Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1

The circadian clock regulates a wide range of physiological and metabolic processes, and its disruption leads to metabolic disorders such as diabetes and obesity. Accumulating evidence reveals that the circadian clock regulates levels of metabolites that, in turn, may regulate the clock. Here we dem...

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Veröffentlicht in:	The Journal of biological chemistry Jg. 289; H. 9; S. 6091
Hauptverfasser:	Sahar, Saurabh, Masubuchi, Satoru, Eckel-Mahan, Kristin, Vollmer, Simone, Galla, Luisa, Ceglia, Nicholas, Masri, Selma, Barth, Teresa K, Grimaldi, Benedetto, Oluyemi, Opeyemi, Astarita, Giuseppe, Hallows, William C, Piomelli, Daniele, Imhof, Axel, Baldi, Pierre, Denu, John M, Sassone-Corsi, Paolo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 28.02.2014
Schlagworte:	Acetate-CoA Ligase - genetics Acetate-CoA Ligase - metabolism Acetylation Animals Cells, Cultured Circadian Clocks - physiology Fatty Acids - biosynthesis Fatty Acids - genetics Mice Mice, Knockout NAD - genetics NAD - metabolism Sirtuin 1 - genetics Sirtuin 1 - metabolism Gene Regulation Signal Transduction Post-translational Modification Acetyl Coenzyme A Circadian Clock SIRT1
ISSN:	1083-351X, 1083-351X
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