways. The first was a simple tube model consisting of a nozzle to simulate the nasal valve area, connected to a cylindrical tube to simulate the nasal cavity. The second was a more complex anatomically representative upper airway model, constructed from segmented CT-scan images of a healthy volunteer. After filling the models with tracer gases, NHF was delivered at rates of 15, 30, and 45 l/min. The tracer gas clearance was determined using dynamic infrared CO2 spectroscopy and 81mKr-gas radioactive gamma camera imaging. There was a similar tracer-gas clearance characteristic in the tube model and the upper airway model: clearance half-times were below 1.0 s and decreased with increasing NHF rates. For both models, the anterior compartments demonstrated faster clearance levels (half-times < 0.5 s) and the posterior sections showed slower clearance (half-times < 1.0 s). Both imaging methods showed similar flow-dependent tracer-gas clearance in the models. For the anatomically based model, there was complete tracer-gas removal from the nasal cavities within 1.0 s. The level of clearance in the nasal cavities increased by 1.8 ml/s for every 1.0 l/min increase in the rate of NHF. The study has demonstrated the fast-occurring clearance of nasal cavities by NHF therapy, which is capable of reducing of dead space rebreathing.
AbstractList	Recent studies showed that nasal high flow (NHF) with or without supplemental oxygen can assist ventilation of patients with chronic respiratory and sleep disorders. The hypothesis of this study was to test whether NHF can clear dead space in two different models of the upper nasal airways. The first was a simple tube model consisting of a nozzle to simulate the nasal valve area, connected to a cylindrical tube to simulate the nasal cavity. The second was a more complex anatomically representative upper airway model, constructed from segmented CT-scan images of a healthy volunteer. After filling the models with tracer gases, NHF was delivered at rates of 15, 30, and 45 l/min. The tracer gas clearance was determined using dynamic infrared CO2 spectroscopy and 81mKr-gas radioactive gamma camera imaging. There was a similar tracer-gas clearance characteristic in the tube model and the upper airway model: clearance half-times were below 1.0 s and decreased with increasing NHF rates. For both models, the anterior compartments demonstrated faster clearance levels (half-times < 0.5 s) and the posterior sections showed slower clearance (half-times < 1.0 s). Both imaging methods showed similar flow-dependent tracer-gas clearance in the models. For the anatomically based model, there was complete tracer-gas removal from the nasal cavities within 1.0 s. The level of clearance in the nasal cavities increased by 1.8 ml/s for every 1.0 l/min increase in the rate of NHF. The study has demonstrated the fast-occurring clearance of nasal cavities by NHF therapy, which is capable of reducing of dead space rebreathing.
Author	Oliver, Eickelberg Meyer, Gabriele Schmid, Otmar Celik, Gülnaz Möller, Winfried Tatkov, Stanislav Feng, Sheng Bartenstein, Peter
