The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells

Aging is known to be the single most important risk factor for multiple diseases. Sirtuin 6, or SIRT6, has recently been identified as a critical regulator of transcription, genome stability, telomere integrity, DNA repair, and metabolic homeostasis. A knockout mouse model of SIRT6 has displayed dra...

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Veröffentlicht in:	The Journal of biological chemistry Jg. 288; H. 25; S. 18439
Hauptverfasser:	Sharma, Amit, Diecke, Sebastian, Zhang, Wendy Y, Lan, Feng, He, Chunjiang, Mordwinkin, Nicholas M, Chua, Katrin F, Wu, Joseph C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.06.2013
Schlagworte:	Adolescent Age Factors Aging - genetics Aging - physiology Cells, Cultured Cellular Reprogramming - genetics Cellular Reprogramming - physiology Cluster Analysis Dermis - cytology Embryoid Bodies - metabolism Embryoid Bodies - physiology Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - physiology Gene Expression Profiling Humans Immunohistochemistry Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - physiology MicroRNAs - genetics Middle Aged Models, Genetic Pluripotent Stem Cells - metabolism Pluripotent Stem Cells - physiology Reverse Transcriptase Polymerase Chain Reaction RNA Processing, Post-Transcriptional Sirtuins - genetics Sirtuins - metabolism Sirtuins - physiology Gene Expression MicroRNA Induced pluripotent Stem Cells Molecular Biology Aging Transcription Factors Embryonic Stem Cell
ISSN:	1083-351X, 1083-351X
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