Worldwide phylogenetic relationship of avian poxviruses

Poxvirus infections have been found in 230 species of wild and domestic birds worldwide in both terrestrial and marine environments. This ubiquity raises the question of how infection has been transmitted and globally dispersed. We present a comprehensive global phylogeny of 111 novel poxvirus isola...

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Vydáno v:Journal of virology Ročník 87; číslo 9; s. 4938
Hlavní autoři: Gyuranecz, Miklós, Foster, Jeffrey T, Dán, Ádám, Ip, Hon S, Egstad, Kristina F, Parker, Patricia G, Higashiguchi, Jenni M, Skinner, Michael A, Höfle, Ursula, Kreizinger, Zsuzsa, Dorrestein, Gerry M, Solt, Szabolcs, Sós, Endre, Kim, Young Jun, Uhart, Marcela, Pereda, Ariel, González-Hein, Gisela, Hidalgo, Hector, Blanco, Juan-Manuel, Erdélyi, Károly
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.05.2013
Témata:
Animals
Avipoxvirus - classification
Avipoxvirus - genetics
Avipoxvirus - isolation & purification
Avipoxvirus - physiology
Bird Diseases - virology
Birds
Host Specificity
Molecular Sequence Data
Phylogeny
Poxviridae Infections - veterinary
Poxviridae Infections - virology
Recombination, Genetic
ISSN:1098-5514, 1098-5514
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Shrnutí:Poxvirus infections have been found in 230 species of wild and domestic birds worldwide in both terrestrial and marine environments. This ubiquity raises the question of how infection has been transmitted and globally dispersed. We present a comprehensive global phylogeny of 111 novel poxvirus isolates in addition to all available sequences from GenBank. Phylogenetic analysis of the Avipoxvirus genus has traditionally relied on one gene region (4b core protein). In this study we expanded the analyses to include a second locus (DNA polymerase gene), allowing for a more robust phylogenetic framework, finer genetic resolution within specific groups, and the detection of potential recombination. Our phylogenetic results reveal several major features of avipoxvirus evolution and ecology and propose an updated avipoxvirus taxonomy, including three novel subclades. The characterization of poxviruses from 57 species of birds in this study extends the current knowledge of their host range and provides the first evidence of the phylogenetic effect of genetic recombination of avipoxviruses. The repeated occurrence of avian family or order-specific grouping within certain clades (e.g., starling poxvirus, falcon poxvirus, raptor poxvirus, etc.) indicates a marked role of host adaptation, while the sharing of poxvirus species within prey-predator systems emphasizes the capacity for cross-species infection and limited host adaptation. Our study provides a broad and comprehensive phylogenetic analysis of the Avipoxvirus genus, an ecologically and environmentally important viral group, to formulate a genome sequencing strategy that will clarify avipoxvirus taxonomy.
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ISSN:1098-5514
1098-5514
DOI:10.1128/JVI.03183-12