TGFβ1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial–mesenchymal transition in Sjögren’s syndrome

Interleukin-17 (IL-17) is a pleiotropic cytokine that plays a primary role in triggering epithelial–mesenchymal transition (EMT) in many chronic inflammatory diseases. EMT plays a critical role in the progression of salivary gland (SG) fibrosis in primary Sjögren’s syndrome (pSS). This study focused...

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Bibliographic Details
Published in:	Laboratory investigation Vol. 100; no. 6; pp. 824 - 836
Main Authors:	Sisto, Margherita, Lorusso, Loredana, Ingravallo, Giuseppe, Ribatti, Domenico, Lisi, Sabrina
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2020 Nature Publishing Group
Subjects:	13/21 13/31 14/63 38/77 692/308/575 692/420/256/2515 82/80 Activation Activation analysis Aged Cells, Cultured Cytokines Enzyme inhibitors Epithelial cells Epithelial-Mesenchymal Transition - physiology Extracellular signal-regulated kinase Fibrosis Humans Inflammatory diseases Interleukin 17 Interleukin-17 - metabolism Interleukins Kinases Laboratory Medicine Lip - cytology MAP Kinase Signaling System - physiology Medicine Medicine & Public Health Mesenchyme Middle Aged Pathology Salivary gland Salivary glands Signal transduction Sjogren's syndrome Sjogren's Syndrome - metabolism Sjogren's Syndrome - pathology Smad protein Smad Proteins - metabolism Smad2 protein Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1
ISSN:	0023-6837, 1530-0307, 1530-0307
Online Access:	Get full text
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