The genetics of human personality

Genome‐wide association studies hits (log10 transformed) discovered as a function of sample size and personality trait. Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin a...

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Vydané v:Genes, brain and behavior Ročník 17; číslo 3; s. e12439 - n/a
Hlavní autori: Sanchez‐Roige, S., Gray, J. C., MacKillop, J., Chen, C.‐H., Palmer, A. A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Oxford, UK Blackwell Publishing Ltd 01.03.2018
John Wiley & Sons, Inc
Predmet:
agreeableness
conscientiousness
EPQ
Etiology
extraversion
Family - psychology
Family studies
gene
Genetic analysis
Genetic diversity
Genetic Linkage
Genetic Variation
Genome-wide association studies
Genome-Wide Association Study - methods
Genomes
Genotype & phenotype
GWAS
Humans
Mental depression
Mental disorders
Multifactorial Inheritance - genetics
NEO
Neurosis
neuroticism
openness
Personality
Personality - genetics
Personality Inventory
Personality traits
Polygenic inheritance
Polymorphism, Single Nucleotide - genetics
Psychopathology
Risk Factors
Self Report
Surveys and Questionnaires
TPQ
Transcriptome - genetics
Twins - genetics
GWAS
TPQ
conscientiousness
personality
gene
openness
EPQ
neuroticism
NEO
extraversion
agreeableness
ISSN:1601-1848, 1601-183X, 1601-183X
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Abstract Genome‐wide association studies hits (log10 transformed) discovered as a function of sample size and personality trait. Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder. Despite considerable efforts over the past several decades, the genetic variants that influence personality are only beginning to be identified. We review these recent and increasingly rapid developments, which focus on the assessment of personality via several commonly used personality questionnaires in healthy human subjects. Study designs covered include twin, linkage, candidate gene association studies, genome‐wide association studies and polygenic analyses. Findings from genetic studies of personality have furthered our understanding about the genetic etiology of personality, which, like neuropsychiatric diseases themselves, is highly polygenic. Polygenic analyses have showed genetic correlations between personality and psychopathology, confirming that genetic studies of personality can help to elucidate the etiology of several neuropsychiatric diseases.
AbstractList Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder. Despite considerable efforts over the past several decades, the genetic variants that influence personality are only beginning to be identified. We review these recent and increasingly rapid developments, which focus on the assessment of personality via several commonly used personality questionnaires in healthy human subjects. Study designs covered include twin, linkage, candidate gene association studies, genome-wide association studies and polygenic analyses. Findings from genetic studies of personality have furthered our understanding about the genetic etiology of personality, which, like neuropsychiatric diseases themselves, is highly polygenic. Polygenic analyses have showed genetic correlations between personality and psychopathology, confirming that genetic studies of personality can help to elucidate the etiology of several neuropsychiatric diseases.Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder. Despite considerable efforts over the past several decades, the genetic variants that influence personality are only beginning to be identified. We review these recent and increasingly rapid developments, which focus on the assessment of personality via several commonly used personality questionnaires in healthy human subjects. Study designs covered include twin, linkage, candidate gene association studies, genome-wide association studies and polygenic analyses. Findings from genetic studies of personality have furthered our understanding about the genetic etiology of personality, which, like neuropsychiatric diseases themselves, is highly polygenic. Polygenic analyses have showed genetic correlations between personality and psychopathology, confirming that genetic studies of personality can help to elucidate the etiology of several neuropsychiatric diseases.
Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder. Despite considerable efforts over the past several decades, the genetic variants that influence personality are only beginning to be identified. We review these recent and increasingly rapid developments, which focus on the assessment of personality via several commonly used personality questionnaires in healthy human subjects. Study designs covered include twin, linkage, candidate gene association studies, genome-wide association studies and polygenic analyses. Findings from genetic studies of personality have furthered our understanding about the genetic etiology of personality, which, like neuropsychiatric diseases themselves, is highly polygenic. Polygenic analyses have showed genetic correlations between personality and psychopathology, confirming that genetic studies of personality can help to elucidate the etiology of several neuropsychiatric diseases.
Personality traits are the relatively enduring patterns of thoughts, feelings, and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have demonstrated that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria (RDoC) characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder (MDD). Despite considerable efforts over the past several decades, the genetic variants that influence personality are only beginning to be identified. We review these recent and increasingly rapid developments, which focus on the assessment of personality via several commonly used personality questionnaires in healthy human subjects. Study designs covered include twin, linkage, candidate gene association studies, genome-wide association studies (GWAS) and polygenic analyses. Findings from genetic studies of personality have furthered our understanding about the genetic etiology of personality, which, like neuropsychiatric diseases themselves, is highly polygenic. Polygenic analyses have demonstrated genetic correlations between personality and psychopathology, confirming that genetic studies of personality can help to elucidate the etiology of several neuropsychiatric diseases.
Genome‐wide association studies hits (log10 transformed) discovered as a function of sample size and personality trait. Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder. Despite considerable efforts over the past several decades, the genetic variants that influence personality are only beginning to be identified. We review these recent and increasingly rapid developments, which focus on the assessment of personality via several commonly used personality questionnaires in healthy human subjects. Study designs covered include twin, linkage, candidate gene association studies, genome‐wide association studies and polygenic analyses. Findings from genetic studies of personality have furthered our understanding about the genetic etiology of personality, which, like neuropsychiatric diseases themselves, is highly polygenic. Polygenic analyses have showed genetic correlations between personality and psychopathology, confirming that genetic studies of personality can help to elucidate the etiology of several neuropsychiatric diseases.
Author Sanchez‐Roige, S.
Gray, J. C.
Palmer, A. A.
Chen, C.‐H.
MacKillop, J.
AuthorAffiliation 4 Department of Radiology, University of California San Diego, La Jolla, CA, 92093, USA
5 Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA
3 Peter Boris Centre for Addictions Research, McMaster University/St. Joseph’s Healthcare Hamilton, Hamilton, ON L8N 3K7, Canada; Homewood Research Institute, Guelph, ON N1E 6K9, Canada
1 Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
2 Center for Deployment Psychology, Uniformed Services University, Bethesda, MD, 20814
AuthorAffiliation_xml – name: 1 Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
– name: 5 Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA
– name: 3 Peter Boris Centre for Addictions Research, McMaster University/St. Joseph’s Healthcare Hamilton, Hamilton, ON L8N 3K7, Canada; Homewood Research Institute, Guelph, ON N1E 6K9, Canada
– name: 2 Center for Deployment Psychology, Uniformed Services University, Bethesda, MD, 20814
– name: 4 Department of Radiology, University of California San Diego, La Jolla, CA, 92093, USA
Author_xml – sequence: 1
  givenname: S.
  orcidid: 0000-0001-6137-5699
  surname: Sanchez‐Roige
  fullname: Sanchez‐Roige, S.
  organization: University of California San Diego
– sequence: 2
  givenname: J. C.
  surname: Gray
  fullname: Gray, J. C.
  organization: Uniformed Services University
– sequence: 3
  givenname: J.
  surname: MacKillop
  fullname: MacKillop, J.
  organization: McMaster University/St. Joseph's Healthcare Hamilton
– sequence: 4
  givenname: C.‐H.
  surname: Chen
  fullname: Chen, C.‐H.
  organization: University of California San Diego
– sequence: 5
  givenname: A. A.
  orcidid: 0000-0003-3634-0747
  surname: Palmer
  fullname: Palmer, A. A.
  email: aap@ucsd.edu
  organization: University of California San Diego
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29152902$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society
2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society
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– notice: 2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society
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ISSN 1601-1848
1601-183X
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Issue 3
Keywords GWAS
TPQ
conscientiousness
personality
gene
openness
EPQ
neuroticism
NEO
extraversion
agreeableness
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
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Authors’ Contribution
SSR wrote the manuscript; AAP, CHC, JCG, JM edited the manuscript.
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0000-0003-3634-0747
OpenAccessLink https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/gbb.12439
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PublicationTitle Genes, brain and behavior
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  doi: 10.1037/0022-3514.66.4.762
– ident: e_1_2_12_73_1
  doi: 10.1016/j.biopsycho.2010.07.018
– ident: e_1_2_12_31_1
  doi: 10.1111/j.1467-6494.1997.tb00324.x
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Snippet Genome‐wide association studies hits (log10 transformed) discovered as a function of sample size and personality trait. Personality traits are the relatively...
Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain...
Personality traits are the relatively enduring patterns of thoughts, feelings, and behaviors that reflect the tendency to respond in certain ways under certain...
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StartPage e12439
SubjectTerms agreeableness
conscientiousness
EPQ
Etiology
extraversion
Family - psychology
Family studies
gene
Genetic analysis
Genetic diversity
Genetic Linkage
Genetic Variation
Genome-wide association studies
Genome-Wide Association Study - methods
Genomes
Genotype & phenotype
GWAS
Humans
Mental depression
Mental disorders
Multifactorial Inheritance - genetics
NEO
Neurosis
neuroticism
openness
Personality
Personality - genetics
Personality Inventory
Personality traits
Polygenic inheritance
Polymorphism, Single Nucleotide - genetics
Psychopathology
Risk Factors
Self Report
Surveys and Questionnaires
TPQ
Transcriptome - genetics
Twins - genetics
Title The genetics of human personality
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fgbb.12439
https://www.ncbi.nlm.nih.gov/pubmed/29152902
https://www.proquest.com/docview/2019624275
https://www.proquest.com/docview/1966442689
https://pubmed.ncbi.nlm.nih.gov/PMC7012279
Volume 17
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