Posttranscriptional Gene Regulation by Long Noncoding RNA

Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs...

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Veröffentlicht in:	Journal of molecular biology Jg. 425; H. 19; S. 3723 - 3730
Hauptverfasser:	Yoon, Je-Hyun, Abdelmohsen, Kotb, Gorospe, Myriam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 09.10.2013
Schlagworte:	Cell Line, Tumor eukaryotic cells gene expression genes genetics human diseases Humans lincRNA lncRNA messenger RNA metabolism microRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism mRNA turnover non-coding RNA RNA precursors RNA Processing, Post-Transcriptional RNA Splicing RNA Stability RNA, Long Noncoding RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding protein RNA-binding proteins RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism transcription (genetics) translation (genetics) translational regulation BACE1 pre-mRNA RNA-binding protein lncRNA sno-lncRNA mRNA turnover lincRNA PABP translational regulation poly(A)-binding protein β amyloid-cleaving enzyme 1 precursor mRNA small nucleolar lncRNA long noncoding RNA
ISSN:	0022-2836, 1089-8638, 1089-8638
Online-Zugang:	Volltext
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Abstract	Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease. In this review, we summarize the mechanisms of posttranscriptional gene regulation by lncRNAs identified until now. [Display omitted] ► LncRNAs are emerging as key posttranscriptional gene regulatory factors. ► LncRNAs can control splicing by sequestering splicing regulatory proteins. ► LncRNAs can modulate target mRNA turnover via partial or extended complementarity. ► LncRNAs can affect translation by interacting with target mRNAs, recruiting proteins. ► LncRNAs can function by competing or cooperating with microRNAs.
AbstractList	Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease. In this review, we summarize the mechanisms of posttranscriptional gene regulation by lncRNAs identified until now.Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease. In this review, we summarize the mechanisms of posttranscriptional gene regulation by lncRNAs identified until now. Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease. In this review, we summarize the mechanisms of posttranscriptional gene regulation by lncRNAs identified until now. Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease. In this review, we summarize the mechanisms of posttranscriptional gene regulation by lncRNAs identified until now. [Display omitted] ► LncRNAs are emerging as key posttranscriptional gene regulatory factors. ► LncRNAs can control splicing by sequestering splicing regulatory proteins. ► LncRNAs can modulate target mRNA turnover via partial or extended complementarity. ► LncRNAs can affect translation by interacting with target mRNAs, recruiting proteins. ► LncRNAs can function by competing or cooperating with microRNAs.
Author	Gorospe, Myriam Abdelmohsen, Kotb Yoon, Je-Hyun
Author_xml	– sequence: 1 givenname: Je-Hyun surname: Yoon fullname: Yoon, Je-Hyun – sequence: 2 givenname: Kotb surname: Abdelmohsen fullname: Abdelmohsen, Kotb – sequence: 3 givenname: Myriam surname: Gorospe fullname: Gorospe, Myriam email: myriam-gorospe@nih.gov
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23178169$$D View this record in MEDLINE/PubMed
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Snippet	Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of...
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SubjectTerms	Cell Line, Tumor eukaryotic cells gene expression genes genetics human diseases Humans lincRNA lncRNA messenger RNA metabolism microRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism mRNA turnover non-coding RNA RNA precursors RNA Processing, Post-Transcriptional RNA Splicing RNA Stability RNA, Long Noncoding RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding protein RNA-binding proteins RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism transcription (genetics) translation (genetics) translational regulation
Title	Posttranscriptional Gene Regulation by Long Noncoding RNA
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