Extracellular Histones Bind Vascular Glycosaminoglycans and Inhibit the Anti-Inflammatory Function of Antithrombin

Binding of histones to molecular pattern recognition receptors on endothelial cells and leukocytes provokes proinflammatory responses and promotes activation of coagulation. Histones also bind therapeutic heparins, thereby neutralizing their anticoagulant functions. The aim of this study was to test...

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Bibliographic Details

Published in:	Cellular physiology and biochemistry Vol. 55; no. 5; pp. 605 - 617
Main Authors:	Biswas, Indranil, Panicker, Sumith R, Cai, Xiaofeng S, Giri, Hemant, Rezaie, Alireza R
Format:	Journal Article
Language:	English
Published:	Germany Cell Physiol Biochem Press GmbH & Co KG 16.10.2021
Subjects:	Antithrombin III - metabolism Blood Coagulation Endothelial Cells - metabolism Glycosaminoglycans - metabolism Histones - metabolism Human Umbilical Vein Endothelial Cells Humans Inflammation - blood Inflammation - metabolism Protein Binding Histones; Antithrombin; Glycosaminoglycans; Signaling
ISSN:	1015-8987, 1421-9778, 1421-9778
Online Access:	Get full text
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