Role of cancer stem cells in pancreatic ductal adenocarcinoma

With greater understanding of the biology of pancreatic cancer a role for cancer stem cells is becoming clear. The authors of this Review discuss the current knowledge on pancreatic cancer stem cells and their potential use as targets in therapeutic regimens. As our understanding of pancreatic cance...

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Veröffentlicht in:Nature reviews. Clinical oncology Jg. 6; H. 10; S. 580 - 586
Hauptverfasser: Sergeant, Gregory, Vankelecom, Hugo, Gremeaux, Lies, Topal, Baki
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.10.2009
Nature Publishing Group
Schlagworte:
Animals
Biomarkers, Tumor - metabolism
Cancer cells
Carcinoma, Pancreatic Ductal - genetics
Carcinoma, Pancreatic Ductal - metabolism
Carcinoma, Pancreatic Ductal - pathology
Care and treatment
Cell Line, Tumor
Forecasting
Genetic aspects
Health aspects
Humans
Medicine
Medicine & Public Health
Neoplasm Metastasis
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Oncology
Pancreatic cancer
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
review-article
Stem cells
Belgium
ISSN:1759-4774, 1759-4782, 1759-4782
Online-Zugang:Volltext
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Zusammenfassung:With greater understanding of the biology of pancreatic cancer a role for cancer stem cells is becoming clear. The authors of this Review discuss the current knowledge on pancreatic cancer stem cells and their potential use as targets in therapeutic regimens. As our understanding of pancreatic cancer evolves, evidence is growing to support a role for cancer stem cells in this devastating disease. Cancer stem cells constitute a distinct subpopulation in the tumor and are considered to drive both tumorigenesis and metastasis; these cells are thought to be highly resistant to standard treatment modalities. Here we review the current knowledge on pancreatic cancer stem cells and the implementation of cancer stem cell markers as prognostic or predictive biomarkers. We also discuss prospects for the use of cancer stem cells as targets for future therapeutic regimens in pancreatic cancer. Key Points Conventional chemotherapy and radiotherapy affect rapidly dividing pancreatic cancer cells but fail to target cancer stem cells that drive tumorigenesis and metastasis Pancreatic cancer stem cells with either a CD44 + CD24 + ESA + or a CD133 + phenotype have been identified from primary human pancreatic ductal adenocarcinoma The metastatic potential of pancreatic ductal adenocarcinoma seems to be determined by a subpopulation of CD133 + cells that co-express CXCR4 Developmental signaling pathways that regulate self-renewal and cell fate in normal stem cells are also involved in pancreatic cancer stem cells and might serve as novel biomarkers and therapeutic targets Any treatment designed to eradicate pancreatic cancer needs to eliminate all cancer stem cells from the tumor The success of any approach that targets pancreatic cancer stem cells will depend upon further identification and characterization of normal pancreatic stem cells, cancer stem cells and the surrounding tumor stroma
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ISSN:1759-4774
1759-4782
1759-4782
DOI:10.1038/nrclinonc.2009.127