Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years

Line-field confocal optical coherence tomography (LC-OCT) can help the clinical diagnosis of skin diseases. The present study aimed to evaluate the sensitivity, specificity, and diagnostic accuracy of LC-OCT for the diagnosis of the most frequent non-melanoma skin cancers (NMSCs), i.e., basal cell c...

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Vydáno v:Current oncology (Toronto) Ročník 30; číslo 10; s. 8853 - 8864
Hlavní autoři: Donelli, Carolina, Suppa, Mariano, Tognetti, Linda, Perrot, Jean Luc, Calabrese, Laura, Pérez-Anker, Javiera, Malvehy, Josep, Rubegni, Pietro, Cinotti, Elisa
Médium: Journal Article
Jazyk:angličtina
Vydáno: MDPI AG 28.09.2023
MDPI
Témata:
basal cell carcinoma
Diagnosis
LC-OCT
Medical research
Medicine, Experimental
Melanoma
non-melanoma skin cancer
optical coherence tomography
sensitivity
Skin
Skin cancer
Squamous cell carcinoma
Tomography
ISSN:1718-7729, 1198-0052, 1718-7729
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Shrnutí:Line-field confocal optical coherence tomography (LC-OCT) can help the clinical diagnosis of skin diseases. The present study aimed to evaluate the sensitivity, specificity, and diagnostic accuracy of LC-OCT for the diagnosis of the most frequent non-melanoma skin cancers (NMSCs), i.e., basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Comparing LC-OCT diagnostic performances with those of dermoscopy, histopathological examination was used as a gold standard. For every study endpoint, the diagnostic ability of LC-OCT revealed superiority over the dermoscopic examination. In particular, a significant increase in specificity was observed. Sensitivity, specificity, and diagnostic accuracy of dermoscopy and LC-OCT for the diagnosis of malignancy were, respectively, 0.97 (CI 0.94–0.99), 0.43 (CI 0.36–0.51), and 0.77 (CI 0.72–0.81) for dermoscopy and 0.99 (CI 0.97–1.00), 0.90 (CI 0.84–0.94), and 0.96 (CI 0.93–0.97) for LC-OCT. The positive predictive value (PPV) resulted in 0.74 (CI 0.69–0.78) for dermoscopy and 0.94 (CI 0.91–0.97) for LC-OCT, and the negative predictive value (NPV) was 0.89 (CI 0.81–0.95) for dermoscopy and 0.98 (CI 0.95–1.00) for LC-OCT. Finally, our real-life study showed a potentially important role of LC-OCT in the non-invasive diagnosis of NMSCs, especially BCC. The real-time imaging technique could spare unnecessary biopsies with an increased sensitivity, a much higher specificity, and better accuracy than clinical assessment with dermoscopy alone.
Bibliografie:ObjectType-Article-1
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content type line 23
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol30100639