Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls—a pilot study

Rationale In premenstrual dysphoric disorder (PMDD), a condition that afflicts 3–8 % of women in fertile ages, the cyclic recurrence of debilitating mood symptoms is restricted to the luteal phase of the menstrual cycle. The progesterone metabolite allopregnanolone is produced by the corpus luteum,...

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Bibliographic Details
Published in:	Psychopharmacology Vol. 233; no. 11; pp. 2109 - 2117
Main Authors:	Timby, Erika, Bäckström, Torbjörn, Nyberg, Sigrid, Stenlund, Hans, Wihlbäck, Anna-Carin N., Bixo, Marie
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2016 Springer Springer Nature B.V
Subjects:	Adolescent Adult Anxiety - psychology Biomedical and Life Sciences Biomedicine Complications and side effects Drug interactions Electrooculography Female GABA GABA Modulators - pharmacology Gonadal Steroid Hormones - blood Gonadal Steroid Hormones - pharmacology Humans Hypnotics and Sedatives - pharmacology Medical disorders Menstrual cycle Menstrual Cycle - drug effects Menstruation Neurosciences Neurosteroid Observations Original Investigation Panic - drug effects Pharmacology/Toxicology Physiological aspects Pilot Projects Pregnanolone - blood Pregnanolone - pharmacology Premenstrual dysphoric disorder Premenstrual Dysphoric Disorder - physiopathology Premenstrual syndrome Psychiatry Psychopharmacology Receptors, GABA-A - drug effects Saccades - drug effects Saccadic eye velocity Steroids Steroids (Drugs) Young Adult GABA Saccadic eye velocity Neurosteroid Menstrual cycle Premenstrual dysphoric disorder
ISSN:	0033-3158, 1432-2072, 1432-2072
Online Access:	Get full text
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