Extracellular Histones Bind Vascular Glycosaminoglycans and Inhibit the Anti-Inflammatory Function of Antithrombin

Binding of histones to molecular pattern recognition receptors on endothelial cells and leukocytes provokes proinflammatory responses and promotes activation of coagulation. Histones also bind therapeutic heparins, thereby neutralizing their anticoagulant functions. The aim of this study was to test...

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Veröffentlicht in:	Cellular physiology and biochemistry Jg. 55; H. 5; S. 605 - 617
Hauptverfasser:	Biswas, Indranil, Panicker, Sumith R, Cai, Xiaofeng S, Giri, Hemant, Rezaie, Alireza R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany Cell Physiol Biochem Press GmbH & Co KG 16.10.2021
Schlagworte:	Antithrombin III - metabolism Blood Coagulation Endothelial Cells - metabolism Glycosaminoglycans - metabolism Histones - metabolism Human Umbilical Vein Endothelial Cells Humans Inflammation - blood Inflammation - metabolism Protein Binding Histones; Antithrombin; Glycosaminoglycans; Signaling
ISSN:	1015-8987, 1421-9778, 1421-9778
Online-Zugang:	Volltext
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