Sepsis in Intensive Care Unit Patients: Worldwide Data From the Intensive Care over Nations Audit
There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe. The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for le...
Saved in:
| Published in: | Open forum infectious diseases Vol. 5; no. 12; p. ofy313 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Oxford University Press
01.12.2018
|
| Subjects: | |
| ISSN: | 2328-8957, 2328-8957 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe.
The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for less than 24 hours for routine postoperative surveillance. Data were collected daily for a maximum of 28 days in the ICU, and patients were followed up for outcome data until death, hospital discharge, or for 60 days. Participation was entirely voluntary.
The audit included 10069 patients from Europe (54.1%), Asia (19.2%), America (17.1%), and other continents (9.6%). Sepsis, defined as infection with associated organ failure, was identified during the ICU stay in 2973 (29.5%) patients, including in 1808 (18.0%) already at ICU admission. Occurrence rates of sepsis varied from 13.6% to 39.3% in the different regions. Overall ICU and hospital mortality rates were 25.8% and 35.3%, respectively, in patients with sepsis, but it varied from 11.9% and 19.3% (Oceania) to 39.5% and 47.2% (Africa), respectively. After adjustment for possible confounders in a multilevel analysis, independent risk factors for in-hospital death included older age, higher simplified acute physiology II score, comorbid cancer, chronic heart failure (New York Heart Association Classification III/IV), cirrhosis, use of mechanical ventilation or renal replacement therapy, and infection with
spp.
Sepsis remains a major health problem in ICU patients worldwide and is associated with high mortality rates. However, there is wide variability in the sepsis rate and outcomes in ICU patients around the globe. |
|---|---|
| AbstractList | There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe.BACKGROUNDThere is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe.The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for less than 24 hours for routine postoperative surveillance. Data were collected daily for a maximum of 28 days in the ICU, and patients were followed up for outcome data until death, hospital discharge, or for 60 days. Participation was entirely voluntary.METHODSThe Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for less than 24 hours for routine postoperative surveillance. Data were collected daily for a maximum of 28 days in the ICU, and patients were followed up for outcome data until death, hospital discharge, or for 60 days. Participation was entirely voluntary.The audit included 10069 patients from Europe (54.1%), Asia (19.2%), America (17.1%), and other continents (9.6%). Sepsis, defined as infection with associated organ failure, was identified during the ICU stay in 2973 (29.5%) patients, including in 1808 (18.0%) already at ICU admission. Occurrence rates of sepsis varied from 13.6% to 39.3% in the different regions. Overall ICU and hospital mortality rates were 25.8% and 35.3%, respectively, in patients with sepsis, but it varied from 11.9% and 19.3% (Oceania) to 39.5% and 47.2% (Africa), respectively. After adjustment for possible confounders in a multilevel analysis, independent risk factors for in-hospital death included older age, higher simplified acute physiology II score, comorbid cancer, chronic heart failure (New York Heart Association Classification III/IV), cirrhosis, use of mechanical ventilation or renal replacement therapy, and infection with Acinetobacter spp.RESULTSThe audit included 10069 patients from Europe (54.1%), Asia (19.2%), America (17.1%), and other continents (9.6%). Sepsis, defined as infection with associated organ failure, was identified during the ICU stay in 2973 (29.5%) patients, including in 1808 (18.0%) already at ICU admission. Occurrence rates of sepsis varied from 13.6% to 39.3% in the different regions. Overall ICU and hospital mortality rates were 25.8% and 35.3%, respectively, in patients with sepsis, but it varied from 11.9% and 19.3% (Oceania) to 39.5% and 47.2% (Africa), respectively. After adjustment for possible confounders in a multilevel analysis, independent risk factors for in-hospital death included older age, higher simplified acute physiology II score, comorbid cancer, chronic heart failure (New York Heart Association Classification III/IV), cirrhosis, use of mechanical ventilation or renal replacement therapy, and infection with Acinetobacter spp.Sepsis remains a major health problem in ICU patients worldwide and is associated with high mortality rates. However, there is wide variability in the sepsis rate and outcomes in ICU patients around the globe.CONCLUSIONSSepsis remains a major health problem in ICU patients worldwide and is associated with high mortality rates. However, there is wide variability in the sepsis rate and outcomes in ICU patients around the globe. Background There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe. Methods The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for less than 24 hours for routine postoperative surveillance. Data were collected daily for a maximum of 28 days in the ICU, and patients were followed up for outcome data until death, hospital discharge, or for 60 days. Participation was entirely voluntary. Results The audit included 10069 patients from Europe (54.1%), Asia (19.2%), America (17.1%), and other continents (9.6%). Sepsis, defined as infection with associated organ failure, was identified during the ICU stay in 