Palladium-Catalyzed Asymmetric Quaternary Stereocenter Formation

An efficient palladium catalyst is presented for the formation of benzylic quaternary stereocenters by conjugate addition of arylboronic acids to a variety of β,β‐disubstituted carbocyclic, heterocyclic, and acyclic enones. The catalyst is readily prepared from PdCl2, PhBOX, and AgSbF6, and provides...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 18; no. 22; pp. 6907 - 6914
Main Authors:	Gottumukkala, Aditya L., Matcha, Kiran, Lutz, Martin, de Vries , Johannes G., Minnaard, Adriaan J.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 29.05.2012 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc
Subjects:	arylboronic acids Asymmetry Boronic Acids - chemical synthesis Boronic Acids - chemistry Catalysis Catalysts Chemistry Chemistry, Multidisciplinary Conjugates cuparenone Formations Michael addition Molecular Structure Palladium Palladium - chemistry Physical Sciences quaternary stereocenters Science & Technology Sesquiterpenes - chemical synthesis Sesquiterpenes - chemistry Stereoisomerism Strategy Michael addition ENANTIOSELECTIVE SYNTHESIS ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS SUBSTITUTED CYCLIC ENONES TRISUBSTITUTED ENONES arylboronic acids quaternary stereocenters cuparenone CONSTRUCTION palladium STEREOGENIC CENTERS PALLADIUM(II)-CATALYZED 1,4-ADDITION ARYL ALUMINUM REAGENTS CONJUGATE ADDITION
ISSN:	0947-6539, 1521-3765, 1521-3765
Online Access:	Get full text
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