Antibody responses following induction of antigen-specific tolerance with antigen-coupled cells

We have recently demonstrated the safety and tolerability of a novel therapeutic regimen employing autologous blood cells chemically coupled with seven myelin peptides to induce antigen-specific tolerance in MS (ETIMS study). The aim of the current study was an extended safety analysis to assess the...

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Vydané v:Multiple sclerosis Ročník 21; číslo 5; s. 651 - 655
Hlavní autori: Peschl, Patrick, Reindl, Markus, Schanda, Kathrin, Sospedra, Mireia, Martin, Roland, Lutterotti, Andreas
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London, England SAGE Publications 01.04.2015
Sage Publications Ltd
Predmet:
Adult
Antibody Formation - drug effects
Autoantibodies - analysis
Autoantigens - adverse effects
Autoantigens - therapeutic use
Blood Cells - immunology
Dose-Response Relationship, Immunologic
Female
Humans
Immune Tolerance
Immunoglobulin G - analysis
Male
Middle Aged
Multiple Sclerosis - therapy
Myelin-Oligodendrocyte Glycoprotein - immunology
Vaccines - adverse effects
Vaccines - therapeutic use
myelin
antigen-coupled cell
Multiple sclerosis
antibody
tolerance
ISSN:1352-4585, 1477-0970, 1477-0970
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Abstract We have recently demonstrated the safety and tolerability of a novel therapeutic regimen employing autologous blood cells chemically coupled with seven myelin peptides to induce antigen-specific tolerance in MS (ETIMS study). The aim of the current study was an extended safety analysis to assess the effect of the ETIMS approach on antibodies to common autoantigens, the myelin peptides used and common recall antigens. None of the patients showed induction of autoantibody responses. One patient had a measurable myelin peptide-specific response at baseline, which was reduced after treatment. Total immunoglobulins and recall antibody responses showed no significant change.
AbstractList We have recently demonstrated the safety and tolerability of a novel therapeutic regimen employing autologous blood cells chemically coupled with seven myelin peptides to induce antigen-specific tolerance in MS (ETIMS study). The aim of the current study was an extended safety analysis to assess the effect of the ETIMS approach on antibodies to common autoantigens, the myelin peptides used and common recall antigens. None of the patients showed induction of autoantibody responses. One patient had a measurable myelin peptide-specific response at baseline, which was reduced after treatment. Total immunoglobulins and recall antibody responses showed no significant change.
We have recently demonstrated the safety and tolerability of a novel therapeutic regimen employing autologous blood cells chemically coupled with seven myelin peptides to induce antigen-specific tolerance in MS (ETIMS study). The aim of the current study was an extended safety analysis to assess the effect of the ETIMS approach on antibodies to common autoantigens, the myelin peptides used and common recall antigens. None of the patients showed induction of autoantibody responses. One patient had a measurable myelin peptide-specific response at baseline, which was reduced after treatment. Total immunoglobulins and recall antibody responses showed no significant change.We have recently demonstrated the safety and tolerability of a novel therapeutic regimen employing autologous blood cells chemically coupled with seven myelin peptides to induce antigen-specific tolerance in MS (ETIMS study). The aim of the current study was an extended safety analysis to assess the effect of the ETIMS approach on antibodies to common autoantigens, the myelin peptides used and common recall antigens. None of the patients showed induction of autoantibody responses. One patient had a measurable myelin peptide-specific response at baseline, which was reduced after treatment. Total immunoglobulins and recall antibody responses showed no significant change.
Author Martin, Roland
Peschl, Patrick
Sospedra, Mireia
Reindl, Markus
Lutterotti, Andreas
Schanda, Kathrin
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  organization: Clinical Department of Neurology, Innsbruck Medical University, Austria
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  organization: Clinical Department of Neurology, Innsbruck Medical University, Austria
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  surname: Schanda
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  organization: Clinical Department of Neurology, Innsbruck Medical University, Austria
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  givenname: Mireia
  surname: Sospedra
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  organization: Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich, Switzerland
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  givenname: Roland
  surname: Martin
  fullname: Martin, Roland
  organization: Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich, Switzerland
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  fullname: Lutterotti, Andreas
  email: andreas.lutterotti@i-med.ac.at
  organization: Clinical Department of Neurology, Innsbruck Medical University, Austria/Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich, Switzerland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25200502$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1016_j_msard_2021_103284
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Cites_doi 10.1146/annurev.immunol.23.021704.115707
10.4049/jimmunol.178.4.2212
10.1073/pnas.0806310105
10.1038/nbt859
10.1038/80516
10.1177/1352458506072189
10.1038/nrneurol.2012.203
10.1016/j.clim.2010.11.013
10.1126/scitranslmed.3006168
10.1016/j.jneuroim.2006.01.012
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Keywords myelin
antigen-coupled cell
Multiple sclerosis
antibody
tolerance
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Sospedra, Martin 2005; 23
Robinson, Fontoura, Lee 2003; 21
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Pittock, Reindl, Achenbach 2007; 13
Lutterotti, Yousef, Sputtek 2013; 5
Di Pauli, Mader, Rostasy 2011; 138
Bielekova, Goodwin, Richert 2000; 6
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SubjectTerms Adult
Antibody Formation - drug effects
Autoantibodies - analysis
Autoantigens - adverse effects
Autoantigens - therapeutic use
Blood Cells - immunology
Dose-Response Relationship, Immunologic
Female
Humans
Immune Tolerance
Immunoglobulin G - analysis
Male
Middle Aged
Multiple Sclerosis - therapy
Myelin-Oligodendrocyte Glycoprotein - immunology
Vaccines - adverse effects
Vaccines - therapeutic use
Title Antibody responses following induction of antigen-specific tolerance with antigen-coupled cells
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