2973 (29.5%) patients, including in 1808 (18.0%) already at ICU admission. Occurrence rates of sepsis varied from 13.6% to 39.3% in the different regions. Overall ICU and hospital mortality rates were 25.8% and 35.3%, respectively, in patients with sepsis, but it varied from 11.9% and 19.3% (Oceania) to 39.5% and 47.2% (Africa), respectively. After adjustment for possible confounders in a multilevel analysis, independent risk factors for in-hospital death included older age, higher simplified acute physiology II score, comorbid cancer, chronic heart failure (New York Heart Association Classification III/IV), cirrhosis, use of mechanical ventilation or renal replacement therapy, and infection with Acinetobacter spp. Conclusions Sepsis remains a major health problem in ICU patients worldwide and is associated with high mortality rates. However, there is wide variability in the sepsis rate and outcomes in ICU patients around the globe. There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe. The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted to the ICU between May 8 and May 18, 2012, except those admitted for less than 24 hours for routine postoperative surveillance. Data were collected daily for a maximum of 28 days in the ICU, and patients were followed up for outcome data until death, hospital discharge, or for 60 days. Participation was entirely voluntary. The audit included 10069 patients from Europe (54.1%), Asia (19.2%), America (17.1%), and other continents (9.6%). Sepsis, defined as infection with associated organ failure, was identified during the ICU stay in 2973 (29.5%) patients, including in 1808 (18.0%) already at ICU admission. Occurrence rates of sepsis varied from 13.6% to 39.3% in the different regions. Overall ICU and hospital mortality rates were 25.8% and 35.3%, respectively, in patients with sepsis, but it varied from 11.9% and 19.3% (Oceania) to 39.5% and 47.2% (Africa), respectively. After adjustment for possible confounders in a multilevel analysis, independent risk factors for in-hospital death included older age, higher simplified acute physiology II score, comorbid cancer, chronic heart failure (New York Heart Association Classification III/IV), cirrhosis, use of mechanical ventilation or renal replacement therapy, and infection with spp. Sepsis remains a major health problem in ICU patients worldwide and is associated with high mortality rates. However, there is wide variability in the sepsis rate and outcomes in ICU patients around the globe. |
| Author | Szakmany, Tamas Wittebole, Xavier Lipman, Jeffrey Martin-Loeches, Ignacio Vincent, Jean-Louis Jaschinski, Ulrich Leone, Marc Ñamendys-Silva, Silvio A Sakr, Yasser Lupu, Mary-Nicoleta |
| AuthorAffiliation | 9 Department of Anesthesia and Intensive Care, Spitalul Clinic Judetean de Urgenta “Sfantul Apostol Andrei”, Galati, Romania 2 Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Germany 7 Department of Clinical Medicine, Trinity Centre for Health Sciences, Multidisciplinary Intensive Care Research Organization, Wellcome Trust, Health Research Board-Clinical Research, St. James’s University Hospital Dublin, Ireland 8 Aix Marseille Université, Assistance Publique Hpitaux de Marseille, Service d’Anesthésie et de Réanimation, Hôpital Nord, Marseille, France 4 Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Wales, United Kingdom 3 Department of Critical Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium 5 Intensive Care Services, Royal Brisbane and Women’s Hospital, The University of Queensland, Australia 1 Department of Anaesthesiology and Intensive Care, Uniklini |
| AuthorAffiliation_xml | – name: 3 Department of Critical Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium – name: 2 Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Germany – name: 9 Department of Anesthesia and Intensive Care, Spitalul Clinic Judetean de Urgenta “Sfantul Apostol Andrei”, Galati, Romania – name: 7 Department of Clinical Medicine, Trinity Centre for Health Sciences, Multidisciplinary Intensive Care Research Organization, Wellcome Trust, Health Research Board-Clinical Research, St. James’s University Hospital Dublin, Ireland – name: 10 Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium – name: 8 Aix Marseille Université, Assistance Publique Hpitaux de Marseille, Service d’Anesthésie et de Réanimation, Hôpital Nord, Marseille, France – name: 1 Department of Anaesthesiology and Intensive Care, Uniklinikum Jena, Germany – name: 4 Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Wales, United Kingdom – name: 5 Intensive Care Services, Royal Brisbane and Women’s Hospital, The University of Queensland, Australia – name: 6 Department of Critical Care Medicine, Instituto Nacional de Cancerología, Ciudad de México |
| Author_xml | – sequence: 1 givenname: Yasser surname: Sakr fullname: Sakr, Yasser organization: Department of Anaesthesiology and Intensive Care, Uniklinikum Jena, Germany – sequence: 2 givenname: Ulrich surname: Jaschinski fullname: Jaschinski, Ulrich organization: Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Germany – sequence: 3 givenname: Xavier surname: Wittebole fullname: Wittebole, Xavier organization: Department of Critical Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium – sequence: 4 givenname: Tamas surname: Szakmany fullname: Szakmany, Tamas organization: Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Wales, United Kingdom – sequence: 5 givenname: Jeffrey surname: Lipman fullname: Lipman, Jeffrey organization: Intensive Care Services, Royal Brisbane and Women’s Hospital, The University of Queensland, Australia – sequence: 6 givenname: Silvio