The protective effect of biotin supplementation and swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer's disease: A behavioral, biochemical, and histological study
Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the biochemical and behavioral effects of biotin supplementation (BS) and swimming training (ST) on Alzheimer's disease (AD), the most common type of dementia, in male rats. Sixty rats were randomly assigned...
Uloženo v:
| Vydáno v: | Heliyon Ročník 10; číslo 13; s. e32299 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Elsevier Ltd
15.07.2024
Elsevier |
| Témata: | |
| ISSN: | 2405-8440, 2405-8440 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the biochemical and behavioral effects of biotin supplementation (BS) and swimming training (ST) on Alzheimer's disease (AD), the most common type of dementia, in male rats. Sixty rats were randomly assigned to six groups: control, sham (receiving phosphate-buffered saline), AD (receiving a single injection of Aβ into the lateral ventricle), ST (for 28 days and before Aβ injection), and BS (receiving BS through oral gavage for 28 days before Aβ injection). The treatments were continued until the end of the behavioral tests. Learning and memory functions were investigated through the Morris water maze (MWM) and depression and anxiety-like behaviors were tested by elevated plus-maze (EPM) and forced swimming tests. In addition, oxidative stress biomarkers, such as total thiol groups (TTG) and malondialdehyde (MDA) in serum were assessed and histological studies were performed using brain tissues. In the AD group, Aβ increased the distance traveled and escape latency in the MWM, but co-administration of BS and ST attenuated the results of the MWM, EPM, and FST tests. Furthermore, BS decreased the litigious biochemical effects of Aβ by enhancing the levels of TTG, in addition to reducing serum MDA levels. The use of BS as a potent antioxidant improved Aβ-induced memory impairment. It attenuated oxidative stress biomarkers in the brain (number of Aβ plaques) and serum of AD rats. We provide evidence for the use of BS in neurodegenerative disorders, such as AD, to elucidate the possible mechanisms.
[Display omitted]
•Biotin has neuroprotective and antioxidant properties.•Injection of β-amyloid (Aβ) causes impairment of memory and learning.•Biotin attenuate the effects of Aβ on learning and memory.•Biotin is a potential neuroprotective agent against Alzheimer's disease. |
|---|---|
| AbstractList | Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the biochemical and behavioral effects of biotin supplementation (BS) and swimming training (ST) on Alzheimer's disease (AD), the most common type of dementia, in male rats. Sixty rats were randomly assigned to six groups: control, sham (receiving phosphate-buffered saline), AD (receiving a single injection of Aβ into the lateral ventricle), ST (for 28 days and before Aβ injection), and BS (receiving BS through oral gavage for 28 days before Aβ injection). The treatments were continued until the end of the behavioral tests. Learning and memory functions were investigated through the Morris water maze (MWM) and depression and anxiety-like behaviors were tested by elevated plus-maze (EPM) and forced swimming tests. In addition, oxidative stress biomarkers, such as total thiol groups (TTG) and malondialdehyde (MDA) in serum were assessed and histological studies were performed using brain tissues. In the AD group, Aβ increased the distance traveled and escape latency in the MWM, but co-administration of BS and ST attenuated the results of the MWM, EPM, and FST tests. Furthermore, BS decreased the litigious biochemical effects of Aβ by enhancing the levels of TTG, in addition to reducing serum MDA levels. The use of BS as a potent antioxidant improved Aβ-induced memory impairment. It attenuated oxidative stress biomarkers in the brain (number of Aβ plaques) and serum of AD rats. We provide evidence for the use of BS in neurodegenerative disorders, such as AD, to elucidate the possible mechanisms. Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the biochemical and behavioral effects of biotin supplementation (BS) and swimming training (ST) on Alzheimer's disease (AD), the most common type of dementia, in male rats. Sixty rats were randomly assigned to six groups: control, sham (receiving phosphate-buffered saline), AD (receiving a single injection of Aβ into the lateral ventricle), ST (for 28 days and before Aβ injection), and BS (receiving BS through oral gavage for 28 days before Aβ injection). The treatments were continued until the end of the behavioral tests. Learning and memory functions were investigated through the Morris water maze (MWM) and depression and anxiety-like behaviors were tested by elevated plus-maze (EPM) and forced swimming tests. In addition, oxidative stress biomarkers, such as total thiol groups (TTG) and malondialdehyde (MDA) in serum were assessed and histological studies were performed using brain tissues. In the AD group, Aβ increased the distance traveled and escape latency in the MWM, but co-administration of BS and ST attenuated the results of the MWM, EPM, and FST tests. Furthermore, BS decreased the litigious biochemical effects of Aβ by enhancing the levels of TTG, in addition to reducing serum MDA levels. The use of BS as a potent antioxidant improved Aβ-induced memory impairment. It attenuated oxidative stress biomarkers in the brain (number of Aβ plaques) and serum of AD rats. We provide evidence for the use of BS in neurodegenerative disorders, such as AD, to elucidate the possible mechanisms. [Display omitted] •Biotin has neuroprotective and antioxidant properties.•Injection of β-amyloid (Aβ) causes impairment of memory and learning.•Biotin attenuate the effects of Aβ on learning and memory.•Biotin is a potential neuroprotective agent against Alzheimer's disease. Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the biochemical and behavioral effects of biotin supplementation (BS) and swimming training (ST) on Alzheimer's disease (AD), the most common type of dementia, in male rats. Sixty rats were randomly assigned to six groups: control, sham (receiving phosphate-buffered saline), AD (receiving a single injection of Aβ into the lateral ventricle), ST (for 28 days and before Aβ injection), and BS (receiving BS through oral gavage for 28 days before Aβ injection). The treatments were continued until the end of the behavioral tests. Learning and memory functions were investigated through the Morris water maze (MWM) and depression and anxiety-like behaviors were tested by elevated plus-maze (EPM) and forced swimming tests. In addition, oxidative stress biomarkers, such as total thiol groups (TTG) and malondialdehyde (MDA) in serum were assessed and histological studies were performed using brain tissues. In the AD group, Aβ increased the distance traveled and escape latency in the MWM, but co-administration of BS and ST attenuated the results of the MWM, EPM, and FST tests. Furthermore, BS decreased the litigious biochemical effects of Aβ by enhancing the levels of TTG, in addition to reducing serum MDA levels. The use of BS as a potent antioxidant improved Aβ-induced memory impairment. It attenuated oxidative stress biomarkers in the brain (number of Aβ plaques) and serum of AD rats. We provide evidence for the use of BS in neurodegenerative disorders, such as AD, to elucidate the possible mechanisms.Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the biochemical and behavioral effects of biotin supplementation (BS) and swimming training (ST) on Alzheimer's disease (AD), the most common type of dementia, in male rats. Sixty rats were randomly assigned to six groups: control, sham (receiving phosphate-buffered saline), AD (receiving a single injection of Aβ into the lateral ventricle), ST (for 28 days and before Aβ injection), and BS (receiving BS through oral gavage for 28 days before Aβ injection). The treatments were continued until the end of the behavioral tests. Learning and memory functions were investigated through the Morris water maze (MWM) and depression and anxiety-like behaviors were tested by elevated plus-maze (EPM) and forced swimming tests. In addition, oxidative stress biomarkers, such as total thiol groups (TTG) and malondialdehyde (MDA) in serum were assessed and histological studies were performed using brain tissues. In the AD group, Aβ increased the distance traveled and escape latency in the MWM, but co-administration of BS and ST attenuated the results of the MWM, EPM, and FST tests. Furthermore, BS decreased the litigious biochemical effects of Aβ by enhancing the levels of TTG, in addition to reducing serum MDA levels. The use of BS as a potent antioxidant improved Aβ-induced memory impairment. It attenuated oxidative stress biomarkers in the brain (number of Aβ plaques) and serum of AD rats. We provide evidence for the use of BS in neurodegenerative disorders, such as AD, to elucidate the possible mechanisms. |
| ArticleNumber | e32299 |
| Author | Ramezani, Mahdi Salehi, Iraj Pegah, Atefeh Rezvani, Mohammad Reza Komaki, Alireza Almasi, Shadi Jafarzadeh Shirazi, Mohammad Reza |
| Author_xml | – sequence: 1 givenname: Shadi surname: Almasi fullname: Almasi, Shadi organization: Department of Animal Science, School of Agriculture, Shiraz University, Shiraz, Iran – sequence: 2 givenname: Mohammad Reza surname: Jafarzadeh Shirazi fullname: Jafarzadeh Shirazi, Mohammad Reza email: Jafarzd@shirazu.ac.ir organization: Department of Animal Science, School of Agriculture, Shiraz University, Shiraz, Iran – sequence: 3 givenname: Mohammad Reza surname: Rezvani fullname: Rezvani, Mohammad Reza organization: Department of Animal Science, School of Agriculture, Shiraz University, Shiraz, Iran – sequence: 4 givenname: Mahdi surname: Ramezani fullname: Ramezani, Mahdi organization: Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran – sequence: 5 givenname: Iraj surname: Salehi fullname: Salehi, Iraj organization: Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran – sequence: 6 givenname: Atefeh surname: Pegah fullname: Pegah, Atefeh organization: Hamadan University of Medical Sciences, Hamadan, Iran – sequence: 7 givenname: Alireza orcidid: 0000-0003-3865-9583 surname: Komaki fullname: Komaki, Alireza email: alirezakomaki@gmail.com, Komaki@umsha.ac.ir organization: Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39035497$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUk2P0zAQjdAidln2J4B8gwMttpM0CRxQteJjpZW4LGfLcSbNVP4ItltUfiK_CqcpK8SlJ49n3nszmnnPswvrLGTZS0aXjLLVu-1yAI0HZ5ec8mIJOedN8yS74gUtF3VR0It_4svsJoQtpZSV9aqp8mfZZd7QvCya6ir7_TAAGb2LoCLugUDfp4i4nrToIloSduOowYCNMqKzRNqOhJ9oDNoNiV6inYJUUG5j8aiBZpToJ8oRfeRqEg5mjM4EkkQl8TIS4zrQU6u1_jUAGvCvA-kwgAzwnqxJC4Pco_NSv52mUQMYVNNnUh0wRKfdZsqQEHfd4UX2tJc6wM3pvc6-f_70cPt1cf_ty93t-n6hSsbiIm0KADqmgNddw3suaZfzVVU0hSz6vGQgOdR92_ZKrVQP_bRDJWsFwDljXX6d3c26nZNbMXo00h-EkyiOCec3QvqISoNgsmUNq9rUpi1UVUspeZFXlPG6rlrOk9abWSud4McOQhQGgwKtpQW3CyJnZV4zxhPrLJTWOWcVK2mCvjpBd62B7nHGv2dPgHIGKO9C8NA_QhgVk8PEVpwcJiaHidlhiffhP57C2ReTE_RZ9seZDek6ewQvgkKwCjr0yXRpfXhG4Q-kaPTS |
| CitedBy_id | crossref_primary_10_1016_j_foodres_2025_115747 crossref_primary_10_1016_j_addicn_2025_100199 crossref_primary_10_1016_j_jnutbio_2025_110081 crossref_primary_10_1002_mnfr_70252 |
| Cites_doi | 10.1007/s12640-012-9373-0 10.1016/S0272-7358(99)00032-X 10.3389/fnagi.2022.935973 10.3934/Neuroscience.2021020 10.1001/jamapsychiatry.2014.2476 10.1016/j.physbeh.2020.113003 10.1016/j.mam.2005.07.007 10.3945/an.117.015610 10.3390/antiox10122011 10.1016/j.arr.2004.02.002 10.1016/j.cbi.2006.04.014 10.3233/JAD-160869 10.1177/147323000703500101 10.1002/j.2040-4603.2013.tb00485.x 10.1016/j.bbr.2020.112512 10.1207/s15327752jpa4306_10 10.3390/nu12113458 10.1016/j.nutres.2018.06.007 10.1016/j.peptides.2017.12.027 10.1186/s12576-021-00823-z 10.1093/ajcn/71.2.621s 10.1016/j.brainresbull.2017.04.001 10.1017/S0029665199000567 10.1080/10284150500047161 10.1186/s40035-023-00341-5 10.1016/j.mehy.2017.10.012 10.1016/j.jnutbio.2005.03.025 10.4103/indianjpsychiatry.indianjpsychiatry_111_22 10.1016/0165-0270(85)90031-7 10.1002/jbt.22519 10.1016/j.bbr.2019.02.030 10.1186/s13195-022-01068-7 10.1155/2012/472932 10.1016/j.jchemneu.2020.101804 10.3233/JAD-2009-1152 10.1016/j.neuropharm.2015.08.028 10.2174/1567205012666150710115506 10.1002/fsn3.851 10.1007/s12031-007-0060-1 10.1093/brain/awv407 10.1186/s12974-020-01960-9 10.3390/antiox12010180 10.1016/j.neuroscience.2011.11.054 10.1176/appi.ajp.2017.17040442 10.1016/j.arr.2016.03.007 10.1016/j.sjbs.2015.09.027 10.1016/j.jad.2021.10.007 10.3390/nu8020068 10.1016/j.bbr.2013.03.007 10.1111/jnc.14037 10.1038/s41380-021-01249-0 10.1017/S1461145713001351 10.1016/j.brainresbull.2018.01.008 10.1080/00207454.2018.1526795 10.3389/fnagi.2022.1026688 10.32598/jams.23.4.6135.1 10.1016/j.biopha.2020.111088 10.1242/dmm.049327 10.1249/MSS.0000000000000612 10.1016/j.lfs.2016.05.034 10.1016/S0165-6147(02)02017-5 10.3390/ijms22084052 10.1177/1533317512473193 10.3233/JAD-150660 |
| ContentType | Journal Article |
| Copyright | 2024 2024 Published by Elsevier Ltd. |
| Copyright_xml | – notice: 2024 – notice: 2024 Published by Elsevier Ltd. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 7S9 L.6 DOA |
| DOI | 10.1016/j.heliyon.2024.e32299 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic Open Access: DOAJ - Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | PubMed AGRICOLA MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Open Access Full Text url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2405-8440 |
| ExternalDocumentID | oai_doaj_org_article_1ab1917b92fb4c78aaa2437012887b22 39035497 10_1016_j_heliyon_2024_e32299 S2405844024083300 |
| Genre | Journal Article |