Author_xml	– sequence: 1 givenname: Winfried surname: Möller fullname: Möller, Winfried – sequence: 2 givenname: Gülnaz surname: Celik fullname: Celik, Gülnaz – sequence: 3 givenname: Sheng surname: Feng fullname: Feng, Sheng – sequence: 4 givenname: Peter surname: Bartenstein fullname: Bartenstein, Peter – sequence: 5 givenname: Gabriele surname: Meyer fullname: Meyer, Gabriele – sequence: 6 givenname: Eickelberg surname: Oliver fullname: Oliver, Eickelberg – sequence: 7 givenname: Otmar surname: Schmid fullname: Schmid, Otmar – sequence: 8 givenname: Stanislav surname: Tatkov fullname: Tatkov, Stanislav
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25882385$$D View this record in MEDLINE/PubMed
BookMark	eNo1j8tOwzAURC0Eog_4BfCSTYqvE-exRBUFpAo2sI5unGvqyolN3Kjq3xOJshppztFIs2CXve-JsXsQKwAlH_cYggu7U7TerYSo0mwlBWQXbD5RmUAuYMYWMe7F1GYKrtlMqrKUaanmbP2OER3f2e8dN84fuXaEQ-TY48F3Vk-sJWx5DKiJ256PIdDA0Q5HPPHOt-TiDbsy6CLdnnPJvjbPn-vXZPvx8rZ-2iZaARySVJYpYSMqKYpcZ2gKamSZT0GZEaAaIRrCoiGQICWgNMaQzvJSV6hIkFyyh7_dMPifkeKh7mzU5Bz25MdYQyGyVEFeVpN6d1bHpqO2DoPtcDjV_8flL93BXek
CitedBy_id	crossref_primary_10_3390_jcm12072663 crossref_primary_10_1055_a_2381_1408 crossref_primary_10_1111_anae_14036 crossref_primary_10_1513_AnnalsATS_201801_009ED crossref_primary_10_1152_japplphysiol_00692_2022 crossref_primary_10_3390_healthcare10030536 crossref_primary_10_7759_cureus_43063 crossref_primary_10_1016_j_resp_2015_06_011 crossref_primary_10_1002_ppul_23664 crossref_primary_10_1016_j_chest_2024_12_021 crossref_primary_10_1007_s10439_019_02377_z crossref_primary_10_1111_resp_13435 crossref_primary_10_1111_resp_13677 crossref_primary_10_1164_rccm_202201_0065OC crossref_primary_10_1183_23120541_00331_2019 crossref_primary_10_1186_s13613_019_0591_y crossref_primary_10_1186_s12890_024_03397_9 crossref_primary_10_4187_respcare_05337 crossref_primary_10_1183_13993003_02251_2017 crossref_primary_10_1007_s15033_017_0655_3 crossref_primary_10_1155_2021_6638048 crossref_primary_10_1007_s00134_021_06459_2 crossref_primary_10_1016_j_resinv_2025_03_016 crossref_primary_10_1080_20018525_2023_2178600 crossref_primary_10_1016_j_addr_2020_09_002 crossref_primary_10_3390_jcm14030868 crossref_primary_10_1016_j_medin_2024_05_010 crossref_primary_10_1016_j_jcrc_2020_12_022 crossref_primary_10_1089_jamp_2020_1643 crossref_primary_10_5005_jp_journals_10071_24919 crossref_primary_10_1183_23120541_00467_2022 crossref_primary_10_3390_jcm10102079 crossref_primary_10_1152_japplphysiol_00769_2021 crossref_primary_10_1016_j_ajem_2020_04_091 crossref_primary_10_1177_0003489417720220 crossref_primary_10_1177_1753466620956459 crossref_primary_10_1152_japplphysiol_00871_2019 crossref_primary_10_1016_j_aucc_2023_03_005 crossref_primary_10_1016_j_heliyon_2023_e15500 crossref_primary_10_1007_s00134_016_4277_8 crossref_primary_10_3390_biomedicines10102353 crossref_primary_10_3390_jcm10122738 crossref_primary_10_1186_s13613_019_0597_5 crossref_primary_10_1183_13993003_00735_2022 crossref_primary_10_1136_bmjopen_2023_083232 crossref_primary_10_1016_j_medin_2016_11_009 crossref_primary_10_1016_j_ajem_2019_03_004 crossref_primary_10_1002_14651858_CD014509_pub2 crossref_primary_10_1016_j_emc_2015_08_007 crossref_primary_10_1016_j_medengphy_2022_103805 crossref_primary_10_1016_j_rmr_2022_03_012 crossref_primary_10_1097_ACO_0000000000000682 