STRUM: structure-based prediction of protein stability changes upon single-point mutation

Motivation: Mutations in human genome are mainly through single nucleotide polymorphism, some of which can affect stability and function of proteins, causing human diseases. Several methods have been proposed to predict the effect of mutations on protein stability; but most require features from exp...

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Vydané v:	Bioinformatics (Oxford, England) Ročník 32; číslo 19; s. 2936 - 2946
Hlavní autori:	Quan, Lijun, Lv, Qiang, Zhang, Yang
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 01.10.2016
Predmet:	Algorithms Humans Models, Molecular Original Papers Point Mutation Protein Stability Proteins Software Structure-Activity Relationship
ISSN:	1367-4803, 1367-4811, 1367-4811
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