Evaluation of K18- hACE2 Mice as a Model of SARS-CoV-2 Infection

Murine models of SARS-CoV-2 infection are critical for elucidating the biological pathways underlying COVID-19. Because human angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV-2, mice expressing the human gene have shown promise as a potential model for COVID-19. Five mice from the...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene Jg. 103; H. 3; S. 1215
Hauptverfasser:	Moreau, Gregory Brett, Burgess, Stacey L, Sturek, Jeffrey M, Donlan, Alexandra N, Petri, William A, Mann, Barbara J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2020
Schlagworte:	Angiotensin-Converting Enzyme 2 Animals Betacoronavirus Coronavirus Infections - etiology COVID-19 Disease Models, Animal Humans Keratin-18 - genetics Male Mice Mice, Transgenic Pandemics Peptidyl-Dipeptidase A - genetics Pneumonia, Viral - etiology SARS-CoV-2
ISSN:	1476-1645, 1476-1645
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