Immunological Effects of Human Milk Oligosaccharides

Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested in the gastrointestinal tract and reach the colon intact, where they shape the microbiota. A small fraction of HMOs is absorbed, reach...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Frontiers in pediatrics Jg. 6; S. 190
Hauptverfasser: Triantis, Vassilis, Bode, Lars, van Neerven, R. J. Joost
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Media S.A 2018
Schlagworte:
Allergy
Benefit
Health
HMO
Human milk oligosaccharides
Immunity
Infant
Infection
Pediatrics
human milk oligosaccharides
infection
allergy
health
HMO
immunity
infant
benefit
ISSN:2296-2360, 2296-2360
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested in the gastrointestinal tract and reach the colon intact, where they shape the microbiota. A small fraction of HMOs is absorbed, reaches the systemic circulation, and is excreted in urine. HMOs can bind to cell surface receptors expressed on epithelial cells and cells of the immune system and thus modulate neonatal immunity in the infant gut, and possibly also sites throughout the body. In addition, they have been shown to act as soluble decoy receptors to block the attachment of various microbial pathogens to cells. This review summarizes the current knowledge of the effects HMOs can have on infections, allergies, auto-immune diseases and inflammation, and will focus on the role of HMOs in altering immune responses through binding to immune-related receptors.
AbstractList Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested in the gastrointestinal tract and reach the colon intact, where they shape the microbiota. A small fraction of HMOs is absorbed, reaches the systemic circulation, and is excreted in urine. HMOs can bind to cell surface receptors expressed on epithelial cells and cells of the immune system and thus modulate neonatal immunity in the infant gut, and possibly also sites throughout the body. In addition, they have been shown to act as soluble decoy receptors to block the attachment of various microbial pathogens to cells. This review summarizes the current knowledge of the effects HMOs can have on infections, allergies, auto-immune diseases and inflammation, and will focus on the role of HMOs in altering immune responses through binding to immune-related receptors.
Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested in the gastrointestinal tract and reach the colon intact, where they shape the microbiota. A small fraction of HMOs is absorbed, reaches the systemic circulation, and is excreted in urine. HMOs can bind to cell surface receptors expressed on epithelial cells and cells of the immune system and thus modulate neonatal immunity in the infant gut, and possibly also sites throughout the body. In addition, they have been shown to act as soluble decoy receptors to block the attachment of various microbial pathogens to cells. This review summarizes the current knowledge of the effects HMOs can have on infections, allergies, auto-immune diseases and inflammation, and will focus on the role of HMOs in altering immune responses through binding to immune-related receptors.Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested in the gastrointestinal tract and reach the colon intact, where they shape the microbiota. A small fraction of HMOs is absorbed, reaches the systemic circulation, and is excreted in urine. HMOs can bind to cell surface receptors expressed on epithelial cells and cells of the immune system and thus modulate neonatal immunity in the infant gut, and possibly also sites throughout the body. In addition, they have been shown to act as soluble decoy receptors to block the attachment of various microbial pathogens to cells. This review summarizes the current knowledge of the effects HMOs can have on infections, allergies, auto-immune diseases and inflammation, and will focus on the role of HMOs in altering immune responses through binding to immune-related receptors.
Author Bode, Lars
van Neerven, R. J. Joost
Triantis, Vassilis
AuthorAffiliation 2 Department of Pediatrics, University of California, San Diego , San Diego, CA , United States
3 Wageningen University and Research, Cell Biology and Immunology , Wageningen , Netherlands
1 FrieslandCampina , Amersfoort , Netherlands
AuthorAffiliation_xml – name: 1 FrieslandCampina , Amersfoort , Netherlands
– name: 2 Department of Pediatrics, University of California, San Diego , San Diego, CA , United States
– name: 3 Wageningen University and Research, Cell Biology and Immunology , Wageningen , Netherlands
Author_xml – sequence: 1
  givenname: Vassilis
  surname: Triantis
  fullname: Triantis, Vassilis
– sequence: 2
  givenname: Lars
  surname: Bode
  fullname: Bode, Lars
– sequence: 3
  givenname: R. J. Joost
  surname: van Neerven
  fullname: van Neerven, R. J. Joost
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30013961$$D View this record in MEDLINE/PubMed
BookMark eNp1Us9PHCEUJo2m6uq5t2aOvezKj2Vm6KFJY6xuYuNFz4R5wIhlYAszNf3vy-xao00KCQ8e7_vee_CdoIMQg0HoA8ErxlpxbrdGrygm7QpjIvA7dEypqJeU1fjg1f4IneX8iMsQDeaEv0dHrACYqMkxWm-GYQrRx96B8tWltQbGXEVbXU-DCtV3539Ut971MSuAB5WcNvkUHVrlszl7tgt0_-3y7uJ6eXN7tbn4erMETvC4pFpr23FoLNMGyoFp1hJTJhYcmFKcK95arRuCa0HXoGltO4upLWUDp2yBNnteHdWj3CY3qPRbRuXkzhFTL1UaHXgjhTCdLT21VuA1NZ0Q0OjWEE2AM1a6XaDPe64n1ZvgQllkUAlc3hF616WZ_GlKMvjZbKcuS74mha6Av-zBxTkYDSaMSfk3Fb29Ce5B9vGXrDGry6MXgk_PBCn-nEwe5eAyGO9VMHHKkuKG8JrW7Rz68XWulyR__6wEnO8DIMWck7EvIQTLWRhyFoachSF3wigI_g8C3KhGF-dinf8v7g8ymb7E
CitedBy_id crossref_primary_10_3389_fimmu_2020_00801
crossref_primary_10_3390_pathogens10080927
crossref_primary_10_1016_j_jaci_2020_06_027
crossref_primary_10_1128_mSystems_00457_20
crossref_primary_10_3389_fimmu_2022_907529
crossref_primary_10_1080_10408398_2023_2199072
crossref_primary_10_3168_jds_2020_19649
crossref_primary_10_1016_j_jff_2020_104074
crossref_primary_10_3390_nu15112548
crossref_primary_10_1016_j_ajcnut_2025_06_009
crossref_primary_10_3390_nu13041123
crossref_primary_10_3168_jds_2021_20327
crossref_primary_10_3390_nu12103047
crossref_primary_10_1089_bfm_2023_0274
crossref_primary_10_3390_biom13020263
crossref_primary_10_3390_nu11020364
crossref_primary_10_1016_j_clnu_2019_03_002
crossref_primary_10_1136_archdischild_2021_321922
crossref_primary_10_2147_JAA_S272705
crossref_primary_10_1039_D4NP00058G
crossref_primary_10_1016_j_biotechadv_2023_108245
crossref_primary_10_1016_j_carbpol_2021_118738
crossref_primary_10_1016_j_jff_2021_104630
crossref_primary_10_3390_molecules24112033
crossref_primary_10_1016_j_jchromb_2020_122497
crossref_primary_10_3390_nu16121863
crossref_primary_10_3390_nu13072272
crossref_primary_10_3390_nu13093190
crossref_primary_10_3389_fchem_2021_691299
crossref_primary_10_3389_fimmu_2025_1575656
crossref_primary_10_3390_nu13031026
crossref_primary_10_1016_j_enzmictec_2021_109829
crossref_primary_10_1002_anie_202411863
crossref_primary_10_1016_j_jbc_2024_107573
crossref_primary_10_3390_nu12041039
crossref_primary_10_3389_fimmu_2025_1572787
crossref_primary_10_7717_peerj_11303
crossref_primary_10_3390_foods12040858
crossref_primary_10_1016_j_carbpol_2022_120017
crossref_primary_10_1038_s41372_020_00820_x
crossref_primary_10_3390_nu12103212
crossref_primary_10_1016_j_carbpol_2024_121908
crossref_primary_10_1016_j_jff_2021_104529
crossref_primary_10_3390_nu15163622
crossref_primary_10_1055_a_1936_0826
crossref_primary_10_3390_nu12041045
crossref_primary_10_1016_j_foodres_2025_116328
crossref_primary_10_3389_fimmu_2020_02141
crossref_primary_10_1016_j_foodres_2023_113293
crossref_primary_10_3389_fnut_2021_800927
crossref_primary_10_1016_j_tim_2021_01_003
crossref_primary_10_3390_ijms241411422
crossref_primary_10_1016_j_heliyon_2024_e24539
crossref_primary_10_1038_s41598_019_48337_4
crossref_primary_10_3390_nu12030790
crossref_primary_10_3390_nu11112684
crossref_primary_10_1016_j_carres_2020_108029
crossref_primary_10_1093_femsre_fuac004
crossref_primary_10_3389_fnut_2021_646275
crossref_primary_10_3390_nu12030826
crossref_primary_10_3390_nu15061441
crossref_primary_10_1016_j_clp_2022_02_009
crossref_primary_10_1016_j_idairyj_2020_104727
crossref_primary_10_3389_fimmu_2022_841532
crossref_primary_10_3389_fnut_2021_761129
crossref_primary_10_1017_gmb_2022_8
crossref_primary_10_1080_10408398_2020_1761772
crossref_primary_10_1146_annurev_nutr_122221_103916
crossref_primary_10_1016_j_copbio_2018_11_003
crossref_primary_10_1128_msphere_00885_21
crossref_primary_10_3390_diagnostics12092208
crossref_primary_10_1016_j_foodres_2021_110884
crossref_primary_10_1093_nutrit_nuz015
crossref_primary_10_1111_pai_13276
crossref_primary_10_1093_cdn_nzaa113
crossref_primary_10_3389_fped_2024_1439612
crossref_primary_10_1093_jas_skab008
crossref_primary_10_3390_nu12020338
crossref_primary_10_1080_14789450_2021_1940143
crossref_primary_10_1016_j_advnut_2023_09_015
crossref_primary_10_3389_fimmu_2023_1327853
crossref_primary_10_1002_ange_202411863
crossref_primary_10_1038_s41598_022_27317_1
crossref_primary_10_1021_acs_jafc_5c03965
crossref_primary_10_1042_BST20191144
crossref_primary_10_3389_fmicb_2020_569700
crossref_primary_10_1111_imm_13864
crossref_primary_10_1002_fsn3_3801
crossref_primary_10_3390_ijms24032180
crossref_primary_10_1093_advances_nmz093
crossref_primary_10_3389_fped_2023_1090048
crossref_primary_10_1016_j_fct_2024_114592
crossref_primary_10_1080_10408398_2024_2387763
crossref_primary_10_1038_s41598_020_57860_8
