Self‐assembled human placental model from trophoblast stem cells in a dynamic organ‐on‐a‐chip system

The placental barrier plays a key role in protecting the developing fetus from xenobiotics and exchanging substances between the fetus and mother. However, the trophoblast cell lines and animal models are often inadequate to recapitulate the key architecture and functional characteristics of human p...

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Bibliographic Details
Published in:	Cell proliferation Vol. 56; no. 5; pp. e13469 - n/a
Main Authors:	Cao, Rongkai, Wang, Yaqing, Liu, Jiayue, Rong, Lujuan, Qin, Jianhua
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.05.2023 John Wiley and Sons Inc
Subjects:	Animal models Animals Biochips Biomimetics Cell culture Cell Differentiation Cell lines Chorionic gonadotropin Chorionic Gonadotropin - analysis Chorionic Gonadotropin - metabolism Chorionic Gonadotropin - pharmacology Collagen Endocrine disruptors Endothelial cells Endothelial Cells - metabolism Endothelium Epithelium External stimuli Female Fetuses Fluid flow Gene expression Glucose transport Gonadotropins Humans Microphysiological Systems Original Permeability Pituitary (anterior) Placenta Placenta - metabolism Pregnancy RNA transport Scanning electron microscopy Self-assembly Signal transduction Stem Cells Structure-function relationships Toxicants Trophoblasts - metabolism Xenobiotics
ISSN:	0960-7722, 1365-2184, 1365-2184
Online Access:	Get full text
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