Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry

Objective G protein-coupled receptor 126 ( GPR126 ) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis...

Full description

Saved in:

Bibliographic Details
Published in:	BMC research notes Vol. 18; no. 1; pp. 370 - 5
Main Authors:	Chatzopoulou, Eirini, Fanourakis, Galinos, Papanikolaou, Nikolaos, Chatzistamou, Ioulia, Dereka, Xanthippi, Vastardis, Heleni
Format:	Journal Article
Language:	English
Published:	London BioMed Central 22.08.2025 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adult Alleles Biomedical and Life Sciences Biomedicine Case-Control Studies Dental research Dentistry Female Gene polymorphism Genes Genetic aspects Genetic Predisposition to Disease Genomes Genotype Genotype & phenotype Genotyping GPR126 gene Greece Gum disease Homeostasis Humans Life Sciences Ligaments Male Medicine/Public Health Middle Aged Periodontal diseases Periodontitis Periodontitis - genetics Physiological aspects Polymorphism Polymorphism, Single Nucleotide Population studies Proteins Receptors, G-Protein-Coupled - genetics Research Note Single nucleotide polymorphisms Single-nucleotide polymorphism Susceptibility White People - genetics Greece Europe Periodontitis gene Polymorphism GPR126 gene
ISSN:	1756-0500, 1756-0500
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Objective G protein-coupled receptor 126 ( GPR126 ) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
AbstractList	G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility. G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study.OBJECTIVEG protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study.No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.RESULTSNo variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility. Objective G protein-coupled receptor 126 ( GPR126 ) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility. G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility. Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility. Keywords: Periodontitis, GPR126 gene, Polymorphism ObjectiveG protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study.ResultsNo variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility. Abstract Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
ArticleNumber	370
Audience	Academic
Author	Chatzistamou, Ioulia Fanourakis, Galinos Chatzopoulou, Eirini Papanikolaou, Nikolaos Vastardis, Heleni Dereka, Xanthippi
Author_xml	– sequence: 1 givenname: Eirini surname: Chatzopoulou fullname: Chatzopoulou, Eirini organization: U.F.R. d’Odontologie, Université Paris Cité, Service of Odontology, Periodontal and Oral Surgery Unit, Rothschild Hospital (AP-HP) – sequence: 2 givenname: Galinos surname: Fanourakis fullname: Fanourakis, Galinos email: gfanourak@med.uoa.gr organization: Department of Oral Biology, School of Dentistry, National and Kapodistrian University of Athens – sequence: 3 givenname: Nikolaos surname: Papanikolaou fullname: Papanikolaou, Nikolaos organization: EnzyQuest PC, Science and Technology Park of Crete – sequence: 4 givenname: Ioulia surname: Chatzistamou fullname: Chatzistamou, Ioulia organization: Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina – sequence: 5 givenname: Xanthippi surname: Dereka fullname: Dereka, Xanthippi organization: Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens – sequence: 6 givenname: Heleni surname: Vastardis fullname: Vastardis, Heleni organization: Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/40846985$$D View this record in MEDLINE/PubMed