crossref_primary_10_1111_pai_13740
crossref_primary_10_1016_j_carres_2019_107743
crossref_primary_10_3390_nu12041105
crossref_primary_10_1016_j_idairyj_2019_07_001
crossref_primary_10_3168_jds_2019_17645
crossref_primary_10_1080_87559129_2024_2386023
crossref_primary_10_1016_j_advnut_2025_100488
crossref_primary_10_1128_jb_00334_23
crossref_primary_10_3389_fped_2019_00347
crossref_primary_10_21518_ms2025_250
crossref_primary_10_3390_children5120160
crossref_primary_10_3390_ijms22063230
crossref_primary_10_3390_nu17091469
crossref_primary_10_3390_biology12010005
crossref_primary_10_3390_nu12113450
crossref_primary_10_1097_MOG_0000000000000778
crossref_primary_10_1016_j_ymben_2021_03_014
crossref_primary_10_3389_fpubh_2020_589736
crossref_primary_10_1016_j_tifs_2020_12_012
crossref_primary_10_1155_2023_9603576
crossref_primary_10_3390_nu13030938
crossref_primary_10_1128_jvi_00938_24
crossref_primary_10_3389_fcimb_2024_1386421
crossref_primary_10_1128_aem_00648_24
crossref_primary_10_3390_children10030430
crossref_primary_10_5409_wjcp_v14_i2_104797
crossref_primary_10_1111_cea_13409
crossref_primary_10_1016_j_jnma_2024_01_014
crossref_primary_10_1016_j_clnesp_2023_04_014
crossref_primary_10_1016_j_micinf_2021_104929
crossref_primary_10_1080_10408398_2020_1754756
crossref_primary_10_1007_s12026_023_09431_y
crossref_primary_10_3390_nu13124200
crossref_primary_10_1016_j_tjnut_2024_07_009
crossref_primary_10_1038_s41598_022_10276_y
crossref_primary_10_3389_fmolb_2022_968643
crossref_primary_10_1016_j_chom_2023_12_014
crossref_primary_10_1093_cdn_nzab072
crossref_primary_10_1186_s12866_020_01804_9
crossref_primary_10_1007_s00203_024_04104_2
crossref_primary_10_1016_j_jnn_2019_01_001
crossref_primary_10_1007_s00203_023_03787_3
crossref_primary_10_1016_j_csbj_2020_11_057
crossref_primary_10_3390_nu16010030
crossref_primary_10_1186_s42523_024_00309_4
crossref_primary_10_3390_nu17132080
crossref_primary_10_3390_children8090804
crossref_primary_10_1038_s41598_022_05250_7
crossref_primary_10_1080_07328303_2022_2150203
crossref_primary_10_3390_nu12113427
crossref_primary_10_3390_nu14030530
crossref_primary_10_1093_ajcn_nqab103
crossref_primary_10_3390_foods13091298
crossref_primary_10_1038_s41396_020_00798_6
crossref_primary_10_1016_j_biortech_2023_128667
crossref_primary_10_1186_s40104_021_00650_7
crossref_primary_10_3390_foods14060960
crossref_primary_10_1002_jat_4071
crossref_primary_10_1016_j_semperi_2020_151386
crossref_primary_10_1016_j_bej_2022_108567
crossref_primary_10_1093_jn_nxaa162
crossref_primary_10_1002_jms_4885
crossref_primary_10_3390_nu14010173
crossref_primary_10_3389_fped_2018_00270
crossref_primary_10_3390_nu15061408
crossref_primary_10_1016_j_jaip_2019_11_017
crossref_primary_10_3390_nu11081841
crossref_primary_10_1080_10408398_2021_1912706
crossref_primary_10_2147_JAA_S323734
crossref_primary_10_3390_ijms232314745
crossref_primary_10_1038_s41598_024_57158_z
crossref_primary_10_29219_fnr_v68_10456
crossref_primary_10_1177_0890334420942768
crossref_primary_10_1002_chem_202500754
crossref_primary_10_3390_medicina59091535
crossref_primary_10_1038_s41579_022_00768_z
crossref_primary_10_3168_jds_2021_20257
crossref_primary_10_1186_s40348_020_00098_1
crossref_primary_10_1016_j_pedneo_2022_09_017
crossref_primary_10_3390_nu14235112
crossref_primary_10_3389_fped_2018_00385
crossref_primary_10_1016_j_tifs_2024_104445
crossref_primary_10_1111_1541_4337_70018
crossref_primary_10_3390_nu11020431
crossref_primary_10_3389_fcimb_2020_586667
crossref_primary_10_1111_ijfs_16337
crossref_primary_10_1016_j_enzmictec_2023_110196
crossref_primary_10_1080_10408398_2022_2072270
crossref_primary_10_1128_mmbr_00094_23
crossref_primary_10_1016_j_fct_2019_110818
crossref_primary_10_3389_fnut_2021_766606
crossref_primary_10_1161_CIRCRESAHA_123_322055
crossref_primary_10_3389_fnut_2022_931458
crossref_primary_10_1017_S000711451900134X
crossref_primary_10_1111_1541_4337_13271
crossref_primary_10_1038_s44222_023_00112_x
Cites_doi 10.3389/fimmu.2017.01219
10.1016/j.idairyj.2011.09.012
10.1017/S0007114513000391
10.3945/jn.115.214940
10.1177/002215549704500212
10.1126/science.296.5567.490
10.1093/glycob/cwt065
10.1111/j.1600-065X.2009.00799.x
10.1111/pai.12232
10.1097/MPG.0000000000001520
10.1371/journal.pone.0023031
10.1172/JCI25105
10.1016/j.coviro.2014.06.005
10.2527/jas.2008-1347
10.3945/an.111.001404
10.1111/cea.12381
10.1074/jbc.M100467200
10.1189/jlb.0304198
10.1016/j.chom.2012.06.006
10.1017/S0007114516002038
10.1002/mnfr.201300296
10.1007/s00216-014-8025-z
10.1016/j.copbio.2013.01.008
10.1016/j.idairyj.2011.01.005
10.1021/acs.analchem.7b00542
10.1126/science.345.6198.747
10.3390/pathogens6040068
10.1038/s41598-018-22052-y
10.1097/MPG.0000000000000889
10.1136/gut.2005.081646
10.1017/S0007114516002944
10.1016/S0304-4165(02)00311-2
10.1086/338574
10.1073/pnas.1306322110
10.1097/ACI.0b013e3283630bad
10.1016/j.coi.2014.02.006
10.1038/nnano.2016.181
10.1093/glycob/cws074
10.1136/gutjnl-2016-312819
10.1371/journal.pbio.1001658
10.3945/jn.110.136176
10.1017/S0007114513001591
10.1038/nature08530
10.1093/jn/137.11.2420
10.1242/jcs.020800
10.1097/MPG.0000000000001276
10.1093/glycob/cwt072
10.3945/ajcn.112.038596
10.1089/bfm.2006.1.207
10.1016/j.nut.2005.12.009
10.3945/jn.113.187799
10.1034/j.1398-9995.2003.00264.x
10.1172/JCI119142
10.3945/jn.116.230706
10.1002/eji.201444876
10.1038/nri2569
10.1038/nm.3444
10.1074/jbc.M112.425819
10.1016/S0198-8859(99)00136-6
10.1007/s003940200012
10.1038/ismej.2014.10
10.1099/mic.0.064113-0
10.1111/all.12650
10.1016/j.tips.2009.02.005
10.1146/annurev-food-022510-133743
10.1097/MEG.0b013e32832a20dc
10.1038/ncomms8320
10.1111/j.1753-4887.2009.00239.x
10.1096/fasebj.27.1_supplement.629.16
10.1007/s004320000207
10.1016/j.clnu.2009.01.008
10.1186/s12887-014-0306-3
10.1002/mnfr.201400160
10.1093/ajcn/71.6.1589
10.1038/ni.f.203
10.1371/journal.pone.0101692
10.1017/S0007114508055608
10.1164/rccm.201401-0073OC
10.1073/pnas.91.1.18
10.1016/j.jnutbio.2015.12.014
10.4049/jimmunol.167.8.4293
10.3945/jn.114.199794
10.1111/apa.13132
10.1016/0092-8674(90)90230-C
10.1016/j.virol.2017.04.032
10.1371/journal.pone.0075148
10.1042/BCJ20160046
10.1017/S0007114507824068
10.1128/CDLI.12.9.1041-1049.2005
10.1002/9781118817360.ch1
10.1038/ncomms11939
10.1111/j.1749-6632.1994.tb12043.x
10.1159/000177965
10.1093/glycob/cwh143
10.1146/annurev.bi.64.070195.000553
10.1017/S0007114511004016
10.4236/fns.2014.514151
10.1074/jbc.M104805200
10.1160/TH04-01-0055
10.1016/j.carres.2011.08.009
10.1016/j.celrep.2016.05.047
10.1369/jhc.2008.952317
10.1093/glycob/cwx106
10.1136/gutjnl-2011-301404
10.1097/TP.0b013e3181f8f296
10.2337/db08-0331
10.1080/14767058.2018.1450864
10.1074/jbc.272.22.14294
10.1021/jf0615810
10.3945/jn.116.246090
10.1016/j.jaci.2016.08.031
10.1016/j.jaci.2011.07.027
10.1093/glycob/cwh020
10.1111/j.1365-2567.2008.02826.x
10.1016/j.clim.2011.12.006
10.1007/978-1-4757-4242-8_61
10.1203/01.pdr.0000200805.45593.17
10.1136/gut.2006.100164
10.3945/jn.115.220749
10.1002/14651858.CD006474.pub3
10.1016/j.carres.2011.06.034
10.1017/S0007114516002646
10.1111/j.1399-3038.2010.01062.x
10.1111/j.1365-2222.2011.03925.x
10.1017/S0007114516004554
10.3945/jn.116.236919
10.1111/nure.12106
10.1039/C7AN01397C
10.1017/S0007114513003267
10.1016/j.nutres.2013.07.009
10.1111/j.1651-2227.1996.tb14095.x
10.1038/nri2056
10.1073/pnas.1701785114
10.3945/ajcn.112.039503
10.3945/an.111.001594
10.1038/nature09646
10.1016/j.jpeds.2004.04.054
10.1038/mi.2014.20
10.1021/acs.analchem.6b05169
10.1134/S0006297908040032
10.1093/glycob/cwv025
10.1038/nri2536
10.4049/jimmunol.171.11.5837
10.1007/s00394-016-1180-6
10.1074/jbc.M117.789974
10.1093/infdis/jit464
10.1016/j.jpeds.2010.10.043
10.1093/jn/131.10.3067
10.1016/S1590-8658(07)60011-5
10.4014/jmb.1509.09034
10.1093/jn/135.5.1304
10.1038/nm.2962
10.1038/ni.3713
10.3389/fimmu.2018.00452
10.1111/imm.12930
10.1146/annurev.nutr.25.050304.092553
10.1016/j.carres.2003.09.021
10.3389/fmicb.2016.01460
10.1002/psc.1415
10.1016/0092-8674(94)90337-9
10.1080/19490976.2016.1278104
10.1074/jbc.M210602200
10.1146/annurev-nutr-071813-105721
10.1136/gutjnl-2014-307544
10.1093/glycob/cwt077
10.1038/nri3769
10.1023/B:GLYC.0000014072.34840.04
ContentType Journal Article
Copyright Copyright © 2018 Triantis, Bode and van Neerven. 2018 Triantis, Bode and van Neerven
Wageningen University & Research
Copyright_xml – notice: Copyright © 2018 Triantis, Bode and van Neerven. 2018 Triantis, Bode and van Neerven
– notice: Wageningen University & Research
DBID AAYXX
CITATION
NPM
7X8
5PM
QVL
DOA
DOI 10.3389/fped.2018.00190
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
NARCIS:Publications
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
PubMed

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2296-2360
ExternalDocumentID oai_doaj_org_article_99ebf1398f9042eb99c7d8e1d1c53301
oai_library_wur_nl_wurpubs_541042
PMC6036705
30013961
10_3389_fped_2018_00190
Genre Journal Article
Review
GroupedDBID 53G
5VS
9T4
AAFWJ
AAYXX
ACGFO
ACGFS
ADBBV
ADRAZ
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
GROUPED_DOAJ
GX1
HYE
KQ8
M48
M~E
OK1
PGMZT
RNS
RPM
ACXDI
EMOBN
IAO
IEA
IHR
IHW
IPNFZ
NPM
RIG
7X8
5PM
ITC
QVL
ID FETCH-LOGICAL-c510t-2dddfb5c7f3decddd3d381e1e1095c3aa55a58fdd7106924cd26fbf02f236c523
IEDL.DBID DOA
ISICitedReferencesCount 214
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000437000900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2296-2360
IngestDate Fri Oct 03 12:53:50 EDT 2025
