A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose

N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patien...

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Veröffentlicht in:	Clinical and translational science Jg. 14; H. 4; S. 1476 - 1489
Hauptverfasser:	Dear, James W, Ng, Mei Li, Bateman, D. Nicholas, Leroy Sivappiragasam, Pakkiri, Choi, Hyungwon, Khoo, Benjamin Bing Jie, Ibrahim, Baharudin, Drum, Chester Lee
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States John Wiley & Sons, Inc 01.07.2021 John Wiley and Sons Inc Wiley
Schlagworte:	Acetaminophen Acetaminophen - pharmacokinetics Acetaminophen - poisoning Acetylcysteine Acetylcysteine - administration & dosage Adult Alanine Alanine transaminase Analgesics Antidotes - administration & dosage Antioxidants Biomarkers Biomarkers - blood Biomarkers - metabolism Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - prevention & control Clinical trials Cysteine Drug Administration Schedule Drug Monitoring - methods Drug Overdose - blood Drug Overdose - drug therapy Drug Overdose - etiology Female Humans Infusions, Intravenous Liquid chromatography Liver Male Mass spectroscopy Metabolism Metabolites Metabolomics Middle Aged Mitochondria Nonsteroidal anti-inflammatory drugs Overdose Oxidation-Reduction - drug effects Oxidative stress Paracetamol Patients Plasma Regulatory agencies ROC Curve Sulfhydryl Compounds - blood Sulfhydryl Compounds - metabolism United Kingdom > UK Scotland
ISSN:	1752-8054, 1752-8062, 1752-8062
Online-Zugang:	Volltext
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