BookMark	eNp9kktr3DAUhU1JaR7tH-iiGLpJFk4l670qIUzTgUBKabsVsizNKNiSK9khs-lvrzyTJplSihG2pe-cy706x8WBD94UxVsIziHk9EOCCAJcgZpUgGGMKvKiOIKM0AoQAA6efR8WxyndAkAh5_BVcYgBx1RwclT8WtwPXYjOr8pxbcohmmS8NmWw2_-rL19hTcuUzztT-kl3JoyuzWDoNn2Iw9qlvjyNiSDKIEaAnpXOl4OJLrTBj6orBzU648c0Wy6mGAajfKlyjTTGzevipVVdMm8e3ifF90-Lb5efq-ubq-XlxXWlCQSkalSD2gaIhiJUG2IYaLhgAtYEkLa2kAhkEFNAIWE1VJQxTCzRVAErgG0wOimWO982qFs5RNeruJFBObndCHElVRxdbk82jaFaMC6yAW654YRbm2ty3QjWapi9Pu68hqnpTatzc1F1e6b7J96t5SrcSVijfE2QZYfTB4cYfk55ELJ3SZuuU96EKUlUY5oXJjP6_i_0NkzR51nNFIMEClQ_USuVO3DehlxYz6bygpNaIM4AzdT5P6j8tKZ3OmfLury_JzjbE2RmNPfjSk0pyeXNj3323fOpPI7jT9QyUO8AHUNK0dhHBAI551nu8ixznuU2z3IWoZ0oDXNGTXxq_z-q37UW9Ow
Cites_doi	10.1016/j.febslet.2004.05.038 10.1371/journal.pgen.1000445 10.1016/j.ajhg.2015.04.014 10.1242/dev.098061 10.1038/s41598-024-54179-6 10.1172/JCI34772 10.1038/ng.500 10.1016/j.gendis.2023.02.016 10.1038/nature19312 10.1111/j.1600-0757.2010.00371.x 10.1111/j.1600-0757.2011.00415.x 10.1016/j.neuron.2014.12.057 10.1016/S0006-291X(03)00026-3 10.3389/fphar.2024.1349097 10.1177/0022034519842510 10.3233/CBM-170541 10.1038/ng.2639 10.1038/s41598-024-56128-9 10.1111/jcpe.12945 10.1016/j.gene.2006.07.039 10.1038/nrm908 10.1074/jbc.M114.571000 10.1126/scisignal.2005347 10.1124/mol.63.6.1256 10.1126/science.1173474 10.1242/dev.093401 10.1007/s00784-022-04420-1 10.1371/journal.pone.0014047 10.1371/journal.pone.0160765 10.1111/jre.12167 10.1111/j.1356-9597.2004.00743.x 10.1038/s41467-019-10630-1
ContentType	Journal Article
Copyright	The Author(s) 2025 2025. The Author(s). COPYRIGHT 2025 BioMed Central Ltd. 2025. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2025 2025
Copyright_xml	– notice: The Author(s) 2025 – notice: 2025. The Author(s). – notice: COPYRIGHT 2025 BioMed Central Ltd. – notice: 2025. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2025 2025
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV 3V. 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 5PM DOA
DOI	10.1186/s13104-025-07443-5
DatabaseName	Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints ProQuest Central (Corporate) Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea ProQuest Health & Medical Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Collection (ProQuest) ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database (ProQuest) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Publicly Available Content Database
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology Dentistry
EISSN	1756-0500
EndPage	5
ExternalDocumentID	oai_doaj_org_article_bbe6c9789f5c4d8e858ffe5e8cb97dc1 PMC12374417 A852938706 40846985 10_1186_s13104_025_07443_5
Genre	Journal Article
GeographicLocations	Greece Europe
GeographicLocations_xml	– name: Greece – name: Europe
GroupedDBID	--- 0R~ 23N 2WC 53G 5GY 5VS 6J9 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AASML ABDBF ABUWG ACGFO ACGFS ACIHN ACMJI ACPRK ACUHS ADBBV ADRAZ ADUKV AEAQA AFKRA AFPKN AHBYD AHMBA AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BBNVY BCNDV BENPR BFQNJ BHPHI BMC BPHCQ BVXVI C6C CCPQU CS3 DIK E3Z EBD EBLON EBS EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IEA IHR INH INR IOV ITC KQ8 LGEZI LK8 LOTEE M1P M7P MK0 M~E NADUK NXXTH O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PUEGO RBZ RNS ROL RPM RSV SBL SOJ SV3 TR2 TUS UKHRP ~8M AAYXX AFFHD CITATION CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK AZQEC DWQXO GNUQQ K9. M48 PKEHL PQEST PQUKI PRINS 7X8 5PM
