Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential therapeutic target in cancer therapy. It has been well established that transcription factor NF-κB is involved in regulating physiological and pathological events including inflammation, immune response and differentiat...

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Veröffentlicht in:Cancer letters Jg. 509; S. 63 - 80
Hauptverfasser: Mirzaei, Sepideh, Zarrabi, Ali, Hashemi, Farid, Zabolian, Amirhossein, Saleki, Hossein, Ranjbar, Adnan, Seyed Saleh, Seyed Hesam, Bagherian, Morteza, Sharifzadeh, Seyed omid, Hushmandi, Kiavash, Liskova, Alena, Kubatka, Peter, Makvandi, Pooyan, Tergaonkar, Vinay, Kumar, Alan Prem, Ashrafizadeh, Milad, Sethi, Gautam
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Ireland Elsevier B.V 01.07.2021
Elsevier Limited
Schlagworte:
3' Untranslated regions
Angiogenesis
Apoptosis
Breast cancer
Cancer
Cancer therapies
Carcinogenesis
Cell cycle
Cell migration
Cell proliferation
Chemoresistance
Chemotherapy
Circular RNA
Drug resistance
Genes
Immune response
Immunotherapy
Inflammation
Kinases
Long non-coding RNAs
Malignancy
Medical prognosis
Metastases
Metastasis
MicroRNAs
miRNA
NF-κB protein
Non-coding RNA
Nuclear factor-kappaB (NF-κB)
Ovarian cancer
Phosphorylation
Physiology
Proteins
Radiation therapy
Radioresistance
RNA polymerase
Signal transduction
Tumor necrosis factor-TNF
Tumorigenesis
Long non-coding RNAs
Nuclear factor-kappaB (NF-κB)
MicroRNAs
Chemoresistance
Circular RNA
Radioresistance
Cancer
ISSN:0304-3835, 1872-7980, 1872-7980
Online-Zugang:Volltext
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Zusammenfassung:The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential therapeutic target in cancer therapy. It has been well established that transcription factor NF-κB is involved in regulating physiological and pathological events including inflammation, immune response and differentiation. Increasing evidences suggest that deregulated NF-κB signaling can enhance cancer cell proliferation, metastasis and also mediate radio-as well as chemo-resistance. On the contrary, non-coding RNAs (ncRNAs) have been found to modulate NF-κB signaling pathway under different settings. MicroRNAs (miRNAs) can dually inhibit/induce NF-κB signaling thereby affecting the growth and migration of cancer cells. Furthermore, the response of cancer cells to radiotherapy and chemotherapy may also be regulated by miRNAs. Regulation of NF-κB by miRNAs may be mediated via binding to 3/-UTR region. Interestingly, anti-tumor compounds can increase the expression of tumor-suppressor miRNAs in inhibiting NF-κB activation and the progression of cancers. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) can also effectively modulate NF-κB signaling thus affecting tumorigenesis. It is noteworthy that several studies have demonstrated that lncRNAs and circRNAs can affect miRNAs in targeting NF-κB activation. They can act as competing endogenous RNA (ceRNA) thereby reducing miRNA expression to induce NF-κB activation that can in turn promote cancer progression and malignancy. •NF-ĸB acts as a potential regulator of inflammation and is abnormal expressed in tumor cells.•Long non-coding RNAs can regulate NF-ĸB signalling by diverse mechanisms in cancer progression/inhibition.•MicroRNAs can bind to 3/-UTR of NF-ĸB to modulate its activation, and thereby affecting tumorigenesis.•Long non-coding RNAs can regulate miRNA expression that may act as upstream mediators of NF-ĸB.
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ISSN:0304-3835
1872-7980
1872-7980
DOI:10.1016/j.canlet.2021.03.025