Protein microarrays with carbon nanotubes as multicolor Raman labels
The picomolar sensitivity of fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Chen et al . use antibody-tagged single-walled carbon nanotubes as multicolor Raman labels to detect femtomolar levels of serum analytes over a wide dynamic range. T...
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| Vydané v: | Nature biotechnology Ročník 26; číslo 11; s. 1285 - 1292 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
New York
Nature Publishing Group US
01.11.2008
Nature Publishing Group |
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| ISSN: | 1087-0156, 1546-1696, 1546-1696 |
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| Abstract | The picomolar sensitivity of fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Chen
et al
. use antibody-tagged single-walled carbon nanotubes as multicolor Raman labels to detect femtomolar levels of serum analytes over a wide dynamic range.
The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use functionalized, macromolecular single-walled carbon nanotubes (SWNTs) as multicolor Raman labels for highly sensitive, multiplexed protein detection in an arrayed format. Unlike fluorescence methods, Raman detection benefits from the sharp scattering peaks of SWNTs with minimal background interference, affording a high signal-to-noise ratio needed for ultra-sensitive detection. When combined with surface-enhanced Raman scattering substrates, the strong Raman intensity of SWNT tags affords protein detection sensitivity in sandwich assays down to 1 fM—a three-order-of-magnitude improvement over most reports of fluorescence-based detection. We use SWNT Raman tags to detect human autoantibodies against proteinase 3, a biomarker for the autoimmune disease Wegener's granulomatosis, diluted up to 10
7
-fold in 1% human serum. SWNT Raman tags are not subject to photobleaching or quenching. By conjugating different antibodies to pure
12
C and
13
C SWNT isotopes, we demonstrate multiplexed two-color SWNT Raman-based protein detection. |
|---|---|
| AbstractList | The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use functionalized, macromolecular single-walled carbon nanotubes (SWNTs) as multicolor Raman labels for highly sensitive, multiplexed protein detection in an arrayed format. Unlike fluorescence methods, Raman detection benefits from the sharp scattering peaks of SWNTs with minimal background interference, affording a high signal-to-noise ratio needed for ultra-sensitive detection. When combined with surface-enhanced Raman scattering substrates, the strong Raman intensity of SWNT tags affords protein detection sensitivity in sandwich assays down to 1 fM--a three-order-of-magnitude improvement over most reports of fluorescence-based detection. We use SWNT Raman tags to detect human autoantibodies against proteinase 3, a biomarker for the autoimmune disease Wegener's granulomatosis, diluted up to 10(7)-fold in 1% human serum. SWNT Raman tags are not subject to photobleaching or quenching. By conjugating different antibodies to pure (12)C and (13)C SWNT isotopes, we demonstrate multiplexed two-color SWNT Raman-based protein detection.The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use functionalized, macromolecular single-walled carbon nanotubes (SWNTs) as multicolor Raman labels for highly sensitive, multiplexed protein detection in an arrayed format. Unlike fluorescence methods, Raman detection benefits from the sharp scattering peaks of SWNTs with minimal background interference, affording a high signal-to-noise ratio needed for ultra-sensitive detection. When combined with surface-enhanced Raman scattering substrates, the strong Raman intensity of SWNT tags affords protein detection sensitivity in sandwich assays down to 1 fM--a three-order-of-magnitude improvement over most reports of fluorescence-based detection. We use SWNT Raman tags to detect human autoantibodies against proteinase 3, a biomarker for the autoimmune disease Wegener's granulomatosis, diluted up to 10(7)-fold in 1% human serum. SWNT Raman tags are not subject to photobleaching or quenching. By conjugating different antibodies to pure (12)C and (13)C SWNT isotopes, we demonstrate multiplexed two-color SWNT Raman-based protein detection. The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use functionalized, macromolecular single-walled carbon nanotubes (SWNTs) as multicolor Raman labels for highly sensitive, multiplexed protein detection in an arrayed format. Unlike fluorescence methods, Raman detection benefits from the sharp scattering peaks of SWNTs with minimal background