Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe

Ezetimibe undergoes glucuronidation that results in the active metabolite ezetimibe phenoxy‐glucuronide (ezetimibe‐glucuronide). This phase‐II metabolite was shown to interact with the clinically relevant hepatic transporter organic anion transporting polypeptide (OATP) 1B1. In recent years, copropo...

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Veröffentlicht in:	Clinical and translational science Jg. 17; H. 10; S. e70041 - n/a
Hauptverfasser:	Kinzi, Jonny, Grube, Markus, Seibert, Isabell, Siegmund, Werner, Meyer zu Schwabedissen, Henriette E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States John Wiley & Sons, Inc 01.10.2024 John Wiley and Sons Inc Wiley
Schlagworte:	Acids Adult Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - blood Anticholesteremic Agents - pharmacokinetics Anticholesteremic Agents - pharmacology Azetidines Biomarkers Biomarkers - blood Cholesterol Cholesterol - blood Cholesterol - metabolism Coproporphyrins - blood Coproporphyrins - metabolism Coproporphyrins - urine Data analysis Dosage Drug dosages Drug Interactions Ezetimibe - administration & dosage Ezetimibe - pharmacokinetics Ezetimibe - pharmacology Female Glucuronides Healthy Volunteers HEK293 Cells Humans Liver-Specific Organic Anion Transporter 1 - antagonists & inhibitors Liver-Specific Organic Anion Transporter 1 - metabolism Male Metabolites Middle Aged Organic anion transporting polypeptide Pharmacokinetics Proteins Rifampin Rifampin - administration & dosage Rifampin - pharmacology Serum levels Urine Young Adult United States > US Switzerland
ISSN:	1752-8054, 1752-8062, 1752-8062
Online-Zugang:	Volltext
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