Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii

The obligate intracellular and promiscuous protozoan parasite Toxoplasma gondii needs an extensive membrane biogenesis that must be satisfied irrespective of its host-cell milieu. We show that the synthesis of the major lipid in T. gondii, phosphatidylcholine (PtdCho), is initiated by a novel cholin...

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Veröffentlicht in:	The Journal of biological chemistry Jg. 287; H. 20; S. 16289
Hauptverfasser:	Sampels, Vera, Hartmann, Anne, Dietrich, Isabelle, Coppens, Isabelle, Sheiner, Lilach, Striepen, Boris, Herrmann, Andreas, Lucius, Richard, Gupta, Nishith
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.05.2012
Schlagworte:	Base Sequence Choline Kinase - biosynthesis Choline Kinase - genetics Deanol - metabolism Gene Expression Regulation, Enzymologic - physiology Molecular Sequence Data Mutagenesis Mutation Phosphatidylcholines - biosynthesis Phosphatidylcholines - genetics Protein Multimerization - physiology Protozoan Proteins - biosynthesis Protozoan Proteins - genetics Toxoplasma - enzymology Toxoplasma - genetics
ISSN:	1083-351X, 1083-351X
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