Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1

The circadian clock regulates a wide range of physiological and metabolic processes, and its disruption leads to metabolic disorders such as diabetes and obesity. Accumulating evidence reveals that the circadian clock regulates levels of metabolites that, in turn, may regulate the clock. Here we dem...

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Vydané v:	The Journal of biological chemistry Ročník 289; číslo 9; s. 6091
Hlavní autori:	Sahar, Saurabh, Masubuchi, Satoru, Eckel-Mahan, Kristin, Vollmer, Simone, Galla, Luisa, Ceglia, Nicholas, Masri, Selma, Barth, Teresa K, Grimaldi, Benedetto, Oluyemi, Opeyemi, Astarita, Giuseppe, Hallows, William C, Piomelli, Daniele, Imhof, Axel, Baldi, Pierre, Denu, John M, Sassone-Corsi, Paolo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 28.02.2014
Predmet:	Acetate-CoA Ligase - genetics Acetate-CoA Ligase - metabolism Acetylation Animals Cells, Cultured Circadian Clocks - physiology Fatty Acids - biosynthesis Fatty Acids - genetics Mice Mice, Knockout NAD - genetics NAD - metabolism Sirtuin 1 - genetics Sirtuin 1 - metabolism Gene Regulation Signal Transduction Post-translational Modification Acetyl Coenzyme A Circadian Clock SIRT1
ISSN:	1083-351X, 1083-351X
On-line prístup:	Zistit podrobnosti o prístupe
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