ID	FETCH-LOGICAL-c5105-bab3db09b6332e5e70b897912505d2f1593e37a0a39fc1a67745f5c6a0f90fb43
IEDL.DBID	BENPR
ISSN	1756-0500
IngestDate	Fri Oct 03 12:51:35 EDT 2025 Tue Nov 04 02:05:55 EST 2025 Thu Sep 04 12:32:20 EDT 2025 Sat Nov 01 15:20:32 EDT 2025 Tue Nov 11 10:46:44 EST 2025 Tue Nov 04 18:10:58 EST 2025 Thu Nov 13 15:55:59 EST 2025 Thu Sep 04 05:02:57 EDT 2025 Sat Nov 29 07:32:04 EST 2025 Sat Sep 06 07:31:25 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Periodontitis gene Polymorphism GPR126 gene
Language	English
License	2025. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5105-bab3db09b6332e5e70b897912505d2f1593e37a0a39fc1a67745f5c6a0f90fb43
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://www.proquest.com/docview/3247151932?pq-origsite=%requestingapplication%
PMID	40846985
PQID	3247151932
PQPubID	55247
PageCount	5
ParticipantIDs	doaj_primary_oai_doaj_org_article_bbe6c9789f5c4d8e858ffe5e8cb97dc1 pubmedcentral_primary_oai_pubmedcentral_nih_gov_12374417 proquest_miscellaneous_3246324457 proquest_journals_3247151932 gale_infotracmisc_A852938706 gale_infotracacademiconefile_A852938706 gale_incontextgauss_IOV_A852938706 pubmed_primary_40846985 crossref_primary_10_1186_s13104_025_07443_5 springer_journals_10_1186_s13104_025_07443_5
PublicationCentury	2000
PublicationDate	20250822
PublicationDateYYYYMMDD	2025-08-22
PublicationDate_xml	– month: 8 year: 2025 text: 20250822 day: 22
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	BMC research notes
PublicationTitleAbbrev	BMC Res Notes
PublicationTitleAlternate	BMC Res Notes
PublicationYear	2025
Publisher	BioMed Central BioMed Central Ltd Springer Nature B.V BMC
Publisher_xml	– name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V – name: BMC
References	H Waller-Evans (7443_CR11) 2010; 5 DB Hancock (7443_CR21) 2010; 42 ML Laine (7443_CR2) 2012; 58 L Hose (7443_CR27) 2024; 14 R Fredriksson (7443_CR6) 2003; 63 TA Manolio (7443_CR31) 2008; 118 G Ravenscroft (7443_CR23) 2015; 96 RD Vaithilingam (7443_CR32) 2014; 49 KR Monk (7443_CR14) 2009; 325 F-S Geng (7443_CR12) 2013; 140 I Kou (7443_CR19) 2013; 45 KL Pierce (7443_CR5) 2002; 3 T Moriguchi (7443_CR29) 2004; 9 MS Tonetti (7443_CR25) 2018; 45 J Kitagaki (7443_CR24) 2016; 11 A Küffer (7443_CR18) 2016; 536 R Fredriksson (7443_CR9) 2003; 301 F Schwendicke (7443_CR33) 2022; 26 SC Petersen (7443_CR17) 2015; 85 Q Li (7443_CR8) 2024; 11 A Jobe (7443_CR15) 2024; 15 7443_CR20 TD Glenn (7443_CR10) 2013; 140 7443_CR28 N Lu (7443_CR22) 2017; 21 TE Van Dyke (7443_CR1) 2005; 7 J Zhang (7443_CR4) 2011; 56 C Stehlik (7443_CR30) 2004; 569 H Cui (7443_CR13) 2014; 289 L Nibali (7443_CR3) 2019; 98 TK Bjarnadóttir (7443_CR7) 2007; 387 DL Pearce (7443_CR26) 2024; 14 KJ Paavola (7443_CR16) 2014; 7
References_xml	– volume: 569 start-page: 149 year: 2004 ident: 7443_CR30 publication-title: FEBS Lett doi: 10.1016/j.febslet.2004.05.038 – ident: 7443_CR20 doi: 10.1371/journal.pgen.1000445 – volume: 96 start-page: 955 year: 2015 ident: 7443_CR23 publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2015.04.014 – volume: 140 start-page: 4362 year: 2013 ident: 7443_CR12 publication-title: Development doi: 10.1242/dev.098061 – volume: 7 start-page: 3 year: 2005 ident: 7443_CR1 publication-title: J Int Acad Periodontol – volume: 14 start-page: 1 year: 2024 ident: 7443_CR27 publication-title: Sci Rep doi: 10.1038/s41598-024-54179-6 – volume: 118 start-page: 1590 