Genome-wide DNA methylation of lesional and peri-lesional skin in vitiligo: a comparative and integrated analysis of multi-omics in Chinese population
Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains unknown. Here, we aimed to study the DNA methylation profile of vitiligo using pairwise comparisons of lesions, peri-lesions, and healthy skin. We investig...
Saved in:
| Published in: | Human genetics Vol. 143; no. 2; pp. 137 - 149 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.02.2024
Springer Springer Nature B.V |
| Subjects: | |
| ISSN: | 0340-6717, 1432-1203, 1432-1203 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains unknown. Here, we aimed to study the DNA methylation profile of vitiligo using pairwise comparisons of lesions, peri-lesions, and healthy skin. We investigated DNA methylation levels in six lesional skin, six peri-lesional skin, and eight healthy skin samples using an Illumina 850 K methylation chip. We then integrated DNA methylation data with transcriptome data to identify differentially methylated and expressed genes (DMEGs) and analyzed their functional enrichment. Subsequently, we compared the methylation and transcriptome characteristics of all skin samples, and the related genes were further studied using scRNA-seq data. Finally, validation was performed using an external dataset. We observed more DNA hypomethylated sites in patients with vitiligo. Further integrated analysis identified 264 DMEGs that were mainly functionally enriched in cell division, pigmentation, circadian rhythm, fatty acid metabolism, peroxidase activity, synapse regulation, and extracellular matrix. In addition, in the peri-lesional skin, we found that methylation levels of 102 DMEGs differed prior to changes in their transcription levels and identified 16 key pre-DMEGs (
ANLN, CDCA3, CENPA, DEPDC1, ECT2, DEPDC1B
,
HMMR, KIF18A, KIF18B, TTK, KIF23, DCT, EDNRB, MITF, OCA2,
and
TYRP1)
. Single-cell RNA analysis showed that these genes were associated with cycling keratinocytes and melanocytes. Further analysis of cellular communication indicated the involvement of the extracellular matrix. The expression of related genes was verified using an external dataset. To the best of our knowledge, this is the first study to report a comprehensive DNA methylation profile of clinical vitiligo and peri-lesional skin. These findings would contribute to future research on the pathogenesis of vitiligo and potential therapeutic strategies. |
|---|---|
| AbstractList | Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains unknown. Here, we aimed to study the DNA methylation profile of vitiligo using pairwise comparisons of lesions, peri-lesions, and healthy skin. We investigated DNA methylation levels in six lesional skin, six peri-lesional skin, and eight healthy skin samples using an Illumina 850 K methylation chip. We then integrated DNA methylation data with transcriptome data to identify differentially methylated and expressed genes (DMEGs) and analyzed their functional enrichment. Subsequently, we compared the methylation and transcriptome characteristics of all skin samples, and the related genes were further studied using scRNA-seq data. Finally, validation was performed using an external dataset. We observed more DNA hypomethylated sites in patients with vitiligo. Further integrated analysis identified 264 DMEGs that were mainly functionally enriched in cell division, pigmentation, circadian rhythm, fatty acid metabolism, peroxidase activity, synapse regulation, and extracellular matrix. In addition, in the peri-lesional skin, we found that methylation levels of 102 DMEGs differed prior to changes in their transcription levels and identified 16 key pre-DMEGs (
ANLN, CDCA3, CENPA, DEPDC1, ECT2, DEPDC1B
,
HMMR, KIF18A, KIF18B, TTK, KIF23, DCT, EDNRB, MITF, OCA2,
and
TYRP1)
. Single-cell RNA analysis showed that these genes were associated with cycling keratinocytes and melanocytes. Further analysis of cellular communication indicated the involvement of the extracellular matrix. The expression of related genes was verified using an external dataset. To the best of our knowledge, this is the first study to report a comprehensive DNA methylation profile of clinical vitiligo and peri-lesional skin. These findings would contribute to future research on the pathogenesis of vitiligo and potential therapeutic strategies. Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains unknown. Here, we aimed to study the DNA methylation profile of vitiligo using pairwise comparisons of lesions, peri-lesions, and healthy skin. We investigated DNA methylation levels in six lesional skin, six peri-lesional skin, and eight healthy skin samples using an Illumina 850 K methylation chip. We then integrated DNA methylation data with transcriptome data to identify differentially methylated and expressed genes (DMEGs) and analyzed their functional enrichment. Subsequently, we compared the methylation and transcriptome characteristics of all skin samples, and the related genes were further studied using scRNA-seq data. Finally, validation was performed using an external dataset. We observed more DNA hypomethylated sites in patients with vitiligo. Further integrated analysis identified 264 DMEGs that were mainly functionally enriched in cell division, pigmentation, circadian