| GroupedDBID | 0R~ 457 53G 5VS 6I. AAEDW AAFTH AAFWJ AALRI AAYWO ABMAC ACGFS ACLIJ ACVFH ADBBV ADCNI ADEZE ADVLN AEUPX AEXQZ AFJKZ AFPKN AFPUW AFTJW AGHFR AIGII AITUG AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BAWUL BCNDV DIK EBS FDB GROUPED_DOAJ HYE KQ8 M~E O9- OK1 ROL RPM SSZ AAYXX CITATION EJD IPNFZ RIG 0SF AACTN NCXOZ NPM 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c511t-299eeed1ce28d92f2a0d3267494a4f351ea2e8fbbfcc6cfef8440ca8cee2211d3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 4 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001260892200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2405-8440 |
| IngestDate | Fri Oct 03 12:52:14 EDT 2025 Fri Aug 22 21:00:42 EDT 2025 Thu Oct 02 05:49:01 EDT 2025 Thu Jan 02 22:28:53 EST 2025 Thu Nov 20 00:55:29 EST 2025 Tue Nov 18 22:25:28 EST 2025 Sat Nov 29 17:02:50 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 13 |
| Keywords | Swimming training Alzheimer's disease Aβ plaque Biotin supplementation |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. 2024 Published by Elsevier Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c511t-299eeed1ce28d92f2a0d3267494a4f351ea2e8fbbfcc6cfef8440ca8cee2211d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-3865-9583 |
| OpenAccessLink | https://doaj.org/article/1ab1917b92fb4c78aaa2437012887b22 |
| PMID | 39035497 |
| PQID | 3083217150 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_1ab1917b92fb4c78aaa2437012887b22 proquest_miscellaneous_3153811224 proquest_miscellaneous_3083217150 pubmed_primary_39035497 crossref_primary_10_1016_j_heliyon_2024_e32299 crossref_citationtrail_10_1016_j_heliyon_2024_e32299 elsevier_sciencedirect_doi_10_1016_j_heliyon_2024_e32299 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-07-15 |
| PublicationDateYYYYMMDD | 2024-07-15 |
| PublicationDate_xml | – month: 07 year: 2024 text: 2024-07-15 day: 15 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Heliyon |
| PublicationTitleAlternate | Heliyon |
| PublicationYear | 2024 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Belviranlı, Okudan (bib20) 2019; 364 Attia (bib42) 2020; 34 Akinci (bib51) 2022; 14 Siddappaji, Gopal (bib60) 2021; 8 Pietrelli (bib48) 2012; 202 Heidari Soureshjani (bib31) 2020; 23 Liu, Ames (bib41) 2005; 8 Donovan (bib50) 2018; 175 Kothapalli (bib10) 2005; 16 Nuzzo (bib37) 2015; 12 Sadeghmousavi (bib6) 2020; 17 Cui (bib59) 2022; 15 Sirwi (bib35) 2021; 10 Heo, Lee, Lee (bib64) 2013; 28 Christen (bib2) 2000; 71 Lu (bib56) 2023; 12 Pietrzak (bib4) 2015; 72 Guo (bib55) 2022; 14 Huskisson, Maggini, Ruf (bib40) 2007; 35 Ebrahimi (bib15) 2017; 16 Maliszewska-Cyna, Xhima, Aubert (bib18) 2016; 53 Alomari (bib22) 2013; 247 Lu (bib16) 2017; 56 Sedel (bib23) 2016; 110 Feng, Wang (bib63) 2012; 2012 Paxinos, Watson (bib26) 2006 Asadbegi (bib36) 2018; 137 Hamilton (bib70) 2007; 33 Fenech (bib12) 2017; 8 Aguilera-Mendez (bib67) 2018; 57 Ryan, Kelly (bib14) 2016; 27 Grimm, Eckert (bib1) 2017; 143 McCarty, DiNicolantonio (bib68) 2017; 109 Parsa (bib29) 2021; 71 Shekarian (bib32) 2020; 383 Salmon (bib47) 2001; 21 Liu (bib53) 2022; 64 Depeint (bib11) 2006; 163 Duzel, van Praag, Sendtner (bib13) 2016; 139 Perin (bib52) 2022; 296 Bashiri (bib28) 2020; 223 Nay (bib57) 2021; 22 Souza (bib49) 2013; 24 Archer (bib54) 1979; 43 Varesi (bib61) 2023; 12 Amaral (bib45) 2018 Gomez-Pinilla, Hillman (bib46) 2013; 3 Aldahmash, El-Nagar, Ibrahim (bib43) 2016; 23 Mehta, Singh, Banerjee (bib44) 2019; 129 Ames, Atamna, Killilea (bib8) 2005; 26 Mielech (bib38) 2020; 12 Mirzaei (bib25) 2019; 6 Dong, Csernansky (bib3) 2009; 18 Shahidi (bib39) 2017; 131 Mate (bib62) 2022; 14 Cryan, Markou, Lucki (bib34) 2002; 23 Azimi (bib21) 2018; 102 Cho (bib17) 2015; 47 Dao (bib19) 2014; 17 Ramezani (bib27) 2020; 108 Komorowski (bib24) 2018; vol. 1 Bender (bib7) 1999; 58 Talebi (bib65) 2021; 133 Atamna (bib9) 2004; 3 Zarrinkalam (bib30) 2016; 157 Pellow S, File, Briley, Chopin, File, Briley (bib33) 1985; 14 Hampel (bib5) 2021; 26 Kennedy (bib69) 2016; 8 Parle, Vasudevan, Singh (bib58) 2005; 4 Orhan (bib66) 2019; 7 Mate (10.1016/j.heliyon.2024.e32299_bib62) 2022; 14 Heo (10.1016/j.heliyon.2024.e32299_bib64) 2013; 28 Ames (10.1016/j.heliyon.2024.e32299_bib8) 2005; 26 Mirzaei (10.1016/j.heliyon.2024.e32299_bib25) 2019; 6 Gomez-Pinilla (10.1016/j.heliyon.2024.e32299_bib46) 2013; 3 Guo (10.1016/j.heliyon.2024.e32299_bib55) 2022; 14 Zarrinkalam (10.1016/j.heliyon.2024.e32299_bib30) 2016; 157 Komorowski (10.1016/j.heliyon.2024.e32299_bib24) 2018; vol. 1 Dao (10.1016/j.heliyon.2024.e32299_bib19) 2014; 17 Aguilera-Mendez (10.1016/j.heliyon.2024.e32299_bib67) 2018; 57 Fenech (10.1016/j.heliyon.2024.e32299_bib12) 2017; 8 Ramezani (10.1016/j.heliyon.2024.e32299_bib27) 2020; 108 Attia (10.1016/j.heliyon.2024.e32299_bib42) 2020; 34 Grimm (10.1016/j.heliyon.2024.e32299_bib1) 2017; 143 Liu (10.1016/j.heliyon.2024.e32299_bib53) 2022; 64 Archer (10.1016/j.heliyon.2024.e32299_bib54) 1979; 43 Feng (10.1016/j.heliyon.2024.e32299_bib63) 2012; 2012 Siddappaji (10.1016/j.heliyon.2024.e32299_bib60) 2021; 8 Pietrzak (10.1016/j.heliyon.2024.e32299_bib4) 2015; 72 Parle (10.1016/j.heliyon.2024.e32299_bib58) 2005; 4 Paxinos (10.1016/j.heliyon.2024.e32299_bib26) 2006 Heidari Soureshjani (10.1016/j.heliyon.2024.e32299_bib31) 2020; 23 Donovan (10.1016/j.heliyon.2024.e32299_bib50) 2018; 175 Salmon (10.1016/j.heliyon.2024.e32299_bib47) 2001; 21 Varesi (10.1016/j.heliyon.2024.e32299_bib61) 2023; 12 Nay (10.1016/j.heliyon.2024.e32299_bib57) 2021; 22 Hamilton (10.1016/j.heliyon.2024.e32299_bib70) 2007; 33 Huskisson (10.1016/j.heliyon.2024.e32299_bib40) 2007; 35 Belviranlı (10.1016/j.heliyon.2024.e32299_bib20) 2019; 364 Alomari (10.1016/j.heliyon.2024.e32299_bib22) 2013; 247 Parsa (10.1016/j.heliyon.2024.e32299_bib29) 2021; 71 Dong (10.1016/j.heliyon.2024.e32299_bib3) 2009; 18 Shahidi (10.1016/j.heliyon.2024.e32299_bib39) 2017; 131 Cho (10.1016/j.heliyon.2024.e32299_bib17) 2015; 47 Maliszewska-Cyna (10.1016/j.heliyon.2024.e32299_bib18) 2016; 53 Pietrelli (10.1016/j.heliyon.2024.e32299_bib48) 2012; 202 Ryan (10.1016/j.heliyon.2024.e32299_bib14) 2016; 27 Bender (10.1016/j.heliyon.2024.e32299_bib7) 1999; 58 Hampel (10.1016/j.heliyon.2024.e32299_bib5) 2021; 26 Orhan (10.1016/j.heliyon.2024.e32299_bib66) 2019; 7 Souza (10.1016/j.heliyon.2024.e32299_bib49) 2013; 24 Depeint (10.1016/j.heliyon.2024.e32299_bib11) 2006; 163 Akinci (10.1016/j.heliyon.2024.e32299_bib51) 2022; 14 Sadeghmousavi (10.1016/j.heliyon.2024.e32299_bib6) 2020; 17 McCarty (10.1016/j.heliyon.2024.e32299_bib68) 2017; 109 Cui (10.1016/j.heliyon.2024.e32299_bib59) 2022; 15 Lu (10.1016/j.heliyon.2024.e32299_bib16) 2017; 56 Bashiri (10.1016/j.heliyon.2024.e32299_bib28) 2020; 223 Talebi (10.1016/j.heliyon.2024.e32299_bib65) 2021; 133 Perin (10.1016/j.heliyon.2024.e32299_bib52) 2022; 296 Aldahmash (10.1016/j.heliyon.2024.e32299_bib43) 2016; 23 Sedel (10.1016/j.heliyon.2024.e32299_bib23) 2016; 110 Mielech (10.1016/j.heliyon.2024.e32299_bib38) 2020; 12 Christen (10.1016/j.heliyon.2024.e32299_bib2) 2000; 71 Kennedy (10.1016/j.heliyon.2024.e32299_bib69) 2016; 8 Atamna (10.1016/j.heliyon.2024.e32299_bib9) 2004; 3 Asadbegi (10.1016/j.heliyon.2024.e32299_bib36) 2018; 137 Nuzzo (10.1016/j.heliyon.2024.e32299_bib37) 2015; 12 Duzel (10.1016/j.heliyon.2024.e32299_bib13) 2016; 139 Liu (10.1016/j.heliyon.2024.e32299_bib41) 2005; 8 Sirwi (10.1016/j.heliyon.2024.e32299_bib35) 2021; 10 Ebrahimi (10.1016/j.heliyon.2024.e32299_bib15) 2017; 16 Mehta (10.1016/j.heliyon.2024.e32299_bib44) 2019; 129 Amaral (10.1016/j.heliyon.2024.e32299_bib45) 2018 Azimi (10.1016/j.heliyon.2024.e32299_bib21) 2018; 102 Pellow S (10.1016/j.heliyon.2024.e32299_bib33) 1985; 14 Lu (10.1016/j.heliyon.2024.e32299_bib56) 2023; 12 Cryan (10.1016/j.heliyon.2024.e32299_bib34) 2002; 23 Kothapalli (10.1016/j.heliyon.2024.e32299_bib10) 2005; 16 Shekarian (10.1016/j.heliyon.2024.e32299_bib32) 2020; 383 |