Thu Oct 13 09:31:55 EDT 2022
Thu Aug 21 18:04:34 EDT 2025
Thu Oct 02 05:16:39 EDT 2025
Wed Feb 19 02:44:41 EST 2025
Sat Nov 29 02:51:29 EST 2025
Tue Nov 18 22:35:48 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords human milk oligosaccharides
infection
allergy
health
HMO
immunity
infant
benefit
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c510t-2dddfb5c7f3decddd3d381e1e1095c3aa55a58fdd7106924cd26fbf02f236c523
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Edited by: Daniel Munblit, I. M. Sechenov First Moscow State Medical University, Russia
This article was submitted to Pediatric Immunology, a section of the journal Frontiers in Pediatrics
Reviewed by: Belinda van't Land, University Medical Center Utrecht, Netherlands; Gert Folkerts, Utrecht University, Netherlands
OpenAccessLink https://doaj.org/article/99ebf1398f9042eb99c7d8e1d1c53301
PMID 30013961
PQID 2071562685
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_99ebf1398f9042eb99c7d8e1d1c53301
wageningen_narcis_oai_library_wur_nl_wurpubs_541042
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6036705
proquest_miscellaneous_2071562685
pubmed_primary_30013961
crossref_primary_10_3389_fped_2018_00190
crossref_citationtrail_10_3389_fped_2018_00190
PublicationCentury 2000
PublicationDate 2018
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – year: 2018
  text: 2018
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle Frontiers in pediatrics
PublicationTitleAlternate Front Pediatr
PublicationYear 2018
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Bruzzese (B164) 2006; 38
Arslanoglu (B165) 2007; 137
Cilieborg (B120) 2016; 116
Garrido (B143) 2013; 159
Kurakevich (B43) 2013; 110
Schijf (B91) 2013; 8
Angeloni (B97) 2005; 15
Martín-Sosa (B90) 2002; 132
He (B106) 2016; 65
Weichert (B96) 2013; 33
Gura (B1) 2014; 345
Hester (B110) 2013; 110
Yu (B144) 2013; 23
Munblit (B160) 2014; 45
Albrecht (B14) 2011; 346
Bode (B38) 2004; 76
Delacour (B47) 2008; 121
Zenhom (B124) 2011; 141
Rudloff (B16) 1996; 85
Newburg (B6) 2016; 146
Zevgiti (B113) 2012; 18
Kuntz (B122) 2008; 99
Newburg (B87) 2005; 25
Bhunia (B31) 2004; 339
Naarding (B42) 2005; 115
Reilly (B54) 2009; 30
Johansson (B151) 2011; 6
Thomas (B44) 2003; 171
Ruhaak (B19) 2014; 406
Crocker (B53) 2007; 7
Yu (B105) 2016; 146
Marino (B140) 2017; 18
Rapoport (B25) 2008; 73
Morrow (B93) 2005; 135
Morrow (B67) 2004; 145
Lomax (B167) 2009; 101
Penders (B148) 2007; 56
Bode (B39) 2004; 92
Koliwer-Brandl (B30) 2011; 21
Schumacher (B40) 2006; 22
Chen (B101) 2017; 6
Yu (B114) 2012; 287
Atochina (B127) 2008; 125
Velupillai (B130) 1994; 91
Good (B119) 2016; 116
Van der Kleij (B134) 2002; 185
Goehring (B72) 2016; 146
Koromyslova (B109) 2017; 508
Tan (B155) 2016; 15
Autran (B118) 2016; 116
Seppo (B9) 2017; 139
Matheson (B157) 2012; 42
Rochereau (B63) 2013; 11
Bode (B2) 2012; 22
ten Bruggencate (B82) 2014; 72
Shang (B108) 2013; 23
Comstock (B135) 2014; 111
Rudloff (B17) 2012; 3
Bode (B78) 2009; 67
Nguyen (B100) 2016; 26
Hickey (B95) 2012; 22
Lasky (B57) 1995; 64
Biesbroek (B76) 2014; 190
Smilowitz (B80) 2014; 34
Atochina (B129) 2005; 12
Osborn (B166) 2013; 3
Fukuda (B146) 2011; 469
Volman (B62) 2010; 22
Van Niekerk (B74) 2014; 144
Meli (B77) 2014; 14
Facinelli (B98) 2018; 21
Hirabayashi (B23) 2002; 1572
El-Hawiet (B29) 2017; 89
Dotz (B13) 2015; 59
Gonia (B103) 2015; 145
Bhargava (B136) 2012; 18
Castillo-Courtade (B161) 2015; 70
Ortega-González (B123) 2014; 58
van Kooyk (B41) 2008; 9
Nio-Kobayashi (B52) 2009; 57
Radzanowski (B21) 2013
Engfer (B11) 2000; 71
Newburg (B68) 2004; 14
Goehring (B20) 2014; 9
Quintin (B64) 2012; 12
Bode (B79) 2012; 3
Yazdanbakhsh (B131) 2002; 296
El-Hawiet (B28) 2018; 143
Eiwegger (B126) 2010; 21
Geijtenbeek (B60) 2009; 9
Gnoth (B12) 2001; 276
Chichlowski (B35) 2011; 2
Alphey (B33) 2003; 278
Jantscher-Krenn (B116) 2012; 61
Wasano (B49) 1997; 45
Oliveros (B10) 2016; 31
Quintin (B65) 2014
Shams-ud-doha (B26) 2017; 89
Li (B32) 2001; 276
Leffler (B24) 2002; 19
Stepans (B69) 2006; 1
Rudloff (B37) 2002; 41
Rudloff (B4) 2012; 107
Wopereis (B150) 2014; 25
Sprenger (B70) 2017; 56
van Nimwegen (B149) 2011; 128
Lodge (B159) 2015; 104
Li (B111) 2014; 8
Autran (B117) 2018; 67
Kwon (B112) 2017; 12
Zhu (B137) 2012; 142
Kunz (B88) 2014
Noll (B34) 2016; 473
Albrecht (B15) 2011; 346
Barile (B81) 2013; 24
Perdijk (B45) 2018; 28
Prudden (B27) 2017; 114
Rabinovich (B46) 2009; 9
Lin (B8) 2014; 209
Lippert (B51) 2007; 56
Maslowski (B156) 2010; 461
Duska-mcewen (B92) 2014; 5
Dutta (B138) 2010; 90
Kim (B147) 2018; 154
Ninonuevo (B3) 2006; 54
Cilieborg (B107) 2017; 64
Matsuki (B145) 2016; 7
Lane (B125) 2013; 110
Springer (B56) 1994; 76
Etzold (B85) 2014; 7
Varki (B36) 1997; 100
Schwertmann (B59) 1996; 40
Laucirica (B7) 2017; 147
Puccio (B71) 2017; 64
Bondue (B104) 2016; 7
Cohen-Kedar (B61) 2014; 44
Jeurink (B83) 2013; 98
Huflejt (B48) 1997; 272
Xiao (B141) 2017; 8
McEver (B58) 1994; 714
Coppa (B94) 2006; 59
Davis (B5) 2017; 8
Eigenmann (B162) 2013; 13
Thorburn (B152) 2015; 6
He (B121) 2014; 7
Trompette (B153) 2014; 20
Bode (B73) 2012; 96
Xiao (B115) 2018; 9
Peterson (B84) 2013; 23
Vazquez (B22) 2017; 117
Marriage (B18) 2015; 61
Harn (B132) 2009; 230
Marsland (B154) 2014; 14
Osborn (B55) 1990; 62
Xiao (B139) 2018; 8
Lin (B102) 2017; 292
Morrow (B66) 2011; 158
Lahm (B50) 2001; 127
Velupillai (B133) 2000; 61
Atochina (B128) 2001; 167
Kuhn (B75) 2015; 145
Newburg (B86) 2009; 87
El-Hawiet (B99) 2015; 25
Vaarala (B142) 2008; 57
Van Odijk (B158) 2003; 58
Bruzzese (B163) 2009; 28
Morrow (B89) 2004; 554
14638628 - Glycobiology. 2004 Mar;14(3):253-63
15240751 - J Leukoc Biol. 2004 Oct;76(4):820-6
19730386 - Eur J Gastroenterol Hepatol. 2010 Jan;22(1):88-94
14634093 - J Immunol. 2003 Dec 1;171(11):5837-41
23104131 - Nat Med. 2012 Nov;18(11):1665-72
27332875 - Cell Rep. 2016 Jun 21;15(12):2809-24
16492975 - Pediatr Res. 2006 Mar;59(3):377-82
26192405 - Acta Paediatr. 2015 Dec;104(467):38-53
23115247 - J Biol Chem. 2012 Dec 28;287(53):44784-99
9413398 - J Clin Invest. 1997 Dec 1;100(11 Suppl):S31-5
27243420 - J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):310-318
28505592 - Virology. 2017 Aug;508:81-89
23460033 - Microbiology. 2013 Apr;159(Pt 4):649-64
26102221 - Nat Commun. 2015 Jun 23;6:7320
16148169 - Clin Diagn Lab Immunol. 2005 Sep;12(9):1041-9
24000281 - Glycobiology. 2013 Dec;23(12):1425-38
24390308 - Nat Med. 2014 Feb;20(2):159-66
21451128 - J Nutr. 2011 May;141(5):971-7
19231042 - Clin Nutr. 2009 Apr;28(2):156-61
28416607 - J Biol Chem. 2017 Jul 7;292(27):11243-11249
24921688 - Am J Respir Crit Care Med. 2014 Aug 1;190(3):298-308
12438315 - J Biol Chem. 2003 Jan 31;278(5):3372-7
24522264 - ISME J. 2014 Aug;8(8):1609-20
27629573 - J Nutr. 2016 Oct;146(10):1980-1990
24039030 - Mol Nutr Food Res. 2014 Feb;58(2):384-93
25077553 - Clin Exp Allergy. 2015 Mar;45(3):583-601
17002410 - J Agric Food Chem. 2006 Oct 4;54(20):7471-80
24068891 - PLoS Biol. 2013 Sep;11(9):e1001658
19028867 - J Anim Sci. 2009 Apr;87(13 Suppl):26-34
16533594 - Nutrition. 2006 Jun;22(6):620-7
25059723 - Anal Bioanal Chem. 2014 Sep;406(24):5775-84
21270894 - Nature. 2011 Jan 27;469(7331):543-7
28637685 - J Nutr. 2017 Sep;147(9):1709-1714
18490910 - Nat Immunol. 2008 Jun;9(6):593-601
25124424 - Science. 2014 Aug 15;345(6198):747-9
29562795 - J Matern Fetal Neonatal Med. 2018 Mar 21;:1-3
26907090 - Eur J Nutr. 2017 Apr;56(3):1293-1301
7574477 - Annu Rev Biochem. 1995;64:113-39
26180242 - J Nutr. 2015 Sep;145(9):1992-8
15384621 - Adv Exp Med Biol. 2004;554:443-6
16709662 - Gut. 2007 Jan;56(1):43-51
17951479 - J Nutr. 2007 Nov;137(11):2420-4
23990566 - J Infect Dis. 2014 Feb 1;209(3):389-98
28068209 - Gut Microbes. 2017 Mar 4;8(2):143-171
22513036 - Glycobiology. 2012 Sep;22(9):1147-62
20885339 - Transplantation. 2010 Nov 27;90(10):1071-8
12083318 - Eur J Nutr. 2002 Apr;41(2):85-92
25421702 - Nat Rev Immunol. 2014 Dec;14(12):827-35
2194672 - Cell. 1990 Jul 13;62(1):3-6
29257110 - Pathogens. 2017 Dec 19;6(4):null
27340092 - Nat Commun. 2016 Jun 24;7:11939
11414198 - J Cancer Res Clin Oncol. 2001;127(6):375-86
28749685 - Anal Chem. 2017 Sep 5;89(17):8713-8722
27452119 - Br J Nutr. 2016 Sep;116(5):834-41
22264636 - Clin Immunol. 2012 Mar;142(3):351-61
18373667 - Immunology. 2008 Sep;125(1):111-21
11358961 - J Biol Chem. 2001 Jul 27;276(30):28106-12
25251945 - Eur J Immunol. 2014 Dec;44(12):3729-40
10689112 - Hum Immunol. 2000 Mar;61(3):225-32
12368397 - J Nutr. 2002 Oct;132(10):3067-72
28179042 - Br J Nutr. 2017 Jan;117(2):237-247
23710626 - Br J Nutr. 2013 Dec;110(12):2127-37
27609061 - Br J Nutr. 2016 Oct;116(7):1175-1187
24073243 - PLoS One. 2013 Sep 20;8(9):e75148
12911410 - Allergy. 2003 Sep;58(9):833-43
23824724 - Am J Clin Nutr. 2013 Aug;98(2):572S-7S
22138535 - Gut. 2012 Oct;61(10):1417-25
21888740 - Br J Nutr. 2012 Apr;107(7):957-63
28346408 - Nat Immunol. 2017 May;18(5):552-562
12223272 - Biochim Biophys Acta. 2002 Sep 19;1572(2-3):232-54
27133420 - J Nutr Biochem. 2016 May;31:20-7
29239412 - Analyst. 2018 Jan 15;143(2):536-548
24131853 - Br J Nutr. 2014 Mar 14;111(5):819-28
19906222 - Nutr Rev. 2009 Nov;67 Suppl 2:S183-91
17047098 - Gut. 2007 May;56(5):661-7
22276526 - Clin Exp Allergy. 2012 Jun;42(6):827-51
15867329 - J Nutr. 2005 May;135(5):1304-7
24999728 - PLoS One. 2014 Jul 07;9(7):e101692
23434179 - Curr Opin Biotechnol. 2013 Apr;24(2):214-9
23799337 - Curr Opin Allergy Clin Immunol. 2013 Aug;13(4):426-31
20444147 - Pediatr Allergy Immunol. 2010 Dec;21(8):1179-88