rhythm, fatty acid metabolism, peroxidase activity, synapse regulation, and extracellular matrix. In addition, in the peri-lesional skin, we found that methylation levels of 102 DMEGs differed prior to changes in their transcription levels and identified 16 key pre-DMEGs (ANLN, CDCA3, CENPA, DEPDC1, ECT2, DEPDC1B, HMMR, KIF18A, KIF18B, TTK, KIF23, DCT, EDNRB, MITF, OCA2, and TYRP1). Single-cell RNA analysis showed that these genes were associated with cycling keratinocytes and melanocytes. Further analysis of cellular communication indicated the involvement of the extracellular matrix. The expression of related genes was verified using an external dataset. To the best of our knowledge, this is the first study to report a comprehensive DNA methylation profile of clinical vitiligo and peri-lesional skin. These findings would contribute to future research on the pathogenesis of vitiligo and potential therapeutic strategies. Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains unknown. Here, we aimed to study the DNA methylation profile of vitiligo using pairwise comparisons of lesions, peri-lesions, and healthy skin. We investigated DNA methylation levels in six lesional skin, six peri-lesional skin, and eight healthy skin samples using an Illumina 850 K methylation chip. We then integrated DNA methylation data with transcriptome data to identify differentially methylated and expressed genes (DMEGs) and analyzed their functional enrichment. Subsequently, we compared the methylation and transcriptome characteristics of all skin samples, and the related genes were further studied using scRNA-seq data. Finally, validation was performed using an external dataset. We observed more DNA hypomethylated sites in patients with vitiligo. Further integrated analysis identified 264 DMEGs that were mainly functionally enriched in cell division, pigmentation, circadian rhythm, fatty acid metabolism, peroxidase activity, synapse regulation, and extracellular matrix. In addition, in the peri-lesional skin, we found that methylation levels of 102 DMEGs differed prior to changes in their transcription levels and identified 16 key pre-DMEGs (ANLN, CDCA3, CENPA, DEPDC1, ECT2, DEPDC1B, HMMR, KIF18A, KIF18B, TTK, KIF23, DCT, EDNRB, MITF, OCA2, and TYRP1). Single-cell RNA analysis showed that these genes were associated with cycling keratinocytes and melanocytes. Further analysis of cellular communication indicated the involvement of the extracellular matrix. The expression of related genes was verified using an external dataset. To the best of our knowledge, this is the first study to report a comprehensive DNA methylation profile of clinical vitiligo and peri-lesional skin. These findings would contribute to future research on the pathogenesis of vitiligo and potential therapeutic strategies.Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains unknown. Here, we aimed to study the DNA methylation profile of vitiligo using pairwise comparisons of lesions, peri-lesions, and healthy skin. We investigated DNA methylation levels in six lesional skin, six peri-lesional skin, and eight healthy skin samples using an Illumina 850 K methylation chip. We then integrated DNA methylation data with transcriptome data to identify differentially methylated and expressed genes (DMEGs) and analyzed their functional enrichment. Subsequently, we compared the methylation and transcriptome characteristics of all skin samples, and the related genes were further studied using scRNA-seq data. Finally, validation was performed using an external dataset. We observed more DNA hypomethylated sites in patients with vitiligo. Further integrated analysis identified 264 DMEGs that were mainly functionally enriched in cell division, pigmentation, circadian rhythm, fatty acid metabolism, peroxidase activity, synapse regulation, and extracellular matrix. In addition, in the peri-lesional skin, we found that methylation levels of 102 DMEGs differed prior to changes in their transcription levels and identified 16 key pre-DMEGs (ANLN, CDCA3, CENPA, DEPDC1, ECT2, DEPDC1B, HMMR, KIF18A, KIF18B, TTK, KIF23, DCT, EDNRB, MITF, OCA2, and TYRP1). Single-cell RNA analysis showed that these genes were associated with cycling keratinocytes and melanocytes. Further analysis of cellular communication indicated the involvement of the extracellular matrix. The expression of related genes was verified using an external dataset. To the best of our knowledge, this is the first study to report a comprehensive DNA methylation profile of clinical vitiligo and peri-lesional skin. These findings would contribute to future research on the pathogenesis of vitiligo and potential therapeutic strategies. Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains unknown. Here, we aimed to study the DNA methylation profile of vitiligo using pairwise comparisons of lesions, peri-lesions, and healthy skin. We investigated DNA methylation levels in six lesional skin, six peri-lesional skin, and eight healthy skin samples using an Illumina 850 K methylation chip. We then integrated DNA methylation data with transcriptome data to identify differentially methylated and expressed genes (DMEGs) and analyzed their functional enrichment. Subsequently, we compared the methylation and transcriptome characteristics of all skin samples, and the related genes were further studied using scRNA-seq data. Finally, validation was performed using an external dataset. We observed more DNA hypomethylated sites in patients with vitiligo. Further integrated analysis identified 264 DMEGs that were mainly functionally enriched in cell division, pigmentation, circadian rhythm, fatty acid metabolism, peroxidase activity, synapse regulation, and extracellular matrix. In addition, in the peri-lesional skin, we found that methylation levels of 102 DMEGs differed prior to changes in their transcription levels and identified 16 key pre-DMEGs (ANLN, CDCA3, CENPA, DEPDC1, ECT2, DEPDC1B, HMMR, KIF18A, KIF18B, TTK, KIF23, DCT, EDNRB, MITF, OCA2, and TYRP1). Single-cell RNA analysis showed that these genes were associated with cycling keratinocytes and melanocytes. Further analysis of cellular communication indicated the involvement of the extracellular matrix. The expression of related genes was verified using an external dataset. To the best of our knowledge, this is the first study to report a comprehensive DNA methylation profile of clinical vitiligo and peri-lesional skin. These findings would contribute to future research on the pathogenesis of vitiligo and potential therapeutic strategies. |
| Audience | Academic |
| Author | Pan, Xingyu Huang, Yujing Chen, Tingqiao Zhong, Judan Chen, Jin Shao, Xinyi Li, Yuxin Chen, Yangmei Xue, Yuzhou Pu, Yihuan Liu, Lin |
| Author_xml | – sequence: 1 givenname: Lin surname: Liu fullname: Liu, Lin organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University – sequence: 2 givenname: Yuzhou surname: Xue fullname: Xue, Yuzhou organization: Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital – sequence: 3 givenname: Yuxin surname: Li fullname: Li, Yuxin organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University – sequence: 4 givenname: Yangmei surname: Chen fullname: Chen, Yangmei organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University – sequence: 5 givenname: Xingyu surname: Pan fullname: Pan, Xingyu organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University – sequence: 6 givenname: Yujing surname: Huang fullname: Huang, Yujing organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University – sequence: 7 givenname: Tingqiao surname: Chen fullname: Chen, Tingqiao organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University – sequence: 8 givenname: Judan surname: Zhong fullname: Zhong, Judan organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University – sequence: 9 givenname: Xinyi surname: Shao fullname: Shao, Xinyi organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University – sequence: 10 givenname: Yihuan surname: Pu fullname: Pu, Yihuan email: 18282211122@qq.com organization: Department of Dermatology, Chongqing People’s Hospital, Chongqing Academy of Medical Sciences – sequence: 11 givenname: Jin surname: Chen fullname: Chen, Jin email: chenjin19771010@163.com organization: Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38182908$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkstu1DAUhi1URKcDL8ACRWJDFyl2HDsxu9FQSqUKJC5ry3FOpi6OncZOYV6E58UzU1pNhYovsn30_ce3_wgdOO8AoZcEnxCMq7cB45KKHBc0dU5xzp6gGSlpkZMC0wM0w7TEOa9IdYiOQrjCmDBRsGfokNakLgSuZ-j3GTjfQ_7TtJC9_7TIeoiXa6ui8S7zXWYhpJmymXJtNsBo8rtI-GFcltqNicaalX-XqUz7flBjUt_AVmFchFVaQ5uWyq6DCZus_WSjyX1vdNhkWF4aBwGywQ_Tbuvn6GmnbIAXt-Mcff9w-m35Mb_4fHa-XFzkmmERc6a5Fo2guATV1A1tOoypToVyrlhBdaVFhUWlU7hsaaMaVVOhq7JqacuB0Dl6s8s7jP56ghBlb4IGa5UDPwVJCaOcMFaL_6KFKGohOE8fMEevH6BXfhrT_bdUqoSX5J5aKQvSuM7HUelNUrmoasqIwIwn6uQfVKotpOdLhuhMiu8JjvcEiYnwK67UFII8__pln311e9Cp6aGVw2h6Na7lX38koNgBevQhjNDdIQTLjQnlzoQymVBuTShZEtUPRNrE7bemoxv7uJTupCHt41Yw3r_cI6o_okru1Q |
| CitedBy_id | crossref_primary_10_1016_j_coi_2025_102580 crossref_primary_10_1007_s12016_025_09048_z |
| Cites_doi | 10.1016/j.jpba.2022.114643 10.1016/j.tcb.2010.08.002 10.1034/j.1600-0749.2002.02052.x 10.1016/j.jid.2017.11.036 10.3389/fimmu.2021.587440 10.1111/jdv.18257 10.1126/scitranslmed.abd8995 10.1007/s00403-023-02628-z 10.1101/gr.100289.109 10.1038/jid.2011.348 10.1159/000506103 10.1016/j.jid.2019.05.011 10.1155/2022/8498472 10.1111/j.1365-2133.2012.11007.x 10.1016/0190-9622(90)70029-H 10.1002/med.21754 10.1046/j.1365-2133.1997.18011894.x 10.1016/S0140-6736(14)60763-7 10.1172/jci.insight.154585 10.1016/j.abd.2021.04.014 10.1097/PAT.0b013e328363b3bd 10.1177/0394632016662475 10.1111/j.1469-8137.2010.03374.x 10.1038/jid.2015.335 10.1186/s13148-016-0297-z 10.3389/fimmu.2022.839167 10.1111/j.1365-2133.2011.10646.x 10.1016/j.jid.2021.06.025 10.1016/S0190-9622(89)70069-4 10.1111/j.1365-2133.2010.09919.x 10.1080/03009740902758875 10.1016/0190-9622(92)70094-V 10.1016/j.jdermsci.2019.11.003 10.1007/s40257-021-00631-6 10.1038/s41598-017-10253-w 10.5021/ad.2016.28.3.279 10.1111/phpp.12169 10.1146/annurev-immunol-100919-023531 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. COPYRIGHT 2024 Springer |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. – notice: COPYRIGHT 2024 Springer |
| DBID | AAYXX CITATION NPM ISR 3V. 7QP 7TK 7TM 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 7S9 L.6 |
| DOI | 10.1007/s00439-023-02630-5 |
| DatabaseName | CrossRef PubMed Gale In Context: Science ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef PubMed ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA MEDLINE - Academic ProQuest Central Student PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1432-1203 |