| References_xml | – volume: 17 start-page: 289 year: 2020 ident: bib6 article-title: The effect of insomnia on development of Alzheimer's disease publication-title: J. Neuroinflammation – volume: 14 year: 2022 ident: bib55 article-title: Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases publication-title: Front. Aging Neurosci. – volume: 18 start-page: 459 year: 2009 end-page: 469 ident: bib3 article-title: Effects of stress and stress hormones on amyloid-β protein and plaque deposition publication-title: J. Alzheim. Dis. – volume: 22 start-page: 4052 year: 2021 ident: bib57 article-title: Molecular mechanisms underlying the beneficial effects of exercise on brain function and neurological disorders publication-title: Int. J. Mol. Sci. – volume: 133 year: 2021 ident: bib65 article-title: Zingiber officinale ameliorates Alzheimer's disease and cognitive impairments: lessons from preclinical studies publication-title: Biomed. Pharmacother. – volume: 14 start-page: 149 year: 1985 end-page: 167 ident: bib33 article-title: Validation of open: closed arm entries in an elevated plus maze as a measure of anxiety in the rat publication-title: J. Neurosci. Methods – year: 2006 ident: bib26 article-title: The Rat Brain in Stereotaxic Coordinates: Hard Cover Edition – volume: 53 start-page: 243 year: 2016 end-page: 257 ident: bib18 article-title: A comparative study evaluating the impact of physical exercise on disease progression in a mouse model of Alzheimer's disease publication-title: J. Alzheim. Dis. – volume: 71 start-page: 1 year: 2021 end-page: 12 ident: bib29 article-title: Swimming training and Plantago psyllium ameliorate cognitive impairment and glucose tolerance in streptozotocin–nicotinamide-induced type 2 diabetic rats publication-title: J. Physiol. Sci. – volume: 16 start-page: 446 year: 2005 end-page: 448 ident: bib10 article-title: Biological functions of biotinylated histones publication-title: J. Nutr. Biochem. – volume: 6 year: 2019 ident: bib25 article-title: Multitarget effects of coconut oil (virgin type) on aβ-induced alzheimer's disease animal model publication-title: Archives of Neuroscience – volume: vol. 1 year: 2018 ident: bib24 article-title: The absorption and activity of a novel form of biotin, JDS-MB-001, in a hippocampal demyelination animal model publication-title: MULTIPLE SCLEROSIS JOURNAL – volume: 26 start-page: 5481 year: 2021 end-page: 5503 ident: bib5 article-title: The amyloid-β pathway in Alzheimer's disease publication-title: Mol. Psychiatr. – volume: 7 start-page: 183 year: 2019 end-page: 194 ident: bib66 article-title: Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high‐fat diet publication-title: Food Sci. Nutr. – volume: 157 start-page: 19 year: 2016 end-page: 24 ident: bib30 article-title: Effects of endurance, resistance, and concurrent exercise on learning and memory after morphine withdrawal in rats publication-title: Life Sci. – volume: 110 start-page: 644 year: 2016 end-page: 653 ident: bib23 article-title: Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis publication-title: Neuropharmacology – volume: 57 start-page: 86 year: 2018 end-page: 96 ident: bib67 article-title: Protective effect of supplementation with biotin against high-fructose-induced metabolic syndrome in rats publication-title: Nutr. Res. (N.Y.) – volume: 202 start-page: 252 year: 2012 end-page: 266 ident: bib48 article-title: Aerobic exercise prevents age-dependent cognitive decline and reduces anxiety-related behaviors in middle-aged and old rats publication-title: Neuroscience – volume: 64 start-page: 560 year: 2022 end-page: 566 ident: bib53 article-title: Correlation between Aβ1–42, Dnmt3a2, urinary AD7c-NTP and cognitive dysfunction in first-episode and recurrent MDD: a case–control study publication-title: Indian J. Psychiatr. – volume: 72 start-page: 284 year: 2015 end-page: 291 ident: bib4 article-title: Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study publication-title: JAMA Psychiatr. – volume: 23 start-page: 238 year: 2002 end-page: 245 ident: bib34 article-title: Assessing antidepressant activity in rodents: recent developments and future needs publication-title: Trends Pharmacol. Sci. – volume: 139 start-page: 662 year: 2016 end-page: 673 ident: bib13 article-title: Can physical exercise in old age improve memory and hippocampal function? publication-title: Brain – volume: 21 start-page: 33 year: 2001 end-page: 61 ident: bib47 article-title: Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory publication-title: Clin. Psychol. Rev. – volume: 14 start-page: 126 year: 2022 ident: bib51 article-title: Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid? publication-title: Alzheimer's Res. Ther. – volume: 364 start-page: 245 year: 2019 end-page: 255 ident: bib20 article-title: Voluntary, involuntary and forced exercises almost equally reverse behavioral impairment by regulating hippocampal neurotrophic factors and oxidative stress in experimental Alzheimer's disease model publication-title: Behav. Brain Res. – volume: 223 year: 2020 ident: bib28 article-title: Swimming exercise improves cognitive and behavioral disorders in male NMRI mice with sporadic Alzheimer-like disease publication-title: Physiol. Behav. – volume: 102 start-page: 78 year: 2018 end-page: 88 ident: bib21 article-title: Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway publication-title: Peptides – volume: 109 start-page: 145 year: 2017 end-page: 149 ident: bib68 article-title: Neuroprotective potential of high-dose biotin publication-title: Med. Hypotheses – volume: 296 start-page: 559 year: 2022 end-page: 566 ident: bib52 article-title: Elucidating the association between depression, anxiety, and cognition in middle-aged adults: application of dimensional and categorical approaches publication-title: J. Affect. Disord. – volume: 15 start-page: dmm049327 year: 2022 ident: bib59 article-title: Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway publication-title: Disease Models & Mechanisms – volume: 16 start-page: 959 year: 2017 ident: bib15 article-title: Physical activity and beta-amyloid pathology in Alzheimer's disease: a sound mind in a sound body publication-title: EXCLI journal – volume: 108 year: 2020 ident: bib27 article-title: Therapeutic effects of melatonin-treated bone marrow mesenchymal stem cells (BMSC) in a rat model of Alzheimer's disease publication-title: J. Chem. Neuroanat. – volume: 28 start-page: 120 year: 2013 end-page: 125 ident: bib64 article-title: The possible role of antioxidant vitamin C in Alzheimer's disease treatment and prevention publication-title: Am. J. Alzheimer's Dis. Other Dementias – volume: 383 year: 2020 ident: bib32 article-title: The protective and therapeutic effects of vinpocetine, a PDE1 inhibitor, on oxidative stress and learning and memory impairment induced by an intracerebroventricular (ICV) injection of amyloid beta (aβ) peptide publication-title: Behav. Brain Res. – volume: 8 start-page: 357 year: 2021 ident: bib60 article-title: Molecular mechanisms in Alzheimer's disease and the impact of physical exercise with advancements in therapeutic approaches publication-title: AIMS Neurosci. – volume: 10 start-page: 2011 year: 2021 ident: bib35 article-title: Umuhengerin neuroprotective effects in streptozotocin-induced alzheimer's disease mouse model via targeting Nrf2 and NF-kβ signaling cascades publication-title: Antioxidants – volume: 43 start-page: 617 year: 1979 end-page: 626 ident: bib54 article-title: Relationships between locus of control and anxiety publication-title: J. Pers. Assess. – volume: 8 start-page: 68 year: 2016 ident: bib69 article-title: B vitamins and the brain: mechanisms, dose and efficacy—a review publication-title: Nutrients – volume: 58 start-page: 427 year: 1999 end-page: 433 ident: bib7 article-title: Optimum nutrition: thiamin, biotin and pantothenate publication-title: Proc. Nutr. Soc. – volume: 8 start-page: 67 year: 2005 end-page: 89 ident: bib41 article-title: Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease publication-title: Nutr. Neurosci. – volume: 12 start-page: 180 year: 2023 ident: bib61 article-title: Non-enzymatic antioxidants against alzheimer's disease: prevention, diagnosis and therapy publication-title: Antioxidants – volume: 17 start-page: 593 year: 2014 end-page: 602 ident: bib19 article-title: Regular exercise prevents non-cognitive disturbances in a rat model of Alzheimer's disease publication-title: Int. J. Neuropsychopharmacol. – volume: 14 year: 2022 ident: bib62 article-title: Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy publication-title: Front. Aging Neurosci. – volume: 12 start-page: 723 year: 2015 end-page: 735 ident: bib37 article-title: Insulin resistance as common molecular denominator linking obesity to Alzheimer's disease publication-title: Curr. Alzheimer Res. – volume: 27 start-page: 77 year: 2016 end-page: 92 ident: bib14 article-title: Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease publication-title: Ageing Res. Rev. – volume: 35 start-page: 1 year: 2007 end-page: 19 ident: bib40 article-title: The influence of micronutrients on cognitive function and performance publication-title: J. Int. Med. Res. – volume: 34 year: 2020 ident: bib42 article-title: Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride‐induced Alzheimer's disease via attenuating neuroinflammation and improving brain insulin signaling publication-title: J. Biochem. Mol. Toxicol. – volume: 33 start-page: 2 year: 2007 end-page: 11 ident: bib70 article-title: Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders publication-title: J. Mol. Neurosci. – volume: 56 start-page: 1469 year: 2017 end-page: 1484 ident: bib16 article-title: Treadmill exercise exerts neuroprotection and regulates microglial polarization and oxidative stress in a streptozotocin-induced rat model of sporadic Alzheimer's disease publication-title: J. Alzheim. Dis. – volume: 12 start-page: 3458 year: 2020 ident: bib38 article-title: Vitamins in alzheimer's disease—review of the latest reports publication-title: Nutrients – volume: 26 start-page: 363 year: 2005 end-page: 378 ident: bib8 article-title: Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging publication-title: Mol. Aspect. Med. – volume: 23 start-page: 524 year: 2020 end-page: 539 ident: bib31 article-title: Effect of donepezil and hyoscyamoside on improving spatial memory in rats with Alzheimer's disease publication-title: J. Arak Univ. Med. Sci. – volume: 129 start-page: 252 year: 2019 end-page: 263 ident: bib44 article-title: Effect of exercise on type 2 diabetes-associated cognitive impairment in rats publication-title: Int. J. Neurosci. – volume: 24 start-page: 148 year: 2013 end-page: 163 ident: bib49 article-title: Neuroprotective effect of physical exercise in a mouse model of Alzheimer's disease induced by β-amyloid 1–40 peptide publication-title: Neurotox. Res. – volume: 4 start-page: 37 year: 2005 ident: bib58 article-title: Swim everyday to keep dementia away publication-title: J. Sports Sci. Med. – volume: 23 start-page: 311 year: 2016 end-page: 317 ident: bib43 article-title: Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in Swiss albino mice publication-title: Saudi J. Biol. Sci. – volume: 143 start-page: 418 year: 2017 end-page: 431 ident: bib1 article-title: Brain aging and neurodegeneration: from a mitochondrial point of view publication-title: J. Neurochem. – volume: 47 start-page: 1814 year: 2015 end-page: 1824 ident: bib17 article-title: Treadmill running reverses cognitive declines due to Alzheimer disease publication-title: Med. Sci. Sports Exerc. – volume: 163 start-page: 94 year: 2006 end-page: 112 ident: bib11 article-title: Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism publication-title: Chem. Biol. Interact. – volume: 247 start-page: 34 year: 2013 end-page: 39 ident: bib22 article-title: Forced and voluntary exercises equally improve spatial learning and memory and hippocampal BDNF levels publication-title: Behav. Brain Res. – volume: 2012 year: 2012 ident: bib63 article-title: Antioxidant therapies for Alzheimer's disease publication-title: Oxid. Med. Cell. Longev. – volume: 137 start-page: 338 year: 2018 end-page: 350 ident: bib36 article-title: Effects of thymol on amyloid-β-induced impairments in hippocampal synaptic plasticity in rats fed a high-fat diet publication-title: Brain Res. Bull. – volume: 3 start-page: 403 year: 2013 ident: bib46 article-title: The influence of exercise on cognitive abilities publication-title: Compr. Physiol. – volume: 71 start-page: 621S year: 2000 end-page: 629S ident: bib2 article-title: Oxidative stress and Alzheimer disease publication-title: Am. J. Clin. Nutr. – volume: 175 start-page: 530 year: 2018 end-page: 537 ident: bib50 article-title: Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults publication-title: Am. J. Psychiatr. – volume: 3 start-page: 303 year: 2004 end-page: 318 ident: bib9 article-title: Heme, iron, and the mitochondrial decay of ageing publication-title: Ageing Res. Rev. – volume: 131 start-page: 142 year: 2017 end-page: 149 ident: bib39 article-title: Influence of N-acetyl cysteine on beta-amyloid-induced Alzheimer's disease in a rat model: a behavioral and electrophysiological study publication-title: Brain Res. Bull. – start-page: 2018 year: 2018 ident: bib45 article-title: Previous exercise training reduces markers of