26976925 - Biochem J. 2016 May 15;473(10):1343-53
29497108 - Sci Rep. 2018 Mar 1;8(1):3829
8827106 - Acta Paediatr. 1996 May;85(5):598-603
25527660 - J Nutr. 2015 Jan;145(1):66-72
11591752 - J Immunol. 2001 Oct 15;167(8):4293-302
29593719 - Front Immunol. 2018 Mar 09;9:452
16011458 - Annu Rev Nutr. 2005;25:37-58
22901542 - Cell Host Microbe. 2012 Aug 16;12(2):223-32
27775724 - Nat Nanotechnol. 2017 Jan;12(1):48-54
28381523 - Gut. 2018 Jun;67(6):1064-1070
29033938 - Front Immunol. 2017 Sep 28;8:1219
9001685 - Ann Nutr Metab. 1996;40(5):252-62
19865172 - Nature. 2009 Oct 29;461(7268):1282-6
22585918 - Adv Nutr. 2012 May 01;3(3):398S-405S
24919691 - J Nutr. 2014 Aug;144(8):1227-33
25966668 - Allergy. 2015 Sep;70(9):1091-102
9162064 - J Biol Chem. 1997 May 30;272(22):14294-303
24850388 - Annu Rev Nutr. 2014;34:143-69
24828428 - Nutr Rev. 2014 Jun;72(6):377-89
25941008 - Glycobiology. 2015 Aug;25(8):845-54
19594641 - Immunol Rev. 2009 Jul;230(1):247-57
21962590 - Carbohydr Res. 2011 Nov 29;346(16):2540-50
25431457 - Gut. 2016 Jan;65(1):33-46
28107288 - J Pediatr Gastroenterol Nutr. 2017 Apr;64(4):624-631
15583750 - Thromb Haemost. 2004 Dec;92(6):1402-10
14758066 - Glycoconj J. 2004;19(7-9):433-40
18796404 - J Histochem Cytochem. 2009 Jan;57(1):41-50
27798337 - J Nutr. 2016 Dec;146(12):2559-2566
17925055 - Br J Nutr. 2008 Mar;99(3):462-71
26701795 - J Nutr. 2016 Feb;146(2):358-67
17259092 - Dig Liver Dis. 2006 Dec;38 Suppl 2:S283-7
7517114 - Ann N Y Acad Sci. 1994 Apr 18;714:185-9
21872915 - J Allergy Clin Immunol. 2011 Nov;128(5):948-55.e1-3
11423546 - J Biol Chem. 2001 Sep 14;276(37):34363-70
24026239 - Glycobiology. 2013 Dec;23(12):1491-8
24013960 - Glycobiology. 2013 Nov;23(11):1281-92
26718473 - J Microbiol Biotechnol. 2016 Apr 28;26(4):659-65
15342550 - Glycobiology. 2005 Jan;15(1):31-41
18814803 - Br J Nutr. 2009 Mar;101(5):633-58
27212112 - Br J Nutr. 2016 Jul;116(2):294-9
17380156 - Nat Rev Immunol. 2007 Apr;7(4):255-66
7904066 - Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):18-22
29281012 - Glycobiology. 2018 Mar 1;28(3):126-130
24691111 - Mucosal Immunol. 2014 Nov;7(6):1326-39
17661601 - Breastfeed Med. 2006 Winter;1(4):207-15
24899389 - Pediatr Allergy Immunol. 2014 Aug;25(5):428-38
9016316 - J Histochem Cytochem. 1997 Feb;45(2):275-83
11964470 - Science. 2002 Apr 19;296(5567):490-4
7507411 - Cell. 1994 Jan 28;76(2):301-14
27702672 - J Allergy Clin Immunol. 2017 Feb;139(2):708-711.e5
29569377 - Immunology. 2018 Jun;154(2):220-229
23543544 - Cochrane Database Syst Rev. 2013 Mar 28;(3):CD006474
25047751 - Curr Opin Virol. 2014 Aug;7:101-7
28345865 - Anal Chem. 2017 May 2;89(9):4914-4921
25527244 - BMC Pediatr. 2014 Dec 20;14:306
24101501 - Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17444-9
25330044 - Mol Nutr Food Res. 2015 Feb;59(2):355-64
24637148 - Curr Opin Immunol. 2014 Aug;29:1-7
23442265 - Br J Nutr. 2013 Oct;110(7):1233-42
21256510 - J Pediatr. 2011 May;158(5):745-51
18211959 - J Cell Sci. 2008 Feb 15;121(Pt 4):458-65
28630345 - Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):6954-6959
26154029 - J Pediatr Gastroenterol Nutr. 2015 Dec;61(6):649-58
22585916 - Adv Nutr. 2012 May 01;3(3):383S-91S
16239964 - J Clin Invest. 2005 Nov;115(11):3256-64
11865406 - J Infect Dis. 2002 Feb 15;185(4):531-9
19359050 - Trends Pharmacol Sci. 2009 May;30(5):240-8
10837303 - Am J Clin Nutr. 2000 Jun;71(6):1589-96
22129386 - Annu Rev Food Sci Technol. 2011;2:331-51
21829685 - PLoS One. 2011;6(8):e23031
27713728 - Front Microbiol. 2016 Sep 22;7:1460
18820210 - Diabetes. 2008 Oct;57(10):2555-62
24074741 - Nutr Res. 2013 Oct;33(10):831-8
22894939 - Am J Clin Nutr. 2012 Oct;96(4):831-9
15343178 - J Pediatr. 2004 Sep;145(3):297-303
19521399 - Nat Rev Immunol. 2009 Jul;9(7):465-79
21782161 - Carbohydr Res. 2011 Oct 18;346(14):2173-81
18457568 - Biochemistry (Mosc). 2008 Apr;73(4):393-405
22052803 - J Pept Sci. 2012 Jan;18(1):52-8
19365409 - Nat Rev Immunol. 2009 May;9(5):338-52
14698884 - Carbohydr Res. 2004 Jan 22;339(2):259-67
References_xml – volume: 8
  start-page: 1219
  year: 2017
  ident: B141
  article-title: Early-life nutritional factors and mucosal immunity in the development of autoimmune diabetes
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.01219
– volume: 22
  start-page: 141
  year: 2012
  ident: B95
  article-title: The role of oligosaccharides from human milk and other sources in prevention of pathogen adhesion
  publication-title: Int Dairy J.
  doi: 10.1016/j.idairyj.2011.09.012
– volume: 110
  start-page: 1233
  year: 2013
  ident: B110
  article-title: Human milk oligosaccharides inhibit rotavirus infectivity in vitro and in acutely infected piglets
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114513000391
– volume: 145
  start-page: 1992
  year: 2015
  ident: B103
  article-title: Human milk oligosaccharides inhibit Candida albicans invasion of human premature intestinal epithelial cells
  publication-title: J Nutr.
  doi: 10.3945/jn.115.214940
– volume: 45
  start-page: 275
  year: 1997
  ident: B49
  article-title: Recombinant galectin-1 recognizes mucin and epithelial cell surface glycocalyces of gastrointestinal tract
  publication-title: J Histochem Cytochem.
  doi: 10.1177/002215549704500212
– volume: 296
  start-page: 490
  year: 2002
  ident: B131
  article-title: Immunology: allergy, parasites, and the hygiene hypothesis
  publication-title: Science
  doi: 10.1126/science.296.5567.490
– volume: 23
  start-page: 1281
  year: 2013
  ident: B144
  article-title: Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwt065
– volume: 230
  start-page: 247
  year: 2009
  ident: B132
  publication-title: Immunol Rev.
  doi: 10.1111/j.1600-065X.2009.00799.x
– volume: 25
  start-page: 428
  year: 2014
  ident: B150
  article-title: The first thousand days - intestinal microbiology of early life: establishing a symbiosis
  publication-title: Pediatr Allergy Immunol.
  doi: 10.1111/pai.12232
– volume: 64
  start-page: 624
  year: 2017
  ident: B71
  article-title: Effects of Infant formula with human milk oligosaccharides on growth and morbidity: a randomized multicenter trial
  publication-title: J Pediatr Gastroenterol Nutr.
  doi: 10.1097/MPG.0000000000001520
– volume: 6
  start-page: e23031
  year: 2011
  ident: B151
  article-title: Early colonization with a group of lactobacilli decreases the risk for allergy at five years of age despite allergic heredity
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0023031
– volume: 115
  start-page: 3256
  year: 2005
  ident: B42
  article-title: Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4 + T lymphocytes
  publication-title: J Clin Invest.
  doi: 10.1172/JCI25105
– volume: 7
  start-page: 101
  year: 2014
  ident: B85
  article-title: Glycan-dependent viral infection in infants and the role of human milk oligosaccharides
  publication-title: Curr Opin Virol.
  doi: 10.1016/j.coviro.2014.06.005
– volume: 87
  start-page: 26
  year: 2009
  ident: B86
  article-title: Neonatal protection by an innate immune system of human milk consisting of oligosaccharides and glycans
  publication-title: J Anim Sci.
  doi: 10.2527/jas.2008-1347
– volume: 3
  start-page: 383S
  year: 2012
  ident: B79
  article-title: Structure-function relationships of human milk oligosaccharides
  publication-title: Adv Nutr.
  doi: 10.3945/an.111.001404
– volume: 45
  start-page: 583
  year: 2014
  ident: B160
  article-title: Factors affecting breast milk composition and potential consequences for development of the allergic phenotype
  publication-title: Clin Exp Allergy
  doi: 10.1111/cea.12381
– volume: 276
  start-page: 28106
  year: 2001
  ident: B32
  article-title: Cloning and Characterization of Siglec-10, a novel sialic acid binding member of the ig superfamily, from human dendritic cells *
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M100467200
– volume: 76
  start-page: 820
  year: 2004
  ident: B38
  article-title: Human milk oligosaccharides reduce platelet-neutrophil complex formation leading to a decrease in neutrophil beta 2 integrin expression
  publication-title: J Leukoc Biol.
  doi: 10.1189/jlb.0304198
– volume: 12
  start-page: 223
  year: 2012
  ident: B64
  article-title: Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes
  doi: 10.1016/j.chom.2012.06.006
– volume: 116
  start-page: 294
  year: 2016
  ident: B118
  article-title: Sialylated galacto-oligosaccharides and 2′-fucosyllactose reduce necrotising enterocolitis in neonatal rats
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114516002038
– volume: 58
  start-page: 384
  year: 2014
  ident: B123
  article-title: Nondigestible oligosaccharides exert nonprebiotic effects on intestinal epithelial cells enhancing the immune response via activation of TLR4-NFκB
  publication-title: Mol Nutr Food Res.
  doi: 10.1002/mnfr.201300296
– volume: 406
  start-page: 5775
  year: 2014
  ident: B19
  article-title: Detection of milk oligosaccharides in plasma of infants
  publication-title: Anal Bioanal Chem.
  doi: 10.1007/s00216-014-8025-z
– volume: 24
  start-page: 214
  year: 2013
  ident: B81
  article-title: Human milk and related oligosaccharides as prebiotics
  publication-title: Curr Opin Biotechnol.
  doi: 10.1016/j.copbio.2013.01.008
– volume: 21
  start-page: 413
  year: 2011
  ident: B30
  article-title: Lectin inhibition assay for the analysis of bioactive milk sialo glycoconjugates
  publication-title: Int Dairy J.