A surname: Ñamendys-Silva fullname: Ñamendys-Silva, Silvio A organization: Department of Critical Care Medicine, Instituto Nacional de Cancerología, Ciudad de México – sequence: 7 givenname: Ignacio surname: Martin-Loeches fullname: Martin-Loeches, Ignacio organization: Department of Clinical Medicine, Trinity Centre for Health Sciences, Multidisciplinary Intensive Care Research Organization, Wellcome Trust, Health Research Board-Clinical Research, St. James’s University Hospital Dublin, Ireland – sequence: 8 givenname: Marc surname: Leone fullname: Leone, Marc organization: Aix Marseille Université, Assistance Publique Hpitaux de Marseille, Service d’Anesthésie et de Réanimation, Hôpital Nord, Marseille, France – sequence: 9 givenname: Mary-Nicoleta surname: Lupu fullname: Lupu, Mary-Nicoleta organization: Department of Anesthesia and Intensive Care, Spitalul Clinic Judetean de Urgenta “Sfantul Apostol Andrei”, Galati, Romania – sequence: 10 givenname: Jean-Louis surname: Vincent fullname: Vincent, Jean-Louis organization: Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30555852$$D View this record in MEDLINE/PubMed https://amu.hal.science/hal-02439048$$DView record in HAL |
| BookMark | eNptkk1vEzEQhi1UREvpiTuyxAWEAuOv3TUHpChQWikCJKg4Wo53Qlxt7GB7g_rvcUipSsTB9mj8vDNjzzwmRyEGJOQpg9cMtHgTl76v241g4gE54YJ3k06r9uiefUzOcr4GAMZAQasfkWMBSqlO8RNiv-Im-0x9oJehYMh-i3RmE9Kr4Av9YovHUPJb-j2mof_le6TvbbH0PMU1LSs8VMUtJvqpqmLIdDr2vjwhD5d2yHh2e56Sq_MP32YXk_nnj5ez6XziFOgyQdlDBwjNooHGSmydXNimcUshccGVbJlzXPfLRkiu61LKQTUa0bZC9VqKU_JuH3czLtbYu1p2soPZJL-26cZE682_N8GvzI-4NQ3vNHBeA7zcB1gdyC6mc7PzAZdCg-y2rLIvbpOl-HPEXMzaZ4fDYAPGMRvOVNsoIaGt6PMD9DqOKdSvMIK1oJXsACr17H71d_n_dqoCr_aASzHnhMs7hIHZjYLZjYLZj0Kl2QHtfPnTlfp0P_xX8xu4QLbF |
| CitedBy_id | crossref_primary_10_1097_MD_0000000000026132 crossref_primary_10_2147_IDR_S343264 crossref_primary_10_3390_cells12050762 crossref_primary_10_3389_fimmu_2022_907646 crossref_primary_10_1136_bmjopen_2022_061876 crossref_primary_10_1016_j_iccn_2022_103345 crossref_primary_10_1039_D4EW00572D crossref_primary_10_1016_j_autrev_2022_103205 crossref_primary_10_2147_IJGM_S357978 crossref_primary_10_3389_fmicb_2025_1574998 crossref_primary_10_1097_JTCCM_D_24_00032 crossref_primary_10_1590_2175_8239_jbn_2025_0028en crossref_primary_10_7759_cureus_48080 crossref_primary_10_1093_jacamr_dlad120 crossref_primary_10_1097_MCC_0000000000000639 crossref_primary_10_1128_spectrum_05003_22 crossref_primary_10_1136_bmjopen_2019_032289 crossref_primary_10_1080_0886022X_2021_1871922 crossref_primary_10_1093_clinchem_hvab239 crossref_primary_10_1186_s13613_025_01419_1 crossref_primary_10_3390_antibiotics12081305 crossref_primary_10_3390_biom11091327 crossref_primary_10_3390_biomedicines9101297 crossref_primary_10_1089_sur_2024_137 crossref_primary_10_1016_j_chest_2021_03_062 crossref_primary_10_1097_SHK_0000000000002291 crossref_primary_10_1186_s40560_019_0424_y crossref_primary_10_1186_s40560_022_00628_1 crossref_primary_10_1016_j_ajem_2024_11_045 crossref_primary_10_1080_0142159X_2024_2331055 crossref_primary_10_1080_17476348_2021_1848555 crossref_primary_10_3389_fmed_2025_1608388 crossref_primary_10_3390_biom12121803 crossref_primary_10_1186_s13054_024_05188_4 crossref_primary_10_1016_j_amjsurg_2020_07_016 crossref_primary_10_1016_j_jiph_2023_08_015 crossref_primary_10_5500_wjt_v15_i1_98975 crossref_primary_10_3389_fmed_2020_593808 crossref_primary_10_3389_fcvm_2025_1491331 crossref_primary_10_3390_medicina61050864 crossref_primary_10_1515_med_2023_0859 crossref_primary_10_2196_28000 crossref_primary_10_1016_j_jhin_2023_11_012 crossref_primary_10_1016_j_ebiom_2022_104318 crossref_primary_10_1042_CS20255458 crossref_primary_10_1136_tsaco_2022_001024 crossref_primary_10_1097_CCM_0000000000004322 crossref_primary_10_1089_sur_2022_329 crossref_primary_10_1080_14756366_2023_2287420 crossref_primary_10_3389_fimmu_2025_1624014 crossref_primary_10_20960_nh_04227 crossref_primary_10_1097_CCE_0000000000000788 crossref_primary_10_1186_s13054_024_05176_8 crossref_primary_10_1111_aas_70117 crossref_primary_10_3389_fimmu_2024_1450118 crossref_primary_10_1590_1806_9282_20211105 crossref_primary_10_1007_s00134_019_05819_3 crossref_primary_10_1136_bmjopen_2021_050305 crossref_primary_10_1016_j_surg_2019_04_010 crossref_primary_10_1089_sur_2023_232 crossref_primary_10_3390_geriatrics9020045 crossref_primary_10_1007_s10753_021_01501_3 crossref_primary_10_7759_cureus_76433 crossref_primary_10_1016_j_envres_2021_112162 crossref_primary_10_3390_diagnostics13081427 crossref_primary_10_1097_CCM_0000000000005886 crossref_primary_10_1177_0885066621997090 crossref_primary_10_25259_JLP_273_2024 crossref_primary_10_3390_antibiotics11121786 crossref_primary_10_1016_j_tvir_2025_101041 crossref_primary_10_5005_jp_journals_10071_23374 crossref_primary_10_1097_MEJ_0000000000001219 crossref_primary_10_1097_NCM_0000000000000805 crossref_primary_10_3390_ijms25179413 crossref_primary_10_5005_jp_journals_10071_24855 crossref_primary_10_3389_fdgth_2022_773387 crossref_primary_10_1186_s12916_025_04202_y crossref_primary_10_1186_s13017_021_00387_8 crossref_primary_10_1016_j_jinf_2024_106300 crossref_primary_10_3389_fmed_2023_1347791 crossref_primary_10_1186_s12877_021_02276_w crossref_primary_10_1111_liv_15285 crossref_primary_10_3233_ISB_200474 crossref_primary_10_1080_17843286_2020_1824749 crossref_primary_10_3389_fimmu_2022_878755 crossref_primary_10_1016_j_atherosclerosis_2021_08_039 crossref_primary_10_1016_j_compbiomed_2021_104255 crossref_primary_10_3389_fimmu_2024_1432307 crossref_primary_10_1016_j_jclinepi_2020_06_014 crossref_primary_10_1109_TBME_2023_3349104 crossref_primary_10_1371_journal_pone_0228966 