Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage

In recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative application of adipose tissue has only recently proven its usefulness; for example, the method is useful in reducing dermal scarring and acc...

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Bibliographic Details
Published in:Bioengineering (Basel) Vol. 10; no. 3; p. 328
Main Authors: Vriend, Linda, van der Lei, Berend, Harmsen, Martin, van Dongen, Joris
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 05.03.2023
MDPI
Subjects:
Adipocytes
Adipose tissue
Angiogenesis
ASC secretome
ASCs
Bioengineering
Body fat
Collagen
Deposition
dermal damage
Diabetes
ECM
Extracellular matrix
Fibroblasts
Granulocytes
Growth factors
Hydrogels
Hyperglycemia
Immunomodulation
Inflammation
Liposuction
Patients
Prevention
Reconstructive surgery
Regeneration
Review
Secretome
Skin
Stromal cells
SVF
Transplantation
Trophic factors
Wound healing
acellular hydrogels
SVF
wound healing
ASC secretome
Extracellular matrix
hydrogels
native hydrogels
ASCs
dermal damage
ECM
ISSN:2306-5354, 2306-5354
Online Access:Get full text
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Summary:In recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative application of adipose tissue has only recently proven its usefulness; for example, the method is useful in reducing dermal scarring and accelerating skin-wound healing. The therapeutic effect is ascribed to the tissue stromal vascular fraction (tSVF) in adipose tissue. This consists of stromal cells, the trophic factors they secrete and the extracellular matrix (ECM), which have immune-modulating, pro-angiogenic and anti-fibrotic properties. This concise review focused on dermal regeneration using the following adipose-tissue components: adipose-tissue-derived stromal cells (ASCs), their secreted trophic factors (ASCs secretome), and the ECM. The opportunities of using a therapeutically functional scaffold, composed of a decellularized ECM hydrogel loaded with trophic factors of ASCs, to enhance wound healing are explored as well. An ECM-based hydrogel loaded with trophic factors combines all regenerative components of adipose tissue, while averting the possible disadvantages of the therapeutic use of adipose tissue, e.g., the necessity of liposuction procedures with a (small) risk of complications, the impossibility of interpatient use, and the limited storage options.
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ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering10030328