renal oxidative stress and inflammation in streptozotocin-induced diabetic female rats publication-title: J. Diabetes Res. – volume: 12 start-page: 9 year: 2023 ident: bib56 article-title: Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction publication-title: Transl. Neurodegener. – volume: 8 start-page: 958 year: 2017 end-page: 970 ident: bib12 article-title: Vitamins associated with brain aging, mild cognitive impairment, and Alzheimer disease: biomarkers, epidemiological and experimental evidence, plausible mechanisms, and knowledge gaps publication-title: Adv. Nutr. – volume: 24 start-page: 148 issue: 2 year: 2013 ident: 10.1016/j.heliyon.2024.e32299_bib49 article-title: Neuroprotective effect of physical exercise in a mouse model of Alzheimer's disease induced by β-amyloid 1–40 peptide publication-title: Neurotox. Res. doi: 10.1007/s12640-012-9373-0 – volume: 21 start-page: 33 issue: 1 year: 2001 ident: 10.1016/j.heliyon.2024.e32299_bib47 article-title: Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory publication-title: Clin. Psychol. Rev. doi: 10.1016/S0272-7358(99)00032-X – volume: 14 year: 2022 ident: 10.1016/j.heliyon.2024.e32299_bib62 article-title: Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2022.935973 – volume: 8 start-page: 357 issue: 3 year: 2021 ident: 10.1016/j.heliyon.2024.e32299_bib60 article-title: Molecular mechanisms in Alzheimer's disease and the impact of physical exercise with advancements in therapeutic approaches publication-title: AIMS Neurosci. doi: 10.3934/Neuroscience.2021020 – volume: 72 start-page: 284 issue: 3 year: 2015 ident: 10.1016/j.heliyon.2024.e32299_bib4 article-title: Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study publication-title: JAMA Psychiatr. doi: 10.1001/jamapsychiatry.2014.2476 – volume: 223 year: 2020 ident: 10.1016/j.heliyon.2024.e32299_bib28 article-title: Swimming exercise improves cognitive and behavioral disorders in male NMRI mice with sporadic Alzheimer-like disease publication-title: Physiol. Behav. doi: 10.1016/j.physbeh.2020.113003 – volume: 4 start-page: 37 issue: 1 year: 2005 ident: 10.1016/j.heliyon.2024.e32299_bib58 article-title: Swim everyday to keep dementia away publication-title: J. Sports Sci. Med. – volume: 26 start-page: 363 issue: 4–5 year: 2005 ident: 10.1016/j.heliyon.2024.e32299_bib8 article-title: Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging publication-title: Mol. Aspect. Med. doi: 10.1016/j.mam.2005.07.007 – volume: 8 start-page: 958 issue: 6 year: 2017 ident: 10.1016/j.heliyon.2024.e32299_bib12 article-title: Vitamins associated with brain aging, mild cognitive impairment, and Alzheimer disease: biomarkers, epidemiological and experimental evidence, plausible mechanisms, and knowledge gaps publication-title: Adv. Nutr. doi: 10.3945/an.117.015610 – volume: 10 start-page: 2011 issue: 12 year: 2021 ident: 10.1016/j.heliyon.2024.e32299_bib35 article-title: Umuhengerin neuroprotective effects in streptozotocin-induced alzheimer's disease mouse model via targeting Nrf2 and NF-kβ signaling cascades publication-title: Antioxidants doi: 10.3390/antiox10122011 – volume: 3 start-page: 303 issue: 3 year: 2004 ident: 10.1016/j.heliyon.2024.e32299_bib9 article-title: Heme, iron, and the mitochondrial decay of ageing publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2004.02.002 – volume: 163 start-page: 94 issue: 1–2 year: 2006 ident: 10.1016/j.heliyon.2024.e32299_bib11 article-title: Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2006.04.014 – volume: 56 start-page: 1469 issue: 4 year: 2017 ident: 10.1016/j.heliyon.2024.e32299_bib16 article-title: Treadmill exercise exerts neuroprotection and regulates microglial polarization and oxidative stress in a streptozotocin-induced rat model of sporadic Alzheimer's disease publication-title: J. Alzheim. Dis. doi: 10.3233/JAD-160869 – volume: 35 start-page: 1 issue: 1 year: 2007 ident: 10.1016/j.heliyon.2024.e32299_bib40 article-title: The influence of micronutrients on cognitive function and performance publication-title: J. Int. Med. Res. doi: 10.1177/147323000703500101 – volume: 3 start-page: 403 issue: 1 year: 2013 ident: 10.1016/j.heliyon.2024.e32299_bib46 article-title: The influence of exercise on cognitive abilities publication-title: Compr. Physiol. doi: 10.1002/j.2040-4603.2013.tb00485.x – volume: 383 year: 2020 ident: 10.1016/j.heliyon.2024.e32299_bib32 article-title: The protective and therapeutic effects of vinpocetine, a PDE1 inhibitor, on oxidative stress and learning and memory impairment induced by an intracerebroventricular (ICV) injection of amyloid beta (aβ) peptide publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2020.112512 – volume: 43 start-page: 617 issue: 6 year: 1979 ident: 10.1016/j.heliyon.2024.e32299_bib54 article-title: Relationships between locus of control and anxiety publication-title: J. Pers. Assess. doi: 10.1207/s15327752jpa4306_10 – volume: 12 start-page: 3458 issue: 11 year: 2020 ident: 10.1016/j.heliyon.2024.e32299_bib38 article-title: Vitamins in alzheimer's disease—review of the latest reports publication-title: Nutrients doi: 10.3390/nu12113458 – start-page: 2018 year: 2018 ident: 10.1016/j.heliyon.2024.e32299_bib45 article-title: Previous exercise training reduces markers of renal oxidative stress and inflammation in streptozotocin-induced diabetic female rats publication-title: J. Diabetes Res. – volume: 6 issue: 2 year: 2019 ident: 10.1016/j.heliyon.2024.e32299_bib25 article-title: Multitarget effects of coconut oil (virgin type) on aβ-induced alzheimer's disease animal model publication-title: Archives of Neuroscience – volume: 57 start-page: 86 year: 2018 ident: 10.1016/j.heliyon.2024.e32299_bib67 article-title: Protective effect of supplementation with biotin against high-fructose-induced metabolic syndrome in rats publication-title: Nutr. Res. (N.Y.) doi: 10.1016/j.nutres.2018.06.007 – volume: 102 start-page: 78 year: 2018 ident: 10.1016/j.heliyon.2024.e32299_bib21 article-title: Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway publication-title: Peptides doi: 10.1016/j.peptides.2017.12.027 – volume: 71 start-page: 1 issue: 1 year: 2021 ident: 10.1016/j.heliyon.2024.e32299_bib29 article-title: Swimming training and Plantago psyllium ameliorate cognitive impairment and glucose tolerance in streptozotocin–nicotinamide-induced type 2 diabetic rats publication-title: J. Physiol. Sci. doi: 10.1186/s12576-021-00823-z – volume: 71 start-page: 621S issue: 2 year: 2000 ident: 10.1016/j.heliyon.2024.e32299_bib2 article-title: Oxidative stress and Alzheimer disease publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/71.2.621s – volume: 131 start-page: 142 year: 2017 ident: 10.1016/j.heliyon.2024.e32299_bib39 article-title: Influence of N-acetyl cysteine on beta-amyloid-induced Alzheimer's disease in a rat model: a behavioral and electrophysiological study publication-title: Brain Res. Bull. doi: 10.1016/j.brainresbull.2017.04.001 – volume: 58 start-page: 427 issue: 2 year: 1999 ident: 