crossref_primary_10_1111_aas_13658 crossref_primary_10_1042_BST20190029 crossref_primary_10_7554_eLife_79014 crossref_primary_10_1038_s41598_022_19539_0 crossref_primary_10_3390_cells11091566 crossref_primary_10_3390_ijms26136476 crossref_primary_10_1177_10815589231220573 crossref_primary_10_12688_f1000research_20498_1 crossref_primary_10_1536_ihj_24_601 crossref_primary_10_1016_j_autneu_2023_103116 crossref_primary_10_1097_CCM_0000000000005262 crossref_primary_10_3390_photonics10121334 crossref_primary_10_12688_f1000research_20498_2 crossref_primary_10_3389_fimmu_2023_1130214 crossref_primary_10_3390_microorganisms10020391 crossref_primary_10_3389_fimmu_2024_1386586 crossref_primary_10_1038_s41598_022_14231_9 crossref_primary_10_2217_fvl_2021_0189 crossref_primary_10_1016_j_biopha_2023_115493 crossref_primary_10_1186_s12882_024_03766_w crossref_primary_10_1186_s13613_022_01080_y crossref_primary_10_1186_s13017_025_00615_5 crossref_primary_10_3390_microorganisms11092165 crossref_primary_10_1007_s00134_020_06106_2 crossref_primary_10_1080_14787210_2020_1788387 crossref_primary_10_3390_biomedicines12051004 crossref_primary_10_1038_s41598_021_98165_8 crossref_primary_10_1016_j_biomaterials_2021_120845 crossref_primary_10_1080_21548331_2024_2359363 crossref_primary_10_1186_s40560_022_00633_4 crossref_primary_10_3389_fimmu_2023_1223014 crossref_primary_10_1007_s11845_020_02387_0 crossref_primary_10_1093_cid_ciac506 crossref_primary_10_1007_s11010_021_04170_w crossref_primary_10_1124_jpet_123_002095 crossref_primary_10_3390_metabo12050376 crossref_primary_10_4103_ejpi_EJPI_D_25_00033 crossref_primary_10_3389_fpubh_2022_852410 crossref_primary_10_1016_j_ajem_2025_04_060 crossref_primary_10_1515_nanoph_2019_0401 crossref_primary_10_1016_j_ebiom_2025_105678 crossref_primary_10_5492_wjccm_v11_i3_169 crossref_primary_10_1001_jama_2020_2241 crossref_primary_10_3390_jof8080832 crossref_primary_10_3389_fphys_2019_01071 crossref_primary_10_3390_antibiotics11010120 crossref_primary_10_1001_jama_2024_6096 crossref_primary_10_1016_j_jss_2021_07_014 crossref_primary_10_2147_JMDH_S533848 crossref_primary_10_3389_fcimb_2023_1256382 crossref_primary_10_1097_CCE_0000000000001200 crossref_primary_10_3390_membranes11040273 crossref_primary_10_3390_jpm11090910 crossref_primary_10_1097_HC9_0000000000000762 crossref_primary_10_1016_j_jcrc_2024_154844 crossref_primary_10_1186_s13613_021_00952_z crossref_primary_10_3389_fnut_2025_1566422 crossref_primary_10_1186_s13054_022_03948_8 crossref_primary_10_3390_antibiotics13090885 crossref_primary_10_3390_pathogens10030306 crossref_primary_10_1186_s12879_025_11474_5 crossref_primary_10_1016_j_jcrc_2022_154170 crossref_primary_10_1016_j_surge_2020_08_006 crossref_primary_10_1097_CCM_0000000000004023 crossref_primary_10_1007_s11064_025_04355_5 crossref_primary_10_3390_pathogens11121526 crossref_primary_10_1080_14656566_2024_2409950 crossref_primary_10_1093_jimmun_vkaf140 crossref_primary_10_1016_j_jcrc_2022_153985 crossref_primary_10_1186_s12890_023_02729_5 crossref_primary_10_1371_journal_pone_0275739 crossref_primary_10_31893_multirev_2025249 crossref_primary_10_2147_JIR_S521655 crossref_primary_10_1186_s12879_020_05330_x crossref_primary_10_1097_SHK_0000000000002571 crossref_primary_10_3390_biomedicines10020357 crossref_primary_10_1016_j_jclinepi_2021_11_006 crossref_primary_10_5492_wjccm_v9_i1_1 crossref_primary_10_1177_08850666251340631 crossref_primary_10_3390_antibiotics13010046 crossref_primary_10_1016_j_yexcr_2022_113405 crossref_primary_10_36469_jheor_2020_12637 crossref_primary_10_1007_s10404_024_02771_7 crossref_primary_10_1089_sur_2021_344 crossref_primary_10_2174_0929867331666230726095222 crossref_primary_10_3390_nu13093106 crossref_primary_10_3389_fmed_2021_741914 crossref_primary_10_4103_ija_ija_726_23 crossref_primary_10_1016_j_jcrc_2023_154427 crossref_primary_10_1007_s12273_023_1023_3 crossref_primary_10_1016_S0140_6736_19_32989_7 crossref_primary_10_3390_biomedicines12122892 crossref_primary_10_1038_s41598_025_10776_7 crossref_primary_10_1186_s12911_022_01970_y crossref_primary_10_3389_fimmu_2024_1447901 crossref_primary_10_1016_j_heliyon_2022_e09983 crossref_primary_10_1007_s13318_021_00709_w crossref_primary_10_1038_s41598_021_92874_w crossref_primary_10_1053_j_semnuclmed_2023_05_003 crossref_primary_10_1186_s12879_025_10937_z crossref_primary_10_1097_CCE_0000000000000388 crossref_primary_10_1055_s_0041_1741053 crossref_primary_10_3390_cells11244070 crossref_primary_10_1080_17512433_2021_1978287 crossref_primary_10_1186_s43168_022_00135_9 crossref_primary_10_1186_s13613_024_01377_0 crossref_primary_10_3389_fimmu_2025_1546474 crossref_primary_10_1038_s41598_025_10848_8 crossref_primary_10_1371_journal_pone_0322293 crossref_primary_10_14814_phy2_70033 crossref_primary_10_3390_pathogens13010089 crossref_primary_10_1186_s12967_022_03228_7 crossref_primary_10_1039_D5AY00937E crossref_primary_10_1080_21548331_2022_2133414 crossref_primary_10_1186_s13104_019_4635_z crossref_primary_10_7759_cureus_82816 crossref_primary_10_1038_s41598_025_98584_x crossref_primary_10_1007_s00063_021_00777_5 crossref_primary_10_18502_sjms_v20i1_15663 crossref_primary_10_1016_j_imu_2023_101236 crossref_primary_10_1007_s00404_019_05262_1 crossref_primary_10_3390_jcm11092482 crossref_primary_10_3389_fphar_2023_1132367 crossref_primary_10_3390_diagnostics13030440 crossref_primary_10_1088_1361_6579_adf0bf crossref_primary_10_3389_fcimb_2023_1330900 crossref_primary_10_1186_s12879_023_08745_4 crossref_primary_10_1080_24740527_2020_1732809 crossref_primary_10_1089_sur_2023_149 crossref_primary_10_1186_s40635_025_00786_0 crossref_primary_10_1016_j_intimp_2023_110662 crossref_primary_10_7759_cureus_75256 