  doi: 10.1016/j.idairyj.2011.01.005
– volume: 89
  start-page: 8713
  year: 2017
  ident: B29
  article-title: High-throughput label- and immobilization-free screening of human milk oligosaccharides against lectins
  publication-title: Anal Chem.
  doi: 10.1021/acs.analchem.7b00542
– volume: 345
  start-page: 747
  year: 2014
  ident: B1
  article-title: Nature's first functional food
  publication-title: Science
  doi: 10.1126/science.345.6198.747
– volume: 6
  start-page: E68
  year: 2017
  ident: B101
  article-title: Prebiotic oligosaccharides potentiate host protective responses against L. Monocytogenes infection
  publication-title: Pathogens
  doi: 10.3390/pathogens6040068
– volume: 8
  start-page: 3829
  year: 2018
  ident: B139
  article-title: Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice
  publication-title: Sci Rep.
  doi: 10.1038/s41598-018-22052-y
– volume: 61
  start-page: 649
  year: 2015
  ident: B18
  article-title: Infants fed a lower calorie formula with 2′FL show growth and 2′FL uptake like breast-fed infants
  publication-title: J Pediatr Gastroenterol.
  doi: 10.1097/MPG.0000000000000889
– volume: 56
  start-page: 43
  year: 2007
  ident: B51
  article-title: Soluble galectin-3 is a strong, colonic epithelial-cell-derived, lamina propria fibroblast-stimulating factor
  publication-title: Gut
  doi: 10.1136/gut.2005.081646
– volume: 116
  start-page: 1175
  year: 2016
  ident: B119
  article-title: The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114516002944
– volume: 1572
  start-page: 232
  year: 2002
  ident: B23
  article-title: Oligosaccharide specificity of galectins: a search by frontal affinity chromatography
  publication-title: Biochim Biophys Acta
  doi: 10.1016/S0304-4165(02)00311-2
– volume: 185
  start-page: 531
  year: 2002
  ident: B134
  article-title: Triggering of innate immune responses by schistosome egg glycolipids and their carbohydrate epitope GalNAc beta 1-4(Fuc alpha 1-2Fuc alpha 1-3)GlcNAc
  publication-title: J Infect Dis.
  doi: 10.1086/338574
– volume: 110
  start-page: 17444
  year: 2013
  ident: B43
  article-title: Milk oligosaccharide sialyl(α)lactose activates intestinal CD11c+ cells through TLR4
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1306322110
– volume: 13
  start-page: 426
  year: 2013
  ident: B162
  article-title: Evidence of preventive effect of probiotics and prebiotics for infantile eczema
  publication-title: Curr Opin Allergy Clin Immunol.
  doi: 10.1097/ACI.0b013e3283630bad
– start-page: 1
  year: 2014
  ident: B65
  article-title: Innate immune memory: towards a better understanding of host defense mechanisms
  publication-title: Curr Opin Immunol.
  doi: 10.1016/j.coi.2014.02.006
– volume: 12
  start-page: 48
  year: 2017
  ident: B112
  article-title: Nanostructured glycan architecture is important in the inhibition of influenza A virus infection
  publication-title: Nat Nanotechnol.
  doi: 10.1038/nnano.2016.181
– volume: 22
  start-page: 1147
  year: 2012
  ident: B2
  article-title: Human milk oligosaccharides : every baby needs a sugar mama
  publication-title: Glycobiology
  doi: 10.1093/glycob/cws074
– volume: 67
  start-page: 1064
  year: 2018
  ident: B117
  article-title: Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants
  publication-title: Gut
  doi: 10.1136/gutjnl-2016-312819
– volume: 11
  start-page: e1001658
  year: 2013
  ident: B63
  article-title: Dectin-1 is essential for reverse transcytosis of glycosylated SIgA-antigen complexes by intestinal M cells
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1001658
– volume: 141
  start-page: 971
  year: 2011
  ident: B124
  article-title: Prebiotic oligosaccharides reduce proinflammatory cytokines in intestinal caco-2 cells via activation of PPARg and peptidoglycan recognition protein
  publication-title: J. Nutr.
  doi: 10.3945/jn.110.136176
– volume: 110
  start-page: 2127
  year: 2013
  ident: B125
  article-title: Transcriptional response of HT-29 intestinal epithelial cells to human and bovine milk oligosaccharides
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114513001591
– volume: 461
  start-page: 1282
  year: 2010
  ident: B156
  article-title: Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
  publication-title: Nature
  doi: 10.1038/nature08530
– volume: 137
  start-page: 2420
  year: 2007
  ident: B165
  article-title: Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life
  publication-title: J Nutr.
  doi: 10.1093/jn/137.11.2420
– volume: 121
  start-page: 458
  year: 2008
  ident: B47
  article-title: Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo
  publication-title: J Cell Sci.
  doi: 10.1242/jcs.020800
– volume: 64
  start-page: 310
  year: 2017
  ident: B107
  article-title: α1,2-Fucosyllactose does not improve intestinal function or prevent Escherichia coli F18 diarrhea in newborn pigs
  publication-title: J Pediatr Gastroenterol Nutr.
  doi: 10.1097/MPG.0000000000001276
– volume: 23
  start-page: 1425
  year: 2013
  ident: B84
  article-title: Glycoconjugates in human milk: protecting infants from disease
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwt072
– volume: 98
  start-page: 572S
  year: 2013
  ident: B83
  article-title: Mechanisms underlying immune effects of dietary oligosaccharides
  publication-title: Am J Clin Nutr.
  doi: 10.3945/ajcn.112.038596
– volume: 1
  start-page: 207
  year: 2006
  ident: B69
  article-title: Early consumption of human milk oligosaccharides is inversely related to subsequent risk of respiratory and enteric disease in infants
  publication-title: Breastfeed Med.
  doi: 10.1089/bfm.2006.1.207
– volume: 22
  start-page: 620
  year: 2006
  ident: B40
  article-title: Human milk oligosaccharides affect P-selectin binding capacities: in vitro investigation
  publication-title: Nutrition
  doi: 10.1016/j.nut.2005.12.009
– volume: 144
  start-page: 1227
  year: 2014
  ident: B74
  article-title: Human milk oligosaccharides differ between HIV-infected and HIV-uninfected mothers and are related to necrotizing enterocolitis incidence in their preterm very-low-birth-weight infants
  publication-title: J Nutr.
  doi: 10.3945/jn.113.187799
– volume: 58
  start-page: 833
  year: 2003
  ident: B158
  article-title: Breastfeeding and allergic disease : a multidisciplinary review of the literature (1966-2001) on the mode of early feeding in infancy and its impact on later atopic manifestations
  publication-title: Allergy
  doi: 10.1034/j.1398-9995.2003.00264.x
– volume: 100
  start-page: S31
  year: 1997
  ident: B36
  article-title: Selectin ligands: will the real ones please stand up?
  publication-title: J Clin Invest.
  doi: 10.1172/JCI119142
– volume: 146
  start-page: 1980
  year: 2016
  ident: B105
  article-title: The human milk oligosaccharide 2′-fucosyllactose quenches Campylobacter jejuni-induced inflammation in human epithelial cells HEp-2 and HT-29 and in mouse intestinal mucosa
  publication-title: J Nutr.
  doi: 10.3945/jn.116.230706
– volume: 44
  start-page: 3729
  year: 2014
  ident: B61
  article-title: Human intestinal epithelial cells respond to beta-glucans via Dectin-1 and Syk
  publication-title: Eur J Immunol.
  doi: 10.1002/eji.201444876
– volume: 9
  start-page: 465
  year: 2009
  ident: B60
  article-title: Signalling through C-type lectin receptors: shaping immune responses
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri2569
– volume: 20
  start-page: 159
  year: 2014
  ident: B153
  article-title: Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
  publication-title: Nat Med.
  doi: 10.1038/nm.3444
– volume: 287
  start-page: 44784
  year: 2012
  ident: B114
  article-title: Functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M112.425819
– volume: 61
  start-page: 225
  year: 2000
  ident: B133
  article-title: Lewis(x)-containing oligosaccharide attenuates schistosome egg antigen-induced immune depression in human schistosomiasis
  publication-title: Hum Immunol.
  doi: 10.1016/S0198-8859(99)00136-6
– volume: 41
  start-page: 85
  year: 2002
  ident: B37
  article-title: Detection of ligands for selectins in the oligosaccharide fraction of human milk
  publication-title: Eur J Nutr.
  doi: 10.1007/s003940200012
– volume: 8
  start-page: 1609
  year: 2014
  ident: B111
  article-title: Human milk oligosaccharides shorten rotavirus-induced diarrhea and modulate piglet mucosal immunity and colonic microbiota
  publication-title: ISME J
  doi: 10.1038/ismej.2014.10
– volume: 159
  start-page: 649
  year: 2013
  ident: B143
  article-title: Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications
  publication-title: Microbiology
  doi: 10.1099/mic.0.064113-0
– volume: 70
  start-page: 1091
  year: 2015
  ident: B161
  article-title: Attenuation of food allergy symptoms following treatment with human milk oligosaccharides in a mouse model
  publication-title: Allergy
  doi: 10.1111/all.12650
– volume: 30
  start-page: 240
  year: 2009
  ident: B54
  article-title: Siglecs as targets for therapy in immune-cell-mediated disease
  publication-title: Trends Pharmacol Sci.
  doi: 10.1016/j.tips.2009.02.005
– volume: 2
  start-page: 331
  year: 2011
  ident: B35
  article-title: The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas
  publication-title: Annu Rev Food Sci Technol.
  doi: 10.1146/annurev-food-022510-133743
– volume: 22
  start-page: 88
  year: 2010
  ident: B62
  article-title: The absence of functional dectin-1 on enterocytes may serve to prevent intestinal damage
  publication-title: Eur J Gastroenterol Hepatol.
  doi: 10.1097/MEG.0b013e32832a20dc
– volume: 6
  start-page: 1
  year: 2015
  ident: B152
  article-title: Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
  publication-title: Nat Commun.
  doi: 10.1038/ncomms8320
– volume: 67
  start-page: S183
  year: 2009
  ident: B78
  article-title: Human milk oligosaccharides: prebiotics and beyond
  publication-title: Nutr Rev.
  doi: 10.1111/j.1753-4887.2009.00239.x
– year: 2013
  ident: B21
  article-title: Short-chain milk oligosaccharide levels in human milk and infant plasma
  publication-title: FASEB J.
  doi: 10.1096/fasebj.27.1_supplement.629.16
– volume: 127
  start-page: 375
  year: 2001
  ident: B50
  article-title: Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures
  publication-title: J Cancer Res Clin Oncol.
  doi: 10.1007/s004320000207
– volume: 28
  start-page: 156
  year: 2009
  ident: B163
  article-title: A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: an observational study
  publication-title: Clin Nutr.
  doi: 10.1016/j.clnu.2009.01.008
– volume: 14
  start-page: 306
  year: 2014
  ident: B77
  article-title: Growth and safety evaluation of infant formulae containing oligosaccharides derived from bovine milk: a randomized, double-blind, noninferiority trial
  publication-title: BMC Pediatr.
  doi: 10.1186/s12887-014-0306-3
– volume: 59
  start-page: 355
  year: 2015
  ident: B13
  article-title: Metabolic fate of neutral human milk oligosaccharides in exclusively breast-fed infants
  publication-title: Mol Nutr Food Res.
  doi: 10.1002/mnfr.201400160
– volume: 71
  start-page: 1589
  year: 2000
  ident: B11
  article-title: Human milk oligosaccharides are resistant to enzymatic hydrolysis in the upper gastrointestinal tract
  publication-title: Am J Clin Nutr.
  doi: 10.1093/ajcn/71.6.1589
– volume: 9
  start-page: 593
  year: 2008
  ident: B41
  article-title: Protein-glycan interactions in the control of innate and adaptive immune responses
  publication-title: Nat Immunol.