crossref_primary_10_1016_j_rmr_2024_06_002 crossref_primary_10_1152_japplphysiol_00584_2016 crossref_primary_10_1016_j_resinv_2022_05_002 crossref_primary_10_7759_cureus_50738 crossref_primary_10_1053_j_sempedsurg_2019_01_004 crossref_primary_10_1186_s13613_019_0482_2 crossref_primary_10_1016_j_hrtlng_2020_03_008 crossref_primary_10_3390_jcm14186658 crossref_primary_10_1016_j_jointm_2025_01_001 crossref_primary_10_1186_s12871_025_03267_9 crossref_primary_10_2147_COPD_S283020 crossref_primary_10_1016_j_rmed_2021_106523 crossref_primary_10_4187_respcare_07306 crossref_primary_10_3390_jcm13216350 crossref_primary_10_1111_resp_14684 crossref_primary_10_1136_bmjopen_2019_034701 crossref_primary_10_4187_respcare_10170 crossref_primary_10_4187_respcare_07441 crossref_primary_10_1089_jamp_2022_0056 crossref_primary_10_1111_den_14315 crossref_primary_10_3390_jcm12206685 crossref_primary_10_1007_s00540_019_02697_3 crossref_primary_10_1186_s12871_020_01073_z crossref_primary_10_1183_13993003_00396_2024 crossref_primary_10_1152_japplphysiol_00279_2016 crossref_primary_10_1016_j_rmed_2021_106638 crossref_primary_10_1186_s13054_023_04361_5 crossref_primary_10_1016_j_resp_2017_03_012 crossref_primary_10_3390_jcm10091814 crossref_primary_10_1016_j_ajem_2016_02_020 crossref_primary_10_1183_16000617_0028_2017 crossref_primary_10_1016_j_jbiomech_2020_110022 crossref_primary_10_1016_j_medine_2024_05_017 crossref_primary_10_1186_s12871_021_01432_4 crossref_primary_10_1007_s00520_022_07330_w crossref_primary_10_1177_0300060516664621 crossref_primary_10_3389_fmed_2024_1213169 crossref_primary_10_1016_S2213_2600_18_30375_8 crossref_primary_10_21037_ajo_2019_05_02 crossref_primary_10_1080_25310429_2024_2411813 crossref_primary_10_1183_23120541_00482_2024 crossref_primary_10_1016_j_tacc_2017_12_001 crossref_primary_10_1136_archdischild_2020_321094 crossref_primary_10_3390_jcm12082878 crossref_primary_10_1002_ppul_24216 crossref_primary_10_1016_j_medine_2016_11_011 crossref_primary_10_1016_j_medin_2019_07_012 crossref_primary_10_1097_CCM_0000000000002693 crossref_primary_10_1089_jamp_2021_0067 crossref_primary_10_1097_YCT_0000000000000556 crossref_primary_10_1007_s00520_017_3710_z crossref_primary_10_1016_j_tacc_2019_06_003 crossref_primary_10_1111_crj_13695 crossref_primary_10_1016_j_jcrc_2016_01_014 crossref_primary_10_1038_s41598_022_10873_x crossref_primary_10_1186_s12890_023_02525_1 crossref_primary_10_1097_ALN_0000000000004540 crossref_primary_10_4187_respcare_05728 crossref_primary_10_1002_ppul_26082 crossref_primary_10_1183_23120541_00532_2022 crossref_primary_10_1016_j_resp_2020_103429 crossref_primary_10_1097_JCMA_0000000000000408 crossref_primary_10_1016_j_rmcr_2016_08_010 crossref_primary_10_1136_thoraxjnl_2016_209673 crossref_primary_10_1016_j_bja_2023_07_002 crossref_primary_10_1007_s11325_023_02785_5 crossref_primary_10_3389_fddev_2024_1456538 crossref_primary_10_4187_respcare_06031 crossref_primary_10_4187_respcare_06271 crossref_primary_10_1097_MCC_0000000000000477 crossref_primary_10_1016_j_arbres_2025_04_010 crossref_primary_10_1016_j_clineuro_2024_108359 crossref_primary_10_1016_j_tacc_2019_02_001 crossref_primary_10_1111_anae_14544 