crossref_primary_10_1016_j_iccn_2023_103399 crossref_primary_10_1007_s12028_019_00835_z crossref_primary_10_1287_ijoc_2022_1176 crossref_primary_10_1080_23744235_2021_2017475 crossref_primary_10_1186_s13613_025_01543_y crossref_primary_10_1186_s12889_022_14725_1 crossref_primary_10_3390_ijms24076330 crossref_primary_10_5812_chbs_161333 crossref_primary_10_1016_j_bbih_2024_100823 crossref_primary_10_1007_s15010_023_01983_3 crossref_primary_10_1155_2021_2741271 crossref_primary_10_1177_17511437251326774 crossref_primary_10_3390_chemosensors12120264 crossref_primary_10_3390_s25113343 crossref_primary_10_3389_fcimb_2022_899508 crossref_primary_10_3390_app112311549 crossref_primary_10_1111_nicc_13006 crossref_primary_10_3390_jcm8091337 crossref_primary_10_1007_s00134_019_05672_4 crossref_primary_10_1016_j_heliyon_2024_e34538 crossref_primary_10_1016_j_iccn_2024_103930 crossref_primary_10_1177_17511437221136831 crossref_primary_10_1097_QAD_0000000000003086 crossref_primary_10_1038_s41467_023_39269_9 crossref_primary_10_1177_10815589221150641 crossref_primary_10_1016_j_rmed_2025_107994 crossref_primary_10_1371_journal_pone_0265240 crossref_primary_10_1186_s13054_022_04098_7 crossref_primary_10_3389_fpubh_2022_977094 crossref_primary_10_1098_rsta_2020_0252 crossref_primary_10_3390_ijms24065455 crossref_primary_10_3389_fphar_2025_1621959 crossref_primary_10_1177_10600280231164210 crossref_primary_10_1590_2175_8239_jbn_2025_0028pt crossref_primary_10_1080_03007995_2025_2466730 crossref_primary_10_1186_s12877_020_01893_1 crossref_primary_10_1038_s41598_021_85443_8 crossref_primary_10_1016_j_jep_2020_113301 crossref_primary_10_1186_s12879_021_05883_5 crossref_primary_10_1186_s44158_024_00139_5 crossref_primary_10_2298_MPNS2108265G crossref_primary_10_3390_diagnostics13142445 crossref_primary_10_1177_08850666241312621 crossref_primary_10_3390_biomedicines11071801 crossref_primary_10_3390_diagnostics13193091 crossref_primary_10_1136_bmjopen_2022_064870 crossref_primary_10_2147_IJGM_S380195 crossref_primary_10_1093_ajhp_zxac340 crossref_primary_10_5554_22562087_e996 crossref_primary_10_1213_XAA_0000000000002004 crossref_primary_10_1371_journal_pone_0305895 crossref_primary_10_1186_s13017_023_00496_6 crossref_primary_10_1099_mgen_0_001383 crossref_primary_10_1002_hsr2_1161 crossref_primary_10_1007_s13755_022_00199_3 crossref_primary_10_1080_14737175_2021_1981289 crossref_primary_10_1016_j_ijnurstu_2023_104529 crossref_primary_10_3389_fmicb_2024_1415274 crossref_primary_10_3390_diagnostics13142433 crossref_primary_10_1016_j_phymed_2024_155707 crossref_primary_10_1371_journal_pmed_1004202 crossref_primary_10_2147_IJGM_S354258 crossref_primary_10_1155_2020_8364247 |
| Cites_doi | 10.4331/wjbc.v8.i1.95 10.1016/S2214-109X(17)30007-4 10.1001/jama.2016.2691 10.1093/bja/aex234 10.1164/rccm.201504-0781OC 10.1001/jama.2009.1754 10.1016/S0140-6736(10)60446-1 10.1016/S2213-2600(14)70061-X 10.1016/j.jcrc.2016.04.035 10.1186/s13054-016-1276-7 10.1097/01.CCM.0000085141.75513.2B 10.1007/s00134-003-2136-x 10.1007/s00134-015-3906-y 10.1001/jama.2016.0287 10.1186/s12873-015-0049-y 10.1097/00003246-198510000-00009 10.1164/rccm.201510-1976ED 10.1097/01.CCM.0000168253.91200.83 10.1001/jama.1995.03530080055041 10.1007/s00134-016-4504-3 10.1097/CCM.0000000000000754 10.1186/cc4869 10.1086/500202 10.1164/rccm.201402-0289OC 10.1007/BF01709751 10.1097/CCM.0b013e318232db65 10.1001/jama.1993.03510240069035 10.1007/s00134-016-4529-7 10.1186/s13613-017-0241-1 10.1016/S0140-6736(12)61815-7 10.1371/journal.pone.0107181 10.1097/01.CCM.0000194725.48928.3A |
| ContentType | Journal Article |
| Copyright | The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. licence_http://creativecommons.org/publicdomain/zero The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2018 |
| Copyright_xml | – notice: The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: licence_http://creativecommons.org/publicdomain/zero – notice: The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2018 |
| CorporateAuthor | ICON Investigators |
| CorporateAuthor_xml | – name: ICON Investigators |
| DBID | AAYXX CITATION NPM 3V. 7X7 7XB 8C1 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 1XC 5PM |
| DOI | 10.1093/ofid/ofy313 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Public Health Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One ProQuest Central Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic Hyper Article en Ligne (HAL) PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Public Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2328-8957 |
| ExternalDocumentID | PMC6289022 oai:HAL:hal-02439048v1 30555852 10_1093_ofid_ofy313 |
| Genre | Journal Article |
| GroupedDBID | 0R~ 53G 5VS 7X7 8C1 8FI 8FJ AAFWJ AAMVS AAPXW AAVAP AAYXX ABDBF ABEJV ABGNP ABPTD ABUWG ABXVV ACGFS ACUHS ADBBV ADHZD ADPDF ADRAZ AENZO AFFHD AFKRA AFPKN ALMA_UNASSIGNED_HOLDINGS ALUQC AMNDL AOIJS BAWUL BAYMD BCNDV BENPR CCPQU CIDKT CITATION DIK EBS EJD FYUFA GROUPED_DOAJ H13 HMCUK HYE IAO KQ8 KSI M48 M~E O9- OAWHX OJQWA OK1 OVD OVEED PEELM PHGZM PHGZT PIMPY PJZUB PPXIY ROL RPM TEORI TJX TOX UKHRP AAPPN AFULF BTTYL IHR ITC NPM ROX 3V. 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQQKQ PQUKI PRINS 7X8 PUEGO 1XC 5PM |
| ID | FETCH-LOGICAL-c509t-e4d080e06b606a4e7c4ba66cf34eb25471cc29df6342934255c0293637735d943 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 339 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000457596300017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2328-8957 |
