Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids

Chronic hepatitis B virus (HBV) infection, a serious public health problem leading to cirrhosis and hepatocellular carcinoma, is currently treated with either pegylated alpha interferon (pegIFN-α) or one of the five nucleos(t)ide analogue viral DNA polymerase inhibitors. However, neither pegIFN-α no...

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Veröffentlicht in:	Journal of virology Jg. 87; H. 12; S. 6931
Hauptverfasser:	Campagna, Matthew R, Liu, Fei, Mao, Richeng, Mills, Courtney, Cai, Dawei, Guo, Fang, Zhao, Xuesen, Ye, Hong, Cuconati, Andrea, Guo, Haitao, Chang, Jinhong, Xu, Xiaodong, Block, Timothy M, Guo, Ju-Tao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.06.2013
Schlagworte:	Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Benzamides - chemistry Benzamides - pharmacology Cell Line, Transformed Hep G2 Cells Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B virus - metabolism Hepatitis B Virus, Woodchuck - drug effects Hepatitis B Virus, Woodchuck - genetics Hepatitis B Virus, Woodchuck - metabolism Hepatocytes - virology High-Throughput Screening Assays Humans Mice Nucleocapsid - drug effects Nucleocapsid - metabolism Structure-Activity Relationship Virus Assembly - drug effects Virus Replication - drug effects
ISSN:	1098-5514, 1098-5514
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