STRUM: structure-based prediction of protein stability changes upon single-point mutation

Motivation: Mutations in human genome are mainly through single nucleotide polymorphism, some of which can affect stability and function of proteins, causing human diseases. Several methods have been proposed to predict the effect of mutations on protein stability; but most require features from exp...

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Bibliographic Details

Published in:	Bioinformatics (Oxford, England) Vol. 32; no. 19; pp. 2936 - 2946
Main Authors:	Quan, Lijun, Lv, Qiang, Zhang, Yang
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.10.2016
Subjects:	Algorithms Humans Models, Molecular Original Papers Point Mutation Protein Stability Proteins Software Structure-Activity Relationship
ISSN:	1367-4803, 1367-4811, 1367-4811
Online Access:	Get full text
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