10.1016/j.heliyon.2024.e32299_bib7 article-title: Optimum nutrition: thiamin, biotin and pantothenate publication-title: Proc. Nutr. Soc. doi: 10.1017/S0029665199000567 – volume: 8 start-page: 67 issue: 2 year: 2005 ident: 10.1016/j.heliyon.2024.e32299_bib41 article-title: Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease publication-title: Nutr. Neurosci. doi: 10.1080/10284150500047161 – volume: 12 start-page: 9 issue: 1 year: 2023 ident: 10.1016/j.heliyon.2024.e32299_bib56 article-title: Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction publication-title: Transl. Neurodegener. doi: 10.1186/s40035-023-00341-5 – volume: 109 start-page: 145 year: 2017 ident: 10.1016/j.heliyon.2024.e32299_bib68 article-title: Neuroprotective potential of high-dose biotin publication-title: Med. Hypotheses doi: 10.1016/j.mehy.2017.10.012 – volume: 16 start-page: 446 issue: 7 year: 2005 ident: 10.1016/j.heliyon.2024.e32299_bib10 article-title: Biological functions of biotinylated histones publication-title: J. Nutr. Biochem. doi: 10.1016/j.jnutbio.2005.03.025 – volume: 64 start-page: 560 issue: 6 year: 2022 ident: 10.1016/j.heliyon.2024.e32299_bib53 article-title: Correlation between Aβ1–42, Dnmt3a2, urinary AD7c-NTP and cognitive dysfunction in first-episode and recurrent MDD: a case–control study publication-title: Indian J. Psychiatr. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_111_22 – volume: 14 start-page: 149 year: 1985 ident: 10.1016/j.heliyon.2024.e32299_bib33 article-title: Validation of open: closed arm entries in an elevated plus maze as a measure of anxiety in the rat publication-title: J. Neurosci. Methods doi: 10.1016/0165-0270(85)90031-7 – volume: 34 issue: 9 year: 2020 ident: 10.1016/j.heliyon.2024.e32299_bib42 article-title: Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride‐induced Alzheimer's disease via attenuating neuroinflammation and improving brain insulin signaling publication-title: J. Biochem. Mol. Toxicol. doi: 10.1002/jbt.22519 – volume: 364 start-page: 245 year: 2019 ident: 10.1016/j.heliyon.2024.e32299_bib20 article-title: Voluntary, involuntary and forced exercises almost equally reverse behavioral impairment by regulating hippocampal neurotrophic factors and oxidative stress in experimental Alzheimer's disease model publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2019.02.030 – volume: 14 start-page: 126 issue: 1 year: 2022 ident: 10.1016/j.heliyon.2024.e32299_bib51 article-title: Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid? publication-title: Alzheimer's Res. Ther. doi: 10.1186/s13195-022-01068-7 – volume: 2012 year: 2012 ident: 10.1016/j.heliyon.2024.e32299_bib63 article-title: Antioxidant therapies for Alzheimer's disease publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2012/472932 – volume: 108 year: 2020 ident: 10.1016/j.heliyon.2024.e32299_bib27 article-title: Therapeutic effects of melatonin-treated bone marrow mesenchymal stem cells (BMSC) in a rat model of Alzheimer's disease publication-title: J. Chem. Neuroanat. doi: 10.1016/j.jchemneu.2020.101804 – volume: 18 start-page: 459 issue: 2 year: 2009 ident: 10.1016/j.heliyon.2024.e32299_bib3 article-title: Effects of stress and stress hormones on amyloid-β protein and plaque deposition publication-title: J. Alzheim. Dis. doi: 10.3233/JAD-2009-1152 – volume: 110 start-page: 644 year: 2016 ident: 10.1016/j.heliyon.2024.e32299_bib23 article-title: Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2015.08.028 – volume: 12 start-page: 723 issue: 8 year: 2015 ident: 10.1016/j.heliyon.2024.e32299_bib37 article-title: Insulin resistance as common molecular denominator linking obesity to Alzheimer's disease publication-title: Curr. Alzheimer Res. doi: 10.2174/1567205012666150710115506 – volume: 7 start-page: 183 issue: 1 year: 2019 ident: 10.1016/j.heliyon.2024.e32299_bib66 article-title: Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high‐fat diet publication-title: Food Sci. Nutr. doi: 10.1002/fsn3.851 – volume: 33 start-page: 2 year: 2007 ident: 10.1016/j.heliyon.2024.e32299_bib70 article-title: Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders publication-title: J. Mol. Neurosci. doi: 10.1007/s12031-007-0060-1 – volume: 139 start-page: 662 issue: 3 year: 2016 ident: 10.1016/j.heliyon.2024.e32299_bib13 article-title: Can physical exercise in old age improve memory and hippocampal function? publication-title: Brain doi: 10.1093/brain/awv407 – volume: 17 start-page: 289 issue: 1 year: 2020 ident: 10.1016/j.heliyon.2024.e32299_bib6 article-title: The effect of insomnia on development of Alzheimer's disease publication-title: J. Neuroinflammation doi: 10.1186/s12974-020-01960-9 – volume: 12 start-page: 180 issue: 1 year: 2023 ident: 10.1016/j.heliyon.2024.e32299_bib61 article-title: Non-enzymatic antioxidants against alzheimer's disease: prevention, diagnosis and therapy publication-title: Antioxidants doi: 10.3390/antiox12010180 – volume: 202 start-page: 252 year: 2012 ident: 10.1016/j.heliyon.2024.e32299_bib48 article-title: Aerobic exercise prevents age-dependent cognitive decline and reduces anxiety-related behaviors in middle-aged and old rats publication-title: Neuroscience doi: 10.1016/j.neuroscience.2011.11.054 – volume: 175 start-page: 530 issue: 6 year: 2018 ident: 10.1016/j.heliyon.2024.e32299_bib50 article-title: Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults publication-title: Am. J. Psychiatr. doi: 10.1176/appi.ajp.2017.17040442 – volume: 27 start-page: 77 year: 2016 ident: 10.1016/j.heliyon.2024.e32299_bib14 article-title: Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2016.03.007 – volume: 23 start-page: 311 issue: 2 year: 2016 ident: 10.1016/j.heliyon.2024.e32299_bib43 article-title: Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in Swiss albino mice publication-title: Saudi J. Biol. Sci. doi: 10.1016/j.sjbs.2015.09.027 – volume: 296 start-page: 559 year: 2022 ident: 10.1016/j.heliyon.2024.e32299_bib52 article-title: Elucidating the association between depression, anxiety, and cognition in middle-aged adults: application of dimensional and categorical approaches publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2021.10.007 – volume: 8 start-page: 68 issue: 2 year: 2016 ident: 10.1016/j.heliyon.2024.e32299_bib69 article-title: B vitamins and the brain: mechanisms, dose and efficacy—a review publication-title: Nutrients doi: 10.3390/nu8020068 – volume: 247 start-page: 34 year: 2013 ident: 10.1016/j.heliyon.2024.e32299_bib22 article-title: Forced and voluntary exercises equally improve spatial learning and memory and hippocampal BDNF levels publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2013.03.007 – volume: 143 start-page: 418 issue: 4 year: 2017 ident: 10.1016/j.heliyon.2024.e32299_bib1 article-title: Brain aging and neurodegeneration: from a mitochondrial point of view publication-title: J. Neurochem. doi: 10.1111/jnc.14037 – volume: 16 start-page: 959 year: 2017 ident: 10.1016/j.heliyon.2024.e32299_bib15 article-title: Physical