Trends in primary multidrug-resistant tuberculosis in the State of Rio de Janeiro: a retrospective study conducted during 2000-2019

We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpo...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical Vol. 54; p. e00862021
Main Authors: Bhering, Marcela, Kritski, Afrânio
Format: Journal Article
Language:English
Published: Brazil Sociedade Brasileira de Medicina Tropical - SBMT 01.01.2021
Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects:
Antitubercular Agents - therapeutic use
Brazil - epidemiology
Drug resistance
Epidemiological monitoring
Humans
Research Design
Retrospective Studies
Short Communication
Time-series studies
TROPICAL MEDICINE
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
Brazil
Time-series studies
Tuberculosis
Drug resistance
Epidemiological monitoring
ISSN:0037-8682, 1678-9849, 1678-9849
Online Access:Get full text
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Summary:We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis. The percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001). The trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.
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Conflict of Interest: The authors declare that there is no conflict of interest.
Authors' contribution: MB: conception and design of the study, data acquisition, analysis, and interpretation of data, and drafting the article. AK: analysis and interpretation of data, drafting the paper, and final approval of the version to be submitted.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0086-2021