| EndPage | 149 |
| ExternalDocumentID | A783519056 38182908 10_1007_s00439_023_02630_5 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Natural Science Foundation of Chongqing grantid: CSTB2023NSCQ- MSX0664; CSTB2023NSCQ- MSX0075 funderid: http://dx.doi.org/10.13039/501100005230 – fundername: National Natural Science Foundation of China grantid: 82073462 – fundername: Natural Science Foundation of Chongqing grantid: CSTB2023NSCQ- MSX0075 – fundername: Natural Science Foundation of Chongqing grantid: CSTB2023NSCQ- MSX0664 |
| GroupedDBID | --- --Z -4W -56 -5G -BR -EM -Y2 -~C -~X .55 .86 .GJ .VR 06C 06D 0R~ 0VY 199 1N0 1SB 2.D 203 28- 29I 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 36B 3O- 3SX 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5VS 67N 67Z 6NX 78A 7X7 85S 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABLJU ABMNI ABMQK ABNWP ABOCM ABPLI ABQBU ABQSL ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFDYV AFEXP AFFNX AFGCZ AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BPHCQ BSONS BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 EBD EBLON EBS EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS H13 HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IAO IHE IHR IJ- IKXTQ INH INR ISR ITC ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAS LK8 LLZTM M0L M1P M4Y M7P MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM P19 P2P PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R89 R9I RHV RIG RNI RNS ROL RPX RRX RSV RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TSG TSK TSV TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK6 WK8 X7J X7M YLTOR Z45 Z7U Z7W Z81 Z82 Z83 Z87 Z8O Z8Q Z8U Z8V Z8W Z91 ZGI ZMTXR ZOVNA ~EX ~KM AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC ADHKG AEZWR AFDZB AFFHD AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB NPM 7QP 7TK 7TM 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ K9. P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 7S9 L.6 |
| ID | FETCH-LOGICAL-c509t-5c6c9b9304eab8b3bf003cccc366a523c7c97097c0034d3baba839c747d3d6e13 |
| IEDL.DBID | RSV |
| ISICitedReferencesCount | 4 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001136799700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0340-6717 1432-1203 |
| IngestDate | Sun Nov 09 14:06:40 EST 2025 Thu Oct 02 05:40:28 EDT 2025 Wed Nov 05 01:49:50 EST 2025 Sat Nov 29 13:52:32 EST 2025 Sat Nov 29 10:35:27 EST 2025 Wed Nov 26 10:46:35 EST 2025 Thu Apr 03 07:09:06 EDT 2025 Sat Nov 29 02:19:01 EST 2025 Tue Nov 18 22:33:02 EST 2025 Fri Feb 21 02:41:57 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c509t-5c6c9b9304eab8b3bf003cccc366a523c7c97097c0034d3baba839c747d3d6e13 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 38182908 |
| PQID | 2929291641 |
| PQPubID | 47178 |
| PageCount | 13 |
| ParticipantIDs | proquest_miscellaneous_3153615589 proquest_miscellaneous_2928996614 proquest_journals_2929291641 gale_infotracmisc_A783519056 gale_infotracacademiconefile_A783519056 gale_incontextgauss_ISR_A783519056 pubmed_primary_38182908 crossref_primary_10_1007_s00439_023_02630_5 crossref_citationtrail_10_1007_s00439_023_02630_5 springer_journals_10_1007_s00439_023_02630_5 |
| PublicationCentury | 2000 |
| PublicationDate | 20240200 2024-02-00 2024-Feb 20240201 |
| PublicationDateYYYYMMDD | 2024-02-01 |
| PublicationDate_xml | – month: 2 year: 2024 text: 20240200 |
| PublicationDecade | 2020 |
| PublicationPlace | Berlin/Heidelberg |
| PublicationPlace_xml | – name: Berlin/Heidelberg – name: Germany – name: Heidelberg |
| PublicationTitle | Human genetics |
| PublicationTitleAbbrev | Hum. Genet |
| PublicationTitleAlternate | Hum Genet |
| PublicationYear | 2024 |
| Publisher | Springer Berlin Heidelberg Springer Springer Nature B.V |
| Publisher_xml | – name: Springer Berlin Heidelberg – name: Springer – name: Springer Nature B.V |
| References | Chen, Li, Li (CR6) 2021; 41 Hirobe, Furuya, Akiu, Ifuku, Fukuda (CR14) 2002; 15 López, Alonso, García de Galdeano, Smith-Zubiaga (CR19) 2015; 31 Delić, Wolk, Schmid, Gabrielyan, Christou, Rieber (CR8) 2020; 97 Pu, Chen, Chen, Zhang, Chen, Zhang (CR25) 2021; 12 Michel, Tonon, Scornet, Cock, Kloareg (CR21) 2010; 188 Bergqvist, Ezzedine (CR3) 2020; 236 Rasheed, El-Komy, Hegazy, Gawdat, AlOrbani, Shaker (CR27) 2016; 29 Zhao, Liang, Wu, Wang, Zhang, Su (CR37) 2012; 166 Bibeau, Pandya, Ezzedine, Jones, Gao, Lindley (CR4) 2022; 36 Singh, Gotherwal, Junni, Vijayan, Tiwari, Ganju (CR31) 2017; 7 Mozzanica, Frigerio, Finzi, Cattaneo, Negri, Scaglione (CR23) 1990; 22 Gellatly, Strassner, Essien, Refat, Murphy, Coffin-Schmitt (CR13) 2021; 13 Verma, Ekman, BivikEding, Enerbäck (CR32) 2018; 138 Bastonini, Kovacs, Picardo (CR2) 2016; 28 Le Poole, van den Wijngaard, Westerhof, Das (CR17) 1997; 137 Ezzedine, Eleftheriadou, Whitton, van Geel (CR9) 2015; 386 Zhou, Shen, Xu, Gao, Zheng, Ko (CR38) 2016; 8 Mozzanica, Villa, Foppa, Vignati, Cattaneo, Diotti (CR24) 1992; 26 Mozzanica, Frigerio, Negri, Tadini, Villa, Mantovani (CR22) 1989; 20 Köhler, Rodríguez-Paredes (CR16) 2020; 140 Lei, Luo, Lei, Luo, Yan, Zhao (CR18) 2009; 38 Rani, Pervaiz, Parsad, Kumar (CR26) 2023 Mei, Ying, Wang, Xu, Ye, Yang (CR20) 2022; 1 Javierre, Fernandez, Richter, Al-Shahrour, Martin-Subero, Rodriguez-Ubreva (CR15) 2010; 20 Farag, Badr, El-Shafey, Elshaib (CR11) 2022; 97 Zhao, Gao, Wu, Tang, Lu (CR35) 2010; 163 Regazzetti, Joly, Marty, Rivier, Mehul, Reiniche (CR28) 2015; 135 Zhao, Huang, Zhang, Gao, Wang, Zhang (CR36) 2012; 167 Chen, Huang, Guo, Chang, Chu, Bu (CR7) 2022; 142 Shiu, Zhang, Lentsch, Flesher, Jin, Polleys (CR30) 2022 Roberson, Liu, Ryan, Joyce, Duan, Cao (CR29) 2012; 132 Ezzedine, Eleftheriadou, Jones, Bibeau, Kuo, Sturm (CR10) 2021; 22 Xuan, Yang, Xiang, Zhang (CR33) 2022; 2022 Ye, Chen, Du, Ni, Li, Zhang (CR34) 2022; 13 Abedin, King (CR1) 2010; 20 Brandner, Haass (CR5) 2013; 45 Frisoli, Essien, Harris (CR12) 2020; 26 J Shiu (2630_CR30) 2022 E Bastonini (2630_CR2) 2016; 28 F Köhler (2630_CR16) 2020; 140 N Mozzanica (2630_CR24) 1992; 26 S López (2630_CR19) 2015; 31 KJ Gellatly (2630_CR13) 2021; 13 L Mei (2630_CR20) 2022; 1 N Mozzanica (2630_CR22) 1989; 20 M Abedin (2630_CR1) 2010; 20 JM Brandner (2630_CR5) 2013; 45 BM Javierre (2630_CR15) 2010; 20 S Rani (2630_CR26) 2023 ML Frisoli (2630_CR12) 2020; 26 IC Le Poole (2630_CR17) 1997; 137 M Zhao (2630_CR37) 2012; 166 D Verma (2630_CR32) 2018; 138 K Ezzedine (2630_CR10) 2021; 22 Y Xuan (2630_CR33) 2022; 2022 M Zhao (2630_CR35) 2010; 163 Y Pu (2630_CR25) 2021; 12 C Bergqvist (2630_CR3) 2020; 236 T Hirobe (2630_CR14) 2002; 15 D Delić (2630_CR8) 2020; 97 ED Roberson (2630_CR29) 2012; 132 M Zhao (2630_CR36) 2012; 167 F Zhou (2630_CR38) 2016; 8 C Regazzetti (2630_CR28) 2015; 135 W Lei (2630_CR18) 2009; 38 G Michel (2630_CR21) 2010; 188 J Chen (2630_CR6) 2021; 41 Z Ye (2630_CR34) 2022; 13 K Bibeau (2630_CR4) 2022; 36 KD Chen (2630_CR7) 2022; 142 K Ezzedine (2630_CR9) 2015; 386 N Mozzanica (2630_CR23) 1990; 22 A Singh (2630_CR31) 2017; 7 AGA Farag (2630_CR11) 2022; 97 H Rasheed (2630_CR27) 2016; 29 |
| References_xml | – volume: 1 issue: 212 year: 2022 ident: CR20 article-title: (1)H NMR-based metabolomics of skin squamous cell carcinoma and peri-tumoral region tissues publication-title: J Pharm Biomed Anal doi: 10.1016/j.jpba.2022.114643 – volume: 20 start-page: 734 issue: 12 year: 2010 end-page: 742 ident: CR1 article-title: Diverse evolutionary paths to cell adhesion publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2010.08.002 – volume: 15 start-page: 391 issue: 5 year: 2002 end-page: 399 ident: CR14 article-title: Keratinocytes control the proliferation and differentiation of cultured epidermal melanocytes from ultraviolet radiation B-induced pigmented spots in the dorsal skin of hairless mice publication-title: Pigment Cell Res doi: 10.1034/j.1600-0749.2002.02052.x – volume: 138 start-page: 1088 issue: 5 year: 2018 end-page: 1093 ident: CR32 article-title: Genome-wide DNA methylation profiling identifies differential methylation in uninvolved psoriatic epidermis publication-title: J Invest Dermatol doi: 10.1016/j.jid.2017.11.036 – volume: 12 year: 2021 ident: CR25 article-title: Transcriptome and differential methylation integration analysis identified important differential methylation annotation genes and functional epigenetic modules related to vitiligo publication-title: Front Immunol doi: 10.3389/fimmu.2021.587440 – volume: 36 start-page: 1831 issue: 10 year: 2022 end-page: 1844 ident: CR4 article-title: Vitiligo prevalence and quality of life among adults in Europe, Japan and the USA publication-title: J Eur Acad Dermatol Venereol doi: 10.1111/jdv.18257 – volume: 13 start-page: eabd8995 issue: 610 year: 2021 ident: CR13 article-title: scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T(reg) function publication-title: Sci Transl Med doi: 10.1126/scitranslmed.abd8995 – year: 2023 ident: CR26 article-title: Differential expression of extracellular matrix proteins in the lesional skin of vitiligo patients publication-title: Arch Dermatol Res doi: 10.1007/s00403-023-02628-z – volume: 20 start-page: 170 issue: 2 year: 2010 end-page: 179 ident: CR15 article-title: Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus publication-title: Genome Res doi: 10.1101/gr.100289.109 – volume: 132 start-page: 583 issue: 3 Pt 1 year: 2012 end-page: 592 ident: CR29 article-title: A subset of methylated CpG sites differentiate psoriatic from normal skin publication-title: J Invest Dermatol doi: 10.1038/jid.2011.348 – volume: 236 start-page: 571 issue: 6 year: 2020 end-page: 592 ident: CR3 article-title: Vitiligo: a review publication-title: Dermatology (Basel, Switzerland) doi: 10.1159/000506103 – volume: 140 start-page: 38 issue: 1 year: 2020 end-page: 47 ident: CR16 article-title: DNA methylation in epidermal differentiation, aging, and cancer publication-title: J Invest Dermatol doi: 10.1016/j.jid.2019.05.011 – volume: 2022 start-page: 8498472 year: 2022 ident: CR33 article-title: The role of oxidative stress in the pathogenesis of vitiligo: a culprit for melanocyte death publication-title: Oxid Med Cell Longev doi: 10.1155/2022/8498472 – volume: 167 start-page: 523 issue: 3 year: 2012 end-page: 531 ident: CR36 article-title: Aberrant epigenetic modifications in peripheral blood mononuclear cells from patients with pemphigus vulgaris publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.2012.11007.x – volume: 22 start-page: 223 issue: 2 Pt 1 year: 1990 end-page: 230 ident: CR23 article-title: T cell subpopulations in vitiligo: a chronobiologic study publication-title: J Am Acad