| IngestDate | Tue Nov 04 02:01:23 EST 2025 Tue Nov 25 06:21:20 EST 2025 Thu Sep 04 17:17:29 EDT 2025 Tue Oct 07 07:23:00 EDT 2025 Wed Feb 19 02:27:30 EST 2025 Tue Nov 18 21:17:12 EST 2025 Sat Nov 29 05:39:56 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Keywords | mortality septic shock critically ill international |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc-nd/4.0 licence_http://creativecommons.org/publicdomain/zero/: http://creativecommons.org/publicdomain/zero This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c509t-e4d080e06b606a4e7c4ba66cf34eb25471cc29df6342934255c0293637735d943 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC6289022 |
| ORCID | 0000-0002-3097-758X 0000-0001-6011-6951 |
| OpenAccessLink | https://www.proquest.com/docview/3170954800?pq-origsite=%requestingapplication% |
| PMID | 30555852 |
| PQID | 3170954800 |
| PQPubID | 7089189 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6289022 hal_primary_oai_HAL_hal_02439048v1 proquest_miscellaneous_2157653407 proquest_journals_3170954800 pubmed_primary_30555852 crossref_primary_10_1093_ofid_ofy313 crossref_citationtrail_10_1093_ofid_ofy313 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-12-01 |
| PublicationDateYYYYMMDD | 2018-12-01 |
| PublicationDate_xml | – month: 12 year: 2018 text: 2018-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Oxford – name: US |
| PublicationTitle | Open forum infectious diseases |
| PublicationTitleAlternate | Open Forum Infect Dis |
| PublicationYear | 2018 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| References | Falagas (2020081004290366500_CIT0031) 2006; 10 Yergens (2020081004290366500_CIT0035) 2015; 15 Knaus (2020081004290366500_CIT0012) 1985; 13 Brunelli (2020081004290366500_CIT0026) 2016; 35 van Vught (2020081004290366500_CIT0023) 2016; 315 Adhikari (2020081004290366500_CIT0007) 2010; 376 Zhou (2020081004290366500_CIT0021) 2014; 9 Vincent (2020081004290366500_CIT0013) 1996; 22 Vincent (2020081004290366500_CIT0002) 2009; 302 Fleischmann (2020081004290366500_CIT0008) 2016; 193 Brun-Buisson (2020081004290366500_CIT0019) 2004; 30 Padkin (2020081004290366500_CIT0020) 2003; 31 Singer (2020081004290366500_CIT0037) 2016; 315 Fournier (2020081004290366500_CIT0032) 2006; 42 Vincent (2020081004290366500_CIT0028) 1995; 274 Shankar-Hari (2020081004290366500_CIT0024) 2016; 20 Vincent (2020081004290366500_CIT0027) 2009; 302 Shankar-Hari (2020081004290366500_CIT0018) 2017; 119 Vincent (2020081004290366500_CIT0015) 2013; 381 Sakr (2020081004290366500_CIT0005) 2013; 79 Southeast Asia Infectious Disease Clinical Research Network (2020081004290366500_CIT0022) 2017; 5 SepNet Critical Care Trials Group (2020081004290366500_CIT0004) 2016; 42 Salgado Yepez (2020081004290366500_CIT0025) 2017; 8 Calandra (2020081004290366500_CIT0014) 2005; 33 Minderhoud (2020081004290366500_CIT0029) 2017; 75 Le Gall (2020081004290366500_CIT0011) 1993; 270 Martin-Loeches (2020081004290366500_CIT0017) 2016; 42 Vincent (2020081004290366500_CIT0001) 2006; 34 Lagu (2020081004290366500_CIT0003) 2012; 40 Sakr (2020081004290366500_CIT0033) 2015; 43 Vincent (2020081004290366500_CIT0010) 2014; 2 World Health Organization (2020081004290366500_CIT0036) Gaieski (2020081004290366500_CIT0034) 2014; 190 The World Bank (2020081004290366500_CIT0016) Rhodes (2020081004290366500_CIT0030) 2015; 41 Yébenes (2020081004290366500_CIT0006) 2017; 7 Finfer (2020081004290366500_CIT0009) 2016; 193 |
| References_xml | – volume: 8 start-page: 95 year: 2017 ident: 2020081004290366500_CIT0025 article-title: Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium’s findings publication-title: World J Biol Chem doi: 10.4331/wjbc.v8.i1.95 – volume: 5 start-page: e157 year: 2017 ident: 2020081004290366500_CIT0022 article-title: Causes and outcomes of sepsis in Southeast Asia: a multinational multicentre cross-sectional study publication-title: Lancet Glob Health doi: 10.1016/S2214-109X(17)30007-4 – volume: 315 start-page: 1469 year: 2016 ident: 2020081004290366500_CIT0023 article-title: Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis publication-title: JAMA doi: 10.1001/jama.2016.2691 – volume: 119 start-page: 626 year: 2017 ident: 2020081004290366500_CIT0018 article-title: Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database publication-title: Br J Anaesth doi: 10.1093/bja/aex234 – volume: 193 start-page: 259 year: 2016 ident: 2020081004290366500_CIT0008 article-title: Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201504-0781OC – volume: 302 start-page: 2323 year: 2009 ident: 2020081004290366500_CIT0027 article-title: International study of the prevalence and outcomes of infection in intensive care units publication-title: JAMA doi: 10.1001/jama.2009.1754 – volume: 376 start-page: 1339 year: 2010 ident: 2020081004290366500_CIT0007 article-title: Critical care and the global burden of critical illness in adults publication-title: Lancet doi: 10.1016/S0140-6736(10)60446-1 – volume: 2 start-page: 380 year: 2014 ident: 2020081004290366500_CIT0010 article-title: Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(14)70061-X – volume: 35 start-page: 69 year: 2016 ident: 2020081004290366500_CIT0026 article-title: Clinical and economic burden of bloodstream infections in critical care patients with central venous catheters publication-title: J Crit Care doi: 10.1016/j.jcrc.2016.04.035 – volume: 20 start-page: 101 year: 2016 ident: 2020081004290366500_CIT0024 article-title: Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies publication-title: Crit Care doi: 10.1186/s13054-016-1276-7 – volume: 31 start-page: 2332 year: 2003 ident: 2020081004290366500_CIT0020 article-title: Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland publication-title: Crit Care Med doi: 10.1097/01.CCM.0000085141.75513.2B – volume: 