year: 2008 ident: 7443_CR31 publication-title: J Clin Invest doi: 10.1172/JCI34772 – volume: 42 start-page: 45 year: 2010 ident: 7443_CR21 publication-title: Nat Genet doi: 10.1038/ng.500 – volume: 11 start-page: 294 year: 2024 ident: 7443_CR8 publication-title: Genes Dis doi: 10.1016/j.gendis.2023.02.016 – volume: 536 start-page: 464 year: 2016 ident: 7443_CR18 publication-title: Nature doi: 10.1038/nature19312 – volume: 56 start-page: 102 year: 2011 ident: 7443_CR4 publication-title: Periodontol 2000 doi: 10.1111/j.1600-0757.2010.00371.x – volume: 58 start-page: 37 year: 2012 ident: 7443_CR2 publication-title: Periodontol 2000 doi: 10.1111/j.1600-0757.2011.00415.x – volume: 85 start-page: 755 year: 2015 ident: 7443_CR17 publication-title: Neuron doi: 10.1016/j.neuron.2014.12.057 – volume: 301 start-page: 725 year: 2003 ident: 7443_CR9 publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(03)00026-3 – volume: 15 start-page: 1 year: 2024 ident: 7443_CR15 publication-title: Front Pharmacol doi: 10.3389/fphar.2024.1349097 – volume: 98 start-page: 632 year: 2019 ident: 7443_CR3 publication-title: J Dent Res doi: 10.1177/0022034519842510 – volume: 21 start-page: 161 year: 2017 ident: 7443_CR22 publication-title: Cancer Biomark doi: 10.3233/CBM-170541 – volume: 45 start-page: 676 year: 2013 ident: 7443_CR19 publication-title: Nat Genet doi: 10.1038/ng.2639 – volume: 14 start-page: 1 year: 2024 ident: 7443_CR26 publication-title: Sci Rep doi: 10.1038/s41598-024-56128-9 – volume: 45 start-page: S149 year: 2018 ident: 7443_CR25 publication-title: J Clin Periodontol doi: 10.1111/jcpe.12945 – volume: 387 start-page: 38 year: 2007 ident: 7443_CR7 publication-title: Gene doi: 10.1016/j.gene.2006.07.039 – volume: 3 start-page: 639 year: 2002 ident: 7443_CR5 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm908 – volume: 289 start-page: 34871 year: 2014 ident: 7443_CR13 publication-title: J Biol Chem doi: 10.1074/jbc.M114.571000 – volume: 7 start-page: ra76 year: 2014 ident: 7443_CR16 publication-title: Sci Signal doi: 10.1126/scisignal.2005347 – volume: 63 start-page: 1256 year: 2003 ident: 7443_CR6 publication-title: Mol Pharmacol doi: 10.1124/mol.63.6.1256 – volume: 325 start-page: 1402 year: 2009 ident: 7443_CR14 publication-title: Science doi: 10.1126/science.1173474 – volume: 140 start-page: 3167 year: 2013 ident: 7443_CR10 publication-title: Dev doi: 10.1242/dev.093401 – volume: 26 start-page: 3395 year: 2022 ident: 7443_CR33 publication-title: Clin Oral Investig doi: 10.1007/s00784-022-04420-1 – volume: 5 start-page: 1 year: 2010 ident: 7443_CR11 publication-title: PLoS ONE doi: 10.1371/journal.pone.0014047 – volume: 11 start-page: 1 year: 2016 ident: 7443_CR24 publication-title: PLoS ONE doi: 10.1371/journal.pone.0160765 – volume: 49 start-page: 683 year: 2014 ident: 7443_CR32 publication-title: J Periodontal Res doi: 10.1111/jre.12167 – volume: 9 start-page: 549 year: 2004 ident: 7443_CR29 publication-title: Genes Cells doi: 10.1111/j.1356-9597.2004.00743.x – ident: 7443_CR28 doi: 10.1038/s41467-019-10630-1
SSID	ssj0061881
Score	2.3960452
Snippet	Objective G protein-coupled receptor 126 ( GPR126 ) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese... G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This... Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese... ObjectiveG protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese... Abstract Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in...