crossref_primary_10_1186_s13613_024_01389_w crossref_primary_10_1016_j_jointm_2024_12_003 crossref_primary_10_1016_j_medine_2019_07_008 crossref_primary_10_3390_jcm9123832 crossref_primary_10_1186_s12871_022_01627_3 crossref_primary_10_1007_s00134_023_07033_8 crossref_primary_10_1016_j_jcrc_2022_154023 crossref_primary_10_1164_rccm_201806_1124LE crossref_primary_10_7759_cureus_65709 crossref_primary_10_1186_s12931_022_02260_x crossref_primary_10_1183_20734735_0185_2023 crossref_primary_10_1007_s11517_022_02649_2 crossref_primary_10_1183_23120541_01063_2024 crossref_primary_10_1111_resp_13050 crossref_primary_10_1186_s13613_023_01203_z crossref_primary_10_2147_IJGM_S294906 crossref_primary_10_1186_s12871_018_0623_4 crossref_primary_10_1002_lary_31733 crossref_primary_10_1371_journal_pone_0272372 crossref_primary_10_4187_respcare_12487 crossref_primary_10_1186_s13054_019_2429_2 crossref_primary_10_1089_respcare_12082 crossref_primary_10_1186_s12890_020_1048_7 crossref_primary_10_1016_j_ejim_2025_04_018 crossref_primary_10_1186_s13054_019_2361_5 crossref_primary_10_4187_respcare_07278 crossref_primary_10_1002_jhm_13571 crossref_primary_10_1002_14651858_CD014895_pub2 crossref_primary_10_1177_03000605221140685 crossref_primary_10_1093_ejcts_ezx450 crossref_primary_10_1097_MOP_0000000000000494 crossref_primary_10_1152_japplphysiol_01063_2018 crossref_primary_10_1016_S0140_6736_16_30245_8 crossref_primary_10_4187_respcare_11400 crossref_primary_10_1007_s00408_016_9885_0 crossref_primary_10_4187_respcare_06193 crossref_primary_10_1055_a_2271_4113 crossref_primary_10_1183_20734735_0224_2020 crossref_primary_10_1213_ANE_0000000000007620 crossref_primary_10_3389_fmed_2025_1594128 crossref_primary_10_1016_j_bja_2021_03_022 crossref_primary_10_1016_j_bja_2021_03_020 crossref_primary_10_1089_jpm_2017_0108 crossref_primary_10_1016_j_clinbiomech_2017_11_003 crossref_primary_10_1097_SPC_0000000000000566 crossref_primary_10_1016_j_asjsur_2024_04_141 crossref_primary_10_3390_antiox10050640 crossref_primary_10_1186_s43168_025_00429_8 crossref_primary_10_1016_j_rmed_2016_08_004 crossref_primary_10_1007_s10405_016_0065_y crossref_primary_10_1016_j_annemergmed_2017_12_006 crossref_primary_10_1038_jp_2017_24 crossref_primary_10_1136_archdischild_2018_316773 crossref_primary_10_1016_j_jfma_2024_08_006 crossref_primary_10_1097_CM9_0000000000000769 crossref_primary_10_1089_jamp_2017_1432 crossref_primary_10_1097_EJA_0000000000001890 crossref_primary_10_1186_s44158_021_00001_y crossref_primary_10_1177_17534666221087847 crossref_primary_10_17116_respmed2025102117 crossref_primary_10_1016_j_suc_2021_09_012 crossref_primary_10_4187_respcare_06718 crossref_primary_10_1177_17534666241246637 crossref_primary_10_1016_j_chest_2018_04_003 crossref_primary_10_1111_anae_13999 crossref_primary_10_1111_resp_13092 crossref_primary_10_1097_pq9_0000000000000348 crossref_primary_10_1164_rccm_202204_0629OC crossref_primary_10_1513_AnnalsATS_201706_425OC crossref_primary_10_4187_respcare_11755 crossref_primary_10_1186_s13054_017_1640_2
ContentType	Journal Article
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1152/japplphysiol.00934.2014
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine Anatomy & Physiology