activity and beta-amyloid pathology in Alzheimer's disease: a sound mind in a sound body publication-title: EXCLI journal – volume: 26 start-page: 5481 issue: 10 year: 2021 ident: 10.1016/j.heliyon.2024.e32299_bib5 article-title: The amyloid-β pathway in Alzheimer's disease publication-title: Mol. Psychiatr. doi: 10.1038/s41380-021-01249-0 – volume: 17 start-page: 593 issue: 4 year: 2014 ident: 10.1016/j.heliyon.2024.e32299_bib19 article-title: Regular exercise prevents non-cognitive disturbances in a rat model of Alzheimer's disease publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/S1461145713001351 – volume: 137 start-page: 338 year: 2018 ident: 10.1016/j.heliyon.2024.e32299_bib36 article-title: Effects of thymol on amyloid-β-induced impairments in hippocampal synaptic plasticity in rats fed a high-fat diet publication-title: Brain Res. Bull. doi: 10.1016/j.brainresbull.2018.01.008 – volume: 129 start-page: 252 issue: 3 year: 2019 ident: 10.1016/j.heliyon.2024.e32299_bib44 article-title: Effect of exercise on type 2 diabetes-associated cognitive impairment in rats publication-title: Int. J. Neurosci. doi: 10.1080/00207454.2018.1526795 – volume: 14 year: 2022 ident: 10.1016/j.heliyon.2024.e32299_bib55 article-title: Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2022.1026688 – volume: 23 start-page: 524 issue: 4 year: 2020 ident: 10.1016/j.heliyon.2024.e32299_bib31 article-title: Effect of donepezil and hyoscyamoside on improving spatial memory in rats with Alzheimer's disease publication-title: J. Arak Univ. Med. Sci. doi: 10.32598/jams.23.4.6135.1 – volume: 133 year: 2021 ident: 10.1016/j.heliyon.2024.e32299_bib65 article-title: Zingiber officinale ameliorates Alzheimer's disease and cognitive impairments: lessons from preclinical studies publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2020.111088 – volume: vol. 1 year: 2018 ident: 10.1016/j.heliyon.2024.e32299_bib24 article-title: The absorption and activity of a novel form of biotin, JDS-MB-001, in a hippocampal demyelination animal model – volume: 15 start-page: dmm049327 issue: 3 year: 2022 ident: 10.1016/j.heliyon.2024.e32299_bib59 article-title: Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway publication-title: Disease Models & Mechanisms doi: 10.1242/dmm.049327 – volume: 47 start-page: 1814 issue: 9 year: 2015 ident: 10.1016/j.heliyon.2024.e32299_bib17 article-title: Treadmill running reverses cognitive declines due to Alzheimer disease publication-title: Med. Sci. Sports Exerc. doi: 10.1249/MSS.0000000000000612 – volume: 157 start-page: 19 year: 2016 ident: 10.1016/j.heliyon.2024.e32299_bib30 article-title: Effects of endurance, resistance, and concurrent exercise on learning and memory after morphine withdrawal in rats publication-title: Life Sci. doi: 10.1016/j.lfs.2016.05.034 – volume: 23 start-page: 238 issue: 5 year: 2002 ident: 10.1016/j.heliyon.2024.e32299_bib34 article-title: Assessing antidepressant activity in rodents: recent developments and future needs publication-title: Trends Pharmacol. Sci. doi: 10.1016/S0165-6147(02)02017-5 – volume: 22 start-page: 4052 issue: 8 year: 2021 ident: 10.1016/j.heliyon.2024.e32299_bib57 article-title: Molecular mechanisms underlying the beneficial effects of exercise on brain function and neurological disorders publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22084052 – volume: 28 start-page: 120 issue: 2 year: 2013 ident: 10.1016/j.heliyon.2024.e32299_bib64 article-title: The possible role of antioxidant vitamin C in Alzheimer's disease treatment and prevention publication-title: Am. J. Alzheimer's Dis. Other Dementias doi: 10.1177/1533317512473193 – volume: 53 start-page: 243 issue: 1 year: 2016 ident: 10.1016/j.heliyon.2024.e32299_bib18 article-title: A comparative study evaluating the impact of physical exercise on disease progression in a mouse model of Alzheimer's disease publication-title: J. Alzheim. Dis. doi: 10.3233/JAD-150660 – year: 2006 ident: 10.1016/j.heliyon.2024.e32299_bib26 |
| SSID | ssj0001586973 |
| Score | 2.2962847 |
| Snippet | Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the biochemical and behavioral effects of biotin supplementation (BS)... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e32299 |
| SubjectTerms | Alzheimer disease Alzheimer's disease animal models antioxidants Aβ plaque biomarkers biotin Biotin supplementation blood serum brain cognition cognitive disorders histology males malondialdehyde memory memory disorders oral gavage oxidative stress protective effect Swimming training thiols |
| Title | The protective effect of biotin supplementation and swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer's disease: A behavioral, biochemical, and histological study |
| URI | https://dx.doi.org/10.1016/j.heliyon.2024.e32299 https://www.ncbi.nlm.nih.gov/pubmed/39035497 https://www.proquest.com/docview/3083217150 https://www.proquest.com/docview/3153811224 https://doaj.org/article/1ab1917b92fb4c78aaa2437012887b22 |
| Volume | 10 |
| WOSCitedRecordID | wos001260892200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Open Access Full Text customDbUrl: eissn: 2405-8440 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001586973 issn: 2405-8440 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2405-8440 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001586973 issn: 2405-8440 databaseCode: M~E dateStart: 20150101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELWgQogL4pvloxokJC7NdhM7G4fbglpxoBUHQHuzHMdRU22SapOCyoEfyK9ixnZ2ywH2wmUPWdtxPC-e53j8hrHXFjl0nhoZIXVNI1FIEWk9ryKZlugcuJ1zd8L768fs9FQul_mna6m-KCbMywP7gTuMdUFLiiJPqkKYTGqtSUOP5lWZFYmbfZH1XFtM-fPBcp5nfHtk5_B8emZX9VVHmqeJmFoEstN73Tojp9n_h0_6G-d0vuf4HrsbSCMsfGfvsxu2fcBun4Rt8YfsFxobguICzl7ggzSgq6Cou6FuoafcnT5OnAwBui2h_143DTouGLNEAP6xiSYCOj5Zr6mKK-1zAEB_1VwMXdMDNqoB0QMulQ7darH6cWbrxq7f9BC2fd7CArY6AAfUGxMECg5cq07tOMy-4JRuH7Evx0ef33-IQpKGyCBXGyIcRYt-NjY2kSUaKdGzEilhJnKhRcXT2OrEyqooKmPmprKVFGJmtETnnODis-SP2V7btfYpA-4uJdZq0o8oETgIolIaLTSpCvIJE6O1lAkK5jREKzWGqp2rYGRFRlbeyBM23VS78BIeuyq8IyhsCpMCt7uAuFQBl2oXLidMjkBSgcx4koJN1bvu_2oEnsKXnXZwdGu7y17xGSWWypDE_6MM-bCYNkwn7IlH7eZJeD7jqcizZ__jCZ-zO9Rp-tAdpy_Y3rC-tC_ZLfNtqPv1PruZLeW-eyvx9-Tn0W9ZsUEp |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+protective+effect+of+biotin+supplementation+and+swimming+training+on+cognitive+impairment+and+mental+symptoms+in+a+rat+model+of+Alzheimer%27s+disease%3A+A+behavioral%2C+biochemical%2C+and+histological+study&rft.jtitle=Heliyon&rft.au=Shadi+Almasi&rft.au=Mohammad+Reza+Jafarzadeh+Shirazi&rft.au=Mohammad+Reza+Rezvani&rft.au=Mahdi+Ramezani&rft.date=2024-07-15&rft.pub=Elsevier&rft.eissn=2405-8440&rft.volume=10&rft.issue=13&rft.spage=e32299&rft_id=info:doi/10.1016%2Fj.heliyon.2024.e32299&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_1ab1917b92fb4c78aaa2437012887b22 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2405-8440&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2405-8440&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2405-8440&client=summon |