Sepsis in Intensive Care Unit Patients: Worldwide Data From the Intensive Care over Nations Audit

There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe. The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for le...

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Vydáno v:Open forum infectious diseases Ročník 5; číslo 12; s. ofy313
Hlavní autoři: Sakr, Yasser, Jaschinski, Ulrich, Wittebole, Xavier, Szakmany, Tamas, Lipman, Jeffrey, Ñamendys-Silva, Silvio A, Martin-Loeches, Ignacio, Leone, Marc, Lupu, Mary-Nicoleta, Vincent, Jean-Louis
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Oxford University Press 01.12.2018
Témata:
Bacteriology
Cardiology and cardiovascular system
Emerging diseases
Human health and pathology
Infectious diseases
Intensive care
Life Sciences
Major
Microbiology and Parasitology
Mortality
Parasitology
Sepsis
Virology
mortality
septic shock
critically ill
international
ISSN:2328-8957, 2328-8957
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Shrnutí:There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe. The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for less than 24 hours for routine postoperative surveillance. Data were collected daily for a maximum of 28 days in the ICU, and patients were followed up for outcome data until death, hospital discharge, or for 60 days. Participation was entirely voluntary. The audit included 10069 patients from Europe (54.1%), Asia (19.2%), America (17.1%), and other continents (9.6%). Sepsis, defined as infection with associated organ failure, was identified during the ICU stay in 2973 (29.5%) patients, including in 1808 (18.0%) already at ICU admission. Occurrence rates of sepsis varied from 13.6% to 39.3% in the different regions. Overall ICU and hospital mortality rates were 25.8% and 35.3%, respectively, in patients with sepsis, but it varied from 11.9% and 19.3% (Oceania) to 39.5% and 47.2% (Africa), respectively. After adjustment for possible confounders in a multilevel analysis, independent risk factors for in-hospital death included older age, higher simplified acute physiology II score, comorbid cancer, chronic heart failure (New York Heart Association Classification III/IV), cirrhosis, use of mechanical ventilation or renal replacement therapy, and infection with spp. Sepsis remains a major health problem in ICU patients worldwide and is associated with high mortality rates. However, there is wide variability in the sepsis rate and outcomes in ICU patients around the globe.
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PMCID: PMC6289022
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofy313