17β‐estradiol upregulates GREB1 and accelerates ovarian tumor progression in vivo

Exogenous 17β‐estradiol (E2) accelerates the progression of ovarian cancer in the transgenic tgCAG‐LS‐TAg mouse model of the disease. We hypothesized that E2 has direct effects on ovarian cancer cells and this study was designed to determine the molecular mechanisms by which E2 accelerates ovarian t...

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Bibliographic Details
Published in:	International journal of cancer Vol. 135; no. 5; pp. 1072 - 1084
Main Authors:	Laviolette, Laura A., Hodgkinson, Kendra M., Minhas, Neha, Perez‐Iratxeta, Carol, Vanderhyden, Barbara C.
Format:	Journal Article
Language:	English
Published:	Hoboken, NJ Wiley-Blackwell 01.09.2014 BlackWell Publishing Ltd
Subjects:	Animals Biological and medical sciences Cancer Genetics Carcinoma, Ovarian Epithelial Cell Line, Tumor Cell Proliferation Disease Progression Down-Regulation Estradiol - pharmacology estrogen Female Female genital diseases Gene Expression Regulation, Neoplastic - drug effects GREB1 Gynecology. Andrology. Obstetrics Humans Medical sciences Mice Mice, SCID microarray mouse model Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - pathology ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology RNA Interference RNA, Small Interfering - genetics Tumor Burden - drug effects Tumors Up-Regulation Animal model mouse model ovarian cancer Ovary cancer Rodentia Estrogen GREB1 17β-Estradiol Malignant tumor Ovarian hormone Female genital diseases Ovarian diseases In vivo Vertebrata microarray Mammalia Cancerology Mouse Tumor progression Sex steroid hormone Cancer Ovarian tumor estrogen
ISSN:	0020-7136, 1097-0215, 1097-0215
Online Access:	Get full text
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