30 start-page: 580 year: 2004 ident: 2020081004290366500_CIT0019 article-title: EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units publication-title: Intensive Care Med doi: 10.1007/s00134-003-2136-x – volume: 41 start-page: 1620 year: 2015 ident: 2020081004290366500_CIT0030 article-title: The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study) publication-title: Intensive Care Med doi: 10.1007/s00134-015-3906-y – volume: 315 start-page: 801 year: 2016 ident: 2020081004290366500_CIT0037 article-title: The Third International Consensus Definitions for sepsis and septic shock (Sepsis-3) publication-title: JAMA doi: 10.1001/jama.2016.0287 – volume: 302 start-page: 2323 year: 2009 ident: 2020081004290366500_CIT0002 article-title: International study of the prevalence and outcomes of infection in intensive care units publication-title: JAMA doi: 10.1001/jama.2009.1754 – volume: 15 start-page: 31 year: 2015 ident: 2020081004290366500_CIT0035 article-title: Assessing the association between occupancy and outcome in critically Ill hospitalized patients with sepsis publication-title: BMC Emerg Med doi: 10.1186/s12873-015-0049-y – volume: 13 start-page: 818 year: 1985 ident: 2020081004290366500_CIT0012 article-title: APACHE II: a severity of disease classification system publication-title: Crit Care Med doi: 10.1097/00003246-198510000-00009 – volume: 193 start-page: 228 year: 2016 ident: 2020081004290366500_CIT0009 article-title: The global epidemiology of sepsis. Does it matter that we know so little publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201510-1976ED – volume: 33 start-page: 1538 year: 2005 ident: 2020081004290366500_CIT0014 article-title: The International Sepsis Forum consensus conference on definitions of infection in the intensive care unit publication-title: Crit Care Med doi: 10.1097/01.CCM.0000168253.91200.83 – volume: 274 start-page: 639 year: 1995 ident: 2020081004290366500_CIT0028 article-title: The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee publication-title: JAMA doi: 10.1001/jama.1995.03530080055041 – volume: 42 start-page: 1980 year: 2016 ident: 2020081004290366500_CIT0004 article-title: Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study publication-title: Intensive Care Med doi: 10.1007/s00134-016-4504-3 – ident: 2020081004290366500_CIT0036 – volume: 43 start-page: 519 year: 2015 ident: 2020081004290366500_CIT0033 article-title: The impact of hospital and ICU organizational factors on outcome in critically ill patients: results from the Extended Prevalence of Infection in Intensive Care study publication-title: Crit Care Med doi: 10.1097/CCM.0000000000000754 – volume: 10 start-page: R48 year: 2006 ident: 2020081004290366500_CIT0031 article-title: Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case-control studies publication-title: Crit Care doi: 10.1186/cc4869 – volume: 42 start-page: 692 year: 2006 ident: 2020081004290366500_CIT0032 article-title: The epidemiology and control of Acinetobacter baumannii in health care facilities publication-title: Clin Infect Dis doi: 10.1086/500202 – volume: 190 start-page: 665 year: 2014 ident: 2020081004290366500_CIT0034 article-title: The relationship between hospital volume and mortality in severe sepsis publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201402-0289OC – volume: 22 start-page: 707 year: 1996 ident: 2020081004290366500_CIT0013 article-title: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine publication-title: Intensive Care Med doi: 10.1007/BF01709751 – volume: 40 start-page: 754 year: 2012 ident: 2020081004290366500_CIT0003 article-title: Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e318232db65 – volume: 270 start-page: 2957 year: 1993 ident: 2020081004290366500_CIT0011 article-title: A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study publication-title: JAMA doi: 10.1001/jama.1993.03510240069035 – volume: 42 start-page: 1835 year: 2016 ident: 2020081004290366500_CIT0017 article-title: Collinearity and multivariable analysis: response to comments by Claret et al publication-title: Intensive Care Med doi: 10.1007/s00134-016-4529-7 – volume: 7 start-page: 19 year: 2017 ident: 2020081004290366500_CIT0006 article-title: Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting publication-title: Ann Intensive Care doi: 10.1186/s13613-017-0241-1 – volume: 381 start-page: 774 year: 2013 ident: 2020081004290366500_CIT0015 article-title: Sepsis definitions: time for change publication-title: Lancet doi: 10.1016/S0140-6736(12)61815-7 – ident: 2020081004290366500_CIT0016 – volume: 79 start-page: 993 year: 2013 ident: 2020081004290366500_CIT0005 article-title: Epidemiology and outcome of sepsis syndromes in Italian ICUs: a muticentre, observational cohort study in the region of Piedmont publication-title: Minerva Anestesiol – volume: 75 start-page: 196 year: 2017 ident: 2020081004290366500_CIT0029 article-title: Microbiological outcomes and antibiotic overuse in emergency department patients with suspected sepsis publication-title: Neth J Med – volume: 9 start-page: e107181 year: 2014 ident: 2020081004290366500_CIT0021 article-title: Epidemiology and outcome of severe sepsis and septic shock in intensive care units in mainland China publication-title: PLoS One doi: 10.1371/journal.pone.0107181 – volume: 34 start-page: 344 year: 2006 ident: 2020081004290366500_CIT0001 article-title: Sepsis in European intensive care units: results of the SOAP study publication-title: Crit Care Med doi: 10.1097/01.CCM.0000194725.48928.3A |
| SSID | ssj0001105079 |
| Score | 2.5822768 |
| Snippet | There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe.
