Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii

The obligate intracellular and promiscuous protozoan parasite Toxoplasma gondii needs an extensive membrane biogenesis that must be satisfied irrespective of its host-cell milieu. We show that the synthesis of the major lipid in T. gondii, phosphatidylcholine (PtdCho), is initiated by a novel cholin...

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Vydáno v:	The Journal of biological chemistry Ročník 287; číslo 20; s. 16289
Hlavní autoři:	Sampels, Vera, Hartmann, Anne, Dietrich, Isabelle, Coppens, Isabelle, Sheiner, Lilach, Striepen, Boris, Herrmann, Andreas, Lucius, Richard, Gupta, Nishith
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 11.05.2012
Témata:	Base Sequence Choline Kinase - biosynthesis Choline Kinase - genetics Deanol - metabolism Gene Expression Regulation, Enzymologic - physiology Molecular Sequence Data Mutagenesis Mutation Phosphatidylcholines - biosynthesis Phosphatidylcholines - genetics Protein Multimerization - physiology Protozoan Proteins - biosynthesis Protozoan Proteins - genetics Toxoplasma - enzymology Toxoplasma - genetics
ISSN:	1083-351X, 1083-351X
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