Immunological Effects of Human Milk Oligosaccharides

Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested in the gastrointestinal tract and reach the colon intact, where they shape the microbiota. A small fraction of HMOs is absorbed, reach...

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Bibliographic Details
Published in:Frontiers in pediatrics Vol. 6; p. 190
Main Authors: Triantis, Vassilis, Bode, Lars, van Neerven, R. J. Joost
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 2018
Subjects:
Allergy
Benefit
Health
HMO
Human milk oligosaccharides
Immunity
Infant
Infection
Pediatrics
human milk oligosaccharides
infection
allergy
health
HMO
immunity
infant
benefit
ISSN:2296-2360, 2296-2360
Online Access:Get full text
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Summary:Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested in the gastrointestinal tract and reach the colon intact, where they shape the microbiota. A small fraction of HMOs is absorbed, reaches the systemic circulation, and is excreted in urine. HMOs can bind to cell surface receptors expressed on epithelial cells and cells of the immune system and thus modulate neonatal immunity in the infant gut, and possibly also sites throughout the body. In addition, they have been shown to act as soluble decoy receptors to block the attachment of various microbial pathogens to cells. This review summarizes the current knowledge of the effects HMOs can have on infections, allergies, auto-immune diseases and inflammation, and will focus on the role of HMOs in altering immune responses through binding to immune-related receptors.
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Edited by: Daniel Munblit, I. M. Sechenov First Moscow State Medical University, Russia
This article was submitted to Pediatric Immunology, a section of the journal Frontiers in Pediatrics
Reviewed by: Belinda van't Land, University Medical Center Utrecht, Netherlands; Gert Folkerts, Utrecht University, Netherlands
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2018.00190