Dermatol doi: 10.1016/0190-9622(90)70029-H – volume: 41 start-page: 1138 issue: 2 year: 2021 end-page: 1166 ident: CR6 article-title: Mechanisms of melanocyte death in vitiligo publication-title: Med Res Rev doi: 10.1002/med.21754 – volume: 137 start-page: 171 issue: 2 year: 1997 end-page: 178 ident: CR17 article-title: Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesion publication-title: Br J Dermatol doi: 10.1046/j.1365-2133.1997.18011894.x – volume: 386 start-page: 74 issue: 9988 year: 2015 end-page: 84 ident: CR9 article-title: Vitiligo publication-title: Lancet (Lond, Engl) doi: 10.1016/S0140-6736(14)60763-7 – year: 2022 ident: CR30 article-title: Multimodal analyses of vitiligo skin identify tissue characteristics of stable disease publication-title: JCI Insight doi: 10.1172/jci.insight.154585 – volume: 97 start-page: 28 issue: 1 year: 2022 end-page: 36 ident: CR11 article-title: Fatty acid-binding protein 4 circulating levels in non-segmental vitiligo publication-title: Anais Bras De Dermatol doi: 10.1016/j.abd.2021.04.014 – volume: 45 start-page: 443 issue: 5 year: 2013 end-page: 452 ident: CR5 article-title: Melanoma's connections to the tumour microenvironment publication-title: Pathology doi: 10.1097/PAT.0b013e328363b3bd – volume: 29 start-page: 764 issue: 4 year: 2016 end-page: 768 ident: CR27 article-title: Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-γ in psoriatic patients publication-title: Int J Immunopathol Pharmacol doi: 10.1177/0394632016662475 – volume: 188 start-page: 82 issue: 1 year: 2010 end-page: 97 ident: CR21 article-title: The cell wall polysaccharide metabolism of the brown alga . Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes publication-title: New Phytol doi: 10.1111/j.1469-8137.2010.03374.x – volume: 135 start-page: 3105 issue: 12 year: 2015 end-page: 3114 ident: CR28 article-title: Transcriptional analysis of vitiligo skin reveals the alteration of WNT pathway: a promising target for repigmenting vitiligo patients publication-title: J Invest Dermatol doi: 10.1038/jid.2015.335 – volume: 8 start-page: 131 year: 2016 ident: CR38 article-title: Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis publication-title: Clin Epigenetics doi: 10.1186/s13148-016-0297-z – volume: 13 year: 2022 ident: CR34 article-title: Metabolomics signature and potential application of serum polyunsaturated fatty acids metabolism in patients with vitiligo publication-title: Front Immunol doi: 10.3389/fimmu.2022.839167 – volume: 166 start-page: 226 issue: 2 year: 2012 end-page: 273 ident: CR37 article-title: Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.2011.10646.x – volume: 142 start-page: 104 issue: 1 year: 2022 end-page: 113 ident: CR7 article-title: DNA methylation array identifies golli-MBP as a biomarker for disease severity in childhood atopic dermatitis publication-title: J Invest Dermatol doi: 10.1016/j.jid.2021.06.025 – volume: 20 start-page: 591 issue: 4 year: 1989 end-page: 596 ident: CR22 article-title: Circadian rhythm of natural killer cell activity in vitiligo publication-title: J Am Acad Dermatol doi: 10.1016/S0190-9622(89)70069-4 – volume: 163 start-page: 736 issue: 4 year: 2010 end-page: 742 ident: CR35 article-title: Abnormal DNA methylation in peripheral blood mononuclear cells from patients with vitiligo publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.2010.09919.x – volume: 38 start-page: 369 issue: 5 year: 2009 end-page: 374 ident: CR18 article-title: Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis publication-title: Scand J Rheumatol doi: 10.1080/03009740902758875 – volume: 26 start-page: 693 issue: 5 Pt 1 year: 1992 end-page: 700 ident: CR24 article-title: Plasma alpha-melanocyte-stimulating hormone, beta-endorphin, met-enkephalin, and natural killer cell activity in vitiligo publication-title: J Am Acad Dermatol doi: 10.1016/0190-9622(92)70094-V – volume: 97 start-page: 9 issue: 1 year: 2020 end-page: 20 ident: CR8 article-title: Integrated microRNA/mRNA expression profiling of the skin of psoriasis patients publication-title: J Dermatol Sci doi: 10.1016/j.jdermsci.2019.11.003 – volume: 22 start-page: 757 issue: 6 year: 2021 end-page: 774 ident: CR10 article-title: Psychosocial effects of vitiligo: a systematic literature Review publication-title: Am J Clin Dermatol doi: 10.1007/s40257-021-00631-6 – volume: 7 start-page: 9860 issue: 1 year: 2017 ident: CR31 article-title: Mapping architectural and transcriptional alterations in non-lesional and lesional epidermis in vitiligo publication-title: Sci Rep doi: 10.1038/s41598-017-10253-w – volume: 28 start-page: 279 issue: 3 year: 2016 end-page: 289 ident: CR2 article-title: Skin pigmentation and pigmentary disorders: focus on epidermal/dermal cross-talk publication-title: Ann Dermatol doi: 10.5021/ad.2016.28.3.279 – volume: 31 start-page: 149 issue: 3 year: 2015 end-page: 158 ident: CR19 article-title: Melanocytes from dark and light skin respond differently after ultraviolet B irradiation: effect of keratinocyte-conditioned medium publication-title: Photodermatol Photoimmunol Photomed doi: 10.1111/phpp.12169 – volume: 26 start-page: 621 issue: 38 year: 2020 end-page: 648 ident: CR12 article-title: Vitiligo: mechanisms of pathogenesis and treatment publication-title: Annu Rev Immunol doi: 10.1146/annurev-immunol-100919-023531 – volume: 