EISSN	1522-1601
EndPage	1532
ExternalDocumentID	25882385
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- -~X .55 18M 29J 2WC 4.4 53G 5VS 85S AAFWJ ABCQX ABDNZ ABHWK ABJNI ABKWE ABOCM ACBEA ACGFO ACGFS ACIWK ACPRK ADBBV ADFNX AEILP AENEX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS BAWUL BKKCC BTFSW CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD EMOBN F5P FRP GX1 H13 H~9 ITBOX KQ8 L7B NPM OK1 P-O P2P P6G PQQKQ RAP RHI RPL RPRKH SJN TR2 UHB UKR UPT W8F WH7 WOQ X7M XSW YBH YQT YWH ~02 7X8
ID	FETCH-LOGICAL-c511t-3283eab092076c4af7eb286f7ee4f015b00bea7be121221a2fffec468c9a5e0e2
IEDL.DBID	7X8
ISICitedReferencesCount	234
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000356238800014&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
IngestDate	Wed Oct 01 12:56:29 EDT 2025 Mon Jul 21 06:05:25 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	12
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c511t-3283eab092076c4af7eb286f7ee4f015b00bea7be121221a2fffec468c9a5e0e2
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://pubmed.ncbi.nlm.nih.gov/PMC4482836
PMID	25882385
PQID	1704351689
PQPubID	23479
PageCount	8
ParticipantIDs	proquest_miscellaneous_1704351689 pubmed_primary_25882385
PublicationCentury	2000
PublicationDate	2015-06-15
PublicationDateYYYYMMDD	2015-06-15
PublicationDate_xml	– month: 06 year: 2015 text: 2015-06-15 day: 15
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Journal of applied physiology (1985)
PublicationTitleAlternate	J Appl Physiol (1985)
PublicationYear	2015
References	22165366 - Anaesth Intensive Care. 2011 Nov;39(6):1103-10 24670392 - Ther Adv Respir Dis. 2014 Apr;8(2):63-4 17363769 - Am J Respir Crit Care Med. 2007 Jul 15;176(2):194-200 22826046 - Adv Exp Med Biol. 2013;755:27-34 21438178 - Pediatr Pulmonol. 2011 Aug;46(8):795-801 24381187 - Respir Care. 2014 Nov;59(11):1611-8 23128844 - Respiration. 2013;85(4):319-25 23412897 - J Appl Physiol (1985). 2013 Apr;114(8):1058-65 23143331 - Intensive Care Med. 2013 Feb;39(2):247-57 25003980 - Am J Respir Crit Care Med. 2014 Aug 1;190(3):282-8 18599676 - J Appl Physiol (1985). 2008 Sep;105(3):854-8 22191396 - J Aerosol Med Pulm Drug Deliv. 2012 Apr;25(2):63-78 23845744 - Rev Port Pneumol. 2013 Sep-Oct;19(5):217-27 15802371 - J Appl Physiol (1985). 2005 Aug;99(2):616-23 18453367 - Proc Am Thorac Soc. 2008 May 1;5(4):530-5 22531566 - Minerva Anestesiol. 2012 Jul;78(7):836-41 21958974 - J Crit Care. 2012 Jun;27(3):324.e9-13 21171186 - Pediatr Pulmonol. 2011 Jan;46(1):67-74 217053 - Respir Physiol. 1979 Jan;36(1):51-63 8727530 - J Appl Physiol (1985). 1996 May;80(5):1485-9 19467849 - Respir Med. 2009 Oct;103(10):1400-5 8099639 - Lancet. 1993 Jun 19;341(8860):1555-7 23271822 - Respir Care. 2013 Jan;58(1):98-122 357464 - Intensive Care Med. 1978 Jul;4(3):145-8 19952061 - Chest. 2010 Mar;137(3):521-8