SourceID	doaj pubmedcentral proquest gale pubmed crossref springer
SourceType	Open Website Open Access Repository Aggregation Database Index Database Publisher
StartPage	370
SubjectTerms	Adult Alleles Biomedical and Life Sciences Biomedicine Case-Control Studies Dental research Dentistry Female Gene polymorphism Genes Genetic aspects Genetic Predisposition to Disease Genomes Genotype Genotype & phenotype Genotyping GPR126 gene Greece Gum disease Homeostasis Humans Life Sciences Ligaments Male Medicine/Public Health Middle Aged Periodontal diseases Periodontitis Periodontitis - genetics Physiological aspects Polymorphism Polymorphism, Single Nucleotide Population studies Proteins Receptors, G-Protein-Coupled - genetics Research Note Single nucleotide polymorphisms Single-nucleotide polymorphism Susceptibility White People - genetics
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9RAEF-kKPgifhutsoqgoqFJ9iO7j1WsClKLqPRtyX7VgzYplzuhL_7tzmySs6mILz7e7dyRzMzu_CaZ-Q0hT72NAIxrkStf6Zxz73PtnMyZLRoeHOeCpUbhj_X-vjo81AfnRn1hTdhADzwobsfaIB2kOjoKx70KSqgYgwjKWV17lxIfQD1TMjWcwbJUqpxaZJTc6UtAMTzH0a0QMjnLxSwMJbb-P8_kc0HpYsHkhbemKRjtXSfXRhRJd4erv0EuhfYmuTLMlTy7RX5uKuso4Dt6mlqMXKBdTJ_fHXwuK0nxKcFxoC0yGnerhQfB7vjspAPNL_oT-nzZCyZxcHkhX9BFS5ETGZJYbJ-kIx1rj385PdCn6EA4O-42-br39sub9_k4aCF3iK9y21jmbaGtZKwC3daFVbrWJcIjX0VAPCywuikapqMrGwmQUYA5ZFNEXUTL2R2y1XZtuEcoBDwrakijmHYcwGETmZPBOqbA9tYXGXk56d2cDnwaJuUhSprBSgasZJKVjMjIazTNRhK5sNMX4CFm9BDzLw_JyBM0rEG2ixbLaY6add-bD5--mV0lAO7gq96MPBuFYgcmds3YnQB3hQRZM8ntmSRsRzdfnvzHjMdBbwC11mXCyhl5vFnGX2KJWxu6dZJB6nwu6ozcHdxtc9-8UDjpE_ShZo44U8x8pV18T2ThgExqHDOXkVeTz_6-rr9r_v7_0PwDcrVKew4O42qbbK2W6_CQXHY_Vot--Sjt2F_RAEQu priority: 102 providerName: Directory of Open Access Journals – databaseName: Springer LINK dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaggNQL70egIIOQAJWIJH7EPhZEAQmVqkDVmxU7drtSm1SbXaRe-O3MOMlCChzguOvJKh7PeD6vZ74h5GltAwDjUqSqLnTKeV2n2jmZMptV3DvOBYuFwh_LnR11cKB3h6Kwbsx2H68k404d3VrJV10OSISn2H4Vwh5nqbhILkG4U-iOe5_3x_1X5krlY3nMH5-bhKDI1P_7fvxLQDqfLHnuxjQGou1r_zeF6-TqADzpVm8pN8gF39wkV_pWlGe3yPdVMh4FSEhPY1WS87QN8fO73b28kBT_WDj2tEES5HYxq0GwPT47aWGxZt0JfT7vBJPY6zyTL-isoUijDOderLikA4Nrhz853gFQtDlsN3ebfN1---XN-3TozZA6hGSprSyrbaatZKzwwpeZVbrUOSKquggAkphnZZVVTAeXVxJQpgjCySoLOguWsztkrWkbf49QiJFWlHDyYtpxwJNVYE5665gCc7F1lpDNcbnMaU_BYeLRRUnTa9SARk3UqBEJeY0rupJE-uz4RTs_NIM3Gmu9dHB-1vBKvFZeCRUCzEI5q8va5Ql5gvZgkCCjwQycw2rZdebDp32zpQQgJLwdTsizQSi0YBmuGgoaYFbIqTWR3JhIgge76fBodmbYQToDQLfMI7xOyOPVMD6JWXGNb5dRBtn2uSgTcre30tW8eaawOSjoQ03sd6KY6UgzO4r84gBmSuxMl5CXoxn_fK-_a_7-v4k_IOtF9ATYqYsNsraYL_1Dctl9W8y6-aPo0j8AqrRGYQ priority: 102 providerName: Springer Nature
