Trends in primary multidrug-resistant tuberculosis in the State of Rio de Janeiro: a retrospective study conducted during 2000-2019

We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpo...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical Vol. 54; p. e00862021
Main Authors: Bhering, Marcela, Kritski, Afrânio
Format: Journal Article
Language:English
Published: Brazil Sociedade Brasileira de Medicina Tropical - SBMT 01.01.2021
Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects:
Antitubercular Agents - therapeutic use
Brazil - epidemiology
Drug resistance
Epidemiological monitoring
Humans
Research Design
Retrospective Studies
Short Communication
Time-series studies
TROPICAL MEDICINE
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
Brazil
Time-series studies
Tuberculosis
Drug resistance
Epidemiological monitoring
ISSN:0037-8682, 1678-9849, 1678-9849
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Abstract We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis. The percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001). The trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.
AbstractList Abstract INTRODUCTION: We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). METHODS: We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis. RESULTS: The percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001). CONCLUSIONS: The trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.
We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis. The percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001). The trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.
We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB).INTRODUCTIONWe analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB).We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis.METHODSWe performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis.The percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001).RESULTSThe percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001).The trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.CONCLUSIONSThe trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.
Author Kritski, Afrânio
Bhering, Marcela
AuthorAffiliation 1 Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa Acadêmico de Tuberculose, Rio de Janeiro, RJ, Brasil
2 Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública Sergio Arouca, Rio de Janeiro, RJ, Brasil
AuthorAffiliation_xml – name: 2 Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública Sergio Arouca, Rio de Janeiro, RJ, Brasil
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10.4136/ambi-agua.2532
10.26633/RPSP.2020.178
10.1016/S2214-109X(19)30068-3
10.1371/journal.pone.0026276
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Keywords Time-series studies
Tuberculosis
Drug resistance
Epidemiological monitoring
Language English
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Conflict of Interest: The authors declare that there is no conflict of interest.
Authors' contribution: MB: conception and design of the study, data acquisition, analysis, and interpretation of data, and drafting the article. AK: analysis and interpretation of data, drafting the paper, and final approval of the version to be submitted.
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Snippet We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). We performed a time series analysis of primary MDR-TB cases reported in the State...
We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB).INTRODUCTIONWe analyzed the trends in primary multidrug-resistant tuberculosis...
Abstract INTRODUCTION: We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). METHODS: We performed a time series analysis of primary...
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SubjectTerms Antitubercular Agents - therapeutic use
Brazil - epidemiology
Drug resistance
Epidemiological monitoring
Humans
Research Design
Retrospective Studies
Short Communication
Time-series studies
TROPICAL MEDICINE
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
Title Trends in primary multidrug-resistant tuberculosis in the State of Rio de Janeiro: a retrospective study conducted during 2000-2019
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