  doi: 10.1038/ni.f.203
– volume: 9
  start-page: e101692
  year: 2014
  ident: B20
  article-title: Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0101692
– volume: 101
  start-page: 633
  year: 2009
  ident: B167
  article-title: Prebiotics, immune function, infection and inflammation: a review of the evidence
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114508055608
– volume: 190
  start-page: 298
  year: 2014
  ident: B76
  article-title: The impact of breastfeeding on nasopharyngeal microbial communities in infants
  publication-title: Am J Respir Crit Care Med.
  doi: 10.1164/rccm.201401-0073OC
– volume: 91
  start-page: 18
  year: 1994
  ident: B130
  article-title: Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.91.1.18
– volume: 31
  start-page: 20
  year: 2016
  ident: B10
  article-title: Oral Supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
  publication-title: J Nutr Biochem.
  doi: 10.1016/j.jnutbio.2015.12.014
– volume: 167
  start-page: 4293
  year: 2001
  ident: B128
  article-title: A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1(+) macrophages that suppress naive CD4(+) T cell proliferation via an IFN-gamma and nitric oxide-dependent mechanism
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.167.8.4293
– volume: 145
  start-page: 66
  year: 2015
  ident: B75
  article-title: Oligosaccharide composition of breast milk influences survival of uninfected children born to HIV-infected mothers in Lusaka, Zambia
  publication-title: J Nutr.
  doi: 10.3945/jn.114.199794
– volume: 104
  start-page: 38
  year: 2015
  ident: B159
  article-title: Breastfeeding and asthma and allergies: a systematic review and meta-analysis
  publication-title: Acta Paediatr.
  doi: 10.1111/apa.13132
– volume: 62
  start-page: 3
  year: 1990
  ident: B55
  article-title: Leukocyte adhesion to endothelium in inflammation
  publication-title: Cell
  doi: 10.1016/0092-8674(90)90230-C
– volume: 508
  start-page: 81
  year: 2017
  ident: B109
  article-title: Human norovirus inhibition by a human milk oligosaccharide
  publication-title: Virology
  doi: 10.1016/j.virol.2017.04.032
– volume: 8
  start-page: e75148
  year: 2013
  ident: B91
  article-title: Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0075148
– volume: 473
  start-page: 1343
  year: 2016
  ident: B34
  article-title: Human DC-SIGN binds specific human milk glycans
  publication-title: Biochem J.
  doi: 10.1042/BCJ20160046
– volume: 99
  start-page: 462
  year: 2008
  ident: B122
  article-title: Oligosaccharides from human milk influence growth-related characteristics of intestinally transformed and non-transformed intestinal cells
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114507824068
– volume: 12
  start-page: 1041
  year: 2005
  ident: B129
  article-title: LNFPIII/LeX-stimulated macrophages activate natural killer cells via CD40-CD40L interaction
  publication-title: Clin Diagn Lab Immunol.
  doi: 10.1128/CDLI.12.9.1041-1049.2005
– start-page: 5
  volume-title: Food Oligosaccharides: Production, Analysis and Bioactivity.
  year: 2014
  ident: B88
  article-title: Bioactivity of human milk oligosaccharides
  doi: 10.1002/9781118817360.ch1
– volume: 7
  start-page: 11939
  year: 2016
  ident: B145
  article-title: A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
  publication-title: Nat Commun.
  doi: 10.1038/ncomms11939
– volume: 714
  start-page: 185
  year: 1994
  ident: B58
  article-title: Role of selectins in leukocyte adhesion to platelets and endothelium
  publication-title: Ann N Y Acad Sci.
  doi: 10.1111/j.1749-6632.1994.tb12043.x
– volume: 40
  start-page: 252
  year: 1996
  ident: B59
  article-title: Potential ligands for cell adhesion molecules in human milk
  publication-title: Ann Nutr Metab.
  doi: 10.1159/000177965
– volume: 15
  start-page: 31
  year: 2005
  ident: B97
  article-title: Glycoprofiling with micro-arrays of glycoconjugates and lectins
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwh143
– volume: 64
  start-page: 113
  year: 1995
  ident: B57
  article-title: Selectin-carbohydrate interactions and the initiation of the inflammatory response
  publication-title: Annu Rev Biochem.
  doi: 10.1146/annurev.bi.64.070195.000553
– volume: 107
  start-page: 957
  year: 2012
  ident: B4
  article-title: Urinary excretion of in vivo 13C-labelled milk oligosaccharides in breastfed infants
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114511004016
– volume: 5
  start-page: 1387
  year: 2014
  ident: B92
  article-title: Human milk oligosaccharides enhance innate immunity to respiratory syncytial virus and influenza in vitro
  publication-title: Food Nutr Sci.
  doi: 10.4236/fns.2014.514151
– volume: 276
  start-page: 34363
  year: 2001
  ident: B12
  article-title: Investigations of the in vitro transport of human milk oligosaccharides by a Caco-2 monolayer using a novel high performance liquid chromatography-mass spectrometry technique
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M104805200
– volume: 92
  start-page: 1402
  year: 2004
  ident: B39
  article-title: Inhibition of monocyte, lymphocyte, and neutrophil adhesion to endothelial cells by human milk oligosaccharides
  publication-title: Thromb Haemost.
  doi: 10.1160/TH04-01-0055
– volume: 346
  start-page: 2540
  year: 2011
  ident: B14
  publication-title: Carbohydr Res.
  doi: 10.1016/j.carres.2011.08.009
– volume: 15
  start-page: 2809
  year: 2016
  ident: B155
  article-title: Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.05.047
– volume: 57
  start-page: 41
  year: 2009
  ident: B52
  article-title: Immunohistochemical localization of six galectin subtypes in the mouse digestive tract
  publication-title: J Histochem Cytochem.
  doi: 10.1369/jhc.2008.952317
– volume: 28
  start-page: 126
  year: 2018
  ident: B45
  article-title: Induction of human tolerogenic dendritic cells by 3′-sialyllactose via TLR4 is explained by LPS contamination
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwx106
– volume: 61
  start-page: 1417
  year: 2012
  ident: B116
  article-title: The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats
  publication-title: Gut
  doi: 10.1136/gutjnl-2011-301404
– volume: 90
  start-page: 1071
  year: 2010
  ident: B138
  article-title: Lacto-N-fucopentaose III, a pentasaccharide, prolongs heart transplant survival
  publication-title: Transplantation
  doi: 10.1097/TP.0b013e3181f8f296
– volume: 57
  start-page: 2555
  year: 2008
  ident: B142
  article-title: The “perfect storm” for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity
  publication-title: Diabetes
  doi: 10.2337/db08-0331
– volume: 21
  start-page: 1
  year: 2018
  ident: B98
  article-title: Breast milk oligosaccharides : effects of 2 ′-fucosyllactose and 6 ′-sialyllactose on the adhesion of Escherichia coli and Salmonella fyris to Caco-2 cells
  publication-title: J Matern Neonatal Med.
  doi: 10.1080/14767058.2018.1450864
– volume: 272
  start-page: 14294
  year: 1997
  ident: B48
  article-title: Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.272.22.14294
– volume: 54
  start-page: 7471
  year: 2006
  ident: B3
  article-title: A strategy for annotating the human milk glycome
  publication-title: J Agric Food Chem.
  doi: 10.1021/jf0615810
– volume: 147
  start-page: 1709
  year: 2017
  ident: B7
  article-title: Milk oligosaccharides inhibit human rotavirus infectivity in MA104 cells
  publication-title: J Nutr.
  doi: 10.3945/jn.116.246090
– volume: 139
  start-page: 708
  year: 2017
  ident: B9
  article-title: Human milk oligosaccharides and development of cow's milk allergy in infants
  publication-title: J Allergy Clin Immunol.
  doi: 10.1016/j.jaci.2016.08.031
– volume: 128
  start-page: 948
  year: 2011
  ident: B149
  article-title: Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy
  publication-title: J Allergy Clin Immunol.
  doi: 10.1016/j.jaci.2011.07.027
– volume: 14
  start-page: 253
  year: 2004
  ident: B68
  article-title: Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwh020
– volume: 125
  start-page: 111
  year: 2008
  ident: B127
  article-title: The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2008.02826.x
– volume: 142
  start-page: 351
  year: 2012
  ident: B137
  article-title: Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis
  publication-title: Clin Immunol.
  doi: 10.1016/j.clim.2011.12.006
– volume: 554
  start-page: 443
  year: 2004
  ident: B89
  article-title: Human milk oligosaccharide blood group epitopes and innate immune protection against campylobacter and calicivirus diarrhea in breastfed infants
  publication-title: Adv Exp Med Biol.
  doi: 10.1007/978-1-4757-4242-8_61
– volume: 59
  start-page: 377
  year: 2006
  ident: B94
  article-title: Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris
  publication-title: Pediatr Res.
  doi: 10.1203/01.pdr.0000200805.45593.17
– volume: 56
  start-page: 661
  year: 2007
  ident: B148
  article-title: Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study
  publication-title: Gut
  doi: 10.1136/gut.2006.100164
– volume: 146
  start-page: 358
  year: 2016
  ident: B6
  article-title: Human milk oligosaccharides and synthetic galactosyloligosaccharides contain 3′-, 4-, and 6′-galactosyllactose and attenuate inflammation in human T84, NCM-460, and H4 cells and intestinal tissue ex vivo
  publication-title: J Nutr.
  doi: 10.3945/jn.115.220749
– volume: 3
  start-page: CD006474
  year: 2013
  ident: B166
  article-title: Prebiotics in infants for prevention of allergy
  publication-title: Cochrane database Syst Rev.
  doi: 10.1002/14651858.CD006474.pub3
– volume: 346
  start-page: 2173
  year: 2011
  ident: B15
  article-title: Oligosaccharides in feces of breast- and formula-fed babies
  publication-title: Carbohydr Res.
  doi: 10.1016/j.carres.2011.06.034
– volume: 116
  start-page: 834
  year: 2016
  ident: B120
  article-title: Minimal short-term effect of dietary 2′-fucosyllactose on bacterial colonisation, intestinal function and necrotising enterocolitis in preterm pigs
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114516002646
– volume: 21
  start-page: 1179
  year: 2010
  ident: B126
  article-title: Prebiotic oligosaccharides: in vitro evidence for gastrointestinal epithelial transfer and immunomodulatory properties
  publication-title: Pediatr Allergy Immunol.
  doi: 10.1111/j.1399-3038.2010.01062.x
– volume: 42
  start-page: 827
  year: 2012
  ident: B157
  article-title: Understanding the evidence for and against the role of breastfeeding in allergy prevention
  publication-title: Clin. Exp Allergy
  doi: 10.1111/j.1365-2222.2011.03925.x
– volume: 117
  start-page: 237
  year: 2017
  ident: B22
  article-title: Major human milk oligosaccharides are absorbed into the systemic circulation after oral administration in rats
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114516004554
– volume: 146
  start-page: 2559
  year: 2016
  ident: B72
  article-title: Similar to those who are breastfed, infants fed a formula containing 2′-fucosyllactose have lower inflammatory cytokines in a randomized controlled trial
  publication-title: J Nutr.
  doi: 10.3945/jn.116.236919
– volume: 72
  start-page: 377
  year: 2014
  ident: B82
  article-title: Functional role and mechanisms of sialyllactose and other sialylated milk oligosaccharides
  publication-title: Nutr Rev.
  doi: 10.1111/nure.12106
– volume: 143
  start-page: 536
  year: 2018
  ident: B28
  article-title: Screening natural libraries of human milk oligosaccharides against lectins using CaR-ESI-MS
  publication-title: Analyst
  doi: 10.1039/C7AN01397C
– volume: 111
  start-page: 819
  year: 2014
  ident: B135
  article-title: Select human milk oligosaccharides directly modulate peripheral blood mononuclear cells isolated from 10-d-old pigs
  publication-title: Br J Nutr.
  doi: 10.1017/S0007114513003267
– volume: 33
  start-page: 831
  year: 2013
  ident: B96
  article-title: Bioengineered 2′-fucosyllactose and 3-fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory cell lines
  publication-title: Nutr Res.
  doi: 10.1016/j.nutres.2013.07.009
– volume: 85
  start-page: 598
  year: 1996
  ident: B16
  article-title: Urinary excretion of lactose and oligosaccharides in preterm infants fed human milk or infant formula
  publication-title: Acta Paediatr.
