Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers

Background More and more preclinical studies support the idea that curcumin, a plant-derived natural polyphenol, could be a promising anticancer drug. However, poor bioavailability has limited its efficacy in clinical trials, and plasma curcumin levels remain low despite patients taking gram doses o...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 69; no. 1; pp. 65 - 70
Main Authors:	Kanai, Masashi, Imaizumi, Atsushi, Otsuka, Yoshihiko, Sasaki, Hiroki, Hashiguchi, Momo, Tsujiko, Kazu, Matsumoto, Shigemi, Ishiguro, Hiroshi, Chiba, Tsutomu
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.01.2012 Springer Springer Nature B.V
Subjects:	Administration, Oral Adult Antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Area Under Curve Biological and medical sciences Biological Availability Cancer Research Chromatography, High Pressure Liquid Curcumin - administration & dosage Curcumin - adverse effects Curcumin - pharmacokinetics Dose-Response Relationship, Drug Female Half-Life Humans Male Medical sciences Medicine Medicine & Public Health Middle Aged Nanoparticles Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Solubility THERACURMIN Curcumin Bioavailability Nanotechnology Antineoplastic agent Human BioavailabilityTHERACURMIN Healthy subject Dose escalation Tyrosine kinase inhibitor Nanoparticle Increasing dose Polyphenol Phenols Microparticle Pharmacokinetics
ISSN:	0344-5704, 1432-0843, 1432-0843
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!