interference, affording a high signal-to-noise ratio needed for ultra-sensitive detection. When combined with surface-enhanced Raman scattering substrates, the strong Raman intensity of SWNT tags affords protein detection sensitivity in sandwich assays down to 1 fM--a three-order-of-magnitude improvement over most reports of fluorescence-based detection. We use SWNT Raman tags to detect human autoantibodies against proteinase 3, a biomarker for the autoimmune disease Wegener's granulomatosis, diluted up to 10(7)-fold in 1% human serum. SWNT Raman tags are not subject to photobleaching or quenching. By conjugating different antibodies to pure (12)C and (13)C SWNT isotopes, we demonstrate multiplexed two-color SWNT Raman-based protein detection. [PUBLICATION ABSTRACT] The picomolar sensitivity of fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Chen et al . use antibody-tagged single-walled carbon nanotubes as multicolor Raman labels to detect femtomolar levels of serum analytes over a wide dynamic range. The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use functionalized, macromolecular single-walled carbon nanotubes (SWNTs) as multicolor Raman labels for highly sensitive, multiplexed protein detection in an arrayed format. Unlike fluorescence methods, Raman detection benefits from the sharp scattering peaks of SWNTs with minimal background interference, affording a high signal-to-noise ratio needed for ultra-sensitive detection. When combined with surface-enhanced Raman scattering substrates, the strong Raman intensity of SWNT tags affords protein detection sensitivity in sandwich assays down to 1 fM—a three-order-of-magnitude improvement over most reports of fluorescence-based detection. We use SWNT Raman tags to detect human autoantibodies against proteinase 3, a biomarker for the autoimmune disease Wegener's granulomatosis, diluted up to 10 7 -fold in 1% human serum. SWNT Raman tags are not subject to photobleaching or quenching. By conjugating different antibodies to pure 12 C and 13 C SWNT isotopes, we demonstrate multiplexed two-color SWNT Raman-based protein detection. The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use functionalized, macromolecular single-walled carbon nanotubes (SWNTs) as multicolor Raman labels for highly sensitive, multiplexed protein detection in an arrayed format. Unlike fluorescence methods, Raman detection benefits from the sharp scattering peaks of SWNTs with minimal background interference, affording a high signal-to-noise ratio needed for ultra- sensitive detection. When combined with surface-enhanced Raman scattering substrates, the strong Raman intensity of SWNT tags affords protein detection sensitivity in sandwich assays down to 1 fM-a three-order-of-magnitude improvement over most reports of fluorescence-based detection. We use SWNT Raman tags to detect human autoantibodies against proteinase 3, a biomarker for the autoimmune disease Wegener's granulomatosis, diluted up to 10 super(7)- fold in 1% human serum. SWNT Raman tags are not subject to photobleaching or quenching. By conjugating different antibodies to pure super(12)C and super(13)C SWNT isotopes, we demonstrate multiplexed two-color SWNT Raman-based protein detection. The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use functionalized, macromolecular single-walled carbon nanotubes (SWNTs) as multicolor Raman labels for highly sensitive, multiplexed protein detection in an arrayed format. Unlike fluorescence methods, Raman detection benefits from the sharp scattering peaks of SWNTs with minimal background interference, affording a high signal-to-noise ratio needed for ultra-sensitive detection. When combined with surface-enhanced Raman scattering substrates, the strong Raman intensity of SWNT tags affords protein detection sensitivity in sandwich assays down to 1 fM--a three-order-of-magnitude improvement over most reports of fluorescence-based detection. We use SWNT Raman tags to detect human autoantibodies against proteinase 3, a biomarker for the autoimmune disease Wegener's granulomatosis, diluted up to 10(7)-fold in 1% human serum. SWNT Raman tags are not subject to photobleaching or quenching. By conjugating different antibodies to pure (12)C and (13)C SWNT isotopes, we demonstrate multiplexed two-color SWNT Raman-based protein detection. The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use functionalized, macromolecular single-walled carbon nanotubes (SWNTs) as multicolor Raman labels for highly sensitive, multiplexed protein detection in an arrayed format. Unlike fluorescence methods, Raman detection benefits from the sharp scattering peaks