22 start-page: 757 issue: 6 year: 2021 ident: 2630_CR10 publication-title: Am J Clin Dermatol doi: 10.1007/s40257-021-00631-6 – year: 2022 ident: 2630_CR30 publication-title: JCI Insight doi: 10.1172/jci.insight.154585 – volume: 166 start-page: 226 issue: 2 year: 2012 ident: 2630_CR37 publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.2011.10646.x – volume: 31 start-page: 149 issue: 3 year: 2015 ident: 2630_CR19 publication-title: Photodermatol Photoimmunol Photomed doi: 10.1111/phpp.12169 – volume: 386 start-page: 74 issue: 9988 year: 2015 ident: 2630_CR9 publication-title: Lancet (Lond, Engl) doi: 10.1016/S0140-6736(14)60763-7 – volume: 20 start-page: 734 issue: 12 year: 2010 ident: 2630_CR1 publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2010.08.002 – volume: 13 start-page: eabd8995 issue: 610 year: 2021 ident: 2630_CR13 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.abd8995 – volume: 38 start-page: 369 issue: 5 year: 2009 ident: 2630_CR18 publication-title: Scand J Rheumatol doi: 10.1080/03009740902758875 – volume: 135 start-page: 3105 issue: 12 year: 2015 ident: 2630_CR28 publication-title: J Invest Dermatol doi: 10.1038/jid.2015.335 – volume: 140 start-page: 38 issue: 1 year: 2020 ident: 2630_CR16 publication-title: J Invest Dermatol doi: 10.1016/j.jid.2019.05.011 – volume: 7 start-page: 9860 issue: 1 year: 2017 ident: 2630_CR31 publication-title: Sci Rep doi: 10.1038/s41598-017-10253-w – volume: 13 year: 2022 ident: 2630_CR34 publication-title: Front Immunol doi: 10.3389/fimmu.2022.839167 – volume: 163 start-page: 736 issue: 4 year: 2010 ident: 2630_CR35 publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.2010.09919.x – volume: 8 start-page: 131 year: 2016 ident: 2630_CR38 publication-title: Clin Epigenetics doi: 10.1186/s13148-016-0297-z – year: 2023 ident: 2630_CR26 publication-title: Arch Dermatol Res doi: 10.1007/s00403-023-02628-z – volume: 12 year: 2021 ident: 2630_CR25 publication-title: Front Immunol doi: 10.3389/fimmu.2021.587440 – volume: 142 start-page: 104 issue: 1 year: 2022 ident: 2630_CR7 publication-title: J Invest Dermatol doi: 10.1016/j.jid.2021.06.025 – volume: 20 start-page: 170 issue: 2 year: 2010 ident: 2630_CR15 publication-title: Genome Res doi: 10.1101/gr.100289.109 – volume: 15 start-page: 391 issue: 5 year: 2002 ident: 2630_CR14 publication-title: Pigment Cell Res doi: 10.1034/j.1600-0749.2002.02052.x – volume: 97 start-page: 9 issue: 1 year: 2020 ident: 2630_CR8 publication-title: J Dermatol Sci doi: 10.1016/j.jdermsci.2019.11.003 – volume: 132 start-page: 583 issue: 3 Pt 1 year: 2012 ident: 2630_CR29 publication-title: J Invest Dermatol doi: 10.1038/jid.2011.348 – volume: 36 start-page: 1831 issue: 10 year: 2022 ident: 2630_CR4 publication-title: J Eur Acad Dermatol Venereol doi: 10.1111/jdv.18257 – volume: 188 start-page: 82 issue: 1 year: 2010 ident: 2630_CR21 publication-title: New Phytol doi: 10.1111/j.1469-8137.2010.03374.x – volume: 2022 start-page: 8498472 year: 2022 ident: 2630_CR33 publication-title: Oxid Med Cell Longev doi: 10.1155/2022/8498472 – volume: 28 start-page: 279 issue: 3 year: 2016 ident: 2630_CR2 publication-title: Ann Dermatol doi: 10.5021/ad.2016.28.3.279 – volume: 236 start-page: 571 issue: 6 year: 2020 ident: 2630_CR3 publication-title: Dermatology (Basel, Switzerland) doi: 10.1159/000506103 – volume: 20 start-page: 591 issue: 4 year: 1989 ident: 2630_CR22 publication-title: J Am Acad Dermatol doi: 10.1016/S0190-9622(89)70069-4 – volume: 41 start-page: 1138 issue: 2 year: 2021 ident: 2630_CR6 publication-title: Med Res Rev doi: 10.1002/med.21754 – volume: 45 start-page: 443 issue: 5 year: 2013 ident: 2630_CR5 publication-title: Pathology doi: 10.1097/PAT.0b013e328363b3bd – volume: 26 start-page: 621 issue: 38 year: 2020 ident: 2630_CR12 publication-title: Annu Rev Immunol doi: 10.1146/annurev-immunol-100919-023531 – volume: 22 start-page: 223 issue: 2 Pt 1 year: 1990 ident: 2630_CR23 publication-title: J Am Acad Dermatol doi: 10.1016/0190-9622(90)70029-H – volume: 137 start-page: 171 issue: 2 year: 1997 ident: 2630_CR17 publication-title: Br J Dermatol doi: 10.1046/j.1365-2133.1997.18011894.x – volume: 26 start-page: 693 issue: 5 Pt 1 year: 1992 ident: 2630_CR24 publication-title: J Am Acad Dermatol doi: 10.1016/0190-9622(92)70094-V – volume: 167 start-page: 523 issue: 3 year: 2012 ident: 2630_CR36 publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.2012.11007.x – volume: 138 start-page: 1088 issue: 5 year: 2018 ident: 2630_CR32 publication-title: J Invest Dermatol doi: 10.1016/j.jid.2017.11.036 – volume: 97 start-page: 28 issue: 1 year: 2022 ident: 2630_CR11 publication-title: Anais Bras De Dermatol doi: 10.1016/j.abd.2021.04.014 – volume: 29 start-page: 764 issue: 4 year: 2016 ident: 2630_CR27 publication-title: Int J Immunopathol Pharmacol doi: 10.1177/0394632016662475 – volume: 1 issue: 212 year: 2022 ident: 2630_CR20 publication-title: J Pharm Biomed Anal doi: 10.1016/j.jpba.2022.114643 |
| SSID | ssj0015925 |
| Score | 2.4436831 |
| Snippet | Several studies have emphasized the role of DNA methylation in vitiligo. However, its profile in human skin of individuals with vitiligo remains unknown. Here,... |
| SourceID | proquest gale pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 137 |