Title	Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry
URI	https://link.springer.com/article/10.1186/s13104-025-07443-5 https://www.ncbi.nlm.nih.gov/pubmed/40846985 https://www.proquest.com/docview/3247151932 https://www.proquest.com/docview/3246324457 https://pubmed.ncbi.nlm.nih.gov/PMC12374417 https://doaj.org/article/bbe6c9789f5c4d8e858ffe5e8cb97dc1
Volume	18
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVADU databaseName: BioMed Central customDbUrl: eissn: 1756-0500 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0061881 issn: 1756-0500 databaseCode: RBZ dateStart: 20080101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1756-0500 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0061881 issn: 1756-0500 databaseCode: DOA dateStart: 20080101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1756-0500 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0061881 issn: 1756-0500 databaseCode: M~E dateStart: 20080101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database (ProQuest) customDbUrl: eissn: 1756-0500 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0061881 issn: 1756-0500 databaseCode: M7P dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection (ProQuest) customDbUrl: eissn: 1756-0500 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0061881 issn: 1756-0500 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Proquest Central customDbUrl: eissn: 1756-0500 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0061881 issn: 1756-0500 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 1756-0500 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0061881 issn: 1756-0500 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: Springer LINK customDbUrl: eissn: 1756-0500 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0061881 issn: 1756-0500 databaseCode: RSV dateStart: 20081201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdYB4IXPsZXYFQGIQGCaEnsxM4T2mCDSVCiMqbyZMWOMyptSWlWpL3wt3PnJh0ZghdeKiW-VD7f-e5n-3xHyNNClwCMRezLIkp9zovCT41JfKaDnFvDeczcReEPYjSSk0matRtuTRtW2dlEZ6iL2uAe-RY4fhE6uPF69t3HqlF4utqW0Fgj65ipjA_I-s7uKBt3tjgJpQy7qzIy2WpCQDPcxxKu4Do58-OeO3JZ-_-0zb85p4uBkxdOT51T2rvxv-zcJNdbOEq3l_pzi1yy1Qa5sixQebZBrr7FYCKsB3eb_FyF61EAjXTm7i0ZS-vSPb_LxmGUUNx6OLa0wjTJ9em0AML6-OykBnFOmxP6fN7ELMFq6EHygk4riomWYWWMdzJpm-O1wb_sTgkoaiV24A75srd78Oa931Zv8A2CNl_nmhU6SHXCWGRjKwItU5GGiLmKqAQYxSwTeZCztDRhngAOjcvYJHlQpkGpObtLBlVd2fuEghfVsYC1GUsNhzHLS2YSqw2ToFC6CDzyshOimi2TdCi3uJGJWopcgciVE7mKPbKDcl5RYoJt96KeH6l2viqtbWJghZ1Cl3ghrYxlWQIX0uhUFCb0yBPUEoUpNCqM0TnKF02j9j8dqm0ZA4bC82OPPGuJyhr0xeTtlQfgCrNu9Sg3e5Qwx02_udMi1dqYRp2rkEcer5rxS4ybq2y9cDSYj5_HwiP3lrq74psHEsuHwnjInlb3BqbfUk2_uQzkAHcE1q7zyKtuApz36-8j_-DfbDwk1yI3NcF2R5tkcDpf2EfksvkBij4fkjUxEe5XDttpPnQ7KEOM183gXbb_MfsKT-PPh78APj1cBg