References_xml	– reference: 23412897 - J Appl Physiol (1985). 2013 Apr;114(8):1058-65 – reference: 19467849 - Respir Med. 2009 Oct;103(10):1400-5 – reference: 23271822 - Respir Care. 2013 Jan;58(1):98-122 – reference: 19952061 - Chest. 2010 Mar;137(3):521-8 – reference: 22531566 - Minerva Anestesiol. 2012 Jul;78(7):836-41 – reference: 24670392 - Ther Adv Respir Dis. 2014 Apr;8(2):63-4 – reference: 8727530 - J Appl Physiol (1985). 1996 May;80(5):1485-9 – reference: 15802371 - J Appl Physiol (1985). 2005 Aug;99(2):616-23 – reference: 23128844 - Respiration. 2013;85(4):319-25 – reference: 21958974 - J Crit Care. 2012 Jun;27(3):324.e9-13 – reference: 18599676 - J Appl Physiol (1985). 2008 Sep;105(3):854-8 – reference: 18453367 - Proc Am Thorac Soc. 2008 May 1;5(4):530-5 – reference: 357464 - Intensive Care Med. 1978 Jul;4(3):145-8 – reference: 217053 - Respir Physiol. 1979 Jan;36(1):51-63 – reference: 22191396 - J Aerosol Med Pulm Drug Deliv. 2012 Apr;25(2):63-78 – reference: 8099639 - Lancet. 1993 Jun 19;341(8860):1555-7 – reference: 25003980 - Am J Respir Crit Care Med. 2014 Aug 1;190(3):282-8 – reference: 17363769 - Am J Respir Crit Care Med. 2007 Jul 15;176(2):194-200 – reference: 21171186 - Pediatr Pulmonol. 2011 Jan;46(1):67-74 – reference: 23143331 - Intensive Care Med. 2013 Feb;39(2):247-57 – reference: 22165366 - Anaesth Intensive Care. 2011 Nov;39(6):1103-10 – reference: 22826046 - Adv Exp Med Biol. 2013;755:27-34 – reference: 24381187 - Respir Care. 2014 Nov;59(11):1611-8 – reference: 21438178 - Pediatr Pulmonol. 2011 Aug;46(8):795-801 – reference: 23845744 - Rev Port Pneumol. 2013 Sep-Oct;19(5):217-27
SSID	ssj0014451
Score	2.5934057
Snippet	Recent studies showed that nasal high flow (NHF) with or without supplemental oxygen can assist ventilation of patients with chronic respiratory and sleep...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	1525
SubjectTerms	Carbon Dioxide - metabolism Continuous Positive Airway Pressure Half-Life Humans Insufflation Krypton Radioisotopes Models, Anatomic Nasal Cavity - anatomy & histology Nasal Cavity - diagnostic imaging Nasal Cavity - physiology Radionuclide Imaging Respiratory Dead Space - physiology Respiratory Physiological Phenomena Tomography, X-Ray Computed
Title	Nasal high flow clears anatomical dead space in upper airway models
URI	https://www.ncbi.nlm.nih.gov/pubmed/25882385 https://www.proquest.com/docview/1704351689
Volume	118
WOSCitedRecordID	wos000356238800014&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7Uinjx0fqoL1YQb2vz3s1JSrF4aehBobewT6nUJDatpf_e2STFkyB4SU4Dy8zszDePnUHoTnMBKNwYYsD3ksAoRXgcKhKpOBCMKqqZqZZN0CRhk0k8bhJuZdNWubGJlaFWubQ58p5LHfDsbsTix-KT2K1RtrrarNDYRi0foIzVajr5qSLY4VtNTxe4qd67rQlXCYN89mBDeZtTsc93fsOWlY8ZHv73dEfooEGXuF-rwzHa0lkbdfoZRNYfa3yPx_Wx8rd1G-2NmrJ6Bw0SXgKZHV2MzSxfYWmXSZSYV4RWjFiBLmCwPlLjaYaXRaHnmE_nK77G1TKd8gS9Dp9eBs-k2a5AJICsBfEBWICknNhzaCQDbigE2SyCnw4MgAS4j0JzKrQL3s1zuWdsg0kQMRnzUDvaO0U7WZ7pc4Q9ASCMMmUERCeRUIIZP1C-pDzkzNFRF91uuJaC9tqSBM90vizTH7510VnN-rSox2ykXgjo32fhxR-oL9E-iDK0PVxueIVaBu6uvka78msxLec3lVrANxmPvgFhbMXN
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nasal+high+flow+clears+anatomical+dead+space+in+upper+airway+models&rft.jtitle=Journal+of+applied+physiology+%281985%29&rft.au=M%C3%B6ller%2C+Winfried&rft.au=Celik%2C+G%C3%BClnaz&rft.au=Feng%2C+Sheng&rft.au=Bartenstein%2C+Peter&rft.date=2015-06-15&rft.eissn=1522-1601&rft.volume=118&rft.issue=12&rft.spage=1525&rft_id=info:doi/10.1152%2Fjapplphysiol.00934.2014&rft_id=info%3Apmid%2F25882385&rft_id=info%3Apmid%2F25882385&rft.externalDocID=25882385