  doi: 10.1111/j.1651-2227.1996.tb14095.x
– volume: 7
  start-page: 255
  year: 2007
  ident: B53
  article-title: Siglecs and their roles in the immune system
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri2056
– volume: 114
  start-page: 6954
  year: 2017
  ident: B27
  article-title: Synthesis of asymmetrical multiantennary human milk oligosaccharides
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1701785114
– volume: 96
  start-page: 831
  year: 2012
  ident: B73
  article-title: Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding
  publication-title: Am J Clin Nutr.
  doi: 10.3945/ajcn.112.039503
– volume: 3
  start-page: 398S
  year: 2012
  ident: B17
  article-title: Milk oligosaccharides and metabolism in infants
  publication-title: Adv Nutr.
  doi: 10.3945/an.111.001594
– volume: 469
  start-page: 543
  year: 2011
  ident: B146
  article-title: Bifidobacteria can protect from enteropathogenic infection through production of acetate
  publication-title: Nature
  doi: 10.1038/nature09646
– volume: 145
  start-page: 297
  year: 2004
  ident: B67
  article-title: Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants
  publication-title: J Pediatr.
  doi: 10.1016/j.jpeds.2004.04.054
– volume: 7
  start-page: 1326
  year: 2014
  ident: B121
  article-title: Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2014.20
– volume: 89
  start-page: 4914
  year: 2017
  ident: B26
  article-title: Human milk oligosaccharide specificities of human galectins
  publication-title: Anal Chem.
  doi: 10.1021/acs.analchem.6b05169
– volume: 73
  start-page: 393
  year: 2008
  ident: B25
  article-title: Mammalian galectins: structure, carbohydrate specificity, and functions
  publication-title: Biochemistry
  doi: 10.1134/S0006297908040032
– volume: 25
  start-page: 845
  year: 2015
  ident: B99
  article-title: Recognition of human milk oligosaccharides by bacterial exotoxins
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwv025
– volume: 9
  start-page: 338
  year: 2009
  ident: B46
  article-title: Turning sweet on immunity : galectin glycan interactions in immune tolerance and inflammation
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri2536
– volume: 171
  start-page: 5837
  year: 2003
  ident: B44
  article-title: Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.171.11.5837
– volume: 56
  start-page: 1293
  year: 2017
  ident: B70
  article-title: FUT2-dependent breast milk oligosaccharides and allergy at 2 and 5 years of age in infants with high hereditary allergy risk
  doi: 10.1007/s00394-016-1180-6
– volume: 292
  start-page: 11243
  year: 2017
  ident: B102
  article-title: Human milk oligosaccharides inhibit growth of group B Streptococcus
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M117.789974
– volume: 209
  start-page: 389
  year: 2014
  ident: B8
  article-title: Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity
  publication-title: J Infect Dis.
  doi: 10.1093/infdis/jit464
– volume: 158
  start-page: 745
  year: 2011
  ident: B66
  article-title: Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infants
  publication-title: J Pediatr.
  doi: 10.1016/j.jpeds.2010.10.043
– volume: 132
  start-page: 3067
  year: 2002
  ident: B90
  article-title: The sialylated fraction of milk oligosaccharides is partially responsible for binding to enterotoxigenic and uropathogenic Escherichia coli human strains
  publication-title: J Nutr.
  doi: 10.1093/jn/131.10.3067
– volume: 38
  start-page: S283
  year: 2006
  ident: B164
  publication-title: Dig Liver Dis.
  doi: 10.1016/S1590-8658(07)60011-5
– volume: 26
  start-page: 659
  year: 2016
  ident: B100
  article-title: Identification of oligosaccharides in human milk bound onto the toxin a carbohydrate binding site of clostridium difficile
  publication-title: J Microbiol Biotechnol
  doi: 10.4014/jmb.1509.09034
– volume: 135
  start-page: 1304
  year: 2005
  ident: B93
  article-title: Symposium : innate immunity and human milk human-milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea 1, 2
  publication-title: J Nutr.
  doi: 10.1093/jn/135.5.1304
– volume: 18
  start-page: 1665
  year: 2012
  ident: B136
  article-title: Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways
  publication-title: Nat Med.
  doi: 10.1038/nm.2962
– volume: 18
  start-page: 552
  year: 2017
  ident: B140
  article-title: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
  publication-title: Nat Immunol.
  doi: 10.1038/ni.3713
– volume: 9
  start-page: 452
  year: 2018
  ident: B115
  article-title: Human milk oligosaccharide 2′-fucosyllactose improves innate and adaptive immunity in an influenza-specific murine vaccination model
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2018.00452
– volume: 154
  start-page: 220
  year: 2018
  ident: B147
  article-title: Immune regulation by microbiome metabolites
  publication-title: Immunology
  doi: 10.1111/imm.12930
– volume: 25
  start-page: 37
  year: 2005
  ident: B87
  article-title: Human milk glycans protect infants against enteric pathogens
  publication-title: Annu Rev Nutr.
  doi: 10.1146/annurev.nutr.25.050304.092553
– volume: 339
  start-page: 259
  year: 2004
  ident: B31
  article-title: Saturation transfer difference NMR and computational modeling of a sialoadhesin-sialyl lactose complex
  publication-title: Carbohydr Res.
  doi: 10.1016/j.carres.2003.09.021
– volume: 7
  start-page: 1460
  year: 2016
  ident: B104
  article-title: Cell-free spent media obtained from Bifidobacterium bifidum and Bifidobacterium crudilactis grown in media supplemented with 3′-sialyllactose modulate virulence gene expression in Escherichia coli O157: H7 and Salmonella Typhimurium
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2016.01460
– volume: 18
  start-page: 52
  year: 2012
  ident: B113
  article-title: Sialic acid and sialyl-lactose glyco-conjugates: design, synthesis and binding assays to lectins and swine influenza H1N1 virus
  publication-title: J Pept Sci.
  doi: 10.1002/psc.1415
– volume: 76
  start-page: 301
  year: 1994
  ident: B56
  article-title: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm
  publication-title: Cell
  doi: 10.1016/0092-8674(94)90337-9
– volume: 8
  start-page: 143
  year: 2017
  ident: B5
  article-title: The role of early life nutrition in the establishment of gastrointestinal microbial composition and function
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2016.1278104
– volume: 278
  start-page: 3372
  year: 2003
  ident: B33
  article-title: High resolution crystal structures of Siglec-7
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M210602200
– volume: 34
  start-page: 143
  year: 2014
  ident: B80
  article-title: Breast milk oligosaccharides: structure-function relationships in the neonate
  doi: 10.1146/annurev-nutr-071813-105721
– volume: 65
  start-page: 33
  year: 2016
  ident: B106
  article-title: The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-307544
– volume: 23
  start-page: 1491
  year: 2013
  ident: B108
  article-title: Identifying human milk glycans that inhibit norovirus binding using surface plasmon resonance
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwt077
– volume: 14
  start-page: 827
  year: 2014
  ident: B154
  article-title: Host–microorganism interactions in lung diseases
  publication-title: Nat Rev Immunol.
  doi: 10.1038/nri3769
– volume: 19
  start-page: 433
  year: 2002
  ident: B24
  article-title: Introduction to galectins
  publication-title: Glycoconj J
  doi: 10.1023/B:GLYC.0000014072.34840.04
– reference: 27775724 - Nat Nanotechnol. 2017 Jan;12(1):48-54
– reference: 15867329 - J Nutr. 2005 May;135(5):1304-7
– reference: 11414198 - J Cancer Res Clin Oncol. 2001;127(6):375-86
– reference: 23115247 - J Biol Chem. 2012 Dec 28;287(53):44784-99
– reference: 28637685 - J Nutr. 2017 Sep;147(9):1709-1714
– reference: 24921688 - Am J Respir Crit Care Med. 2014 Aug 1;190(3):298-308
– reference: 12368397 - J Nutr. 2002 Oct;132(10):3067-72
– reference: 24131853 - Br J Nutr. 2014 Mar 14;111(5):819-28
– reference: 28416607 - J Biol Chem. 2017 Jul 7;292(27):11243-11249
– reference: 14698884 - Carbohydr Res. 2004 Jan 22;339(2):259-67
– reference: 23710626 - Br J Nutr. 2013 Dec;110(12):2127-37
– reference: 18457568 - Biochemistry (Mosc). 2008 Apr;73(4):393-405
– reference: 12083318 - Eur J Nutr. 2002 Apr;41(2):85-92
– reference: 7507411 - Cell. 1994 Jan 28;76(2):301-14
– reference: 19521399 - Nat Rev Immunol. 2009 Jul;9(7):465-79
– reference: 9016316 - J Histochem Cytochem. 1997 Feb;45(2):275-83
– reference: 17047098 - Gut. 2007 May;56(5):661-7
– reference: 22901542 - Cell Host Microbe. 2012 Aug 16;12(2):223-32
– reference: 17002410 - J Agric Food Chem. 2006 Oct 4;54(20):7471-80
– reference: 14758066 - Glycoconj J. 2004;19(7-9):433-40
– reference: 21888740 - Br J Nutr. 2012 Apr;107(7):957-63
– reference: 24039030 - Mol Nutr Food Res. 2014 Feb;58(2):384-93
– reference: 17380156 - Nat Rev Immunol. 2007 Apr;7(4):255-66
– reference: 18373667 - Immunology. 2008 Sep;125(1):111-21
– reference: 23824724 - Am J Clin Nutr. 2013 Aug;98(2):572S-7S
– reference: 23460033 - Microbiology. 2013 Apr;159(Pt 4):649-64
– reference: 20885339 - Transplantation. 2010 Nov 27;90(10):1071-8
– reference: 22129386 - Annu Rev Food Sci Technol. 2011;2:331-51
– reference: 10689112 - Hum Immunol. 2000 Mar;61(3):225-32
– reference: 14634093 - J Immunol. 2003 Dec 1;171(11):5837-41
– reference: 19359050 - Trends Pharmacol Sci. 2009 May;30(5):240-8
– reference: 28068209 - Gut Microbes. 2017 Mar 4;8(2):143-171
– reference: 28381523 - Gut. 2018 Jun;67(6):1064-1070
– reference: 25966668 - Allergy. 2015 Sep;70(9):1091-102
– reference: 26154029 - J Pediatr Gastroenterol Nutr. 2015 Dec;61(6):649-58
– reference: 14638628 - Glycobiology. 2004 Mar;14(3):253-63
– reference: 24691111 - Mucosal Immunol. 2014 Nov;7(6):1326-39
– reference: 29562795 - J Matern Fetal Neonatal Med. 2018 Mar 21;:1-3
– reference: 26102221 - Nat Commun. 2015 Jun 23;6:7320