of SWNTs with minimal background interference, affording a high signal-to-noise ratio needed for ultra-sensitive detection. When combined with surface-enhanced Raman scattering substrates, the strong Raman intensity of SWNT tags affords protein detection sensitivity in sandwich assays down to 1 fM--a three-order-of-magnitude improvement over most reports of fluorescence-based detection. We use SWNT Raman tags to detect human autoantibodies against proteinase 3, a biomarker for the autoimmune disease Wegener's granulomatosis, diluted up to [10.sup.7]-fold in 1% human serum. SWNT Raman tags are not subject to photobleaching or quenching. By conjugating different antibodies to pure [sup.12]C and [sup.13]C SWNT isotopes, we demonstrate multiplexed two-color SWNT Raman-based protein detection. |
| Audience | Academic |
| Author | Zhang, Guangyu Utz, Paul J Chen, Zhuo Wang, Xinran Kattah, Michael G Li, Xiaolin Tabakman, Scott M Fan, Shoushan Dai, Hongjie Liu, Zhuang Jiang, Kaili Goodwin, Andrew P Daranciang, Dan |
| Author_xml | – sequence: 1 givenname: Zhuo surname: Chen fullname: Chen, Zhuo organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University – sequence: 2 givenname: Scott M surname: Tabakman fullname: Tabakman, Scott M organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University – sequence: 3 givenname: Andrew P surname: Goodwin fullname: Goodwin, Andrew P organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University – sequence: 4 givenname: Michael G surname: Kattah fullname: Kattah, Michael G organization: School of Medicine, Stanford University – sequence: 5 givenname: Dan surname: Daranciang fullname: Daranciang, Dan organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University – sequence: 6 givenname: Xinran surname: Wang fullname: Wang, Xinran organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University – sequence: 7 givenname: Guangyu surname: Zhang fullname: Zhang, Guangyu organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University – sequence: 8 givenname: Xiaolin surname: Li fullname: Li, Xiaolin organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University – sequence: 9 givenname: Zhuang surname: Liu fullname: Liu, Zhuang organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University – sequence: 10 givenname: Paul J surname: Utz fullname: Utz, Paul J organization: School of Medicine, Stanford University – sequence: 11 givenname: Kaili surname: Jiang fullname: Jiang, Kaili organization: Department of Physics, Tsinghua-Foxconn Nanotechnology Research Center, Tsinghua University – sequence: 12 givenname: Shoushan surname: Fan fullname: Fan, Shoushan organization: Department of Physics, Tsinghua-Foxconn Nanotechnology Research Center, Tsinghua University – sequence: 13 givenname: Hongjie surname: Dai fullname: Dai, Hongjie email: hdai@stanford.edu organization: Department of Chemistry and Laboratory for Advanced Materials, Stanford University |
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| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2008 2009 INIST-CNRS COPYRIGHT 2008 Nature Publishing Group Copyright Nature Publishing Group Nov 2008 |
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| Keywords | Human Nanotube Autoantibody Biological marker Wegener granulomatosis Autoimmune disease Protein microarray Carbon Protein Raman scattering Serum Diagnosis Detection |
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| Snippet | The picomolar sensitivity of fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Chen
et al
. use... The current sensitivity of standard fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Here, we use... |
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| SubjectTerms | Agriculture Animals Autoantibodies - blood Autoimmune diseases Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Carbon Carbon Isotopes - chemistry Carbon Radioisotopes - chemistry Detection limits Fluorescence Fundamental and applied biological sciences. Psychology Granulomatosis with Polyangiitis - diagnosis Granulomatosis with Polyangiitis - immunology Health. Pharmaceutical industry Humans Identification and classification Industrial applications and implications. Economical aspects Life Sciences Methods Mice Miscellaneous Myeloblastin - immunology Nanotechnology Nanotubes Nanotubes, Carbon - chemistry Photobleaching Protein Array Analysis - methods Protein microarrays Proteins Research methodology Signal to noise ratio Spectrum Analysis, Raman - methods |
| Title | Protein microarrays with carbon nanotubes as multicolor Raman labels |
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