| SubjectTerms | Biomedical and Life Sciences Biomedicine Cell division Cell interactions circadian rhythm Circadian rhythms Comparative analysis data collection DNA DNA methylation Extracellular matrix fatty acid metabolism Fatty acids Gene Function Genes Genomes Genomics Human Genetics Keratinocytes Melanocytes Metabolic Diseases Methylation Molecular Medicine multiomics Original Investigation pathogenesis peroxidase Pigmentation Population studies RNA Skin skin (animal) Skin diseases synapse Synapses therapeutics transcriptome Transcriptomes Vitiligo |
| SummonAdditionalLinks | – databaseName: Public Health Database dbid: 8C1 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdggMTLxvcCAxmExANYS-LUifeCqsEACVWIL-3Nsh1niuiSbmmH9o_w93LnuCmdtL3QNg9tzm4Sn-_O9vn3I-Rlhm5O6AwiN239lhymU56z3AjORZUb7Tkjf37OJ5Pi8FB-CRNuXUirXNpEb6jL1uIc-W4q8Q3BffJ2dsKQNQpXVwOFxnVyI0njDDtmsT-keICn9qSrMfcp7kkeNs34rXO4BCYZeCw4BI_ZaM0xXTTP__inCwum3g8dbP3vHdwhmyECpeNeZe6Sa665R271nJTn98mfD65pjx37XZeOvpuMKXJMn_cZc7St6NT1OB5UNyVFmGQ2_NL9qhsKn7N6Xk_ro3aPampX6OK-xABPUcLXHg8Fa_V5jQx3SHdYA7J6u87R2UAv9oD8OHj_ff8jC-QNzEIMMmcjK6w0kseZ06Yw3FRgPyy8uBAaRr82tzKPZW4RIafkRhsNsZqF0U3JS-ES_pBsNG3jtglNTWZjBxWW0iH8m0msrgTPKpmnhdVZRJJlyykbkM2RYGOqBkxm39oKWlv51lajiLweysx6XI8rpV-gQigEzGgwI-dIL7pOffr2VY1x6gyiqpGIyKsgVLXw91aHDQ5wE4ixtSa5syYJPdqun14qkAoWpVMr7YnI8-E0lsQsuca1Cy9T4Pg1yS6X4eDicC26kBF51Ov08AAwektlXETkzVLJVxdw-dN5fPX1PiG3U4gE-1T3HbIxP124p-SmPZvX3ekz32P_AiOVRA0 priority: 102 providerName: ProQuest |
| Title | Genome-wide DNA methylation of lesional and peri-lesional skin in vitiligo: a comparative and integrated analysis of multi-omics in Chinese population |
| URI | https://link.springer.com/article/10.1007/s00439-023-02630-5 https://www.ncbi.nlm.nih.gov/pubmed/38182908 https://www.proquest.com/docview/2929291641 https://www.proquest.com/docview/2928996614 https://www.proquest.com/docview/3153615589 |
| Volume | 143 |
| WOSCitedRecordID | wos001136799700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1432-1203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015925 issn: 0340-6717 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-xDSRe-P4IjMogJB7AUhInccxbGRsgoarqYOpb5DjOFFGSaWmH9o_w93LnpBmdGBK0TaQ0Zye9nH3n3t3vAF5GpOYSHaHlpo1LyeE6FJLLPBEiKWWuXc3Io89yMknnczXtk8LadbT72iXpZuoh2Y2cVoqjjsEtET6Pt2AH1V1Kw3F2eDT4DmLlSq36wgW2B7JPlflzHxvq6PKk_JtWuuQmddrn4Pb_3fcduNVbm2zcicdduGbre3Cjqz95fh9-frB1893yH1Vh2fvJmFE96fMuOo41JVvYDrOD6bpgBInMh2_ab1XN8HNWLatFddy8ZZqZCyRx12KAoijwsMM-oV5dDCOnbOiWeqAK3ra17GQoJfYAvh7sf9n7yPtCDdzgA1jy2CRG5Ur4kdV5mou8xLnC4EskicaVrpFGSV9JQ2g4hch1rtEuM7iSKUSR2EA8hO26qe1jYGEeGd9ih4WyBPWWB0aXiYhKJcPU6MiDYP28MtOjmFMxjUU24C87fmfI78zxO4s9eD20OekwPP5K_YLEICNwjJqib471qm2zT4ezbEx_k6EFFScevOqJygYvb3SfzIA_gvC0Nih3Nyhx9JrN02tpy_rZo81CRW9cyAYePB9OU0uKiKtts3I0Ka1Vg-hqGoHqjPzOqfLgUSfJAwPIUguVn3rwZi22FzdwNXee_Bv5U7gZohXYhbnvwvbydGWfwXVztqza0xFsybl0-xT36V4wgp13-5PpbEQhuNORG9e_AMU6P2k |
| linkProvider | Springer Nature |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELfGAMEL3x-BAQaBeACLJk7jGAmhijFWbVQIBuqbcRxniihJWdpN_Uf4M_gbuXM-Sidtb3ugbR7anN3UPd-d47vfj5CnIbq5SIcQuWnjSnKYDrhgIok4jzKRaMcZ-W1XjEbxeCw_rZE_bS0MplW2NtEZ6rQ0eI_8VSDxCcG9_3b6iyFrFO6uthQatVrs2MURLNmqN8NN-H-fBcHW-71326xhFWAGnOOM9U1kZCJhGW91Eic8yUCxDTx4FGlYlhlhpOhJYRC6JeWJTjQEEQbC7pSnkfU59HuOnAc7LjCFTIy7BR5EBo7kFdphSr0vmiIdV6qHW26SgYeEI-I91l9xhMfdwT_-8NgGrfN7W1f_txG7Rq40ETYd1FPiOlmzxQ1ysebcXNwkvz_Yovxp2VGeWro5GlDk0F7UGYG0zOjE1jglVBcpRRho1n1S_cgLCq_DfJZP8v3yNdXULNHTXYsOfiOFtzXeC_bq8jYZVoBX2AOyltvK0mlHn3aLfD2TQblN1ouysHcJDZLQ9Cx0mEqL8HaJb3QW8TCTIoiNDj3it5qiTIPcjgQiE9VhTjvtUqBdymmX6nvkRddmWuOWnCr9BBVQISBIgRlH-3peVWr45bMa4K1BiBr7kUeeN0JZCV9vdFPAAT8CMcRWJDdWJMFimdXTrcKqxmJWaqmtHnncncaWmAVY2HLuZGJcn_vhyTIcXDjutcfSI3fqOdQNAEangezFHnnZTqrlBZw8OvdOv95H5NL23sddtTsc7dwnlwOIeuu0_g2yPjuY2wfkgjmc5dXBQ2ctKPl-1pPtL5G6oek |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VFhAX3g9DgQWBOMCqsdexvUgIBdJA1CqKWkC9Lev1urIIdqiTVvkj_Bh-HTPrR0il9tYDSXxIPLtxNvNaz8w3hLzw0cwFygfPTWlbksOUx0MWxgHnQRrGyvaM_LYbjkbRwYEYr5E_TS0MplU2OtEq6qTQeI98yxP4BOfe3UrrtIhxf_B--othBymMtDbtNCoW2TGLE9i-le-GffivX3reYPvLx8-s7jDANBjKGevqQItYwJbeqDiKeZwCk2t48CBQsEXToRZhR4QaYVwSHqtYgUOhwQVPeBIYl8O8l8hGCE4GSNfGh-3ReK-NYXSFbfkKIzHB3g3rkh1buIcBOMHAXsIR8A7rrpjF08bhH-t4KlxrreDgxv-8fjfJ9dr3pr1KWG6RNZPfJleqbpyLO-T3J5MXPw07yRJD-6Mexe7aiypXkBYpnZgKwYSqPKEIEM3aT8ofWU7hdZzNskl2WLyliuolrrod0QJzJPC2QoLBWW1GJ8Pa8BJnwH7mpjR02jZWu0u-Xsii3CPreZGbB4R6sa87BiZMhEHgu9jVKg24n4rQi7TyHeI2XCN1jemOrUUmskWjtpwmgdOk5TTZdcjrdsy0QjQ5l_o5MqNEqJAcmeZQzctSDvf3ZA9vGoI_2Q0c8qomSgv4eq3q0g74EYgutkK5uUIJukyvnm6YV9a6tJRLznXIs_Y0jsT8wNwUc0sT4c7d9c-m4WDcMQofCYfcr-SpXQD0Wz3RiRzyphGw5QWcvToPz7_ep-QqyJjcHY52HpFrHrjDVb7_JlmfHc3NY3JZH8-y8uhJrToo-X7R0vYXJqOsCg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome-wide+DNA+methylation+of+lesional+and+peri-lesional+skin+in+vitiligo%3A+a+comparative+and+integrated+analysis+of+multi-omics+in+Chinese+population&rft.jtitle=Human+genetics&rft.au=Liu%2C+Lin&rft.au=Xue%2C+Yuzhou&rft.au=Li%2C+Yuxin&rft.au=Chen%2C+Yangmei&rft.date=2024-02-01&rft.pub=Springer+Berlin+Heidelberg&rft.issn=0340-6717&rft.eissn=1432-1203&rft.volume=143&rft.issue=2&rft.spage=137&rft.epage=149&rft_id=info:doi/10.1007%2Fs00439-023-02630-5&rft.externalDocID=10_1007_s00439_023_02630_5 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0340-6717&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0340-6717&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0340-6717&client=summon |