Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

Background Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the DNA damage response pathway. The aim of this s...

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Veröffentlicht in:	Breast cancer research : BCR Jg. 18; H. 1; S. 52
Hauptverfasser:	Baert, Annelot, Depuydt, Julie, Van Maerken, Tom, Poppe, Bruce, Malfait, Fransiska, Storm, Katrien, van den Ende, Jenneke, Van Damme, Tim, De Nobele, Sylvia, Perletti, Gianpaolo, De Leeneer, Kim, Claes, Kathleen B. M., Vral, Anne
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 17.05.2016 BioMed Central Ltd
Schlagworte:	Alleles Analysis Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cell Cycle - genetics Cell Cycle - radiation effects Chromosomal Instability Chromosomes, Human - radiation effects Complications and side effects DNA damage Gene mutations Genes, BRCA1 Genetic aspects Heterozygote Humans Micronuclei, Chromosome-Defective - radiation effects Micronucleus Tests Mutation Oncology Radiation Tolerance - genetics Research Article Surgical Oncology M cell-cycle checkpoint DNA damage repair Nonsense-mediated decay Ionizing radiation micronucleus assay mutations Homologous recombination G Radiosensitivity indicator Haploinsufficiency BRCA1 mutations G2 micronucleus assay G2/M cell-cycle checkpoint
ISSN:	1465-542X, 1465-5411, 1465-542X
Online-Zugang:	Volltext
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