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKAZULj_IKFDAIBAiiJrGdOAeECqV01WWpUEF7M7HjlJXaZNl0QXvhJ_EbmfEmW1IEtx447noSxc43D8cz8xHyMNcFBMaJ8GUepT7nee6nxsQ-00HGreFcMFco3E8GAzkcprtL5GdbC4Npla1NdIY6rwx-I18Hx5-ELtx4Of7qI2sUnq62FBpzWOzY2XfYstUvepvwfh9F0dabvdfbfsMq4BsMJnydaZbrINUxY5EVNgm0TJM0xFggjwpw78yyJAsylhYmzGKIj0QhTJwFRRoUmjO47xlyFux4gilkyXCxwYtDKcO2MEfG63UIsRP3kTAWHDVnvug4P8cR8Kcn-M0VnkzTPHFW61zg1qX_bfEuk4tNsE035tpxhSzZcpWcn9NvzlbJyiamSiHb3VXyY5GMSCEkpmNXlWUsrQr3--3uhzCKKX5YObC0xCbQ1dEoB8HqYHZYAVhH9SF9MqkFi5HrPYif0lFJsY007Pux4pQ2HWxrvGV7BkJR5_ABrpGPp7IQ18lyWZX2JqEQI2iRwM6TpYbDO8oKZmKrDZOgLjoPPPKsBY0az1uQKLd1k7GaQ0wBxJSDmBIeeYW4Wkhi-3D3RzXZV401Ulrb2AB-U3gknksrhSwKmIU0Ok1yE3rkAaJSYYOQEjOQ9rNpXave-09qQwqIEPF03COPG6GiAnyarCnogFlhT7GO5FpHEiyY6Q63qFWNBa3VMWQ9cn8xjFdiVmBpq6mTQbYBLhKP3JjrymLePJBIjgrrITta1FmY7kg5-uL6q0MwlyAzn0eetwp3_Fx_X_lb_57GPbKyvfeur_q9wc5tciFyZgG8VLRGlo8mU3uHnDPfAPSTu86oUPL5tBXxF7mXr1E
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zj9MwELZgOcQL9xFYwCAkQBBtUh9xHpejsGJVKo7VvlmxYy-VdpOqaZH2hd_OjJOUzQIPiMfWkyoez9jf1DPfEPKkNB6AcSZiVY7ymPOyjHNrZcxMUnBnORcsFArvZpOJ2t_Ppyeq-EO2e38l2dY0IEtTtdyal751cSW3mhRQCY-xFSscgZzF4iw5x7FpEMbrn_f6vVimSqV9qcwfnxscR4G1__e9-cThdDpx8tTtaTiUxlf-fzpXyeUOkNLt1oKukTOuuk4utC0qj2-QH-skPQpQkc5DtZJ1tPbh87vpp3QkKf7hcOhoheTI9XJWgmB9eHxUwyLOmiP6bNEIJrEHeiKf01lFkV4Z4mGsxKQds2uDP9nfDVC0RWxDd5N8Hb_98vp93PVsiC1CtdgUhpUmyY1kbOSEyxKj8ixPEWmVIw_giTmWFUnBcm_TQgL6FF5YWSQ-T7zh7BbZqOrK3SEUzk4jMojIWG454MzCMyudsUyBGZkyiciLfun0vKXm0CGkUVK3GtWgUR00qkVEXuHqriWRVjt8US8OdOel2hgnLcTVObwSL5VTQnkPs1DW5Flp04g8RtvQSJxRYWbOQbFqGr3zcU9vKwHICW-NI_K0E_I1WIktukIHmBVybQ0kNweS4Nl2ONyboO52lkYDAM7SALsj8mg9jE9itlzl6lWQQRZ-LrKI3G4tdj1vnihsGgr6UANbHihmOFLNvgXecQA5GXasi8jL3qR_vdffNX_338QfkovTN2O9uzP5cI9cGgWngM18tEk2louVu0_O2-_LWbN4EDz9JzsFUik
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exploring+the+presence+of+the+GPR126+single+nucleotide+polymorphism+in+periodontal+patients+of+European+ancestry&rft.jtitle=BMC+research+notes&rft.au=Chatzopoulou%2C+Eirini&rft.au=Fanourakis%2C+Galinos&rft.au=Papanikolaou%2C+Nikolaos&rft.au=Chatzistamou%2C+Ioulia&rft.date=2025-08-22&rft.pub=BioMed+Central+Ltd&rft.issn=1756-0500&rft.eissn=1756-0500&rft.volume=18&rft.issue=1&rft_id=info:doi/10.1186%2Fs13104-025-07443-5&rft.externalDBID=IOV&rft.externalDocID=A852938706
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1756-0500&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1756-0500&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1756-0500&client=summon