Protein microarrays with carbon nanotubes as multicolor Raman labels

The picomolar sensitivity of fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Chen et al . use antibody-tagged single-walled carbon nanotubes as multicolor Raman labels to detect femtomolar levels of serum analytes over a wide dynamic range. T...

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Bibliographic Details
Published in:	Nature biotechnology Vol. 26; no. 11; pp. 1285 - 1292
Main Authors:	Chen, Zhuo, Tabakman, Scott M, Goodwin, Andrew P, Kattah, Michael G, Daranciang, Dan, Wang, Xinran, Zhang, Guangyu, Li, Xiaolin, Liu, Zhuang, Utz, Paul J, Jiang, Kaili, Fan, Shoushan, Dai, Hongjie
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.11.2008 Nature Publishing Group
Subjects:	Agriculture Animals Autoantibodies - blood Autoimmune diseases Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Carbon Carbon Isotopes - chemistry Carbon Radioisotopes - chemistry Detection limits Fluorescence Fundamental and applied biological sciences. Psychology Granulomatosis with Polyangiitis - diagnosis Granulomatosis with Polyangiitis - immunology Health. Pharmaceutical industry Humans Identification and classification Industrial applications and implications. Economical aspects Life Sciences Methods Mice Miscellaneous Myeloblastin - immunology Nanotechnology Nanotubes Nanotubes, Carbon - chemistry Photobleaching Protein Array Analysis - methods Protein microarrays Proteins Research methodology Signal to noise ratio Spectrum Analysis, Raman - methods United States Human Nanotube Autoantibody Biological marker Wegener granulomatosis Autoimmune disease Protein microarray Carbon Protein Raman scattering Serum Diagnosis Detection
ISSN:	1087-0156, 1546-1696, 1546-1696
Online Access:	Get full text
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