– reference: 25047751 - Curr Opin Virol. 2014 Aug;7:101-7
– reference: 24919691 - J Nutr. 2014 Aug;144(8):1227-33
– reference: 11865406 - J Infect Dis. 2002 Feb 15;185(4):531-9
– reference: 2194672 - Cell. 1990 Jul 13;62(1):3-6
– reference: 17259092 - Dig Liver Dis. 2006 Dec;38 Suppl 2:S283-7
– reference: 24073243 - PLoS One. 2013 Sep 20;8(9):e75148
– reference: 12223272 - Biochim Biophys Acta. 2002 Sep 19;1572(2-3):232-54
– reference: 16011458 - Annu Rev Nutr. 2005;25:37-58
– reference: 9162064 - J Biol Chem. 1997 May 30;272(22):14294-303
– reference: 9001685 - Ann Nutr Metab. 1996;40(5):252-62
– reference: 25421702 - Nat Rev Immunol. 2014 Dec;14(12):827-35
– reference: 7574477 - Annu Rev Biochem. 1995;64:113-39
– reference: 15343178 - J Pediatr. 2004 Sep;145(3):297-303
– reference: 24026239 - Glycobiology. 2013 Dec;23(12):1491-8
– reference: 22264636 - Clin Immunol. 2012 Mar;142(3):351-61
– reference: 27609061 - Br J Nutr. 2016 Oct;116(7):1175-1187
– reference: 23990566 - J Infect Dis. 2014 Feb 1;209(3):389-98
– reference: 21829685 - PLoS One. 2011;6(8):e23031
– reference: 26976925 - Biochem J. 2016 May 15;473(10):1343-53
– reference: 9413398 - J Clin Invest. 1997 Dec 1;100(11 Suppl):S31-5
– reference: 24637148 - Curr Opin Immunol. 2014 Aug;29:1-7
– reference: 27452119 - Br J Nutr. 2016 Sep;116(5):834-41
– reference: 17661601 - Breastfeed Med. 2006 Winter;1(4):207-15
– reference: 21270894 - Nature. 2011 Jan 27;469(7331):543-7
– reference: 25059723 - Anal Bioanal Chem. 2014 Sep;406(24):5775-84
– reference: 25431457 - Gut. 2016 Jan;65(1):33-46
– reference: 15240751 - J Leukoc Biol. 2004 Oct;76(4):820-6
– reference: 21872915 - J Allergy Clin Immunol. 2011 Nov;128(5):948-55.e1-3
– reference: 24850388 - Annu Rev Nutr. 2014;34:143-69
– reference: 18211959 - J Cell Sci. 2008 Feb 15;121(Pt 4):458-65
– reference: 24068891 - PLoS Biol. 2013 Sep;11(9):e1001658
– reference: 24899389 - Pediatr Allergy Immunol. 2014 Aug;25(5):428-38
– reference: 12911410 - Allergy. 2003 Sep;58(9):833-43
– reference: 28749685 - Anal Chem. 2017 Sep 5;89(17):8713-8722
– reference: 7517114 - Ann N Y Acad Sci. 1994 Apr 18;714:185-9
– reference: 23799337 - Curr Opin Allergy Clin Immunol. 2013 Aug;13(4):426-31
– reference: 21962590 - Carbohydr Res. 2011 Nov 29;346(16):2540-50
– reference: 29569377 - Immunology. 2018 Jun;154(2):220-229
– reference: 12438315 - J Biol Chem. 2003 Jan 31;278(5):3372-7
– reference: 18796404 - J Histochem Cytochem. 2009 Jan;57(1):41-50
– reference: 27340092 - Nat Commun. 2016 Jun 24;7:11939
– reference: 20444147 - Pediatr Allergy Immunol. 2010 Dec;21(8):1179-88
– reference: 29281012 - Glycobiology. 2018 Mar 1;28(3):126-130
– reference: 22585918 - Adv Nutr. 2012 May 01;3(3):398S-405S
– reference: 22052803 - J Pept Sci. 2012 Jan;18(1):52-8
– reference: 11423546 - J Biol Chem. 2001 Sep 14;276(37):34363-70
– reference: 29257110 - Pathogens. 2017 Dec 19;6(4):null
– reference: 8827106 - Acta Paediatr. 1996 May;85(5):598-603
– reference: 24101501 - Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17444-9
– reference: 23543544 - Cochrane Database Syst Rev. 2013 Mar 28;(3):CD006474
– reference: 27212112 - Br J Nutr. 2016 Jul;116(2):294-9
– reference: 19906222 - Nutr Rev. 2009 Nov;67 Suppl 2:S183-91
– reference: 22276526 - Clin Exp Allergy. 2012 Jun;42(6):827-51
– reference: 28505592 - Virology. 2017 Aug;508:81-89
– reference: 24522264 - ISME J. 2014 Aug;8(8):1609-20
– reference: 25527660 - J Nutr. 2015 Jan;145(1):66-72
– reference: 24999728 - PLoS One. 2014 Jul 07;9(7):e101692
– reference: 15342550 - Glycobiology. 2005 Jan;15(1):31-41
– reference: 25077553 - Clin Exp Allergy. 2015 Mar;45(3):583-601
– reference: 29497108 - Sci Rep. 2018 Mar 1;8(1):3829
– reference: 22585916 - Adv Nutr. 2012 May 01;3(3):383S-91S
– reference: 22138535 - Gut. 2012 Oct;61(10):1417-25
– reference: 17951479 - J Nutr. 2007 Nov;137(11):2420-4
– reference: 26701795 - J Nutr. 2016 Feb;146(2):358-67
– reference: 23104131 - Nat Med. 2012 Nov;18(11):1665-72
– reference: 21782161 - Carbohydr Res. 2011 Oct 18;346(14):2173-81
– reference: 27713728 - Front Microbiol. 2016 Sep 22;7:1460
– reference: 28345865 - Anal Chem. 2017 May 2;89(9):4914-4921
– reference: 24390308 - Nat Med. 2014 Feb;20(2):159-66
– reference: 19865172 - Nature. 2009 Oct 29;461(7268):1282-6
– reference: 17925055 - Br J Nutr. 2008 Mar;99(3):462-71
– reference: 28179042 - Br J Nutr. 2017 Jan;117(2):237-247
– reference: 27702672 - J Allergy Clin Immunol. 2017 Feb;139(2):708-711.e5
– reference: 16533594 - Nutrition. 2006 Jun;22(6):620-7
– reference: 25527244 - BMC Pediatr. 2014 Dec 20;14:306
– reference: 25330044 - Mol Nutr Food Res. 2015 Feb;59(2):355-64
– reference: 11591752 - J Immunol. 2001 Oct 15;167(8):4293-302
– reference: 28346408 - Nat Immunol. 2017 May;18(5):552-562
– reference: 16239964 - J Clin Invest. 2005 Nov;115(11):3256-64
– reference: 24000281 - Glycobiology. 2013 Dec;23(12):1425-38
– reference: 29033938 - Front Immunol. 2017 Sep 28;8:1219
– reference: 18490910 - Nat Immunol. 2008 Jun;9(6):593-601
– reference: 26907090 - Eur J Nutr. 2017 Apr;56(3):1293-1301
– reference: 24013960 - Glycobiology. 2013 Nov;23(11):1281-92
– reference: 22513036 - Glycobiology. 2012 Sep;22(9):1147-62
– reference: 16148169 - Clin Diagn Lab Immunol. 2005 Sep;12(9):1041-9
– reference: 25251945 - Eur J Immunol. 2014 Dec;44(12):3729-40
– reference: 19365409 - Nat Rev Immunol. 2009 May;9(5):338-52
– reference: 19231042 - Clin Nutr. 2009 Apr;28(2):156-61
– reference: 11964470 - Science. 2002 Apr 19;296(5567):490-4
– reference: 26718473 - J Microbiol Biotechnol. 2016 Apr 28;26(4):659-65
– reference: 23434179 - Curr Opin Biotechnol. 2013 Apr;24(2):214-9
– reference: 29239412 - Analyst. 2018 Jan 15;143(2):536-548
– reference: 29593719 - Front Immunol. 2018 Mar 09;9:452
– reference: 22894939 - Am J Clin Nutr. 2012 Oct;96(4):831-9
– reference: 7904066 - Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):18-22
– reference: 16492975 - Pediatr Res. 2006 Mar;59(3):377-82
– reference: 24074741 - Nutr Res. 2013 Oct;33(10):831-8
– reference: 27798337 - J Nutr. 2016 Dec;146(12):2559-2566
– reference: 11358961 - J Biol Chem. 2001 Jul 27;276(30):28106-12
– reference: 15583750 - Thromb Haemost. 2004 Dec;92(6):1402-10
– reference: 28107288 - J Pediatr Gastroenterol Nutr. 2017 Apr;64(4):624-631
– reference: 18814803 - Br J Nutr. 2009 Mar;101(5):633-58
– reference: 15384621 - Adv Exp Med Biol. 2004;554:443-6
– reference: 27629573 - J Nutr. 2016 Oct;146(10):1980-1990
– reference: 21256510 - J Pediatr. 2011 May;158(5):745-51
– reference: 21451128 - J Nutr. 2011 May;141(5):971-7
– reference: 27332875 - Cell Rep. 2016 Jun 21;15(12):2809-24
– reference: 25124424 - Science. 2014 Aug 15;345(6198):747-9
– reference: 26180242 - J Nutr. 2015 Sep;145(9):1992-8
– reference: 19028867 - J Anim Sci. 2009 Apr;87(13 Suppl):26-34
– reference: 27133420 - J Nutr Biochem. 2016 May;31:20-7
– reference: 18820210 - Diabetes. 2008 Oct;57(10):2555-62
– reference: 26192405 - Acta Paediatr. 2015 Dec;104(467):38-53
– reference: 10837303 - Am J Clin Nutr. 2000 Jun;71(6):1589-96
– reference: 19730386 - Eur J Gastroenterol Hepatol. 2010 Jan;22(1):88-94
– reference: 28630345 - Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):6954-6959
– reference: 25941008 - Glycobiology. 2015 Aug;25(8):845-54
– reference: 27243420 - J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):310-318
– reference: 19594641 - Immunol Rev. 2009 Jul;230(1):247-57
– reference: 16709662 - Gut. 2007 Jan;56(1):43-51
– reference: 23442265 - Br J Nutr. 2013 Oct;110(7):1233-42
– reference: 24828428 - Nutr Rev. 2014 Jun;72(6):377-89
SSID ssj0000970515
Score 2.5065994
SecondaryResourceType review_article
Snippet Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs are minimally...
SourceID doaj
wageningen
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 190
SubjectTerms Allergy
Benefit
Health
HMO
Human milk oligosaccharides
Immunity
Infant
Infection
Pediatrics
Title Immunological Effects of Human Milk Oligosaccharides
URI https://www.ncbi.nlm.nih.gov/pubmed/30013961
https://www.proquest.com/docview/2071562685
https://pubmed.ncbi.nlm.nih.gov/PMC6036705
http://www.narcis.nl/publication/RecordID/oai:library.wur.nl:wurpubs%2F541042
https://doaj.org/article/99ebf1398f9042eb99c7d8e1d1c53301
Volume 6
WOSCitedRecordID wos000437000900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2296-2360
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000970515
  issn: 2296-2360
  databaseCode: DOA
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2296-2360
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000970515
  issn: 2296-2360
  databaseCode: M~E
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pb9MwFH6CCaFdEONnGZuCxIFLWGPHSXwEtGk7dHAAqTcrtp8hokqnpmU3_va956SlFUxcpkqpksaO-_nZ_p5jfw_gbVCVC77AtFJkwbnGkGqi-WkYW-Inuaoxq2OwifLysppO9ZetUF-8JqyXB-6BO9EabSCaUgVN9oVWa1f6CjOfOV4YGR0fynXLmYp9sC45eEmv5UNemD4JV8jCoBkvncy4B94ahqJa_78o5t8rJfevqZm3cd_T1jh09hgeDQQy-dAX_ADuYfsEHk6GV-RPIb_gHR_rLi3p1Ym7ZB6SOF-fTJrZz-TzrPk-72rHe64aj90z-HZ2-vXTeTqERkgdNaJlKrz3wSpXBunR0Yn0NPQifYgyOVnXStWqCt4TgSgIe-dFEWwYiyBk4cj5fA577bzFl5BIKyzmlrmQYLFAi6hyKS0VT-Q2EyN4v0bKuEE3nMNXzAz5DwytYWgNQ2sitCN4t0lw1Utm3H7rR4Z-cxtrXccLZAFmsADzPwsYwZt1xRlqG_zCo25xvuroQSW5p6Ko1Ahe9BW5eZSM5Leg1OVOFe-UZfeXtvkR9beLMaveUZ7yjzGYlkM_dTHVMP9mrlcL0874i_LpjMrJ9RWv7uIvH8I-g9hPBb2GveVihUfwwP1aNt3iGO6X0-o4Ngg6Tn6f3gDychKk
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunological+Effects+of+Human+Milk+Oligosaccharides&rft.jtitle=Frontiers+in+pediatrics&rft.au=Triantis%2C+Vassilis&rft.au=Bode%2C+Lars&rft.au=van+Neerven%2C+R+J+Joost&rft.date=2018&rft.issn=2296-2360&rft.eissn=2296-2360&rft.volume=6&rft.spage=190&rft_id=info:doi/10.3389%2Ffped.2018.00190&rft_id=info%3Apmid%2F30013961&rft.externalDocID=30013961
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2296-2360&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2296-2360&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2296-2360&client=summon