The Intensive Care over Nations (ICON) audit... Background There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe. Methods The Intensive Care over Nations... There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around the globe.BACKGROUNDThere is a need to better define the... |
| SourceID | pubmedcentral hal proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | ofy313 |
| SubjectTerms | Bacteriology Cardiology and cardiovascular system Emerging diseases Human health and pathology Infectious diseases Intensive care Life Sciences Major Microbiology and Parasitology Mortality Parasitology Sepsis Virology |
| Title | Sepsis in Intensive Care Unit Patients: Worldwide Data From the Intensive Care over Nations Audit |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30555852 https://www.proquest.com/docview/3170954800 https://www.proquest.com/docview/2157653407 https://amu.hal.science/hal-02439048 https://pubmed.ncbi.nlm.nih.gov/PMC6289022 |
| Volume | 5 |
| WOSCitedRecordID | wos000457596300017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2328-8957 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001105079 issn: 2328-8957 databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2328-8957 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001105079 issn: 2328-8957 databaseCode: M~E dateStart: 20140101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVASL databaseName: Oxford University Press Journals Open Access customDbUrl: eissn: 2328-8957 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001105079 issn: 2328-8957 databaseCode: TOX dateStart: 20140101 isFulltext: true titleUrlDefault: https://academic.oup.com/journals/ providerName: Oxford University Press – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2328-8957 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0001105079 issn: 2328-8957 databaseCode: 7X7 dateStart: 20140401 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2328-8957 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0001105079 issn: 2328-8957 databaseCode: BENPR dateStart: 20140401 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 2328-8957 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0001105079 issn: 2328-8957 databaseCode: 8C1 dateStart: 20140401 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2328-8957 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0001105079 issn: 2328-8957 databaseCode: PIMPY dateStart: 20140401 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NT9swFH9aC5p2GYONkY1VHuI0KSKp4zjhMhVGBRJ0EV8qp8i1XREJ0tIUpv33PMduWdnEZYdYceIolp7t93sf_hlgW7KhkFyHaORI5keRCnwheOAzIZVKtOK0Zvu8POa9XtLvp5lzuFUurXK2JtYLtRpJ4yPfQT0X1ORkwffxnW9OjTLRVXeERgOWDFNZ1ISlvYNedvrkZUH4EPDUbcxD630HRaaw-E1DuqCKGtcmEfJvlPk8WfIP7dNd-d9-v4O3DneSjh0oq_BKl2vw-sRF1t-DONPjqqhIUZJ5Vjsxm5OIQaUks_Sr1S6ps29-FUqTH2IqSHcyuiUIIp9_ZTJDiSXdrkjHbP34ABfdg_P9Q98dv-BLRBFTX6PgkkAH8QCNHBFpLqOBiGM5pBGa4wy1mpTtVA1jijoNL8ZkgDcx5ZwylUZ0HZrlqNQbQJKYR1Kksj2Q2uydTdJQIC7RCC-00in34NtMErl03OTmiIyb3MbIaW7ElluxeTjCZo3HlpLj3822UKTzFoZG-7BznJtnhoUxxaXrIfRgcya13E3eKn8SmQdf569x2plYiij16L7KESnxmFE0hz34aAfI_FeWRI21PeALQ2ehL4tvyuK6pvaO67hv-9PL3foMbxC3JTarZhOa08m9_gLL8mFaVJMWNHif12WCZbIfttysaNUOB6xlRyfZFdbOf_YfAXrrGhQ |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1db9MwFL3aOgS88M0IDDAIXpCiuXESx0gIVYyq1dqqEgONJ-ParhZppKXpNu1P8Ru5jpOODsTbHnhoVNVu6jTH18fxuccAr3QyVZrbNk5ydBLGsaGhUpyGidLGZNZwVrl9fhnw0Sg7PBTjDfjZ5MI4WWUTE6tAbWbaPSPfxXGOVuZk9P38R-h2jXKrq80WGh4W-_b8DKds5bv-Ht7f11HU_XjwoRfWuwqEGgfHZWixPRm1NJ0gd1ex5TqeqDTVUxbjLDPBYK11JMw0ZRiq8ZUkmuKblHHOEiNihufdhK0YS7IWbI37w_HXi6c6SFcoF3UiIBVsFyFi8HDO2mxt6Ns8csLLP1ntZXHmb6Nd9_b_9j_dgVs1ryYd3xHuwoYt7sH1Ya0cuA_qk52XeUnygqxU-8QlXxHHusnY28uWb0mlLjrLjSV7aqlIdzH7TpAkX_6WU74Sbypeko5LbXkAn6_kAh9Cq5gV9hGQLOWxVkJHE21dbnAm2gp5l0X6ZI0VPIA3zZ2XuvZed1uAHEuvAWDSwUR6mATYg5rKc2858vdqLxFCqxrOJrzXGUj3mXOZFBiaT9sB7DQokXVwKuUFRAJ4sSrGsOLWilRhZyelRCbI04ThdD-AbQ_I1U95k7gkCoCvQXWtLeslRX5UWZen1bp29PjfzXoON3oHw4Ec9Ef7T-AmctTMK4h2oLVcnNincE2fLvNy8azufwS-XTWUfwHw4229 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sepsis+in+Intensive+Care+Unit+Patients%3A+Worldwide+Data+From+the+Intensive+Care+over+Nations+Audit&rft.jtitle=Open+forum+infectious+diseases&rft.au=Sakr%2C+Yasser&rft.au=Jaschinski%2C+Ulrich&rft.au=Wittebole%2C+Xavier&rft.au=Szakmany%2C+Tamas&rft.date=2018-12-01&rft.issn=2328-8957&rft.eissn=2328-8957&rft.volume=5&rft.issue=12&rft_id=info:doi/10.1093%2Fofid%2Fofy313&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_ofid_ofy313 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2328-8957&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2328-8957&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2328-8957&client=summon |